LOCUS       NM_001171               5140 bp    mRNA    linear   PRI 30-APR-2025
DEFINITION  Homo sapiens ATP binding cassette subfamily C member 6 (ABCC6),
            transcript variant 1, mRNA.
ACCESSION   NM_001171 XM_936351
VERSION     NM_001171.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5140)
  AUTHORS   Schott,C., Dilliott,A.A., Wang,J., McIntyre,A.D., Son,S.,
            Colaiacovo,S., Baker,C., Gunaratnam,L., House,A.A., Susan
            Huang,S.H., Iyer,H., Johnson,J., Lotfy,K., Masellis,M., Munoz,D.P.,
            Rehman,F., Roshanov,P.S., Swartz,R.H., Weir,M.A., Hegele,R.A. and
            Connaughton,D.M.
  TITLE     Vascular calcification in chronic kidney disease associated with
            pathogenic variants in ABCC6
  JOURNAL   Gene 927, 148731 (2024)
   PUBMED   38944164
  REMARK    GeneRIF: Vascular calcification in chronic kidney disease
            associated with pathogenic variants in ABCC6.
REFERENCE   2  (bases 1 to 5140)
  AUTHORS   Dandurand,J., Monne,M., Samouillan,V., Rosa,M., Laurita,A.,
            Pistone,A., Bisaccia,D., Matera,I., Bisaccia,F. and Ostuni,A.
  TITLE     The 75-99 C-Terminal Peptide of URG7 Protein Promotes
            alpha-Synuclein Disaggregation
  JOURNAL   Int J Mol Sci 25 (2), 1135 (2024)
   PUBMED   38256207
  REMARK    GeneRIF: The 75-99 C-Terminal Peptide of URG7 Protein Promotes
            alpha-Synuclein Disaggregation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5140)
  AUTHORS   Liu,Y., Huang,Y., Zhang,X., Ma,X., He,X., Gan,C., Zou,X., Wang,S.,
            Shu,K., Lei,T. and Zhang,H.
  TITLE     CircZXDC Promotes Vascular Smooth Muscle Cell Transdifferentiation
            via Regulating miRNA-125a-3p/ABCC6 in Moyamoya Disease
  JOURNAL   Cells 11 (23), 3792 (2022)
   PUBMED   36497052
  REMARK    GeneRIF: CircZXDC Promotes Vascular Smooth Muscle Cell
            Transdifferentiation via Regulating miRNA-125a-3p/ABCC6 in Moyamoya
            Disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5140)
  AUTHORS   Uitto,J.
  TITLE     The gene family of ABC transporters--novel mutations, new
            phenotypes
  JOURNAL   Trends Mol Med 11 (8), 341-343 (2005)
   PUBMED   15996518
  REMARK    Review article
REFERENCE   5  (bases 1 to 5140)
  AUTHORS   Belinsky,M.G. and Kruh,G.D.
  TITLE     MOAT-E (ARA) is a full-length MRP/cMOAT subfamily transporter
            expressed in kidney and liver
  JOURNAL   Br J Cancer 80 (9), 1342-1349 (1999)
   PUBMED   10424734
REFERENCE   6  (bases 1 to 5140)
  AUTHORS   Allikmets,R., Gerrard,B., Hutchinson,A. and Dean,M.
  TITLE     Characterization of the human ABC superfamily: isolation and
            mapping of 21 new genes using the expressed sequence tags database
  JOURNAL   Hum Mol Genet 5 (10), 1649-1655 (1996)
   PUBMED   8894702
REFERENCE   7  (bases 1 to 5140)
  AUTHORS   Ziegler,S.G., Gahl,W.A. and Ferreira,C.R.
  TITLE     Generalized Arterial Calcification of Infancy
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   25392903
REFERENCE   8  (bases 1 to 5140)
  AUTHORS   Terry,S.F. and Uitto,J.
  TITLE     Pseudoxanthoma Elasticum
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301292
REFERENCE   9  (bases 1 to 5140)
  AUTHORS   Neldner,K.H.
  TITLE     Pseudoxanthoma elasticum
  JOURNAL   Clin Dermatol 6 (1), 1-159 (1988)
   PUBMED   3359381
REFERENCE   10 (bases 1 to 5140)
  AUTHORS   Pope,F.M.
