LOCUS       NM_001301829            5714 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens ATP binding cassette subfamily C member 4 (PEL blood
            group) (ABCC4), transcript variant 3, mRNA.
ACCESSION   NM_001301829
VERSION     NM_001301829.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5714)
  AUTHORS   Ranjit,S., Wang,Y., Zhu,J., Cheepala,S.B., Schuetz,E.G., Cho,W.J.,
            Xu,B., Robinson,C.G., Wu,G., Naren,A.P. and Schuetz,J.D.
  TITLE     ABCC4 impacts megakaryopoiesis and protects megakaryocytes against
            6-mercaptopurine induced cytotoxicity
  JOURNAL   Drug Resist Updat 72, 101017 (2024)
   PUBMED   37988981
  REMARK    GeneRIF: ABCC4 impacts megakaryopoiesis and protects megakaryocytes
            against 6-mercaptopurine induced cytotoxicity.
REFERENCE   2  (bases 1 to 5714)
  AUTHORS   Bloch,M., Raj,I., Pape,T. and Taylor,N.M.I.
  TITLE     Structural and mechanistic basis of substrate transport by the
            multidrug transporter MRP4
  JOURNAL   Structure 31 (11), 1407-1418 (2023)
   PUBMED   37683641
  REMARK    GeneRIF: Structural and mechanistic basis of substrate transport by
            the multidrug transporter MRP4.
REFERENCE   3  (bases 1 to 5714)
  AUTHORS   Huang,C., Xu,R., Zhu,X. and Jiang,H.
  TITLE     m6A-modified circABCC4 promotes stemness and metastasis of prostate
            cancer by recruiting IGF2BP2 to increase stability of CCAR1
  JOURNAL   Cancer Gene Ther 30 (10), 1426-1440 (2023)
   PUBMED   37563361
  REMARK    GeneRIF: m6A-modified circABCC4 promotes stemness and metastasis of
            prostate cancer by recruiting IGF2BP2 to increase stability of
            CCAR1.
REFERENCE   4  (bases 1 to 5714)
  AUTHORS   Hu,F., Chen,X.Q., Li,X.P., Lu,Y.X., Chen,S.L., Wang,D.W., Liang,Y.
            and Dai,Y.J.
  TITLE     Drug resistance biomarker ABCC4 of selinexor and immune feature in
            multiple myeloma
  JOURNAL   Int Immunopharmacol 108, 108722 (2022)
   PUBMED   35381563
  REMARK    GeneRIF: Drug resistance biomarker ABCC4 of selinexor and immune
            feature in multiple myeloma.
REFERENCE   5  (bases 1 to 5714)
  AUTHORS   Adachi,M., Sampath,J., Lan,L.B., Sun,D., Hargrove,P., Flatley,R.,
            Tatum,A., Edwards,M.Z., Wezeman,M., Matherly,L., Drake,R. and
            Schuetz,J.
  TITLE     Expression of MRP4 confers resistance to ganciclovir and
            compromises bystander cell killing
  JOURNAL   J Biol Chem 277 (41), 38998-39004 (2002)
   PUBMED   12105214
  REMARK    GeneRIF: These findings indicate that a nucleotide transporter,
            such as MRP4, modulates the cellular response to ganciclovir and
            thus may influence not only the efficacy of antiviral therapy, but
            also prodrug-based gene therapy.
REFERENCE   6  (bases 1 to 5714)
  AUTHORS   Lee,K., Belinsky,M.G., Bell,D.W., Testa,J.R. and Kruh,G.D.
  TITLE     Isolation of MOAT-B, a widely expressed multidrug
            resistance-associated protein/canalicular multispecific organic
            anion transporter-related transporter
  JOURNAL   Cancer Res 58 (13), 2741-2747 (1998)
   PUBMED   9661885
REFERENCE   7  (bases 1 to 5714)
  AUTHORS   Kool,M., de Haas,M., Scheffer,G.L., Scheper,R.J., van Eijk,M.J.,
            Juijn,J.A., Baas,F. and Borst,P.
