LOCUS       NP_005836               1325 aa            linear   PRI 30-APR-2025
DEFINITION  ATP-binding cassette sub-family C member 4 isoform 1 [Homo
            sapiens].
ACCESSION   NP_005836
VERSION     NP_005836.2
DBSOURCE    REFSEQ: accession NM_005845.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1325)
  AUTHORS   Ranjit,S., Wang,Y., Zhu,J., Cheepala,S.B., Schuetz,E.G., Cho,W.J.,
            Xu,B., Robinson,C.G., Wu,G., Naren,A.P. and Schuetz,J.D.
  TITLE     ABCC4 impacts megakaryopoiesis and protects megakaryocytes against
            6-mercaptopurine induced cytotoxicity
  JOURNAL   Drug Resist Updat 72, 101017 (2024)
   PUBMED   37988981
  REMARK    GeneRIF: ABCC4 impacts megakaryopoiesis and protects megakaryocytes
            against 6-mercaptopurine induced cytotoxicity.
REFERENCE   2  (residues 1 to 1325)
  AUTHORS   Bloch,M., Raj,I., Pape,T. and Taylor,N.M.I.
  TITLE     Structural and mechanistic basis of substrate transport by the
            multidrug transporter MRP4
  JOURNAL   Structure 31 (11), 1407-1418 (2023)
   PUBMED   37683641
  REMARK    GeneRIF: Structural and mechanistic basis of substrate transport by
            the multidrug transporter MRP4.
REFERENCE   3  (residues 1 to 1325)
  AUTHORS   Huang,C., Xu,R., Zhu,X. and Jiang,H.
  TITLE     m6A-modified circABCC4 promotes stemness and metastasis of prostate
            cancer by recruiting IGF2BP2 to increase stability of CCAR1
  JOURNAL   Cancer Gene Ther 30 (10), 1426-1440 (2023)
   PUBMED   37563361
  REMARK    GeneRIF: m6A-modified circABCC4 promotes stemness and metastasis of
            prostate cancer by recruiting IGF2BP2 to increase stability of
            CCAR1.
REFERENCE   4  (residues 1 to 1325)
  AUTHORS   Hu,F., Chen,X.Q., Li,X.P., Lu,Y.X., Chen,S.L., Wang,D.W., Liang,Y.
            and Dai,Y.J.
  TITLE     Drug resistance biomarker ABCC4 of selinexor and immune feature in
            multiple myeloma
  JOURNAL   Int Immunopharmacol 108, 108722 (2022)
   PUBMED   35381563
  REMARK    GeneRIF: Drug resistance biomarker ABCC4 of selinexor and immune
            feature in multiple myeloma.
REFERENCE   5  (residues 1 to 1325)
  AUTHORS   Adachi,M., Sampath,J., Lan,L.B., Sun,D., Hargrove,P., Flatley,R.,
            Tatum,A., Edwards,M.Z., Wezeman,M., Matherly,L., Drake,R. and
            Schuetz,J.
  TITLE     Expression of MRP4 confers resistance to ganciclovir and
            compromises bystander cell killing
  JOURNAL   J Biol Chem 277 (41), 38998-39004 (2002)
   PUBMED   12105214
  REMARK    GeneRIF: These findings indicate that a nucleotide transporter,
            such as MRP4, modulates the cellular response to ganciclovir and
            thus may influence not only the efficacy of antiviral therapy, but
            also prodrug-based gene therapy.
REFERENCE   6  (residues 1 to 1325)
  AUTHORS   Lee,K., Belinsky,M.G., Bell,D.W., Testa,J.R. and Kruh,G.D.
  TITLE     Isolation of MOAT-B, a widely expressed multidrug
            resistance-associated protein/canalicular multispecific organic
            anion transporter-related transporter
  JOURNAL   Cancer Res 58 (13), 2741-2747 (1998)
   PUBMED   9661885
REFERENCE   7  (residues 1 to 1325)
  AUTHORS   Kool,M., de Haas,M., Scheffer,G.L., Scheper,R.J., van Eijk,M.J.,
            Juijn,J.A., Baas,F. and Borst,P.
  TITLE     Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5,
            homologues of the multidrug resistance-associated protein gene
            (MRP1), in human cancer cell lines
  JOURNAL   Cancer Res 57 (16), 3537-3547 (1997)
   PUBMED   9270026
REFERENCE   8  (residues 1 to 1325)
  AUTHORS   Allikmets,R., Gerrard,B., Hutchinson,A. and Dean,M.
  TITLE     Characterization of the human ABC superfamily: isolation and
            mapping of 21 new genes using the expressed sequence tags database
  JOURNAL   Hum Mol Genet 5 (10), 1649-1655 (1996)
   PUBMED   8894702
REFERENCE   9  (residues 1 to 1325)
  AUTHORS   Pichaud,F., Frendo,J.L., Delage-Mourroux,R., de Vernejoul,M.C.,
            Moukhtar,M.S. and Jullienne,A.
  TITLE     Sequence of a novel mRNA coding for a C-terminal-truncated form of
            human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase
  JOURNAL   Gene 162 (2), 319-322 (1995)
   PUBMED   7557451
REFERENCE   10 (residues 1 to 1325)
  AUTHORS   Ponticelli,A.S. and Smith,G.R.