  TITLE     Autosomal dominant pseudoxanthoma elasticum
  JOURNAL   J Med Genet 11 (2), 152-157 (1974)
   PUBMED   4841083
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC136624.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 1, 2020 this sequence version replaced NM_001171.5.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra- and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The
            encoded protein, a member of the MRP subfamily, is involved in
            multi-drug resistance. Mutations in this gene cause pseudoxanthoma
            elasticum. Alternatively spliced transcript variants that encode
            different proteins have been described for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.3705587.1, AF076622.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000205557.12/ ENSP00000205557.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AC136624.3         79762-79857
            97-279              AC136624.3         81425-81607
            280-405             AC136624.3         83309-83434
            406-534             AC136624.3         83574-83702
            535-660             AC136624.3         88807-88932
            661-722             AC136624.3         91010-91071
            723-854             AC136624.3         94397-94528
            855-1058            AC136624.3         99643-99846
            1059-1236           AC136624.3         101078-101255
            1237-1398           AC136624.3         105074-105235
            1399-1491           AC136624.3         110334-110426
            1492-1695           AC136624.3         112889-113092
            1696-1839           AC136624.3         114282-114425
            1840-1927           AC136624.3         116045-116132
            1928-2003           AC136624.3         118222-118297
            2004-2130           AC136624.3         120326-120452
            2131-2307           AC136624.3         120668-120844
            2308-2475           AC136624.3         124291-124458
            2476-2650           AC136624.3         125630-125804
            2651-2726           AC136624.3         127270-127345
            2727-2847           AC136624.3         129852-129972
            2848-3055           AC136624.3         133403-133610
            3056-3366           AC136624.3         137323-137633
            3367-3566           AC136624.3         140064-140263
            3567-3693           AC136624.3         141692-141818
            3694-3795           AC136624.3         143673-143774
            3796-3942           AC136624.3         145447-145593
            3943-4101           AC136624.3         148225-148383
            4102-4268           AC136624.3         148462-148628
            4269-4463           AC136624.3         152484-152678
            4464-5140           AC136624.3         153015-153691
FEATURES             Location/Qualifiers
     source          1..5140
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.11"
     gene            1..5140
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /note="ATP binding cassette subfamily C member 6"
                     /db_xref="GeneID:368"
                     /db_xref="HGNC:HGNC:57"
                     /db_xref="MIM:603234"
     exon            1..96
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..4572
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /EC_number="7.6.2.3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     multidrug resistance-associated protein 6; anthracycline
                     resistance-associated protein; ATP-binding cassette,
                     sub-family C (CFTR/MRP), member 6; multi-specific organic
                     anion transporter E"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family C member 6
                     isoform 1"
                     /protein_id="NP_001162.5"
                     /db_xref="CCDS:CCDS10568.1"
                     /db_xref="GeneID:368"
                     /db_xref="HGNC:HGNC:57"
                     /db_xref="MIM:603234"
                     /translation="MAAPAEPCAGQGVWNQTEPEPAATSLLSLCFLRTAGVWVPPMYL
                     WVLGPIYLLFIHHHGRGYLRMSPLFKAKMVLGFALIVLCTSSVAVALWKIQQGTPEAP
                     EFLIHPTVWLTTMSFAVFLIHTERKKGVQSSGVLFGYWLLCFVLPATNAAQQASGAGF
                     QSDPVRHLSTYLCLSLVVAQFVLSCLADQPPFFPEDPQQSNPCPETGAAFPSKATFWW
                     VSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAARRHNKAIAFKRKG
                     GSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSL
                     FLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRK
                     VLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGP
                     SALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEG
                     AFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEK
                     AFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPGVVDSSSSGSAA
