LOCUS       NM_003786               5693 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens ATP binding cassette subfamily C member 3 (ABCC3),
            transcript variant 1, mRNA.
ACCESSION   NM_003786
VERSION     NM_003786.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5693)
  AUTHORS   Liu,H., Yue,L., Hong,W. and Zhou,J.
  TITLE     SMARCA4 (BRG1) activates ABCC3 transcription to promote
            hepatocellular carcinogenesis
  JOURNAL   Life Sci 347, 122605 (2024)
   PUBMED   38642845
  REMARK    GeneRIF: SMARCA4 (BRG1) activates ABCC3 transcription to promote
            hepatocellular carcinogenesis.
REFERENCE   2  (bases 1 to 5693)
  AUTHORS   Sato,Y., Kobayashi,M., Ohira,M., Funayama,R., Maekawa,M.,
            Karasawa,H., Kashiwagi,R., Aoyama,Y., Mano,N., Ohnuma,S., Unno,M.
            and Nakayama,K.
  TITLE     Downregulation of ABCC3 activates MAPK signaling through
            accumulation of deoxycholic acid in colorectal cancer cells
  JOURNAL   Cancer Sci 115 (6), 1778-1790 (2024)
   PUBMED   38566304
  REMARK    GeneRIF: Downregulation of ABCC3 activates MAPK signaling through
            accumulation of deoxycholic acid in colorectal cancer cells.
REFERENCE   3  (bases 1 to 5693)
  AUTHORS   Hau,R.K., Klein,R.R., Wright,S.H. and Cherrington,N.J.
  TITLE     Localization of Xenobiotic Transporters Expressed at the Human
            Blood-Testis Barrier
  JOURNAL   Drug Metab Dispos 50 (6), 770-780 (2022)
   PUBMED   35307651
REFERENCE   4  (bases 1 to 5693)
  AUTHORS   Banach,B., Modrzejewski,A., Juzyszyn,Z., Kurzawski,M.,
            Sroczynski,T. and Pawlik,A.
  TITLE     Association Study of SLCO1B3 and ABCC3 Genetic Variants in
            Gallstone Disease
  JOURNAL   Genes (Basel) 13 (3), 512 (2022)
   PUBMED   35328066
  REMARK    GeneRIF: Association Study of SLCO1B3 and ABCC3 Genetic Variants in
            Gallstone Disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5693)
  AUTHORS   Seborova,K., Kloudova-Spalenkova,A., Koucka,K., Holy,P.,
            Ehrlichova,M., Wang,C., Ojima,I., Voleska,I., Daniel,P.,
            Balusikova,K., Jelinek,M., Kovar,J., Rob,L., Hruda,M., Mrhalova,M.,
            Soucek,P. and Vaclavikova,R.
  TITLE     The Role of TRIP6, ABCC3 and CPS1 Expression in Resistance of
            Ovarian Cancer to Taxanes
  JOURNAL   Int J Mol Sci 23 (1), 73 (2021)
   PUBMED   35008510
  REMARK    GeneRIF: The Role of TRIP6, ABCC3 and CPS1 Expression in Resistance
            of Ovarian Cancer to Taxanes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5693)
  AUTHORS   Belinsky,M.G., Bain,L.J., Balsara,B.B., Testa,J.R. and Kruh,G.D.
  TITLE     Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT
            subfamily of transporter proteins
  JOURNAL   J Natl Cancer Inst 90 (22), 1735-1741 (1998)
   PUBMED   9827529
REFERENCE   7  (bases 1 to 5693)
  AUTHORS   Uchiumi,T., Hinoshita,E., Haga,S., Nakamura,T., Tanaka,T., Toh,S.,
            Furukawa,M., Kawabe,T., Wada,M., Kagotani,K., Okumura,K., Kohno,K.,
            Akiyama,S. and Kuwano,M.