  TITLE     Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5,
            homologues of the multidrug resistance-associated protein gene
            (MRP1), in human cancer cell lines
  JOURNAL   Cancer Res 57 (16), 3537-3547 (1997)
   PUBMED   9270026
REFERENCE   8  (bases 1 to 5714)
  AUTHORS   Allikmets,R., Gerrard,B., Hutchinson,A. and Dean,M.
  TITLE     Characterization of the human ABC superfamily: isolation and
            mapping of 21 new genes using the expressed sequence tags database
  JOURNAL   Hum Mol Genet 5 (10), 1649-1655 (1996)
   PUBMED   8894702
REFERENCE   9  (bases 1 to 5714)
  AUTHORS   Pichaud,F., Frendo,J.L., Delage-Mourroux,R., de Vernejoul,M.C.,
            Moukhtar,M.S. and Jullienne,A.
  TITLE     Sequence of a novel mRNA coding for a C-terminal-truncated form of
            human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase
  JOURNAL   Gene 162 (2), 319-322 (1995)
   PUBMED   7557451
REFERENCE   10 (bases 1 to 5714)
  AUTHORS   Ponticelli,A.S. and Smith,G.R.
  TITLE     Meiotic recombination-deficient mutants of Schizosaccharomyces
            pombe
  JOURNAL   Genetics 123 (1), 45-54 (1989)
   PUBMED   2806887
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356257.14, AL157818.12 and
            AL139381.24.
            
            On Jun 2, 2019 this sequence version replaced NM_001301829.1.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra- and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
            protein is a member of the MRP subfamily which is involved in
            multi-drug resistance. This family member plays a role in cellular
            detoxification as a pump for its substrate, organic anions. It may
            also function in prostaglandin-mediated cAMP signaling in
            ciliogenesis. Alternative splicing of this gene results in multiple
            transcript variants. [provided by RefSeq, Sep 2014].
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            exon in the central coding region, compared to variant 1, resulting
            in an isoform (3) that is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.1799149.1, AF541977.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               AL356257.14        72281-72491         c
            212-322             AL356257.14        18683-18793         c
            323-443             AL356257.14        18015-18135         c
            444-668             AL356257.14        5650-5874           c
            669-758             AL157818.12        168755-168844       c
            759-922             AL157818.12        167497-167660       c
            923-1048            AL157818.12        165863-165988       c
            1049-1298           AL157818.12        164595-164844       c
            1299-1400           AL157818.12        152899-153000       c
            1401-1490           AL157818.12        146516-146605       c
            1491-1682           AL157818.12        144764-144955       c
            1683-1777           AL157818.12        136060-136154       c
            1778-1864           AL157818.12        135770-135856       c
            1865-1961           AL157818.12        128595-128691       c
            1962-2171           AL157818.12        124221-124430       c
            2172-2209           AL157818.12        121673-121710       c
            2210-2304           AL157818.12        121185-121279       c
            2305-2451           AL157818.12        119252-119398       c
            2452-2531           AL157818.12        73985-74064         c
            2532-2682           AL157818.12        41203-41353         c
            2683-2802           AL157818.12        33495-33614         c
            2803-2913           AL157818.12        32277-32387         c
            2914-3014           AL157818.12        31267-31367         c
            3015-3206           AL157818.12        29725-29916         c
            3207-3362           AL157818.12        20767-20922         c
            3363-3452           AL157818.12        11158-11247         c
            3453-3625           AL157818.12        2329-2501           c
            3626-3731           AL139381.24        115766-115871       c
