LOCUS       NM_001105515            3081 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens ATP binding cassette subfamily C member 4 (PEL blood
            group) (ABCC4), transcript variant 2, mRNA.
ACCESSION   NM_001105515
VERSION     NM_001105515.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3081)
  AUTHORS   Ranjit,S., Wang,Y., Zhu,J., Cheepala,S.B., Schuetz,E.G., Cho,W.J.,
            Xu,B., Robinson,C.G., Wu,G., Naren,A.P. and Schuetz,J.D.
  TITLE     ABCC4 impacts megakaryopoiesis and protects megakaryocytes against
            6-mercaptopurine induced cytotoxicity
  JOURNAL   Drug Resist Updat 72, 101017 (2024)
   PUBMED   37988981
  REMARK    GeneRIF: ABCC4 impacts megakaryopoiesis and protects megakaryocytes
            against 6-mercaptopurine induced cytotoxicity.
REFERENCE   2  (bases 1 to 3081)
  AUTHORS   Bloch,M., Raj,I., Pape,T. and Taylor,N.M.I.
  TITLE     Structural and mechanistic basis of substrate transport by the
            multidrug transporter MRP4
  JOURNAL   Structure 31 (11), 1407-1418 (2023)
   PUBMED   37683641
  REMARK    GeneRIF: Structural and mechanistic basis of substrate transport by
            the multidrug transporter MRP4.
REFERENCE   3  (bases 1 to 3081)
  AUTHORS   Huang,C., Xu,R., Zhu,X. and Jiang,H.
  TITLE     m6A-modified circABCC4 promotes stemness and metastasis of prostate
            cancer by recruiting IGF2BP2 to increase stability of CCAR1
  JOURNAL   Cancer Gene Ther 30 (10), 1426-1440 (2023)
   PUBMED   37563361
  REMARK    GeneRIF: m6A-modified circABCC4 promotes stemness and metastasis of
            prostate cancer by recruiting IGF2BP2 to increase stability of
            CCAR1.
REFERENCE   4  (bases 1 to 3081)
  AUTHORS   Hu,F., Chen,X.Q., Li,X.P., Lu,Y.X., Chen,S.L., Wang,D.W., Liang,Y.
            and Dai,Y.J.
  TITLE     Drug resistance biomarker ABCC4 of selinexor and immune feature in
            multiple myeloma
  JOURNAL   Int Immunopharmacol 108, 108722 (2022)
   PUBMED   35381563
  REMARK    GeneRIF: Drug resistance biomarker ABCC4 of selinexor and immune
            feature in multiple myeloma.
REFERENCE   5  (bases 1 to 3081)
  AUTHORS   Adachi,M., Sampath,J., Lan,L.B., Sun,D., Hargrove,P., Flatley,R.,
            Tatum,A., Edwards,M.Z., Wezeman,M., Matherly,L., Drake,R. and
            Schuetz,J.
  TITLE     Expression of MRP4 confers resistance to ganciclovir and
            compromises bystander cell killing
  JOURNAL   J Biol Chem 277 (41), 38998-39004 (2002)
   PUBMED   12105214
  REMARK    GeneRIF: These findings indicate that a nucleotide transporter,
            such as MRP4, modulates the cellular response to ganciclovir and
            thus may influence not only the efficacy of antiviral therapy, but
            also prodrug-based gene therapy.
REFERENCE   6  (bases 1 to 3081)
  AUTHORS   Lee,K., Belinsky,M.G., Bell,D.W., Testa,J.R. and Kruh,G.D.
  TITLE     Isolation of MOAT-B, a widely expressed multidrug
            resistance-associated protein/canalicular multispecific organic
            anion transporter-related transporter
  JOURNAL   Cancer Res 58 (13), 2741-2747 (1998)
   PUBMED   9661885
REFERENCE   7  (bases 1 to 3081)
  AUTHORS   Kool,M., de Haas,M., Scheffer,G.L., Scheper,R.J., van Eijk,M.J.,
            Juijn,J.A., Baas,F. and Borst,P.
  TITLE     Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5,
            homologues of the multidrug resistance-associated protein gene
            (MRP1), in human cancer cell lines
  JOURNAL   Cancer Res 57 (16), 3537-3547 (1997)
   PUBMED   9270026
REFERENCE   8  (bases 1 to 3081)
  AUTHORS   Allikmets,R., Gerrard,B., Hutchinson,A. and Dean,M.
  TITLE     Characterization of the human ABC superfamily: isolation and
            mapping of 21 new genes using the expressed sequence tags database
  JOURNAL   Hum Mol Genet 5 (10), 1649-1655 (1996)
   PUBMED   8894702
REFERENCE   9  (bases 1 to 3081)
  AUTHORS   Pichaud,F., Frendo,J.L., Delage-Mourroux,R., de Vernejoul,M.C.,
            Moukhtar,M.S. and Jullienne,A.
