LOCUS       NM_001287174            4924 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens ATP binding cassette subfamily C member 8 (ABCC8),
            transcript variant 1, mRNA.
ACCESSION   NM_001287174 XM_005253088
VERSION     NM_001287174.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4924)
  AUTHORS   Patton,B.L., Zhu,P., ElSheikh,A., Driggers,C.M. and Shyng,S.L.
  TITLE     Dynamic duo: Kir6 and SUR in KATP channel structure and function
  JOURNAL   Channels (Austin) 18 (1), 2327708 (2024)
   PUBMED   38489043
  REMARK    GeneRIF: Dynamic duo: Kir6 and SUR in KATP channel structure and
            function.
            Review article
REFERENCE   2  (bases 1 to 4924)
  AUTHORS   Butnariu,L.I., Bizim,D.A., Paduraru,G., Paduraru,L., Moisa,S.M.,
            Popa,S., Gimiga,N., Ghiga,G., Badescu,M.C., Lupu,A., Vasiliu,I. and
            Trandafir,L.M.
  TITLE     Congenital Hyperinsulinism Caused by Mutations in ABCC8 Gene
            Associated with Early-Onset Neonatal Hypoglycemia: Genetic
            Heterogeneity Correlated with Phenotypic Variability
  JOURNAL   Int J Mol Sci 25 (10), 5533 (2024)
   PUBMED   38791571
  REMARK    GeneRIF: Congenital Hyperinsulinism Caused by Mutations in ABCC8
            Gene Associated with Early-Onset Neonatal Hypoglycemia: Genetic
            Heterogeneity Correlated with Phenotypic Variability.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4924)
  AUTHORS   Alp,E., Doguizi,S., Mutlu Icduygu,F., Akgun,E., Sekeroglu,M.A. and
            Ozer,M.A.
  TITLE     An analysis of the relationship between ABCC8 and KCNJ11 gene
            polymorphisms and diabetic retinopathy in Turkish population
  JOURNAL   Ophthalmic Genet 45 (2), 126-132 (2024)
   PUBMED   38411150
  REMARK    GeneRIF: An analysis of the relationship between ABCC8 and KCNJ11
            gene polymorphisms and diabetic retinopathy in Turkish population.
REFERENCE   4  (bases 1 to 4924)
  AUTHORS   Bryan,J., Munoz,A., Zhang,X., Dufer,M., Drews,G., Krippeit-Drews,P.
            and Aguilar-Bryan,L.
  TITLE     ABCC8 and ABCC9: ABC transporters that regulate K+ channels
  JOURNAL   Pflugers Arch 453 (5), 703-718 (2007)
   PUBMED   16897043
  REMARK    Review article
REFERENCE   5  (bases 1 to 4924)
  AUTHORS   Inagaki,N., Gonoi,T., Clement,J.P. 4th, Namba,N., Inazawa,J.,
            Gonzalez,G., Aguilar-Bryan,L., Seino,S. and Bryan,J.
  TITLE     Reconstitution of IKATP: an inward rectifier subunit plus the
            sulfonylurea receptor
  JOURNAL   Science 270 (5239), 1166-1170 (1995)
   PUBMED   7502040
REFERENCE   6  (bases 1 to 4924)
  AUTHORS   Thomas,P.M., Cote,G.J., Wohllk,N., Haddad,B., Mathew,P.M., Rabl,W.,
            Aguilar-Bryan,L., Gagel,R.F. and Bryan,J.
  TITLE     Mutations in the sulfonylurea receptor gene in familial persistent
            hyperinsulinemic hypoglycemia of infancy
  JOURNAL   Science 268 (5209), 426-429 (1995)
   PUBMED   7716548
REFERENCE   7  (bases 1 to 4924)
  AUTHORS   Aguilar-Bryan,L., Nichols,C.G., Wechsler,S.W., Clement,J.P. 4th,
            Boyd,A.E. 3rd, Gonzalez,G., Herrera-Sosa,H., Nguy,K., Bryan,J. and
            Nelson,D.A.
  TITLE     Cloning of the beta cell high-affinity sulfonylurea receptor: a
            regulator of insulin secretion
  JOURNAL   Science 268 (5209), 423-426 (1995)
   PUBMED   7716547
REFERENCE   8  (bases 1 to 4924)
  AUTHORS   Naylor,R., Knight Johnson,A. and del Gaudio,D.
  TITLE     Maturity-Onset Diabetes of the Young Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   29792621
REFERENCE   9  (bases 1 to 4924)
  AUTHORS   De Leon,D.D. and Pinney,S.E.