            3732-3866           AL139381.24        106689-106823       c
            3867-5714           AL139381.24        91919-93766         c
FEATURES             Location/Qualifiers
     source          1..5714
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q32.1"
     gene            1..5714
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /note="ATP binding cassette subfamily C member 4 (PEL
                     blood group)"
                     /db_xref="GeneID:10257"
                     /db_xref="HGNC:HGNC:55"
                     /db_xref="MIM:605250"
     exon            1..211
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..3974
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /EC_number="7.6.2.2"
                     /EC_number="7.6.2.3"
                     /note="isoform 3 is encoded by transcript variant 3;
                     canalicular multispecific organic anion transporter (ABC
                     superfamily); multidrug resistance-associated protein 4;
                     bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP),
                     member 4); MRP/cMOAT-related ABC transporter;
                     multi-specific organic anion transporter B"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family C member 4
                     isoform 3"
                     /protein_id="NP_001288758.1"
                     /db_xref="CCDS:CCDS86356.1"
                     /db_xref="GeneID:10257"
                     /db_xref="HGNC:HGNC:55"
                     /db_xref="MIM:605250"
                     /translation="MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDM
                     YSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIE
                     ESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQ
                     CAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAG
                     PLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTM
                     NEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFV
                     TFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLL
                     DEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAG
                     KSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVI
                     KACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVD
                     AEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSG
                     IDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDVAYV
                     LQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVF
                     YVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQ
                     TLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSH
                     LSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVI
                     IVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDL
                     EKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRT
                     GAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNL
                     DPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILR
                     KNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGR
                     LKEYDEPYVLLQNKESLFYKMVQQLGKAEAAALTETAKQVYFKRNYPHIGHTDHMVTN
                     TSNGQPSTLTIFETAL"
     exon            212..322
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            323..443
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            444..668
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            669..758
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            759..922
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1048
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1298
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1400
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1490
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1682
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1777
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1864
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1961
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2171
