LOCUS       NM_005688               5790 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens ATP binding cassette subfamily C member 5 (ABCC5),
            transcript variant 1, mRNA.
ACCESSION   NM_005688
VERSION     NM_005688.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5790)
  AUTHORS   Huang,Y., Xue,C., Bu,R., Wu,C., Li,J., Zhang,J., Chen,J., Shi,Z.,
            Chen,Y., Wang,Y. and Liu,Z.
  TITLE     Inhibition and transport mechanisms of the ABC transporter hMRP5
  JOURNAL   Nat Commun 15 (1), 4811 (2024)
   PUBMED   38844452
  REMARK    GeneRIF: Inhibition and transport mechanisms of the ABC transporter
            hMRP5.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5790)
  AUTHORS   Hou,Y., Dong,Z., Zhong,W., Yin,L., Li,X., Kuerban,G. and Huang,H.
  TITLE     FOXM1 Promotes Drug Resistance in Cervical Cancer Cells by
            Regulating ABCC5 Gene Transcription
  JOURNAL   Biomed Res Int 2022, 3032590 (2022)
   PUBMED   35141332
  REMARK    GeneRIF: FOXM1 Promotes Drug Resistance in Cervical Cancer Cells by
            Regulating ABCC5 Gene Transcription.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5790)
  AUTHORS   Huang,W., Chen,K., Lu,Y., Zhang,D., Cheng,Y., Li,L., Huang,W.,
            He,G., Liao,H., Cai,L., Tang,Y., Zhao,L. and Pan,M.
  TITLE     ABCC5 facilitates the acquired resistance of sorafenib through the
            inhibition of SLC7A11-induced ferroptosis in hepatocellular
            carcinoma
  JOURNAL   Neoplasia 23 (12), 1227-1239 (2021)
   PUBMED   34768109
  REMARK    GeneRIF: ABCC5 facilitates the acquired resistance of sorafenib
            through the inhibition of SLC7A11-induced ferroptosis in
            hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 5790)
  AUTHORS   Chen,L., Yang,Z., Cao,Y., Hu,Y., Bao,W., Wu,D., Hu,L., Xie,J. and
            Yu,H.
  TITLE     Pan-cancer analysis and single-cell analysis revealed the role of
            ABCC5 transporter in hepatocellular carcinoma
  JOURNAL   Channels (Austin) 15 (1), 541-554 (2021)
   PUBMED   34494510
  REMARK    GeneRIF: Pan-cancer analysis and single-cell analysis revealed the
            role of ABCC5 transporter in hepatocellular carcinoma.
REFERENCE   5  (bases 1 to 5790)
  AUTHORS   Odland,S.U., Ravna,A.W., Smaglyukova,N., Dietrichs,E.S. and
            Sager,G.
  TITLE     Inhibition of ABCC5-mediated cGMP transport by progesterone,
            testosterone and their analogues
  JOURNAL   J Steroid Biochem Mol Biol 213, 105951 (2021)
   PUBMED   34271023
  REMARK    GeneRIF: Inhibition of ABCC5-mediated cGMP transport by
            progesterone, testosterone and their analogues.
REFERENCE   6  (bases 1 to 5790)
  AUTHORS   Cole,S.P.
  TITLE     Re: Characterization of MOAT-C and MOAT-D, new members of the
            MRP/cMOAT subfamily of transporter proteins
  JOURNAL   J Natl Cancer Inst 91 (10), 888-889 (1999)
   PUBMED   10340910
REFERENCE   7  (bases 1 to 5790)
  AUTHORS   Belinsky,M.G., Bain,L.J., Balsara,B.B., Testa,J.R. and Kruh,G.D.
  TITLE     Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT
            subfamily of transporter proteins
  JOURNAL   J Natl Cancer Inst 90 (22), 1735-1741 (1998)
   PUBMED   9827529
REFERENCE   8  (bases 1 to 5790)
  AUTHORS   Suzuki,T., Nishio,K., Sasaki,H., Kurokawa,H., Saito-Ohara,F.,
            Ikeuchi,T., Tanabe,S., Terada,M. and Saijo,N.
  TITLE     cDNA cloning of a short type of multidrug resistance protein
            homologue, SMRP, from a human lung cancer cell line
  JOURNAL   Biochem Biophys Res Commun 238 (3), 790-794 (1997)
   PUBMED   9325169
REFERENCE   9  (bases 1 to 5790)
  AUTHORS   Kool,M., de Haas,M., Scheffer,G.L., Scheper,R.J., van Eijk,M.J.,
            Juijn,J.A., Baas,F. and Borst,P.