  TITLE     Isolation of a novel human canalicular multispecific organic anion
            transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant
            cancer cells with decreased ATP-dependent drug transport
  JOURNAL   Biochem Biophys Res Commun 252 (1), 103-110 (1998)
   PUBMED   9813153
REFERENCE   8  (bases 1 to 5693)
  AUTHORS   Kiuchi,Y., Suzuki,H., Hirohashi,T., Tyson,C.A. and Sugiyama,Y.
  TITLE     cDNA cloning and inducible expression of human multidrug resistance
            associated protein 3 (MRP3)
  JOURNAL   FEBS Lett 433 (1-2), 149-152 (1998)
   PUBMED   9738950
REFERENCE   9  (bases 1 to 5693)
  AUTHORS   Kool,M., de Haas,M., Scheffer,G.L., Scheper,R.J., van Eijk,M.J.,
            Juijn,J.A., Baas,F. and Borst,P.
  TITLE     Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5,
            homologues of the multidrug resistance-associated protein gene
            (MRP1), in human cancer cell lines
  JOURNAL   Cancer Res 57 (16), 3537-3547 (1997)
   PUBMED   9270026
REFERENCE   10 (bases 1 to 5693)
  AUTHORS   Allikmets,R., Gerrard,B., Hutchinson,A. and Dean,M.
  TITLE     Characterization of the human ABC superfamily: isolation and
            mapping of 21 new genes using the expressed sequence tags database
  JOURNAL   Hum Mol Genet 5 (10), 1649-1655 (1996)
   PUBMED   8894702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC046126.1, BC137347.1,
            AB010887.1 and AC005921.3.
            
            On Nov 23, 2018 this sequence version replaced NM_003786.3.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra- and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
            protein is a member of the MRP subfamily which is involved in
            multi-drug resistance. The specific function of this protein has
            not yet been determined; however, this protein may play a role in
            the transport of biliary and intestinal excretion of organic
            anions. Alternatively spliced variants which encode different
            protein isoforms have been described; however, not all variants
            have been fully characterized. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF085690.1, AB208954.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000285238.13/ ENSP00000285238.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                BC046126.1         25-118
            95-4896             BC137347.1         70-4871
            4897-5142           AB010887.1         4855-5100
            5143-5693           AC005921.3         25119-25669
FEATURES             Location/Qualifiers
     source          1..5693
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..5693
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /note="ATP binding cassette subfamily C member 3"
                     /db_xref="GeneID:8714"
                     /db_xref="HGNC:HGNC:54"
                     /db_xref="MIM:604323"
     exon            1..101
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..4640
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /EC_number="7.6.2.2"
                     /EC_number="7.6.2.3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     canicular multispecific organic anion transporter;
                     canalicular multispecific organic anion transporter 2;
                     multidrug resistance associated protein; multidrug
                     resistance-associated protein 3; ATP-binding cassette
                     sub-family C member 3; multi-specific organic anion
                     transporter D; ATP-binding cassette, sub-family C
                     (CFTR/MRP), member 3"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family C member 3
                     isoform 1"
                     /protein_id="NP_003777.2"
                     /db_xref="CCDS:CCDS32681.1"
                     /db_xref="GeneID:8714"
                     /db_xref="HGNC:HGNC:54"