  TITLE     Sequence of a novel mRNA coding for a C-terminal-truncated form of
            human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase
  JOURNAL   Gene 162 (2), 319-322 (1995)
   PUBMED   7557451
REFERENCE   10 (bases 1 to 3081)
  AUTHORS   Ponticelli,A.S. and Smith,G.R.
  TITLE     Meiotic recombination-deficient mutants of Schizosaccharomyces
            pombe
  JOURNAL   Genetics 123 (1), 45-54 (1989)
   PUBMED   2806887
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356257.14, AK290317.1,
            CN410193.1, BC041560.1 and BX113883.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001105515.2.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra- and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
            protein is a member of the MRP subfamily which is involved in
            multi-drug resistance. This family member plays a role in cellular
            detoxification as a pump for its substrate, organic anions. It may
            also function in prostaglandin-mediated cAMP signaling in
            ciliogenesis. Alternative splicing of this gene results in multiple
            transcript variants. [provided by RefSeq, Sep 2014].
            
            Transcript Variant: This variant (2) lacks several 3' exons but
            contains an alternate 3' terminal exon, and it thus differs in the
            3' coding region and 3' UTR, compared to variant 1. The encoded
            isoform (2) has a distinct and shorter C-terminus, compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290317.1, BC041560.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AL356257.14        72487-72491         c
            6-805               AK290317.1         1-800
            806-1142            CN410193.1         111-447
            1143-2185           AK290317.1         1138-2180
            2186-2908           BC041560.1         2151-2873
            2909-3081           BX113883.1         15-187              c
FEATURES             Location/Qualifiers
     source          1..3081
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q32.1"
     gene            1..3081
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /note="ATP binding cassette subfamily C member 4 (PEL
                     blood group)"
                     /db_xref="GeneID:10257"
                     /db_xref="HGNC:HGNC:55"
                     /db_xref="MIM:605250"
     exon            1..211
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..2717
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /EC_number="7.6.2.2"
                     /EC_number="7.6.2.3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     canalicular multispecific organic anion transporter (ABC
                     superfamily); multidrug resistance-associated protein 4;
                     bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP),
                     member 4); MRP/cMOAT-related ABC transporter;
                     multi-specific organic anion transporter B"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family C member 4
                     isoform 2"
                     /protein_id="NP_001098985.1"
                     /db_xref="CCDS:CCDS45061.1"
                     /db_xref="GeneID:10257"
                     /db_xref="HGNC:HGNC:55"
                     /db_xref="MIM:605250"
                     /translation="MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDM
                     YSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIE
                     ESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQ
                     CAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAG
                     PLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTM
                     NEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFV
                     TFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLL
                     DEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAG
                     KSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVI
                     KACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVD
                     AEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSG
                     IDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTENV
                     PVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWAN
                     KQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLH
                     NKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQRWDLAVLSWLV
                     SNS"
     exon            212..322
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            323..443
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            444..668
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            669..758
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            759..922
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1048
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1298
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1400