  TITLE     Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5,
            homologues of the multidrug resistance-associated protein gene
            (MRP1), in human cancer cell lines
  JOURNAL   Cancer Res 57 (16), 3537-3547 (1997)
   PUBMED   9270026
REFERENCE   10 (bases 1 to 5790)
  AUTHORS   Allikmets,R., Gerrard,B., Hutchinson,A. and Dean,M.
  TITLE     Characterization of the human ABC superfamily: isolation and
            mapping of 21 new genes using the expressed sequence tags database
  JOURNAL   Hum Mol Genet 5 (10), 1649-1655 (1996)
   PUBMED   8894702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY073434.1, AF104942.1,
            AB019002.1, AC068644.15, AW207515.1 and CN410200.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005688.3.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra- and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
            protein is a member of the MRP subfamily which is involved in
            multi-drug resistance. This protein functions in the cellular
            export of its substrate, cyclic nucleotides. This export
            contributes to the degradation of phosphodiesterases and possibly
            an elimination pathway for cyclic nucleotides. Studies show that
            this protein provides resistance to thiopurine anticancer drugs,
            6-mercatopurine and thioguanine, and the anti-HIV drug
            9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved
            in resistance to thiopurines in acute lymphoblastic leukemia and
            antiretroviral nucleoside analogs in HIV-infected patients.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF104942.1, U83661.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334444.11/ ENSP00000333926.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               HY073434.1         79-178
            101-1294            AF104942.1         116-1309
            1295-1310           AB019002.1         1237-1252
            1311-1891           AF104942.1         1326-1906
            1892-1892           AC068644.15        107145-107145       c
            1893-3733           AF104942.1         1908-3748
            3734-3734           AC068644.15        82196-82196         c
            3735-5005           AF104942.1         3750-5020
            5006-5363           AW207515.1         2-359
            5364-5790           CN410200.1         2-428
FEATURES             Location/Qualifiers
     source          1..5790
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.1"
     gene            1..5790
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /note="ATP binding cassette subfamily C member 5"
                     /db_xref="GeneID:10057"
                     /db_xref="HGNC:HGNC:56"
                     /db_xref="MIM:605251"
     exon            1..55
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            56..239
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            240..397
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            398..553
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            554..701
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            702..935
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1109
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1257
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1406
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1514
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1871
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1943
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2068
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2141
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2345
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2489
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2592
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2777
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2778..2924
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2925..3054
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            3055..3208
