LOCUS       NM_001023587            1918 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens ATP binding cassette subfamily C member 5 (ABCC5),
            transcript variant 2, mRNA.
ACCESSION   NM_001023587
VERSION     NM_001023587.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1918)
  AUTHORS   Huang,Y., Xue,C., Bu,R., Wu,C., Li,J., Zhang,J., Chen,J., Shi,Z.,
            Chen,Y., Wang,Y. and Liu,Z.
  TITLE     Inhibition and transport mechanisms of the ABC transporter hMRP5
  JOURNAL   Nat Commun 15 (1), 4811 (2024)
   PUBMED   38844452
  REMARK    GeneRIF: Inhibition and transport mechanisms of the ABC transporter
            hMRP5.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1918)
  AUTHORS   Hou,Y., Dong,Z., Zhong,W., Yin,L., Li,X., Kuerban,G. and Huang,H.
  TITLE     FOXM1 Promotes Drug Resistance in Cervical Cancer Cells by
            Regulating ABCC5 Gene Transcription
  JOURNAL   Biomed Res Int 2022, 3032590 (2022)
   PUBMED   35141332
  REMARK    GeneRIF: FOXM1 Promotes Drug Resistance in Cervical Cancer Cells by
            Regulating ABCC5 Gene Transcription.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1918)
  AUTHORS   Huang,W., Chen,K., Lu,Y., Zhang,D., Cheng,Y., Li,L., Huang,W.,
            He,G., Liao,H., Cai,L., Tang,Y., Zhao,L. and Pan,M.
  TITLE     ABCC5 facilitates the acquired resistance of sorafenib through the
            inhibition of SLC7A11-induced ferroptosis in hepatocellular
            carcinoma
  JOURNAL   Neoplasia 23 (12), 1227-1239 (2021)
   PUBMED   34768109
  REMARK    GeneRIF: ABCC5 facilitates the acquired resistance of sorafenib
            through the inhibition of SLC7A11-induced ferroptosis in
            hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 1918)
  AUTHORS   Chen,L., Yang,Z., Cao,Y., Hu,Y., Bao,W., Wu,D., Hu,L., Xie,J. and
            Yu,H.
  TITLE     Pan-cancer analysis and single-cell analysis revealed the role of
            ABCC5 transporter in hepatocellular carcinoma
  JOURNAL   Channels (Austin) 15 (1), 541-554 (2021)
   PUBMED   34494510
  REMARK    GeneRIF: Pan-cancer analysis and single-cell analysis revealed the
            role of ABCC5 transporter in hepatocellular carcinoma.
REFERENCE   5  (bases 1 to 1918)
  AUTHORS   Odland,S.U., Ravna,A.W., Smaglyukova,N., Dietrichs,E.S. and
            Sager,G.
  TITLE     Inhibition of ABCC5-mediated cGMP transport by progesterone,
            testosterone and their analogues
  JOURNAL   J Steroid Biochem Mol Biol 213, 105951 (2021)
   PUBMED   34271023
  REMARK    GeneRIF: Inhibition of ABCC5-mediated cGMP transport by
            progesterone, testosterone and their analogues.
REFERENCE   6  (bases 1 to 1918)
  AUTHORS   Cole,S.P.
  TITLE     Re: Characterization of MOAT-C and MOAT-D, new members of the
            MRP/cMOAT subfamily of transporter proteins
  JOURNAL   J Natl Cancer Inst 91 (10), 888-889 (1999)
   PUBMED   10340910
REFERENCE   7  (bases 1 to 1918)
  AUTHORS   Belinsky,M.G., Bain,L.J., Balsara,B.B., Testa,J.R. and Kruh,G.D.
  TITLE     Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT
            subfamily of transporter proteins
  JOURNAL   J Natl Cancer Inst 90 (22), 1735-1741 (1998)
   PUBMED   9827529
REFERENCE   8  (bases 1 to 1918)
  AUTHORS   Suzuki,T., Nishio,K., Sasaki,H., Kurokawa,H., Saito-Ohara,F.,
            Ikeuchi,T., Tanabe,S., Terada,M. and Saijo,N.
  TITLE     cDNA cloning of a short type of multidrug resistance protein
            homologue, SMRP, from a human lung cancer cell line
  JOURNAL   Biochem Biophys Res Commun 238 (3), 790-794 (1997)
   PUBMED   9325169
REFERENCE   9  (bases 1 to 1918)
  AUTHORS   Kool,M., de Haas,M., Scheffer,G.L., Scheper,R.J., van Eijk,M.J.,
            Juijn,J.A., Baas,F. and Borst,P.
  TITLE     Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5,
            homologues of the multidrug resistance-associated protein gene
            (MRP1), in human cancer cell lines
  JOURNAL   Cancer Res 57 (16), 3537-3547 (1997)
   PUBMED   9270026
REFERENCE   10 (bases 1 to 1918)
  AUTHORS   Allikmets,R., Gerrard,B., Hutchinson,A. and Dean,M.
  TITLE     Characterization of the human ABC superfamily: isolation and
            mapping of 21 new genes using the expressed sequence tags database
  JOURNAL   Hum Mol Genet 5 (10), 1649-1655 (1996)
   PUBMED   8894702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY754875.1.
