LOCUS       NM_001320032            5905 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens ATP binding cassette subfamily C member 5 (ABCC5),
            transcript variant 3, mRNA.
ACCESSION   NM_001320032
VERSION     NM_001320032.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5905)
  AUTHORS   Huang,Y., Xue,C., Bu,R., Wu,C., Li,J., Zhang,J., Chen,J., Shi,Z.,
            Chen,Y., Wang,Y. and Liu,Z.
  TITLE     Inhibition and transport mechanisms of the ABC transporter hMRP5
  JOURNAL   Nat Commun 15 (1), 4811 (2024)
   PUBMED   38844452
  REMARK    GeneRIF: Inhibition and transport mechanisms of the ABC transporter
            hMRP5.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5905)
  AUTHORS   Hou,Y., Dong,Z., Zhong,W., Yin,L., Li,X., Kuerban,G. and Huang,H.
  TITLE     FOXM1 Promotes Drug Resistance in Cervical Cancer Cells by
            Regulating ABCC5 Gene Transcription
  JOURNAL   Biomed Res Int 2022, 3032590 (2022)
   PUBMED   35141332
  REMARK    GeneRIF: FOXM1 Promotes Drug Resistance in Cervical Cancer Cells by
            Regulating ABCC5 Gene Transcription.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5905)
  AUTHORS   Huang,W., Chen,K., Lu,Y., Zhang,D., Cheng,Y., Li,L., Huang,W.,
            He,G., Liao,H., Cai,L., Tang,Y., Zhao,L. and Pan,M.
  TITLE     ABCC5 facilitates the acquired resistance of sorafenib through the
            inhibition of SLC7A11-induced ferroptosis in hepatocellular
            carcinoma
  JOURNAL   Neoplasia 23 (12), 1227-1239 (2021)
   PUBMED   34768109
  REMARK    GeneRIF: ABCC5 facilitates the acquired resistance of sorafenib
            through the inhibition of SLC7A11-induced ferroptosis in
            hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 5905)
  AUTHORS   Chen,L., Yang,Z., Cao,Y., Hu,Y., Bao,W., Wu,D., Hu,L., Xie,J. and
            Yu,H.
  TITLE     Pan-cancer analysis and single-cell analysis revealed the role of
            ABCC5 transporter in hepatocellular carcinoma
  JOURNAL   Channels (Austin) 15 (1), 541-554 (2021)
   PUBMED   34494510
  REMARK    GeneRIF: Pan-cancer analysis and single-cell analysis revealed the
            role of ABCC5 transporter in hepatocellular carcinoma.
REFERENCE   5  (bases 1 to 5905)
  AUTHORS   Odland,S.U., Ravna,A.W., Smaglyukova,N., Dietrichs,E.S. and
            Sager,G.
  TITLE     Inhibition of ABCC5-mediated cGMP transport by progesterone,
            testosterone and their analogues
  JOURNAL   J Steroid Biochem Mol Biol 213, 105951 (2021)
   PUBMED   34271023
  REMARK    GeneRIF: Inhibition of ABCC5-mediated cGMP transport by
            progesterone, testosterone and their analogues.
REFERENCE   6  (bases 1 to 5905)
  AUTHORS   Cole,S.P.
  TITLE     Re: Characterization of MOAT-C and MOAT-D, new members of the
            MRP/cMOAT subfamily of transporter proteins
  JOURNAL   J Natl Cancer Inst 91 (10), 888-889 (1999)
   PUBMED   10340910
REFERENCE   7  (bases 1 to 5905)
  AUTHORS   Belinsky,M.G., Bain,L.J., Balsara,B.B., Testa,J.R. and Kruh,G.D.
  TITLE     Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT
            subfamily of transporter proteins
  JOURNAL   J Natl Cancer Inst 90 (22), 1735-1741 (1998)
   PUBMED   9827529
REFERENCE   8  (bases 1 to 5905)
  AUTHORS   Suzuki,T., Nishio,K., Sasaki,H., Kurokawa,H., Saito-Ohara,F.,
            Ikeuchi,T., Tanabe,S., Terada,M. and Saijo,N.
  TITLE     cDNA cloning of a short type of multidrug resistance protein
            homologue, SMRP, from a human lung cancer cell line
  JOURNAL   Biochem Biophys Res Commun 238 (3), 790-794 (1997)
   PUBMED   9325169
REFERENCE   9  (bases 1 to 5905)
  AUTHORS   Kool,M., de Haas,M., Scheffer,G.L., Scheper,R.J., van Eijk,M.J.,
            Juijn,J.A., Baas,F. and Borst,P.