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            3209..3337
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            3338..3524
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            3525..3614
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            3615..3804
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            3805..3964
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            3965..4043
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            4044..4157
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            4158..4322
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            4323..5790
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5764..5769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /note="hexamer: AATAAA"
     polyA_site      5790
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /note="major polyA site"
ORIGIN      
        1 atgctcggga gcgtggttga gcggctggcg cggttgtcct ggagcagggg cgcaggaatt
       61 ctgatgtgaa actaacagtc tgtgagccct ggaacctcca ctcagagaag atgaaggata
      121 tcgacatagg aaaagagtat atcatcccca gtcctgggta tagaagtgtg agggagagaa
      181 ccagcacttc tgggacgcac agagaccgtg aagattccaa gttcaggaga actcgaccgt
      241 tggaatgcca agatgccttg gaaacagcag cccgagccga gggcctctct cttgatgcct
      301 ccatgcattc tcagctcaga atcctggatg aggagcatcc caagggaaag taccatcatg
      361 gcttgagtgc tctgaagccc atccggacta cttccaaaca ccagcaccca gtggacaatg
      421 ctgggctttt ttcctgtatg actttttcgt ggctttcttc tctggcccgt gtggcccaca
      481 agaaggggga gctctcaatg gaagacgtgt ggtctctgtc caagcacgag tcttctgacg
      541 tgaactgcag aagactagag agactgtggc aagaagagct gaatgaagtt gggccagacg
      601 ctgcttccct gcgaagggtt gtgtggatct tctgccgcac caggctcatc ctgtccatcg
      661 tgtgcctgat gatcacgcag ctggctggct tcagtggacc agccttcatg gtgaaacacc
      721 tcttggagta tacccaggca acagagtcta acctgcagta cagcttgttg ttagtgctgg
      781 gcctcctcct gacggaaatc gtgcggtctt ggtcgcttgc actgacttgg gcattgaatt
      841 accgaaccgg tgtccgcttg cggggggcca tcctaaccat ggcatttaag aagatcctta
      901 agttaaagaa cattaaagag aaatccctgg gtgagctcat caacatttgc tccaacgatg
      961 ggcagagaat gtttgaggca gcagccgttg gcagcctgct ggctggagga cccgttgttg
     1021 ccatcttagg catgatttat aatgtaatta ttctgggacc aacaggcttc ctgggatcag
     1081 ctgtttttat cctcttttac ccagcaatga tgtttgcatc acggctcaca gcatatttca
     1141 ggagaaaatg cgtggccgcc acggatgaac gtgtccagaa gatgaatgaa gttcttactt
     1201 acattaaatt tatcaaaatg tatgcctggg tcaaagcatt ttctcagagt gttcaaaaaa
     1261 tccgcgagga ggagcgtcgg atattggaaa aagctgggta cttccagagc atcactgtgg
     1321 gtgtggctcc cattgtggtg gtgattgcca gcgtggtgac cttctctgtt catatgaccc
     1381 tgggcttcga tctgacagca gcacaggctt tcacagtggt gacagtcttc aattccatga
     1441 cttttgcttt gaaagtaaca ccgttttcag taaagtccct ctcagaagcc tcagtggctg
     1501 ttgacagatt taagagtttg tttctaatgg aagaggttca catgataaag aacaaaccag
     1561 ccagtcctca catcaagata gagatgaaaa atgccacctt ggcatgggac tcctcccact
     1621 ccagtatcca gaactcgccc aagctgaccc ccaaaatgaa aaaagacaag agggcttcca
     1681 ggggcaagaa agagaaggtg aggcagctgc agcgcactga gcatcaggcg gtgctggcag
     1741 agcagaaagg ccacctcctc ctggacagtg acgagcggcc cagtcccgaa gaggaagaag
     1801 gcaagcacat ccacctgggc cacctgcgct tacagaggac actgcacagc atcgatctgg
     1861 agatccaaga gggtaaactg gttggaatct gtggcagtgt gggaagtgga aaaacctctc
     1921 tcatttcagc cattttaggc cagatgacgc ttctagaggg cagcattgca atcagtggaa
     1981 ccttcgctta tgtggcccag caggcctgga tcctcaatgc tactctgaga gacaacatcc
     2041 tgtttgggaa ggaatatgat gaagaaagat acaactctgt gctgaacagc tgctgcctga
     2101 ggcctgacct ggccattctt cccagcagcg acctgacgga gattggagag cgaggagcca
     2161 acctgagcgg tgggcagcgc cagaggatca gccttgcccg ggccttgtat agtgacagga
     2221 gcatctacat cctggacgac cccctcagtg ccttagatgc ccatgtgggc aaccacatct
     2281 tcaatagtgc tatccggaaa catctcaagt ccaagacagt tctgtttgtt acccaccagt
     2341 tacagtacct ggttgactgt gatgaagtga tcttcatgaa agagggctgt attacggaaa
     2401 gaggcaccca tgaggaactg atgaatttaa atggtgacta tgctaccatt tttaataacc
     2461 tgttgctggg agagacaccg ccagttgaga tcaattcaaa aaaggaaacc agtggttcac