            
            On May 31, 2019 this sequence version replaced NM_001023587.2.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra- and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
            protein is a member of the MRP subfamily which is involved in
            multi-drug resistance. This protein functions in the cellular
            export of its substrate, cyclic nucleotides. This export
            contributes to the degradation of phosphodiesterases and possibly
            an elimination pathway for cyclic nucleotides. Studies show that
            this protein provides resistance to thiopurine anticancer drugs,
            6-mercatopurine and thioguanine, and the anti-HIV drug
            9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved
            in resistance to thiopurines in acute lymphoblastic leukemia and
            antiretroviral nucleoside analogs in HIV-infected patients.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (2) lacks several exons and
            contains an alternate 3' structure, compared to variant 1. It
            encodes isoform 2 which is shorter and has a distinct C-terminus,
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY754875.1, BC142719.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1918              AY754875.1         16-1933
FEATURES             Location/Qualifiers
     source          1..1918
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.1"
     gene            1..1918
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /note="ATP binding cassette subfamily C member 5"
                     /db_xref="GeneID:10057"
                     /db_xref="HGNC:HGNC:56"
                     /db_xref="MIM:605251"
     exon            1..55
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            56..239
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..737
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /EC_number="7.6.2.2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     canalicular multispecific organic anion transporter C;
                     multidrug resistance-associated protein 5; multi-specific
                     organic anion transporter C; ATP-binding cassette,
                     sub-family C (CFTR/MRP), member 5"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family C member 5
                     isoform 2"
                     /protein_id="NP_001018881.1"
                     /db_xref="CCDS:CCDS33898.1"
                     /db_xref="GeneID:10057"
                     /db_xref="HGNC:HGNC:56"
                     /db_xref="MIM:605251"
                     /translation="MKDIDIGKEYIIPSPGYRSVRERTSTSGTHRDREDSKFRRTRPL
                     ECQDALETAARAEGLSLDASMHSQLRILDEEHPKGKYHHGLSALKPIRTTSKHQHPVD
                     NAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNEV
                     GPDAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPNFQDGCILRSE"
     exon            240..397
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            398..553
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            554..701
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            702..776
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            777..1918
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1897..1902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /note="hexamer: AATAAA"
     polyA_site      1918
                     /gene="ABCC5"
                     /gene_synonym="ABC33; EST277145; MOAT-C; MOATC; MRP5;
                     pABC11; SMRP"
                     /note="major polyA site"
ORIGIN      
        1 atgctcggga gcgtggttga gcggctggcg cggttgtcct ggagcagggg cgcaggaatt
       61 ctgatgtgaa actaacagtc tgtgagccct ggaacctcca ctcagagaag atgaaggata
      121 tcgacatagg aaaagagtat atcatcccca gtcctgggta tagaagtgtg agggagagaa
      181 ccagcacttc tgggacgcac agagaccgtg aagattccaa gttcaggaga actcgaccgt
      241 tggaatgcca agatgccttg gaaacagcag cccgagccga gggcctctct cttgatgcct
      301 ccatgcattc tcagctcaga atcctggatg aggagcatcc caagggaaag taccatcatg
      361 gcttgagtgc tctgaagccc atccggacta cttccaaaca ccagcaccca gtggacaatg
      421 ctgggctttt ttcctgtatg actttttcgt ggctttcttc tctggcccgt gtggcccaca
      481 agaaggggga gctctcaatg gaagacgtgt ggtctctgtc caagcacgag tcttctgacg
      541 tgaactgcag aagactagag agactgtggc aagaagagct gaatgaagtt gggccagacg
      601 ctgcttccct gcgaagggtt gtgtggatct tctgccgcac caggctcatc ctgtccatcg
      661 tgtgcctgat gatcacgcag ctggctggct tcagtggacc aaattttcag gatggctgta
      721 ttctgcggtc agaatgagag agtcaagctg ggcagaatct ctcgccaaga gttcagcctt
      781 cctttggaga ctgctccatc agtgccgagg tgtgtgggaa caggcttcac tgcaccgcca
      841 tcttactgag ttgcttcacg tgaggaaaag ggggctttgg ccctgtgact cagttccaca
      901 ttttggattg catactggaa aagaagccaa tcttcttgct agtaaaccag caacccggct
      961 gtatacagtg gtgacccaag caatggatat aaacctaaaa atctgaggga ggggagaggt
     1021 ggaatacagt agttcttgga atctgaagtc tcctatttga tcaggttatt tcctgggact
     1081 tggcaaaaat ctgattggtg gggatctcct aggacctagt ggacatctgg tattaattta
     1141 atctcaggaa aaacaagaaa ttaacccaga gagagtctgg gttttggaat tcagcgtagc
     1201 tacctccaga ccgtggtgtc tggcctccat ttttgtctgt cattcagctc tgacttacag
     1261 ctgcagtcac ctttgctata aggcacctgg gtagaagggt ggatgggctt cacatcaatt
     1321 tttttcttcc tttagggtgg gggattggtt tggctttctt ttgttgtggt tttttgtttt
     1381 atttttgtca agattgattt ttagatgcaa ggacttgaaa agacccagaa ggatgccacc
     1441 agtttttcct tgaggcctag gattttttat tctgtcccga gcagaggtaa ttcctcacaa
     1501 cttagtgcac cagtagcacc agccattttg agcagagtac ctctttgggg agcttttcgt
     1561 tttgttttgt ttttaattct ctttccttag cagcaaggtc ttttttccta gagaatctac
     1621 tccgttgcag aatcattgca acctcaggag ccctcactga ttgagtgctg tcagcctgat
     1681 atactacttt ggactctgga aacagatatg ggttctattc tctatttcta ctgtgtgtcg
     1741 ttaaacaacc gtcggagacc agatgacctg ttagatggct agtcctgtat aactcgactc
     1801 tgtatgtttc aatgtatgtt actgcaatgc ttcacctgct gtacagtgtt tgtgagatgc
     1861 tctttgaaga tggtactttt atattttttc attttcaata aaagtacatt ccttccca
//