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2209
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2304
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2451
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2452..2531
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2682
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2802
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2803..2913
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3014
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3015..3206
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3207..3362
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3363..3452
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3453..3625
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3626..3731
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3732..3866
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3867..5714
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5691..5696
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /note="hexamer: AATAAA"
     polyA_site      5714
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /note="major polyA site"
ORIGIN      
        1 gcttcacagg ctccagccga gcggacaggc gtggcggccg gagccccagc atccctgctt
       61 gaggtccagg agcggagccc gcggccaccg ccgcctgatc agcgcgaccc cggcccgcgc
      121 ccgccccgcc cggcaagatg ctgcccgtgt accaggaggt gaagcccaac ccgctgcagg
      181 acgcgaacct ctgctcacgc gtgttcttct ggtggctcaa tcccttgttt aaaattggcc
      241 ataaacggag attagaggaa gatgatatgt attcagtgct gccagaagac cgctcacagc
      301 accttggaga ggagttgcaa gggttctggg ataaagaagt tttaagagct gagaatgacg
      361 cacagaagcc ttctttaaca agagcaatca taaagtgtta ctggaaatct tatttagttt
      421 tgggaatttt tacgttaatt gaggaaagtg ccaaagtaat ccagcccata tttttgggaa
      481 aaattattaa ttattttgaa aattatgatc ccatggattc tgtggctttg aacacagcgt
      541 acgcctatgc cacggtgctg actttttgca cgctcatttt ggctatactg catcacttat
      601 atttttatca cgttcagtgt gctgggatga ggttacgagt agccatgtgc catatgattt
      661 atcggaaggc acttcgtctt agtaacatgg ccatggggaa gacaaccaca ggccagatag
      721 tcaatctgct gtccaatgat gtgaacaagt ttgatcaggt gacagtgttc ttacacttcc
      781 tgtgggcagg accactgcag gcgattgcag tgactgccct actctggatg gagataggaa
      841 tatcgtgcct tgctgggatg gcagttctaa tcattctcct gcccttgcaa agctgttttg
      901 ggaagttgtt ctcatcactg aggagtaaaa ctgcaacttt cacggatgcc aggatcagga
      961 ccatgaatga agttataact ggtataagga taataaaaat gtacgcctgg gaaaagtcat
     1021 tttcaaatct tattaccaat ttgagaaaga aggagatttc caagattctg agaagttcct
     1081 gcctcagagg gatgaatttg gcttcatttt tcagtgcaag caaaatcatc gtgtttgtga
     1141 ccttcaccac ctacgtgctc ctcggcagtg tgatcacagc cagccgcgtg ttcgtggcag
     1201 tgacgctgta tggggctgtg cggctgacgg ttaccctctt cttcccctca gccattgaga
     1261 gggtgtcaga ggcaatcgtc agcatccgaa gaatccagac ctttttgcta cttgatgaga
     1321 tatcacagcg caaccgtcag ctgccgtcag atggtaaaaa gatggtgcat gtgcaggatt
     1381 ttactgcttt ttgggataag gcatcagaga ccccaactct acaaggcctt tcctttactg
     1441 tcagacctgg cgaattgtta gctgtggtcg gccccgtggg agcagggaag tcatcactgt
     1501 taagtgccgt gctcggggaa ttggccccaa gtcacgggct ggtcagcgtg catggaagaa
     1561 ttgcctatgt gtctcagcag ccctgggtgt tctcgggaac tctgaggagt aatattttat
     1621 ttgggaagaa atacgaaaag gaacgatatg aaaaagtcat aaaggcttgt gctctgaaaa
     1681 aggatttaca gctgttggag gatggtgatc tgactgtgat aggagatcgg ggaaccacgc
     1741 tgagtggagg gcagaaagca cgggtaaacc ttgcaagagc agtgtatcaa gatgctgaca
     1801 tctatctcct ggacgatcct ctcagtgcag tagatgcgga agttagcaga cacttgttcg
     1861 aactgtgtat ttgtcaaatt ttgcatgaga agatcacaat tttagtgact catcagttgc
     1921 agtacctcaa agctgcaagt cagattctga tattgaaaga tggtaaaatg gtgcagaagg
     1981 ggacttacac tgagttccta aaatctggta tagattttgg ctccctttta aagaaggata
     2041 atgaggaaag tgaacaacct ccagttccag gaactcccac actaaggaat cgtaccttct
     2101 cagagtcttc ggtttggtct caacaatctt ctagaccctc cttgaaagat ggtgctctgg
     2161 agagccaaga tgttgcctat gtgcttcaag attggtggct ttcatactgg gcaaacaaac
     2221 aaagtatgct aaatgtcact gtaaatggag gaggaaatgt aaccgagaag ctagatctta
     2281 actggtactt aggaatttat tcaggtttaa ctgtagctac cgttcttttt ggcatagcaa
     2341 gatctctatt ggtattctac gtccttgtta actcttcaca aactttgcac aacaaaatgt