  TITLE     Permanent Neonatal Diabetes Mellitus
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301620
REFERENCE   10 (bases 1 to 4924)
  AUTHORS   Gillis,D.
  TITLE     Nonsyndromic Genetic Hyperinsulinism Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301549
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124798.5, AF087138.1,
            R84665.1, BU950000.1, BM352492.1 and BM313666.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 14, 2021 this sequence version replaced NM_001287174.2.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra- and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
            protein is a member of the MRP subfamily which is involved in
            multi-drug resistance. This protein functions as a modulator of
            ATP-sensitive potassium channels and insulin release. Mutations in
            the ABCC8 gene and deficiencies in the encoded protein have been
            observed in patients with hyperinsulinemic hypoglycemia of infancy,
            an autosomal recessive disorder of unregulated and high insulin
            secretion. Mutations have also been associated with
            non-insulin-dependent diabetes mellitus type II, an autosomal
            dominant disease of defective insulin secretion. Alternatively
            spliced transcript variants have been found for this gene.
            [provided by RefSeq, Jul 2020].
            
            Transcript Variant: This variant (1) uses two alternate in-frame
            splice sites in the 5' coding region compared to variant 3. The
            encoded isoform (1) is shorter than isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.123829.1,
                                           SRR1803616.34281.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145313 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AC124798.5         126650-126702       c
            54-1754             AF087138.1         20-1720
            1755-1755           R84665.1           78-78
            1756-2291           AF087138.1         1722-2257
            2292-2327           BU950000.1         96-131
            2328-4176           AF087138.1         2291-4139
            4177-4177           BM352492.1         34-34               c
            4178-4863           AF087138.1         4141-4826
            4864-4924           BM313666.1         15-75               c
FEATURES             Location/Qualifiers
     source          1..4924
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..4924
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /note="ATP binding cassette subfamily C member 8"
                     /db_xref="GeneID:6833"
                     /db_xref="HGNC:HGNC:59"
                     /db_xref="MIM:600509"
     exon            1..217
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..4818
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sulfonylurea receptor (hyperinsulinemia); ATP-binding
                     cassette transporter sub-family C member 8; sulfonylurea
                     receptor 1; ATP-binding cassette, sub-family C (CFTR/MRP),
                     member 8"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family C member 8
                     isoform 1"
                     /protein_id="NP_001274103.1"
                     /db_xref="CCDS:CCDS73264.1"
                     /db_xref="GeneID:6833"
                     /db_xref="HGNC:HGNC:59"
                     /db_xref="MIM:600509"
                     /translation="MPLAFCGSENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITF
                     PILFIGWGSQSSKVHIHHSTWLHFPGHNLRWILTFMLLFVLVCEIAEGILSDGVTESH
                     HLHLYMPAGMAFMAAVTSVVYYHNIETSNFPKLLIALLVYWTLAFITKTIKFVKFLDH
                     AIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKTPREVKPPEDLQDLGVRFL
                     QPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRK
                     DIQGTQGARAIWQALSHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENDVF
                     QPKTQFLGVYFVSSQEFLANAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQ
                     TKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVI
                     LLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKL
                     LKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVGHVSFF
                     KEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQC
                     APHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIM
                     GGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWS
                     SSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQR
                     YKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDP
                     FSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTL
