LOCUS       NM_001393797            7385 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens ATP binding cassette subfamily C member 12 (ABCC12),
            transcript variant 13, mRNA.
ACCESSION   NM_001393797
VERSION     NM_001393797.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7385)
  AUTHORS   Pham,D.H., Kudira,R., Xu,L., Valencia,C.A., Ellis,J.L., Shi,T.,
            Evason,K.J., Osuji,I., Matuschek,N., Pfuhler,L., Mullen,M.,
            Mohanty,S.K., Husami,A., Bull,L.N., Zhang,K., Wali,S., Yin,C. and
            Miethke,A.
  TITLE     Deleterious Variants in ABCC12 are Detected in Idiopathic Chronic
            Cholestasis and Cause Intrahepatic Bile Duct Loss in Model
            Organisms
  JOURNAL   Gastroenterology 161 (1), 287-300 (2021)
   PUBMED   33771553
  REMARK    GeneRIF: Deleterious Variants in ABCC12 are Detected in Idiopathic
            Chronic Cholestasis and Cause Intrahepatic Bile Duct Loss in Model
            Organisms.
REFERENCE   2  (bases 1 to 7385)
  AUTHORS   Xie,T., Deng,L., Mei,P., Zhou,Y., Wang,B., Zhang,J., Lin,J.,
            Wei,Y., Zhang,X. and Xu,R.
  TITLE     Genome-wide association study combining pathway analysis for
            typical sporadic amyotrophic lateral sclerosis in Chinese Han
            populations
  JOURNAL   Neurobiol Aging 35 (7), 1778 (2014)
   PUBMED   24529757
REFERENCE   3  (bases 1 to 7385)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7385)
  AUTHORS   Ono,N., Van der Heijden,I., Scheffer,G.L., Van de Wetering,K., Van
            Deemter,E., De Haas,M., Boerke,A., Gadella,B.M., De Rooij,D.G.,
            Neefjes,J.J., Groothuis,T.A., Oomen,L., Brocks,L., Ishikawa,T. and
            Borst,P.
  TITLE     Multidrug resistance-associated protein 9 (ABCC12) is present in
            mouse and boar sperm
  JOURNAL   Biochem J 406 (1), 31-40 (2007)
   PUBMED   17472575
REFERENCE   5  (bases 1 to 7385)
  AUTHORS   Haimeur,A., Conseil,G., Deeley,R.G. and Cole,S.P.
  TITLE     The MRP-related and BCRP/ABCG2 multidrug resistance proteins:
            biology, substrate specificity and regulation
  JOURNAL   Curr Drug Metab 5 (1), 21-53 (2004)
   PUBMED   14965249
  REMARK    Review article
REFERENCE   6  (bases 1 to 7385)
  AUTHORS   Bera,T.K., Iavarone,C., Kumar,V., Lee,S., Lee,B. and Pastan,I.
  TITLE     MRP9, an unusual truncated member of the ABC transporter
            superfamily, is highly expressed in breast cancer
  JOURNAL   Proc Natl Acad Sci U S A 99 (10), 6997-7002 (2002)
   PUBMED   12011458
REFERENCE   7  (bases 1 to 7385)
  AUTHORS   Yabuuchi,H., Shimizu,H., Takayanagi,S. and Ishikawa,T.
  TITLE     Multiple splicing variants of two new human ATP-binding cassette
            transporters, ABCC11 and ABCC12
  JOURNAL   Biochem Biophys Res Commun 288 (4), 933-939 (2001)
   PUBMED   11688999
  REMARK    GeneRIF: alternative splice variants and gene expression
REFERENCE   8  (bases 1 to 7385)
  AUTHORS   Tammur,J., Prades,C., Arnould,I., Rzhetsky,A., Hutchinson,A.,
            Adachi,M., Schuetz,J.D., Swoboda,K.J., Ptacek,L.J., Rosier,M.,
            Dean,M. and Allikmets,R.