                     GKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSK
                     VEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPE
                     GIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGP
                     GGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALMCLLDQARQ
                     PGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPD
                     RAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWA
                     DDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVR
                     SPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLAT
                     VAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPF
                     VAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGF
                     SVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQG
                     GQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAE
                     GGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETV
                     QLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGT
                     ELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFY
                     RLAQESGLV"
     exon            97..279
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            280..405
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            406..534
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            535..660
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            661..722
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            723..854
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1058
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1236
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1398
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1491
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1695
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1839
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1927
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2003
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2130
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2307
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2475
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2650
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2726
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..2847
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2848..3055
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3366
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3367..3566
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3567..3693
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3694..3795
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3796..3942
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3943..4101
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4102..4268
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4269..4463
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4464..5140
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5140
                     /gene="ABCC6"
                     /gene_synonym="ABC34; ARA; EST349056; GACI2; MLP1; MOAT-E;
                     MOATE; MRP6; PXE; PXE1; URG7"
                     /note="major polyA site"
ORIGIN      
        1 agtctgccca gagacttagc gacagacaga cgctgggacc cacgacgaca gaaggcgccg
       61 atggccgcgc ctgctgagcc ctgcgcgggg cagggggtct ggaaccagac agagcctgaa
      121 cctgccgcca ccagcctgct gagcctgtgc ttcctgagaa cagcaggggt ctgggtaccc
      181 cccatgtacc tctgggtcct tggtcccatc tacctcctct tcatccacca ccatggccgg
      241 ggctacctcc ggatgtcccc actcttcaaa gccaagatgg tgcttggatt cgccctcata
      301 gtcctgtgta cctccagcgt ggctgtcgct ctttggaaaa tccaacaggg aacgcctgag
      361 gccccagaat tcctcattca tcctactgtg tggctcacca cgatgagctt cgcagtgttc
      421 ctgattcaca ccgagaggaa aaagggagtc cagtcatctg gagtgctgtt tggttactgg
      481 cttctctgct ttgtcttgcc agctaccaac gctgcccagc aggcctccgg agcgggcttc
      541 cagagcgacc ctgtccgcca cctgtccacc tacctatgcc tgtctctggt ggtggcacag
      601 tttgtgctgt cctgcctggc ggatcaaccc cccttcttcc ctgaagaccc ccagcagtct
      661 aacccctgtc cagagactgg ggcagccttc ccctccaaag ccacgttctg gtgggtttct
      721 ggcctggtct ggaggggata caggaggcca ctgagaccaa aagacctctg gtcgcttggg
      781 agagaaaact cctcagaaga acttgtttcc cggcttgaaa aggagtggat gaggaaccgc
      841 agtgcagccc ggaggcacaa caaggcaata gcatttaaaa ggaaaggcgg cagtggcatg
      901 aaggctccag agaccgagcc cttcctacgg caagaaggga gccagtggcg cccactgctg
      961 aaggccatct ggcaggtgtt ccattctacc ttcctcctgg ggaccctcag cctcatcatc
     1021 agtgatgtct tcaggttcac tgtccccaag ctgctcagcc ttttcctgga gtttattggt
     1081 gatcccaagc ctccagcctg gaagggctac ctcctcgccg tgctgatgtt cctctcagcc
     1141 tgcctgcaaa cgctgtttga gcagcagaac atgtacaggc tcaaggtgct gcagatgagg
     1201 ttgcggtcgg ccatcactgg cctggtgtac agaaaggtcc tggctctgtc cagcggctcc