                     KDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQGLSRAMSSRDGLLQDEEE
                     EEEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQLLKHMVLVAI
                     DYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTVEW
                     TGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRS
                     TLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHF
                     AETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLI
                     AAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLK
                     TEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGIC
                     GRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTI
                     RFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLAR
                     AFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVL
                     KRGAILEFDKPEKLLSRKDSVFASFVRADK"
     exon            218..359
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            360..481
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            482..648
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            649..891
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1080
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1245
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1401
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1536
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1699
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1740
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1886
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..1992
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2109
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2185
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2291
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2327
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2363
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2462
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2547
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2628
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2766
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..2892
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2893..2992
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3234
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3235..3401
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3402..3471
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3472..3629
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3630..3722
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3723..3825
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3826..3939
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3940..4060
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4061..4191
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4192..4270
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4271..4379
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4380..4483
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4484..4617
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4618..4680
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4681..4924
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4900..4905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /note="hexamer: AATAAA"
     polyA_site      4924
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /note="major polyA site"
ORIGIN      
        1 agaggcgcgg caggcgcgcg gagccagcgg agccagctga gcccgagccc agcccgcgcc
       61 cgcgccgcca tgcccctggc cttctgcggc agcgagaacc actcggccgc ctaccgggtg
      121 gaccaggggg tcctcaacaa cggctgcttt gtggacgcgc tcaacgtggt gccgcacgtc
      181 ttcctactct tcatcacctt ccccatcctc ttcattggat ggggaagtca gagctccaag
      241 gtgcacatcc accacagcac atggcttcat ttccctgggc acaacctgcg gtggatcctg
      301 accttcatgc tgctcttcgt cctggtgtgt gagattgcag agggcatcct gtctgatggg
      361 gtgaccgaat cccaccatct gcacctgtac atgccagccg ggatggcgtt catggctgct
      421 gtcacctccg tggtctacta tcacaacatc gagacttcca acttccccaa gctgctaatt
      481 gccctgctgg tgtattggac cctggccttc atcaccaaga ccatcaagtt tgtcaagttc
      541 ttggaccacg ccatcggctt ctcgcagcta cgcttctgcc tcacagggct gctggtgatc
      601 ctctatggga tgctgctcct cgtggaggtc aatgtcatca gggtgaggag atacatcttc
      661 ttcaagacac cgagggaggt gaagcctccc gaggacctgc aagacctggg ggtacgcttc
      721 ctgcagccct tcgtgaatct gctgtccaaa ggcacctact ggtggatgaa cgccttcatc
      781 aagactgccc acaagaagcc catcgacttg cgagccatcg ggaagctgcc catcgccatg
      841 agggccctca ccaactacca acggctctgc gaggcctttg acgcccaggt gcggaaggac
      901 attcagggca ctcaaggtgc ccgggccatc tggcaggcac tcagccatgc cttcgggagg
      961 cgcctggtcc tcagcagcac tttccgcatc ttggccgacc tgctgggctt cgccgggcca
     1021 ctgtgcatct ttgggatcgt ggaccacctt gggaaggaga acgacgtctt ccagcccaag