  TITLE     Meiotic recombination-deficient mutants of Schizosaccharomyces
            pombe
  JOURNAL   Genetics 123 (1), 45-54 (1989)
   PUBMED   2806887
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Karyn Megy. The reference sequence was derived
            from AL356257.14, AL157818.12 and AL139381.24.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 25, 2007 this sequence version replaced NP_005836.1.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra- and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
            protein is a member of the MRP subfamily which is involved in
            multi-drug resistance. This family member plays a role in cellular
            detoxification as a pump for its substrate, organic anions. It may
            also function in prostaglandin-mediated cAMP signaling in
            ciliogenesis. Alternative splicing of this gene results in multiple
            transcript variants. [provided by RefSeq, Sep 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY081219.1, AF071202.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000645237.2/ ENSP00000494609.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1325
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q32.1"
     Protein         1..1325
                     /product="ATP-binding cassette sub-family C member 4
                     isoform 1"
                     /EC_number="7.6.2.2"
                     /EC_number="7.6.2.3"
                     /note="canalicular multispecific organic anion transporter
                     (ABC superfamily); multidrug resistance-associated protein
                     4; bA464I2.1 (ATP-binding cassette, sub-family C
                     (CFTR/MRP), member 4); MRP/cMOAT-related ABC transporter;
                     multi-specific organic anion transporter B"
                     /calculated_mol_wt=149396
     Region          12..1277
                     /region_name="PLN03130"
                     /note="ABC transporter C family member; Provisional"
                     /db_xref="CDD:215595"
     Site            93..113
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15439.3)"
     Site            136..156
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15439.3)"
     Site            207..227
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15439.3)"
     Site            228..248
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15439.3)"
     Site            328..348
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15439.3)"
     Site            351..371
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15439.3)"
     Site            440..460
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15439.3)"
     Site            646
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O15439.3)"
     Site            648
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O15439.3)"
     Region          657..688
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15439.3)"
     Site            664
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O15439.3)"
     Site            668
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O15439.3)"
     Site            710..730
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15439.3)"
     Site            746
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:26721430; propagated from
                     UniProtKB/Swiss-Prot (O15439.3)"
     Site            754
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:26721430; propagated from
                     UniProtKB/Swiss-Prot (O15439.3)"
     Site            771..791
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15439.3)"
     Site            836..856
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15439.3)"
     Site            858..878
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15439.3)"
     Site            954..974
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15439.3)"
     Site            977..997
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15439.3)"
     Site            1038..1058
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15439.3)"
     Region          1322..1325
                     /region_name="PDZ-binding"
                     /note="propagated from UniProtKB/Swiss-Prot (O15439.3)"
     CDS             1..1325
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /coded_by="NM_005845.5:138..4115"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS9474.1"
                     /db_xref="GeneID:10257"
                     /db_xref="HGNC:HGNC:55"
                     /db_xref="MIM:605250"
ORIGIN      
        1 mlpvyqevkp nplqdanlcs rvffwwlnpl fkighkrrle eddmysvlpe drsqhlgeel
       61 qgfwdkevlr aendaqkpsl traiikcywk sylvlgiftl ieesakviqp iflgkiinyf
      121 enydpmdsva lntayayatv ltfctlilai lhhlyfyhvq cagmrlrvam chmiyrkalr
      181 lsnmamgktt tgqivnllsn dvnkfdqvtv flhflwagpl qaiavtallw meigisclag
      241 mavliillpl qscfgklfss lrsktatftd arirtmnevi tgiriikmya weksfsnlit
      301 nlrkkeiski lrssclrgmn lasffsaski ivfvtfttyv llgsvitasr vfvavtlyga
      361 vrltvtlffp saiervseai vsirriqtfl lldeisqrnr qlpsdgkkmv hvqdftafwd
      421 kasetptlqg lsftvrpgel lavvgpvgag kssllsavlg elapshglvs vhgriayvsq
      481 qpwvfsgtlr snilfgkkye keryekvika calkkdlqll edgdltvigd rgttlsggqk
      541 arvnlaravy qdadiylldd plsavdaevs rhlfelcicq ilhekitilv thqlqylkaa
      601 sqililkdgk mvqkgtytef lksgidfgsl lkkdneeseq ppvpgtptlr nrtfsessvw
      661 sqqssrpslk dgalesqdte nvpvtlseen rsegkvgfqa yknyfragah wivfiflill
      721 ntaaqvayvl qdwwlsywan kqsmlnvtvn gggnvtekld lnwylgiysg ltvatvlfgi
      781 arsllvfyvl vnssqtlhnk mfesilkapv lffdrnpigr ilnrfskdig hlddllpltf
      841 ldfiqtllqv vgvvsvavav ipwiaiplvp lgiififlrr yfletsrdvk rlesttrspv
      901 fshlssslqg lwtiraykae ercqelfdah qdlhseawfl flttsrwfav rldaicamfv
      961 iivafgslil aktldagqvg lalsyaltlm gmfqwcvrqs aevenmmisv ervieytdle
     1021 keapweyqkr pppawphegv iifdnvnfmy spggplvlkh ltaliksqek vgivgrtgag
     1081 ksslisalfr lsepegkiwi dkiltteigl hdlrkkmsii pqepvlftgt mrknldpfne
     1141 htdeelwnal qevqlketie dlpgkmdtel aesgsnfsvg qrqlvclara ilrknqilii
     1201 deatanvdpr tdeliqkkir ekfahctvlt iahrlntiid sdkimvldsg rlkeydepyv
     1261 llqnkeslfy kmvqqlgkae aaaltetakq vyfkrnyphi ghtdhmvtnt sngqpstlti
     1321 fetal
//