     1261 agaaaggcca gtgcggtggg tgatgtggtc aatctggtgt ccgtggacgt gcagcggctg
     1321 accgagagcg tcctctacct caacgggctg tggctgcctc tcgtctggat cgtggtctgc
     1381 ttcgtctatc tctggcagct cctggggccc tccgccctca ctgccatcgc tgtcttcctg
     1441 agcctcctcc ctctgaattt cttcatctcc aagaaaagga accaccatca ggaggagcaa
     1501 atgaggcaga aggactcacg ggcacggctc accagctcta tcctcaggaa ctcgaagacc
     1561 atcaagttcc atggctggga gggagccttt ctggacagag tcctgggcat ccgaggccag
     1621 gagctgggcg ccttgcggac ctccggcctc ctcttctctg tgtcgctggt gtccttccaa
     1681 gtgtctacat ttctggtcgc actggtggtg tttgctgtcc acactctggt ggccgagaat
     1741 gctatgaatg cagagaaagc ctttgtgact ctcacagttc tcaacatcct caacaaggcc
     1801 caggctttcc tgcccttctc catccactcc ctcgtccagg cccgggtgtc ctttgaccgt
     1861 ctggtcacct tcctctgcct ggaagaagtt gaccctggtg tcgtagactc aagttcctct
     1921 ggaagcgctg ccgggaagga ttgcatcacc atacacagtg ccaccttcgc ctggtcccag
     1981 gaaagccctc cctgcctcca cagaataaac ctcacggtgc cccagggctg tctgctggct
     2041 gttgtcggtc cagtgggggc agggaagtcc tccctgctgt ccgccctcct tggggagctg
     2101 tcaaaggtgg aggggttcgt gagcatcgag ggtgctgtgg cctacgtgcc ccaggaggcc
     2161 tgggtgcaga acacctctgt ggtagagaat gtgtgcttcg ggcaggagct ggacccaccc
     2221 tggctggaga gagtactaga agcctgtgcc ctgcagccag atgtggacag cttccctgag
     2281 ggaatccaca cttcaattgg ggagcagggc atgaatctct ccggaggcca gaagcagcgg
     2341 ctgagcctgg cccgggctgt atacagaaag gcagctgtgt acctgctgga tgaccccctg
     2401 gcggccctgg atgcccacgt tggccagcat gtcttcaacc aggtcattgg gcctggtgga
     2461 ctactccagg gaacaacacg gattctcgtg acgcacgcac tccacatcct gccccaggct
     2521 gattggatca tagtgctggc aaatggggcc atcgcagaga tgggttccta ccaggagctt
     2581 ctgcagagga agggggccct catgtgtctt ctggatcaag ccagacagcc aggagataga
     2641 ggagaaggag aaacagaacc tgggaccagc accaaggacc ccagaggcac ctctgcaggc
     2701 aggaggcccg agcttagacg cgagaggtcc atcaagtcag tccctgagaa ggaccgtacc
     2761 acttcagaag cccagacaga ggttcctctg gatgaccctg acagggcagg atggccagca
     2821 ggaaaggaca gcatccaata cggcagggtg aaggccacag tgcacctggc ctacctgcgt
     2881 gccgtgggca cccccctctg cctctacgca ctcttcctct tcctctgcca gcaagtggcc
     2941 tccttctgcc ggggctactg gctgagcctg tgggcggacg accctgcagt aggtgggcag
     3001 cagacgcagg cagccctgcg tggcgggatc ttcgggctcc tcggctgtct ccaagccatt
     3061 gggctgtttg cctccatggc tgcggtgctc ctaggtgggg cccgggcatc caggttgctc
     3121 ttccagaggc tcctgtggga tgtggtgcga tctcccatca gcttctttga gcggacaccc
     3181 attggtcacc tgctaaaccg cttctccaag gagacagaca cggttgacgt ggacattcca
     3241 gacaaactcc ggtccctgct gatgtacgcc tttggactcc tggaggtcag cctggtggtg
     3301 gcagtggcta ccccactggc cactgtggcc atcctgccac tgtttctcct ctacgctggg
     3361 tttcagagcc tgtatgtggt tagctcatgc cagctgagac gcttggagtc agccagctac
     3421 tcgtctgtct gctcccacat ggctgagacg ttccagggca gcacagtggt ccgggcattc
     3481 cgaacccagg ccccctttgt ggctcagaac aatgctcgcg tagatgaaag ccagaggatc
     3541 agtttcccgc gactggtggc tgacaggtgg cttgcggcca atgtggagct cctggggaat
     3601 ggcctggtgt ttgcagctgc cacgtgtgct gtgctgagca aagcccacct cagtgctggc
     3661 ctcgtgggct tctctgtctc tgctgccctc caggtgaccc agacactgca gtgggttgtt
     3721 cgcaactgga cagacctaga gaacagcatc gtgtcagtgg agcggatgca ggactatgcc
     3781 tggacgccca aggaggctcc ctggaggctg cccacatgtg cagctcagcc cccctggcct
     3841 cagggcgggc agatcgagtt ccgggacttt gggctaagat accgacctga gctcccgctg
     3901 gctgtgcagg gcgtgtcctt caagatccac gcaggagaga aggtgggcat cgttggcagg
     3961 accggggcag ggaagtcctc cctggccagt gggctgctgc ggctccagga ggcagctgag
     4021 ggtgggatct ggatcgacgg ggtccccatt gcccacgtgg ggctgcacac actgcgctcc
     4081 aggatcagca tcatccccca ggaccccatc ctgttccctg gctctctgcg gatgaacctc
     4141 gacctgctgc aggagcactc ggacgaggct atctgggcag ccctggagac ggtgcagctc
     4201 aaagccttgg tggccagcct gcccggccag ctgcagtaca agtgtgctga ccgaggcgag
     4261 gacctgagcg tgggccagaa acagctcctg tgtctggcac gtgcccttct ccggaagacc
     4321 cagatcctca tcctggacga ggctactgct gccgtggacc ctggcacgga gctgcagatg
     4381 caggccatgc tcgggagctg gtttgcacag tgcactgtgc tgctcattgc ccaccgcctg
     4441 cgctccgtga tggactgtgc ccgggttctg gtcatggaca aggggcaggt ggcagagagc
     4501 ggcagcccgg cccagctgct ggcccagaag ggcctgtttt acagactggc ccaggagtca
     4561 ggcctggtct gagccaggac cctcaaccgt accccagttg gaccagcccg cacagcctgc
     4621 agtgctggag atggaagtga cccgtggtca tcgatagctc cacacgatat tgagtctaga
     4681 cctgtgtttg ctctctggga ggaaaatggc agagaaagtg gccaattatc acagagcatc
     4741 agagccggaa ggacctagca atacacaggt ctgcccgggc agggcccatc tcgccctgtc
     4801 caccctgcag ccaatgtcaa cagcgactct cagccccgct gtactctgga ctcacctggg
     4861 ggcctcaagc acatgcccag gctcccggct agacccttaa atcagaatct ctgaggctgg
     4921 gaactgccat gctgtgtgta ctttttacaa attaacactt ttattttggg ataatcccag
     4981 actcacatgc agttaaagaa acaataatat agagagattc gtgtacttgg taccccattt
     5041 cacccaatgg taacatcttg caaaactcta ggataaagca tcacagccag ggtgttgaca
     5101 ttgacacaac aatcttgctc gatttcccgt tttacctgta
//