     1081 acacaatttc tcggggttta ctttgtctca tcccaagagt tccttgccaa tgcctacgtc
     1141 ttagctgtgc ttctgttcct tgccctccta ctgcaaagga catttctgca agcatcctac
     1201 tatgtggcca ttgaaactgg aattaacttg agaggagcaa tacagaccaa gatttacaat
     1261 aaaattatgc acctgtccac ctccaacctg tccatgggag aaatgactgc tggacagatc
     1321 tgtaatctgg ttgccatcga caccaatcag ctcatgtggt ttttcttctt gtgcccaaac
     1381 ctctgggcta tgccagtaca gatcattgtg ggtgtgattc tcctctacta catactcgga
     1441 gtcagtgcct taattggagc agctgtcatc attctactgg ctcctgtcca gtacttcgtg
     1501 gccaccaagc tgtctcaggc ccagcggagc acactggagt attccaatga gcggctgaag
     1561 cagaccaacg agatgctccg cggcatcaag ctgctgaagc tgtacgcctg ggagaacatc
     1621 ttccgcacgc gggtggagac gacccgcagg aaggagatga ccagcctcag ggcctttgcc
     1681 atctatacct ccatctccat tttcatgaac acggccatcc ccattgcagc tgtcctcata
     1741 actttcgtgg gccacgtcag cttcttcaaa gaggccgact tctcgccctc cgtggccttt
     1801 gcctccctct ccctcttcca tatcttggtc acaccgctgt tcctgctgtc cagtgtggtc
     1861 cgatctaccg tcaaagctct agtgagcgtg caaaagctaa gcgagttcct gtccagtgca
     1921 gagatccgtg aggagcagtg tgccccccat gagcccacac ctcagggccc agccagcaag
     1981 taccaggcgg tgcccctcag ggttgtgaac cgcaagcgtc cagcccggga ggattgtcgg
     2041 ggcctcaccg gcccactgca gagcctggtc cccagtgcag atggcgatgc tgacaactgc
     2101 tgtgtccaga tcatgggagg ctacttcacg tggaccccag atggaatccc cacactgtcc
     2161 aacatcacca ttcgtatccc ccgaggccag ctgactatga tcgtggggca ggtgggctgc
     2221 ggcaagtcct cgctccttct agccgcactg ggggagatgc agaaggtctc aggggctgtc
     2281 ttctggagca gcagccttcc tgacagcgag ataggagagg accccagccc agagcgggag
     2341 acagcgaccg acttggatat caggaagaga ggccccgtgg cctatgcttc gcagaaacca
     2401 tggctgctaa atgccactgt ggaggagaac atcatctttg agagtccctt caacaaacaa
     2461 cggtacaaga tggtcattga agcctgctct ctgcagccag acatcgacat cctgccccat
     2521 ggagaccaga cccagattgg ggaacggggc atcaacctgt ctggtggtca acgccagcga
     2581 atcagtgtgg cccgagccct ctaccagcac gccaacgttg tcttcttgga tgaccccttc
     2641 tcagctctgg atatccatct gagtgaccac ttaatgcagg ccggcatcct tgagctgctc
     2701 cgggacgaca agaggacagt ggtcttagtg acccacaagc tacagtacct gccccatgca
     2761 gactggatca ttgccatgaa ggatggcacc atccagaggg agggtaccct caaggacttc
     2821 cagaggtctg aatgccagct ctttgagcac tggaagaccc tcatgaaccg acaggaccaa
     2881 gagctggaga aggagactgt cacagagaga aaagccacag agccacccca gggcctatct
     2941 cgtgccatgt cctcgaggga tggccttctg caggatgagg aagaggagga agaggaggca
     3001 gctgagagcg aggaggatga caacctgtcg tccatgctgc accagcgtgc tgagatccca
     3061 tggcgagcct gcgccaagta cctgtcctcc gccggcatcc tgctcctgtc gttgctggtc
     3121 ttctcacagc tgctcaagca catggtcctg gtggccatcg actactggct ggccaagtgg
     3181 accgacagcg ccctgaccct gacccctgca gccaggaact gctccctcag ccaggagtgc
     3241 accctcgacc agactgtcta tgccatggtg ttcacggtgc tctgcagcct gggcattgtg
     3301 ctgtgcctcg tcacgtctgt cactgtggag tggacagggc tgaaggtggc caagagactg
     3361 caccgcagcc tgctaaaccg gatcatccta gcccccatga ggttttttga gaccacgccc
     3421 cttgggagca tcctgaacag attttcatct gactgtaaca ccatcgacca gcacatccca
     3481 tccacgctgg agtgcctgag ccgctccacc ctgctctgtg tctcagccct ggccgtcatc
     3541 tcctatgtca cacctgtgtt cctcgtggcc ctcttgcccc tggccatcgt gtgctacttc
     3601 atccagaagt acttccgggt ggcgtccagg gacctgcagc agctggatga caccacccag
     3661 cttccacttc tctcacactt tgccgaaacc gtagaaggac tcaccaccat ccgggccttc
     3721 aggtatgagg cccggttcca gcagaagctt ctcgaataca cagactccaa caacattgct
     3781 tccctcttcc tcacagctgc caacagatgg ctggaagtcc gaatggagta catcggtgca
     3841 tgtgtggtgc tcatcgcagc ggtgacctcc atctccaact ccctgcacag ggagctctct
     3901 gctggcctgg tgggcctggg ccttacctac gccctaatgg tctccaacta cctcaactgg
     3961 atggtgagga acctggcaga catggagctc cagctggggg ctgtgaagcg catccatggg
     4021 ctcctgaaaa ccgaggcaga gagctacgag gggctcctgg caccatcgct gatcccaaag
     4081 aactggccag accaagggaa gatccagatc cagaacctga gcgtgcgcta cgacagctcc
     4141 ctgaagccgg tgctgaagca cgtcaatgcc ctcatcgccc ctggacagaa gatcgggatc
     4201 tgcggccgca ccggcagtgg gaagtcctcc ttctctcttg ccttcttccg catggtggac
     4261 acgttcgaag ggcacatcat cattgatggc attgacatcg ccaaactgcc gctgcacacc
     4321 ctgcgctcac gcctctccat catcctgcag gaccccgtcc tcttcagcgg caccatccga
     4381 tttaacctgg accctgagag gaagtgctca gatagcacac tgtgggaggc cctggaaatc
     4441 gcccagctga agctggtggt gaaggcactg ccaggaggcc tcgatgccat catcacagaa
     4501 ggcggggaga atttcagcca gggacagagg cagctgttct gcctggcccg ggccttcgtg
     4561 aggaagacca gcatcttcat catggacgag gccacggctt ccattgacat ggccacggaa
     4621 aacatcctcc aaaaggtggt gatgacagcc ttcgcagacc gcactgtggt caccatcgcg
     4681 catcgagtgc acaccatcct gagtgcagac ctggtgatcg tcctgaagcg gggtgccatc
     4741 cttgagttcg ataagccaga gaagctgctc agccggaagg acagcgtctt cgcctccttc
     4801 gtccgtgcag acaagtgacc tgccagagcc caagtgccat cccacattcg gaccctgccc
     4861 atacccctgc ctgggttttc taactgtaaa tcacttgtaa ataaatagat ttgattattt
     4921 ccta
//