  TITLE     Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5,
            homologues of the multidrug resistance-associated protein gene
            (MRP1), in human cancer cell lines
  JOURNAL   Cancer Res 57 (16), 3537-3547 (1997)
   PUBMED   9270026
REFERENCE   10 (bases 1 to 5905)
  AUTHORS   Allikmets,R., Gerrard,B., Hutchinson,A. and Dean,M.
  TITLE     Characterization of the human ABC superfamily: isolation and
            mapping of 21 new genes using the expressed sequence tags database
  JOURNAL   Hum Mol Genet 5 (10), 1649-1655 (1996)
   PUBMED   8894702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY073434.1, BC144495.1,
            AF104942.1 and CN410200.1.
            
            On May 31, 2019 this sequence version replaced NM_001320032.1.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra- and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
            protein is a member of the MRP subfamily which is involved in
            multi-drug resistance. This protein functions in the cellular
            export of its substrate, cyclic nucleotides. This export
            contributes to the degradation of phosphodiesterases and possibly
            an elimination pathway for cyclic nucleotides. Studies show that
            this protein provides resistance to thiopurine anticancer drugs,
            6-mercatopurine and thioguanine, and the anti-HIV drug
            9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved
            in resistance to thiopurines in acute lymphoblastic leukemia and
            antiretroviral nucleoside analogs in HIV-infected patients.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (3) uses an alternate splice site,
            resulting in the use of a downstream start codon, compared to
            variant 1. It encodes isoform 3 which has a shorter N-terminus
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1972816.1,
                                           SRR14038191.383818.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                HY073434.1         79-133
            56-5311             BC144495.1         8-5263
            5312-5478           AF104942.1         5212-5378
            5479-5905           CN410200.1         2-428
FEATURES             Location/Qualifiers
     source          1..5905
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.1"
     gene            1..5905
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /note="ATP binding cassette subfamily C member 5"
                     /db_xref="GeneID:10057"
                     /db_xref="HGNC:HGNC:56"
                     /db_xref="MIM:605251"
     exon            1..55
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            56..239
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            240..397
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            398..553
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            554..701
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            702..935
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1109
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1257
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1406
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1514
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1986
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2058
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2183
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2256
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2460
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2604
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2707
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..2892
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2893..3039
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            3040..3169
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            3170..3323
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            3324..3452
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            3453..3639