                     /db_xref="MIM:604323"
                     /translation="MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIY
                     LWVALPCYLLYLRHHCRGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPA
                     PVFFVTPLVVGVTMLLATLLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAK
                     AEGEISDPFRFTTFYIHFALVLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRL
                     FFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAP
                     GKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSI
                     LIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRK
                     ALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGP
                     SVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEP
                     SFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAE
                     KAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPG
                     YAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLE
                     GKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGD
                     QTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEG
                     VLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDE
                     DQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDG
                     EGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTL
                     AICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAA
                     MAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVIL
                     MLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSP
                     IYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGN
                     CVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKE
                     YSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVG
                     IVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSG
                     TLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCL
                     ARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVL
                     VLDKGVVAEFDSPANLIAARGIFYGMARDAGLA"
     exon            102..278
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            279..404
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            405..542
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            543..668
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            669..730
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            731..862
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1054
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1232
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1394
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1487
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1691
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1838
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1926
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..1993
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2120
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2297
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2465
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2655
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2770
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..2915
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2916..3123
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3124..3434
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3435..3634
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3635..3761
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3762..3863
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3864..4010
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4011..4169
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4170..4336
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4337..4531
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4532..5693
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5119..5124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /note="hexamer: AATAAA"
     polyA_site      5142
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /note="major polyA site"
     regulatory      5666..5671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
                     /note="hexamer: ATTAAA"
     polyA_site      5693
                     /gene="ABCC3"
                     /gene_synonym="ABC31; cMOAT2; EST90757; MLP2; MOAT-D;
                     MRP3"
ORIGIN      
        1 ctgcccgccg ctgggtccga ccgcgctcgc cttccttgca gccgcgcctc ggccccatgg
       61 acgccctgtg cggttccggg gagctcggct ccaagttctg ggactccaac ctgtctgtgc
      121 acacagaaaa cccggacctc actccctgct tccagaactc cctgctggcc tgggtgccct
      181 gcatctacct gtgggtcgcc ctgccctgct acttgctcta cctgcggcac cattgtcgtg
      241 gctacatcat cctctcccac ctgtccaagc tcaagatggt cctgggtgtc ctgctgtggt
      301 gcgtctcctg ggcggacctt ttttactcct tccatggcct ggtccatggc cgggcccctg
      361 cccctgtttt ctttgtcacc cccttggtgg tgggggtcac catgctgctg gccaccctgc
      421 tgatacagta tgagcggctg cagggcgtac agtcttcggg ggtcctcatt atcttctggt
      481 tcctgtgtgt ggtctgcgcc atcgtcccat tccgctccaa gatcctttta gccaaggcag
      541 agggtgagat ctcagacccc ttccgcttca ccaccttcta catccacttt gccctggtac
      601 tctctgccct catcttggcc tgcttcaggg agaaacctcc atttttctcc gcaaagaatg
      661 tcgaccctaa cccctaccct gagaccagcg ctggctttct ctcccgcctg tttttctggt
      721 ggttcacaaa gatggccatc tatggctacc ggcatcccct ggaggagaag gacctctggt
      781 ccctaaagga agaggacaga tcccagatgg tggtgcagca gctgctggag gcatggagga
      841 agcaggaaaa gcagacggca cgacacaagg cttcagcagc acctgggaaa aatgcctccg
      901 gcgaggacga ggtgctgctg ggtgcccggc ccaggccccg gaagccctcc ttcctgaagg
      961 ccctgctggc caccttcggc tccagcttcc tcatcagtgc ctgcttcaag cttatccagg
     1021 acctgctctc cttcatcaat ccacagctgc tcagcatcct gatcaggttt atctccaacc
     1081 ccatggcccc ctcctggtgg ggcttcctgg tggctgggct gatgttcctg tgctccatga
     1141 tgcagtcgct gatcttacaa cactattacc actacatctt tgtgactggg gtgaagtttc
     1201 gtactgggat catgggtgtc atctacagga aggctctggt tatcaccaac tcagtcaaac
     1261 gtgcgtccac tgtgggggaa attgtcaacc tcatgtcagt ggatgcccag cgcttcatgg
     1321 accttgcccc cttcctcaat ctgctgtggt cagcacccct gcagatcatc ctggcgatct
     1381 acttcctctg gcagaaccta ggtccctctg tcctggctgg agtcgctttc atggtcttgc
     1441 tgattccact caacggagct gtggccgtga agatgcgcgc cttccaggta aagcaaatga
     1501 aattgaagga ctcgcgcatc aagctgatga gtgagatcct gaacggcatc aaggtgctga
     1561 agctgtacgc ctgggagccc agcttcctga agcaggtgga gggcatcagg cagggtgagc
     1621 tccagctgct gcgcacggcg gcctacctcc acaccacaac caccttcacc tggatgtgca
     1681 gccccttcct ggtgaccctg atcaccctct gggtgtacgt gtacgtggac ccaaacaatg
     1741 tgctggacgc cgagaaggcc tttgtgtctg tgtccttgtt taatatctta agacttcccc
     1801 tcaacatgct gccccagtta atcagcaacc tgactcaggc cagtgtgtct ctgaaacgga
     1861 tccagcaatt cctgagccaa gaggaacttg acccccagag tgtggaaaga aagaccatct
     1921 ccccaggcta tgccatcacc atacacagtg gcaccttcac ctgggcccag gacctgcccc
     1981 ccactctgca cagcctagac atccaggtcc cgaaaggggc actggtggcc gtggtggggc
     2041 ctgtgggctg tgggaagtcc tccctggtgt ctgccctgct gggagagatg gagaagctag
     2101 aaggcaaagt gcacatgaag ggctccgtgg cctatgtgcc ccagcaggca tggatccaga
     2161 actgcactct tcaggaaaac gtgcttttcg gcaaagccct gaaccccaag cgctaccagc
     2221 agactctgga ggcctgtgcc ttgctagctg acctggagat gctgcctggt ggggatcaga
     2281 cagagattgg agagaagggc attaacctgt ctgggggcca gcggcagcgg gtcagtctgg
     2341 ctcgagctgt ttacagtgat gccgatattt tcttgctgga tgacccactg tccgcggtgg
     2401 actctcatgt ggccaagcac atctttgacc acgtcatcgg gccagaaggc gtgctggcag
     2461 gcaagacgcg agtgctggtg acgcacggca ttagcttcct gccccagaca gacttcatca
     2521 ttgtgctagc tgatggacag gtgtctgaga tgggcccgta cccagccctg ctgcagcgca