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1490
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1682
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1777
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1864
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1961
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2171
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2312
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2350
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2445
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2592
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2672
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..3081
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2882..2887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /note="hexamer: ATTAAA"
     polyA_site      2908
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /note="major polyA site"
     regulatory      3059..3064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /note="hexamer: CATAAA"
     polyA_site      3081
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /note="major polyA site"
ORIGIN      
        1 gcttcacagg ctccagccga gcggacaggc gtggcggccg gagccccagc atccctgctt
       61 gaggtccagg agcggagccc gcggccaccg ccgcctgatc agcgcgaccc cggcccgcgc
      121 ccgccccgcc cggcaagatg ctgcccgtgt accaggaggt gaagcccaac ccgctgcagg
      181 acgcgaacct ctgctcacgc gtgttcttct ggtggctcaa tcccttgttt aaaattggcc
      241 ataaacggag attagaggaa gatgatatgt attcagtgct gccagaagac cgctcacagc
      301 accttggaga ggagttgcaa gggttctggg ataaagaagt tttaagagct gagaatgacg
      361 cacagaagcc ttctttaaca agagcaatca taaagtgtta ctggaaatct tatttagttt
      421 tgggaatttt tacgttaatt gaggaaagtg ccaaagtaat ccagcccata tttttgggaa
      481 aaattattaa ttattttgaa aattatgatc ccatggattc tgtggctttg aacacagcgt
      541 acgcctatgc cacggtgctg actttttgca cgctcatttt ggctatactg catcacttat
      601 atttttatca cgttcagtgt gctgggatga ggttacgagt agccatgtgc catatgattt
      661 atcggaaggc acttcgtctt agtaacatgg ccatggggaa gacaaccaca ggccagatag
      721 tcaatctgct gtccaatgat gtgaacaagt ttgatcaggt gacagtgttc ttacacttcc
      781 tgtgggcagg accactgcag gcgattgcag tgactgccct actctggatg gagataggaa
      841 tatcgtgcct tgctgggatg gcagttctaa tcattctcct gcccttgcaa agctgttttg
      901 ggaagttgtt ctcatcactg aggagtaaaa ctgcaacttt cacggatgcc aggatcagga
      961 ccatgaatga agttataact ggtataagga taataaaaat gtacgcctgg gaaaagtcat
     1021 tttcaaatct tattaccaat ttgagaaaga aggagatttc caagattctg agaagttcct
     1081 gcctcagagg gatgaatttg gcttcatttt tcagtgcaag caaaatcatc gtgtttgtga
     1141 ccttcaccac ctacgtgctc ctcggcagtg tgatcacagc cagccgcgtg ttcgtggcag
     1201 tgacgctgta tggggctgtg cggctgacgg ttaccctctt cttcccctca gccattgaga
     1261 gggtgtcaga ggcaatcgtc agcatccgaa gaatccagac ctttttgcta cttgatgaga
     1321 tatcacagcg caaccgtcag ctgccgtcag atggtaaaaa gatggtgcat gtgcaggatt
     1381 ttactgcttt ttgggataag gcatcagaga ccccaactct acaaggcctt tcctttactg
     1441 tcagacctgg cgaattgtta gctgtggtcg gccccgtggg agcagggaag tcatcactgt
     1501 taagtgccgt gctcggggaa ttggccccaa gtcacgggct ggtcagcgtg catggaagaa
     1561 ttgcctatgt gtctcagcag ccctgggtgt tctcgggaac tctgaggagt aatattttat
     1621 ttgggaagaa atacgaaaag gaacgatatg aaaaagtcat aaaggcttgt gctctgaaaa
     1681 aggatttaca gctgttggag gatggtgatc tgactgtgat aggagatcgg ggaaccacgc
     1741 tgagtggagg gcagaaagca cgggtaaacc ttgcaagagc agtgtatcaa gatgctgaca
     1801 tctatctcct ggacgatcct ctcagtgcag tagatgcgga agttagcaga cacttgttcg
     1861 aactgtgtat ttgtcaaatt ttgcatgaga agatcacaat tttagtgact catcagttgc
     1921 agtacctcaa agctgcaagt cagattctga tattgaaaga tggtaaaatg gtgcagaagg
     1981 ggacttacac tgagttccta aaatctggta tagattttgg ctccctttta aagaaggata
     2041 atgaggaaag tgaacaacct ccagttccag gaactcccac actaaggaat cgtaccttct
     2101 cagagtcttc ggtttggtct caacaatctt ctagaccctc cttgaaagat ggtgctctgg
     2161 agagccaaga tacagagaat gtcccagtta cactatcaga ggagaaccgt tctgaaggaa
     2221 aagttggttt tcaggcctat aagaattact tcagagctgg tgctcactgg attgtcttca
     2281 ttttccttat tctcctaaac actgcagctc aggttgccta tgtgcttcaa gattggtggc
     2341 tttcatactg ggcaaacaaa caaagtatgc taaatgtcac tgtaaatgga ggaggaaatg
     2401 taaccgagaa gctagatctt aactggtact taggaattta ttcaggttta actgtagcta
     2461 ccgttctttt tggcatagca agatctctat tggtattcta cgtccttgtt aactcttcac
     2521 aaactttgca caacaaaatg tttgagtcaa ttctgaaagc tccggtatta ttctttgata
     2581 gaaatccaat aggaagaatt ttaaatcgtt tctccaaaga cattggacac ttggatgatt
     2641 tgctgccgct gacgttttta gatttcatcc agagatggga tctcgctgtg ttgtcctggc
     2701 tggtctcaaa ctcctaggct caagcaatcc tcctccctcc tcaagcaaac ctcagtgctg
     2761 ggattatagg catgagccac tgtacctggc taaatgttgt ttttttgata ttcaattttt
     2821 gtttatagaa ttttcatttg ttttgctctt atacttttca tctttttatg tttattgacc
     2881 aattaaatat catttgggta agcacctatt taagtgtctt aacaattttt ctattgagta
     2941 ctctgggttt ttgttttgtt tttcttactg atttgtagaa ttctttatgt attctgaatt
     3001 gcagatacct tccttctgta ctaatgctta tctttttagc cctgtaatat tgtgttttca
     3061 taaacatact tatcaatctt t
//