  TITLE     Two new genes from the human ATP-binding cassette transporter
            superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome
            16q12
  JOURNAL   Gene 273 (1), 89-96 (2001)
   PUBMED   11483364
REFERENCE   9  (bases 1 to 7385)
  AUTHORS   Dean,M., Rzhetsky,A. and Allikmets,R.
  TITLE     The human ATP-binding cassette (ABC) transporter superfamily
  JOURNAL   Genome Res 11 (7), 1156-1166 (2001)
   PUBMED   11435397
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC096996.2.
            
            Summary: This gene is a member of the superfamily of ATP-binding
            cassette (ABC) transporters and the encoded protein contains two
            ATP-binding domains and 12 transmembrane regions. ABC proteins
            transport various molecules across extra- and intracellular
            membranes. ABC genes are divided into seven distinct subfamilies:
            ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a
            member of the MRP subfamily which is involved in multi-drug
            resistance. This gene and another subfamily member are arranged
            head-to-tail on chromosome 16q12.1. Increased expression of this
            gene is associated with breast cancer. [provided by RefSeq, Jul
            2008].
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1968968, SAMEA2148093
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000311303.8/ ENSP00000311030.4
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AC096996.2         141741-141893       c
            154-422             AC096996.2         139516-139784       c
            423-591             AC096996.2         132206-132374       c
            592-747             AC096996.2         129810-129965       c
            748-895             AC096996.2         127106-127253       c
            896-1129            AC096996.2         126587-126820       c
            1130-1303           AC096996.2         125063-125236       c
            1304-1451           AC096996.2         124128-124275       c
            1452-1600           AC096996.2         119587-119735       c
            1601-1708           AC096996.2         116688-116795       c
            1709-1987           AC096996.2         114359-114637       c
            1988-2059           AC096996.2         110113-110184       c
            2060-2184           AC096996.2         107616-107740       c
            2185-2257           AC096996.2         103161-103233       c
            2258-2461           AC096996.2         101315-101518       c
            2462-2596           AC096996.2         97676-97810         c
            2597-2681           AC096996.2         97478-97562         c
            2682-2753           AC096996.2         97336-97407         c
            2754-2843           AC096996.2         94340-94429         c
            2844-2947           AC096996.2         93222-93325         c
            2948-3145           AC096996.2         91039-91236         c
            3146-3372           AC096996.2         90042-90268         c
            3373-3510           AC096996.2         86772-86909         c
            3511-3667           AC096996.2         82646-82802         c
            3668-3757           AC096996.2         77020-77109         c
            3758-3947           AC096996.2         74445-74634         c
            3948-4107           AC096996.2         73826-73985         c
            4108-4186           AC096996.2         72641-72719         c
            4187-4300           AC096996.2         71493-71606         c
            4301-4465           AC096996.2         69809-69973         c
            4466-7385           AC096996.2         66782-69701         c
FEATURES             Location/Qualifiers
     source          1..7385
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q12.1"
     gene            1..7385
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /note="ATP binding cassette subfamily C member 12"
                     /db_xref="GeneID:94160"
                     /db_xref="HGNC:HGNC:14640"
                     /db_xref="MIM:607041"
     exon            1..153
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            154..422
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            423..591
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     CDS             473..4552
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /note="isoform 3 is encoded by transcript variant 13;
                     multidrug resistance-associated protein 9; ATP-binding