     2581 acggctcctt tgccaacttt ctctgcaact atgcccccga tgaggaccaa gggcacctgg
     2641 aggacagctg gaccgcgttg gaaggtgcag aggataagga ggcactgctg attgaagaca
     2701 cactcagcaa ccacacggat ctgacagaca atgatccagt cacctatgtg gtccagaagc
     2761 agtttatgag acagctgagt gccctgtcct cagatgggga gggacagggt cggcctgtac
     2821 cccggaggca cctgggtcca tcagagaagg tgcaggtgac agaggcgaag gcagatgggg
     2881 cactgaccca ggaggagaaa gcagccattg gcactgtgga gctcagtgtg ttctgggatt
     2941 atgccaaggc cgtggggctc tgtaccacgc tggccatctg tctcctgtat gtgggtcaaa
     3001 gtgcggctgc cattggagcc aatgtgtggc tcagtgcctg gacaaatgat gccatggcag
     3061 acagtagaca gaacaacact tccctgaggc tgggcgtcta tgctgcttta ggaattctgc
     3121 aagggttctt ggtgatgctg gcagccatgg ccatggcagc gggtggcatc caggctgccc
     3181 gtgtgttgca ccaggcactg ctgcacaaca agatacgctc gccacagtcc ttctttgaca
     3241 ccacaccatc aggccgcatc ctgaactgct tctccaagga catctatgtc gttgatgagg
     3301 ttctggcccc tgtcatcctc atgctgctca attccttctt caacgccatc tccactcttg
     3361 tggtcatcat ggccagcacg ccgctcttca ctgtggtcat cctgcccctg gctgtgctct
     3421 acaccttagt gcagcgcttc tatgcagcca catcacggca actgaagcgg ctggaatcag
     3481 tcagccgctc acctatctac tcccactttt cggagacagt gactggtgcc agtgtcatcc
     3541 gggcctacaa ccgcagccgg gattttgaga tcatcagtga tactaaggtg gatgccaacc
     3601 agagaagctg ctacccctac atcatctcca accggtggct gagcatcgga gtggagttcg
     3661 tggggaactg cgtggtgctc tttgctgcac tatttgccgt catcgggagg agcagcctga
     3721 acccggggct ggtgggcctt tctgtgtcct actccttgca ggtgacattt gctctgaact
     3781 ggatgatacg aatgatgtca gatttggaat ctaacatcgt ggctgtggag agggtcaagg
     3841 agtactccaa gacagagaca gaggcgccct gggtggtgga aggcagccgc cctcccgaag
     3901 gttggccccc acgtggggag gtggagttcc ggaattattc tgtgcgctac cggccgggcc
     3961 tagacctggt gctgagagac ctgagtctgc atgtgcacgg tggcgagaag gtggggatcg
     4021 tgggccgcac tggggctggc aagtcttcca tgaccctttg cctgttccgc atcctggagg
     4081 cggcaaaggg tgaaatccgc attgatggcc tcaatgtggc agacatcggc ctccatgacc
     4141 tgcgctctca gctgaccatc atcccgcagg accccatcct gttctcgggg accctgcgca
     4201 tgaacctgga ccccttcggc agctactcag aggaggacat ttggtgggct ttggagctgt
     4261 cccacctgca cacgtttgtg agctcccagc cggcaggcct ggacttccag tgctcagagg
     4321 gcggggagaa tctcagcgtg ggccagaggc agctcgtgtg cctggcccga gccctgctcc
     4381 gcaagagccg catcctggtt ttagacgagg ccacagctgc catcgacctg gagactgaca
     4441 acctcatcca ggctaccatc cgcacccagt ttgatacctg cactgtcctg accatcgcac
     4501 accggcttaa cactatcatg gactacacca gggtcctggt cctggacaaa ggagtagtag
     4561 ctgaatttga ttctccagcc aacctcattg cagctagagg catcttctac gggatggcca
     4621 gagatgctgg acttgcctaa aatatattcc tgagatttcc tcctggcctt tcctggtttt
     4681 catcaggaag gaaatgacac caaatatgtc cgcagaatgg acttgatagc aaacactggg
     4741 ggcaccttaa gattttgcac ctgtaaagtg ccttacaggg taactgtgct gaatgcttta
     4801 gatgaggaaa tgatccccaa gtggtgaatg acacgcctaa ggtcacagct agtttgagcc
     4861 agttagacta gtccccggtc tcccgattcc caactgagtg ttatttgcac actgcactgt
     4921 tttcaaataa cgattttatg aaatgacctc tgtcctccct ctgatttttc atattttcta
     4981 aagtttcgtt tctgtttttt aataaaaagc tttttcctcc tggaacagaa gacagctgct
     5041 gggtcaggcc acccctagga actcagtcct gtactctggg gtgctgcctg aatccattaa
     5101 aaatgggagt actgatgaaa taaaactaca tggtcaacag tatatacaca gtagtctttt
     5161 tgcacttgtt cacaaggttt ggggattagg atctttggag gaggccaaga ggaagacttt
     5221 ctacacatgt acatggttgt agttacctga acttcagacc caagagctct tggctgcaaa
     5281 tattgccttc acagccaaaa ttccctgggt aattgccagt agctcctgct ctgctgtgca
     5341 gatattgtaa aacggtgaga aaggccctga aatctgacct ggggcctctt gggaaagctg
     5401 ctgtgaacac ctccacgtta atgtcatccc tcagccctct atgcctgttt ctctagggac
     5461 tgagaagtgc atgatgcttt tacttccttg ctcatttcga agtctgttcc agacagttcc
     5521 tataaccagt gaggcctcca agtcattcat tttcctcagt ctagccaaag ctgaatgtgt
     5581 gagcacaaag aagccgagag gccacctcct gcccagagag aagccaccca cactcccagg
     5641 ttggcagaca agatgtgagg ggtgaattaa atttgttttc ttgagcaagc caa
//