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            3640..3729
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            3730..3919
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            3920..4079
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            4080..4158
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            4159..4272
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            4273..4437
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            4438..5905
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5879..5884
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /note="hexamer: AATAAA"
     polyA_site      5905
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /note="major polyA site"
ORIGIN      
        1 atgctcggga gcgtggttga gcggctggcg cggttgtcct ggagcagggg cgcaggaatt
       61 ctgatgtgaa actaacagtc tgtgagccct ggaacctcca ctcagagaag atgaaggata
      121 tcgacatagg aaaagagtat atcatcccca gtcctgggta tagaagtgtg agggagagaa
      181 ccagcacttc tgggacgcac agagaccgtg aagattccaa gttcaggaga actcgaccgt
      241 tggaatgcca agatgccttg gaaacagcag cccgagccga gggcctctct cttgatgcct
      301 ccatgcattc tcagctcaga atcctggatg aggagcatcc caagggaaag taccatcatg
      361 gcttgagtgc tctgaagccc atccggacta cttccaaaca ccagcaccca gtggacaatg
      421 ctgggctttt ttcctgtatg actttttcgt ggctttcttc tctggcccgt gtggcccaca
      481 agaaggggga gctctcaatg gaagacgtgt ggtctctgtc caagcacgag tcttctgacg
      541 tgaactgcag aagactagag agactgtggc aagaagagct gaatgaagtt gggccagacg
      601 ctgcttccct gcgaagggtt gtgtggatct tctgccgcac caggctcatc ctgtccatcg
      661 tgtgcctgat gatcacgcag ctggctggct tcagtggacc agccttcatg gtgaaacacc
      721 tcttggagta tacccaggca acagagtcta acctgcagta cagcttgttg ttagtgctgg
      781 gcctcctcct gacggaaatc gtgcggtctt ggtcgcttgc actgacttgg gcattgaatt
      841 accgaaccgg tgtccgcttg cggggggcca tcctaaccat ggcatttaag aagatcctta
      901 agttaaagaa cattaaagag aaatccctgg gtgagctcat caacatttgc tccaacgatg
      961 ggcagagaat gtttgaggca gcagccgttg gcagcctgct ggctggagga cccgttgttg
     1021 ccatcttagg catgatttat aatgtaatta ttctgggacc aacaggcttc ctgggatcag
     1081 ctgtttttat cctcttttac ccagcaatga tgtttgcatc acggctcaca gcatatttca
     1141 ggagaaaatg cgtggccgcc acggatgaac gtgtccagaa gatgaatgaa gttcttactt
     1201 acattaaatt tatcaaaatg tatgcctggg tcaaagcatt ttctcagagt gttcaaaaaa
     1261 tccgcgagga ggagcgtcgg atattggaaa aagctgggta cttccagagc atcactgtgg
     1321 gtgtggctcc cattgtggtg gtgattgcca gcgtggtgac cttctctgtt catatgaccc
     1381 tgggcttcga tctgacagca gcacaggctt tcacagtggt gacagtcttc aattccatga
     1441 cttttgcttt gaaagtaaca ccgttttcag taaagtccct ctcagaagcc tcagtggctg
     1501 ttgacagatt taagcttcct tccactgtat agcctgatgt gttttgctac gtgagtgtac
     1561 gccctaggct tgtctccctg gtcttgatcc agtgtctcat ctttgcacct ctctcacaac
     1621 tcctatcaga gtttgtttct aatggaagag gttcacatga taaagaacaa accagccagt
     1681 cctcacatca agatagagat gaaaaatgcc accttggcat gggactcctc ccactccagt
     1741 atccagaact cgcccaagct gacccccaaa atgaaaaaag acaagagggc ttccaggggc
     1801 aagaaagaga aggtgaggca gctgcagcgc actgagcatc aggcggtgct ggcagagcag
     1861 aaaggccacc tcctcctgga cagtgacgag cggcccagtc ccgaagagga agaaggcaag
     1921 cacatccacc tgggccacct gcgcttacag aggacactgc acagcatcga tctggagatc
     1981 caagagggta aactggttgg aatctgtggc agtgtgggaa gtggaaaaac ctctctcatt
     2041 tcagccattt taggccagat gacgcttcta gagggcagca ttgcaatcag tggaaccttc
     2101 gcttatgtgg cccagcaggc ctggatcctc aatgctactc tgagagacaa catcctgttt
     2161 gggaaggaat atgatgaaga aagatacaac tctgtgctga acagctgctg cctgaggcct
     2221 gacctggcca ttcttcccag cagcgacctg acggagattg gagagcgagg agccaacctg
     2281 agcggtgggc agcgccagag gatcagcctt gcccgggcct tgtatagtga caggagcatc
     2341 tacatcctgg acgaccccct cagtgcctta gatgcccatg tgggcaacca catcttcaat
     2401 agtgctatcc ggaaacatct caagtccaag acagttctgt ttgttaccca ccagttacag
     2461 tacctggttg actgtgatga agtgatcttc atgaaagagg gctgtattac ggaaagaggc
     2521 acccatgagg aactgatgaa tttaaatggt gactatgcta ccatttttaa taacctgttg
     2581 ctgggagaga caccgccagt tgagatcaat tcaaaaaagg aaaccagtgg ttcacagaag