                     cassette transporter sub-family C member 12; ATP-binding
                     cassette sub-family C member 12; ATP-binding cassette,
                     sub-family C (CFTR/MRP), member 12"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family C member 12
                     isoform 3"
                     /protein_id="NP_001380726.1"
                     /db_xref="CCDS:CCDS92155.1"
                     /db_xref="GeneID:94160"
                     /db_xref="HGNC:HGNC:14640"
                     /db_xref="MIM:607041"
                     /translation="MVGEGPYLISDLDQRGRRRSFAERYDPSLKTMIPVRPCARLAPN
                     PVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVA
                     RVGPEKASLSHVVWKFQRTRVLMDIVANILCIIMAAIGPTVLIHQILQQTERTSGKVW
                     VGIGLCIALFATEFTKVFFWALAWAINYRTAIRLKVALSTLVFENLVSFKTLTHISVG
                     EVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFILGPTALIGISVYVIFIPV
                     QMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERK
                     LLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPVAFSVIAMFNVMKFSIA
                     ILPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLANATLTWEHEASRK
                     STPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSDSLKSVLHSISFVVRKGKI
                     LGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQAWIFHGNVRENILFGEK
                     YDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQRISLARAVYSDRQLY
                     LLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTHQLQFLESCDEVILLEDGEICEK
                     GTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEAFKESPAEREEDAGIIVLAP
                     GNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLFT
                     VFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQWVYT
                     ASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSK
                     DMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRG
                     VQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKKESCITYHLLYFNCALRWFALRMD
                     VLMNILTFTVALLVTLSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVE
                     LLREYISTCVPECTHPLKVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQS
                     GQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDP
                     VLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGER
                     QLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLN
                     CDHVLVMENGKVIEFDKPEVLAEKPDSAFAMLLAAEVRL"
     exon            592..747
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            748..895
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1129
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1303
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1451
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1600
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1708
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1987
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2059
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2184
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2257
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2461
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2596
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2681
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2753
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2754..2843
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2844..2947
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2948..3145
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            3146..3372
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            3373..3510
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            3511..3667
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            3668..3757
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            3758..3947
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            3948..4107
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            4108..4186
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            4187..4300
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            4301..4465
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            4466..7385
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4900..4905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /note="hexamer: AATAAA"
     polyA_site      4925