     2521 agaagaagtc acaagacaag ggtcctaaaa caggatcagt aaagaaggaa aaagcagtaa
     2581 agccagagga agggcagctt gtgcagctgg aagagaaagg gcagggttca gtgccctggt
     2641 cagtatatgg tgtctacatc caggctgctg ggggcccctt ggcattcctg gttattatgg
     2701 cccttttcat gctgaatgta ggcagcaccg ccttcagcac ctggtggttg agttactgga
     2761 tcaagcaagg aagcgggaac accactgtga ctcgagggaa cgagacctcg gtgagtgaca
     2821 gcatgaagga caatcctcat atgcagtact atgccagcat ctacgccctc tccatggcag
     2881 tcatgctgat cctgaaagcc attcgaggag ttgtctttgt caagggcacg ctgcgagctt
     2941 cctcccggct gcatgacgag cttttccgaa ggatccttcg aagccctatg aagttttttg
     3001 acacgacccc cacagggagg attctcaaca ggttttccaa agacatggat gaagttgacg
     3061 tgcggctgcc gttccaggcc gagatgttca tccagaacgt tatcctggtg ttcttctgtg
     3121 tgggaatgat cgcaggagtc ttcccgtggt tccttgtggc agtggggccc cttgtcatcc
     3181 tcttttcagt cctgcacatt gtctccaggg tcctgattcg ggagctgaag cgtctggaca
     3241 atatcacgca gtcacctttc ctctcccaca tcacgtccag catacagggc cttgccacca
     3301 tccacgccta caataaaggg caggagtttc tgcacagata ccaggagctg ctggatgaca
     3361 accaagctcc tttttttttg tttacgtgtg cgatgcggtg gctggctgtg cggctggacc
     3421 tcatcagcat cgccctcatc accaccacgg ggctgatgat cgttcttatg cacgggcaga
     3481 ttcccccagc ctatgcgggt ctcgccatct cttatgctgt ccagttaacg gggctgttcc
     3541 agtttacggt cagactggca tctgagacag aagctcgatt cacctcggtg gagaggatca
     3601 atcactacat taagactctg tccttggaag cacctgccag aattaagaac aaggctccct
     3661 cccctgactg gccccaggag ggagaggtga cctttgagaa cgcagagatg aggtaccgag
     3721 aaaacctccc tctcgtccta aagaaagtat ccttcacgat caaacctaaa gagaagattg
     3781 gcattgtggg gcggacagga tcagggaagt cctcgctggg gatggccctc ttccgtctgg
     3841 tggagttatc tggaggctgc atcaagattg atggagtgag aatcagtgat attggccttg
     3901 ccgacctccg aagcaaactc tctatcattc ctcaagagcc ggtgctgttc agtggcactg
     3961 tcagatcaaa tttggacccc ttcaaccagt acactgaaga ccagatttgg gatgccctgg
     4021 agaggacaca catgaaagaa tgtattgctc agctacctct gaaacttgaa tctgaagtga
     4081 tggagaatgg ggataacttc tcagtggggg aacggcagct cttgtgcata gctagagccc
     4141 tgctccgcca ctgtaagatt ctgattttag atgaagccac agctgccatg gacacagaga
     4201 cagacttatt gattcaagag accatccgag aagcatttgc agactgtacc atgctgacca
     4261 ttgcccatcg cctgcacacg gttctaggct ccgataggat tatggtgctg gcccagggac
     4321 aggtggtgga gtttgacacc ccatcggtcc ttctgtccaa cgacagttcc cgattctatg
     4381 ccatgtttgc tgctgcagag aacaaggtcg ctgtcaaggg ctgactcctc cctgttgacg
     4441 aagtctcttt tctttagagc attgccattc cctgcctggg gcgggcccct catcgcgtcc
     4501 tcctaccgaa accttgcctt tctcgatttt atctttcgca cagcagttcc ggattggctt
     4561 gtgtgtttca cttttaggga gagtcatatt ttgattattg tatttattcc atattcatgt
     4621 aaacaaaatt tagtttttgt tcttaattgc actctaaaag gttcagggaa ccgttattat
     4681 aattgtatca gaggcctata atgaagcttt atacgtgtag ctatatctat atataattct
     4741 gtacatagcc tatatttaca gtgaaaatgt aagctgttta ttttatatta aaataagcac
     4801 tgtgctaata acagtgcata ttcctttcta tcatttttgt acagtttgct gtactagaga
     4861 tctggttttg ctattagact gtaggaagag tagcatttca ttcttctcta gctggtggtt
     4921 tcacggtgcc aggttttctg ggtgtccaaa ggaagacgtg tggcaatagt gggccctccg
     4981 acagccccct ctgccgcctc cccacggccg ctccaggggt ggctggagac gggtgggcgg
     5041 ctggagacca tgcagagcgc cgtgagttct cagggctcct gccttctgtc ctggtgtcac
     5101 ttactgtttc tgtcaggaga gcagcggggc gaagcccagg ccccttttca ctccctccat
     5161 caagaatggg gatcacagag acattcctcc gagccgggga gtttctttcc tgccttcttc
     5221 tttttgctgt tgtttctaaa caagaatcag tctatccaca gagagtccca ctgcctcagg
     5281 ttcctatggc tggccactgc acagagctct ccagctccaa gacctgttgg ttccaagccc
     5341 tggagccaac tgctgctttt tgaggtggca ctttttcatt tgcctattcc cacacctcca
     5401 cagttcagtg gcagggctca ggatttcgtg ggtctgtttt cctttctcac cgcagtcgtc
     5461 gcacagtctc tctctctctc tcccctcaaa gtctgcaact ttaagcagct cttgctaatc
     5521 agtgtctcac actggcgtag aagtttttgt actgtaaaga gacctacctc aggttgctgg
     5581 ttgctgtgtg gtttggtgtg ttcccgcaaa ccccctttgt gctgtggggc tggtagctca
     5641 ggtgggcgtg gtcactgctg tcatcaattg aatggtcagc gttgcatgtc gtgaccaact
     5701 agacattctg tcgccttagc atgtttgctg aacaccttgt ggaagcaaaa atctgaaaat
     5761 gtgaataaaa ttattttgga ttttgtaaaa
//