     2641 aagtcacaag acaagggtcc taaaacagga tcagtaaaga aggaaaaagc agtaaagcca
     2701 gaggaagggc agcttgtgca gctggaagag aaagggcagg gttcagtgcc ctggtcagta
     2761 tatggtgtct acatccaggc tgctgggggc cccttggcat tcctggttat tatggccctt
     2821 ttcatgctga atgtaggcag caccgccttc agcacctggt ggttgagtta ctggatcaag
     2881 caaggaagcg ggaacaccac tgtgactcga gggaacgaga cctcggtgag tgacagcatg
     2941 aaggacaatc ctcatatgca gtactatgcc agcatctacg ccctctccat ggcagtcatg
     3001 ctgatcctga aagccattcg aggagttgtc tttgtcaagg gcacgctgcg agcttcctcc
     3061 cggctgcatg acgagctttt ccgaaggatc cttcgaagcc ctatgaagtt ttttgacacg
     3121 acccccacag ggaggattct caacaggttt tccaaagaca tggatgaagt tgacgtgcgg
     3181 ctgccgttcc aggccgagat gttcatccag aacgttatcc tggtgttctt ctgtgtggga
     3241 atgatcgcag gagtcttccc gtggttcctt gtggcagtgg ggccccttgt catcctcttt
     3301 tcagtcctgc acattgtctc cagggtcctg attcgggagc tgaagcgtct ggacaatatc
     3361 acgcagtcac ctttcctctc ccacatcacg tccagcatac agggccttgc caccatccac
     3421 gcctacaata aagggcagga gtttctgcac agataccagg agctgctgga tgacaaccaa
     3481 gctccttttt ttttgtttac gtgtgcgatg cggtggctgg ctgtgcggct ggacctcatc
     3541 agcatcgccc tcatcaccac cacggggctg atgatcgttc ttatgcacgg gcagattccc
     3601 ccagcctatg cgggtctcgc catctcttat gctgtccagt taacggggct gttccagttt
     3661 acggtcagac tggcatctga gacagaagct cgattcacct cggtggagag gatcaatcac
     3721 tacattaaga ctctgtcctt ggaagcacct gccagaatta agaacaaggc tccctcccct
     3781 gactggcccc aggagggaga ggtgaccttt gagaacgcag agatgaggta ccgagaaaac
     3841 ctccctctcg tcctaaagaa agtatccttc acgatcaaac ctaaagagaa gattggcatt
     3901 gtggggcgga caggatcagg gaagtcctcg ctggggatgg ccctcttccg tctggtggag
     3961 ttatctggag gctgcatcaa gattgatgga gtgagaatca gtgatattgg ccttgccgac
     4021 ctccgaagca aactctctat cattcctcaa gagccggtgc tgttcagtgg cactgtcaga
     4081 tcaaatttgg accccttcaa ccagtacact gaagaccaga tttgggatgc cctggagagg
     4141 acacacatga aagaatgtat tgctcagcta cctctgaaac ttgaatctga agtgatggag
     4201 aatggggata acttctcagt gggggaacgg cagctcttgt gcatagctag agccctgctc
     4261 cgccactgta agattctgat tttagatgaa gccacagctg ccatggacac agagacagac
     4321 ttattgattc aagagaccat ccgagaagca tttgcagact gtaccatgct gaccattgcc
     4381 catcgcctgc acacggttct aggctccgat aggattatgg tgctggccca gggacaggtg
     4441 gtggagtttg acaccccatc ggtccttctg tccaacgaca gttcccgatt ctatgccatg
     4501 tttgctgctg cagagaacaa ggtcgctgtc aagggctgac tcctccctgt tgacgaagtc
     4561 tcttttcttt agagcattgc cattccctgc ctggggcggg cccctcatcg cgtcctccta
     4621 ccgaaacctt gcctttctcg attttatctt tcgcacagca gttccggatt ggcttgtgtg
     4681 tttcactttt agggagagtc atattttgat tattgtattt attccatatt catgtaaaca
     4741 aaatttagtt tttgttctta attgcactct aaaaggttca gggaaccgtt attataattg
     4801 tatcagaggc ctataatgaa gctttatacg tgtagctata tctatatata attctgtaca
     4861 tagcctatat ttacagtgaa aatgtaagct gtttatttta tattaaaata agcactgtgc
     4921 taataacagt gcatattcct ttctatcatt tttgtacagt ttgctgtact agagatctgg
     4981 ttttgctatt agactgtagg aagagtagca tttcattctt ctctagctgg tggtttcacg
     5041 gtgccaggtt ttctgggtgt ccaaaggaag acgtgtggca atagtgggcc ctccgacagc
     5101 cccctctgcc gcctccccac ggccgctcca ggggtggctg gagacgggtg ggcggctgga
     5161 gaccatgcag agcgccgtga gttctcaggg ctcctgcctt ctgtcctggt gtcacttact
     5221 gtttctgtca ggagagcagc ggggcgaagc ccaggcccct tttcactccc tccatcaaga
     5281 atggggatca cagagacatt cctccgagcc ggggagtttc tttcctgcct tcttcttttt
     5341 gctgttgttt ctaaacaaga atcagtctat ccacagagag tcccactgcc tcaggttcct
     5401 atggctggcc actgcacaga gctctccagc tccaagacct gttggttcca agccctggag
     5461 ccaactgctg ctttttgagg tggcactttt tcatttgcct attcccacac ctccacagtt
     5521 cagtggcagg gctcaggatt tcgtgggtct gttttccttt ctcaccgcag tcgtcgcaca
     5581 gtctctctct ctctctcccc tcaaagtctg caactttaag cagctcttgc taatcagtgt
     5641 ctcacactgg cgtagaagtt tttgtactgt aaagagacct acctcaggtt gctggttgct
     5701 gtgtggtttg gtgtgttccc gcaaaccccc tttgtgctgt ggggctggta gctcaggtgg
     5761 gcgtggtcac tgctgtcatc aattgaatgg tcagcgttgc atgtcgtgac caactagaca
     5821 ttctgtcgcc ttagcatgtt tgctgaacac cttgtggaag caaaaatctg aaaatgtgaa
     5881 taaaattatt ttggattttg taaaa
//