     2401 ttgagtcaat tctgaaagct ccggtattat tctttgatag aaatccaata ggaagaattt
     2461 taaatcgttt ctccaaagac attggacact tggatgattt gctgccgctg acgtttttag
     2521 atttcatcca gacattgcta caagtggttg gtgtggtctc tgtggctgtg gccgtgattc
     2581 cttggatcgc aatacccttg gttccccttg gaatcatttt catttttctt cggcgatatt
     2641 ttttggaaac gtcaagagat gtgaagcgcc tggaatctac aactcggagt ccagtgtttt
     2701 cccacttatc atcttctctc caggggctct ggaccatccg ggcatacaaa gcagaagaga
     2761 ggtgtcagga actgtttgat gcacaccagg atttacattc agaggcttgg ttcttgtttt
     2821 tgacaacgtc ccgctggttt gccgtccgtc tggatgccat ctgtgccatg tttgtcatca
     2881 tcgttgcctt tgggtccctg attctggcaa aaactctgga tgccgggcag gttggtttgg
     2941 cactgtccta tgccctcacg ctcatgggga tgtttcagtg gtgtgttcga caaagtgctg
     3001 aagttgagaa tatgatgatc tcagtagaaa gggtcattga atacacagac cttgaaaaag
     3061 aagcaccttg ggaatatcag aaacgcccac caccagcctg gccccatgaa ggagtgataa
     3121 tctttgacaa tgtgaacttc atgtacagtc caggtgggcc tctggtactg aagcatctga
     3181 cagcactcat taaatcacaa gaaaaggttg gcattgtggg aagaaccgga gctggaaaaa
     3241 gttccctcat ctcagccctt tttagattgt cagaacccga aggtaaaatt tggattgata
     3301 agatcttgac aactgaaatt ggacttcacg atttaaggaa gaagatgtca atcatacctc
     3361 aggaacctgt tttgttcact ggaacaatga ggaaaaacct ggatcccttt aatgagcaca
     3421 cggatgagga actgtggaat gccttacaag aggtacaact taaagaaacc attgaagatc
     3481 ttcctggtaa aatggatact gaattagcag aatcaggatc caattttagt gttggacaaa
     3541 gacaactggt gtgccttgcc agggcaattc tcaggaaaaa tcagatattg attattgatg
     3601 aagcgacggc aaatgtggat ccaagaactg atgagttaat acaaaaaaaa atccgggaga
     3661 aatttgccca ctgcaccgtg ctaaccattg cacacagatt gaacaccatt attgacagcg
     3721 acaagataat ggttttagat tcaggaagac tgaaagaata tgatgagccg tatgttttgc
     3781 tgcaaaataa agagagccta ttttacaaga tggtgcaaca actgggcaag gcagaagccg
     3841 ctgccctcac tgaaacagca aaacaggtat acttcaaaag aaattatcca catattggtc
     3901 acactgacca catggttaca aacacttcca atggacagcc ctcgacctta actattttcg
     3961 agacagcact gtgaatccaa ccaaaatgtc aagtccgttc cgaaggcatt ttccactagt
     4021 ttttggacta tgtaaaccac attgtacttt tttttacttt ggcaacaaat atttatacat
     4081 acaagatgct agttcatttg aatatttctc ccaacttatc caaggatctc cagctctaac
     4141 aaaatggttt atttttattt aaatgtcaat agttgttttt taaaatccaa atcagaggtg
     4201 caggccacca gttaaatgcc gtctatcagg ttttgtgcct taagagacta cagagtcaaa
     4261 gctcattttt aaaggagtag gacaaagttg tcacaggttt ttgttgttgt ttttattgcc
     4321 cccaaaatta catgttaatt tccatttata tcagggattc tatttacttg aagactgtga
     4381 agttgccatt ttgtctcatt gttttctttg acataactag gatccattat ttcccctgaa
     4441 ggcttcttgt tagaaaatag tacagttaca accaatagga acaacaaaaa gaaaaagttt
     4501 gtgacattgt agtagggagt gtgtacccct tactccccat caaaaaaaaa aatggataca
     4561 tggttaaagg atagaagggc aatattttat catatgttct aaaagagaag gaagagaaaa
     4621 tactactttc tcaaaatgga agcccttaaa ggtgctttga tactgaagga cacaaatgtg
     4681 accgtccatc ctcctttaga gttgcatgac ttggacacgg taactgttgc agttttagac
     4741 tcagcattgt gacacttccc aagaaggcca aacctctaac cgacattcct gaaatacgtg
     4801 gcattattct tttttggatt tctcatttat ggaaggctaa ccctctgttg actgtaagcc
     4861 ttttggtttg ggctgtattg aaatcctttc taaattgcat gaataggctc tgctaacgtg
     4921 atgagacaaa ctgaaaatta ttgcaagcat tgactataat tatgcagtac gttctcagga
     4981 tgcatccagg ggttcatttt catgagcctg tccaggttag tttactcctg accactaata
     5041 gcattgtcat ttgggctttc tgttgaatga atcaacaaac cacaatactt cctgggacct
     5101 tttgtacttt atttgaacta tgagtcttta atttttcctg atgatggtgg ctgtaatatg
     5161 ttgagttcag tttactaaag gttttactat tatggtttga agtggagtct catgacctct
     5221 cagaataagg tgtcacctcc ctgaaattgc atatatgtat atagacatgc acacgtgtgc
     5281 atttgtttgt atacatatat ttgtccttcg tatagcaagt tttttgctca tcagcagaga
     5341 gcaacagatg ttttattgag tgaagcctta aaaagcacac accacacaca gctaactgcc
     5401 aaaatacatt gaccgtagta gctgttcaac tcctagtact tagaaataca cgtatggtta
     5461 atgttcagtc caacaaacca cacacagtaa atgtttatta atagtcatgg ttcgtatttt
     5521 aggtgactga aattgcatca gtgatcataa tgaggtttgt taaaacgata gctatattca
     5581 aaatgtctat atgtttattt ggacttttga ggttaaagac agtcatataa acgtcctgtt
     5641 tctgttttaa tgttatcata gaatttttta atgaaactaa attcaattga aataaatgat
     5701 agttttcatc tcca
//