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /note="major polyA site"
     regulatory      5137..5142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /note="hexamer: AACAAA"
     polyA_site      5163
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
     regulatory      7360..7365
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /note="hexamer: AATAAA"
     polyA_site      7385
                     /gene="ABCC12"
                     /gene_synonym="MRP9"
                     /note="major polyA site"
ORIGIN      
        1 agttggagag gaggacttca ggcgggtggg acaagagaaa ctgaatctga ggtccttggg
       61 gagaagcagg ccctggagtc ctgggcagca gatgccaggc tctgagcccc atgactgctg
      121 accctcctcc cctccctctc atcctcagcc cagggctgcc aaatttagca aagtgccatt
      181 ccagctgcaa tgcttccaag ccgcctcaga tcatcaaaac ttcacatgcc ctggggagca
      241 ctcaaggaaa ttaccttcta gcaccaattt cctatgcgcg ctgattactc aaacctggcc
      301 agggaggcct ggcctccagt gtttggcatc tgggactcag gagcccttaa gacaagctga
      361 tgacatcttg ctgccagggt cccttaccat tagaaaaggg aaccaaaaaa tagaagttat
      421 agagtgaaag tgtccccagg ccaaaagccc agggctccag gctgccatca ggatggtggg
      481 tgaaggaccc taccttatct cagatctgga ccagcgaggc cggcggagat cctttgcaga
      541 aagatatgac cccagcctga agaccatgat cccagtgcga ccctgtgcaa ggttagcacc
      601 caacccggtg gatgatgccg ggctactctc cttcgccaca ttttcctggc tcacgccggt
      661 gatggtgaaa ggctaccggc aaaggctgac cgtagacacc ctgcccccat tgtcgacata
      721 tgactcatct gacaccaatg ccaaaagatt tcgagtcctt tgggatgaag aggtagcaag
      781 ggtgggtcct gagaaggcct ctctgagcca cgtggtgtgg aaattccaga ggacacgcgt
      841 gttgatggac atcgtggcca acatcctgtg catcatcatg gcagccatag ggccgacagt
      901 tctcattcac caaatcctcc agcagactga gaggacctct gggaaagtct gggttggcat
      961 tggactgtgc atagcccttt ttgccaccga gtttaccaaa gtcttctttt gggcccttgc
     1021 ctgggccatc aactaccgca cggccatccg gttgaaggtg gcgctctcca ccttggtttt
     1081 tgaaaaccta gtgtccttca agacattgac ccacatctct gttggcgagg tgctcaatat
     1141 actgtcaagt gatagctatt ctttgtttga agctgccttg ttttgtcctt tgccagccac
     1201 catcccgatc ctaatggtct tttgtgcggc gtacgccttt ttcattctgg ggcccacagc
     1261 tctcatcggg atatcagtgt atgtcatatt catacccgtc cagatgttta tggccaagct
     1321 caattcagct ttccgaaggt cagcaatttt ggtgacagac aagcgagttc agacaatgaa
     1381 tgagtttctg acctgcatca ggctgatcaa aatgtatgcc tgggagaaat cttttaccaa
     1441 cactatccaa gatataagaa ggagggaaag aaaattactg gaaaaagctg gatttgtcca
     1501 aagtggaaac tctgccctgg cccccatcgt gtccaccata gccatcgtgc tgacattatc
     1561 ctgccacatc ctcctgagac gcaaactcac cgcacccgtg gcatttagtg tgattgccat
     1621 gtttaatgta atgaagtttt ccattgcaat cttgcccttc tccatcaaag caatggctga
     1681 agcgaatgtc tctctaagga gaatgaagaa aattctcata gataaaagcc ccccatctta
     1741 catcacccaa ccagaagacc cagatactgt cttgctttta gcaaatgcca ccttgacatg
     1801 ggagcatgaa gccagcagga aaagtacccc aaagaaattg cagaaccaga aaaggcattt
     1861 atgcaagaaa cagaggtcag aggcatacag tgagaggagt ccaccagcca agggagccac
     1921 tggcccagag gagcaaagtg acagcctcaa atcggttctg cacagcataa gctttgtggt
     1981 gagaaagggg aagatcttgg gaatatgtgg gaatgtggga agtggaaaga gctccctcct
     2041 tgcagctctc ctaggacaga tgcagctgca gaaaggggtg gtggcagtca atggaacttt
     2101 ggcctacgtt tcacagcagg catggatctt tcatggaaat gtgagagaaa acatactctt
     2161 tggagaaaag tatgatcacc aaaggtatca gcacacagtc cgcgtctgtg gcctccagaa
     2221 ggacctgagc aacctcccct atggagacct gactgagatt ggggagcggg gcctcaacct
     2281 ctctgggggg cagaggcaga ggattagcct ggcccgcgct gtctactccg accgtcagct
     2341 ctacctgctg gacgaccccc tgtcggccgt ggacgcccac gtggggaagc acgtctttga
     2401 ggagtgcatt aagaagacgc tcaggggaaa gacagtcgtc ctggtgaccc accagctaca
     2461 gttcttagag tcttgtgatg aagttatttt attagaagat ggagagattt gtgaaaaggg
     2521 aacccacaag gagttaatgg aggagagagg gcgctatgca aaactgattc acaacctgcg
     2581 aggattgcag ttcaaggatc ctgaacacct ttacaatgca gcaatggtgg aagccttcaa
     2641 ggagagccct gctgagagag aggaagatgc tggtataatc gttttggctc caggaaatga
     2701 gaaagatgaa ggaaaagaat ctgaaacagg ctcagaattt gtagacacaa aagttcctga
     2761 gcaccagctc atccagactg aatcccccca ggaaggaacc gtgacctgga aaacatatca
     2821 cacgtacatt aaggcttctg gagggtacct cctttctctc ttcactgtgt tcctcttcct
     2881 cctgatgatt ggcagcgctg ccttcagcaa ctggtggctg ggtctctggt tggacaaggg
     2941 ctcacggatg acctgtgggc cccagggcaa caggaccatg tgtgaggtcg gcgcggtgct
     3001 ggcagacatc ggtcagcatg tgtaccagtg ggtgtacact gcaagcatgg tgttcatgct
     3061 ggtgtttggc gtcaccaaag gcttcgtctt caccaagacc acactgatgg catcctcctc
     3121 tctgcatgac acggtgtttg ataagatctt aaagagccca atgagtttct ttgacacgac
     3181 tcccactggc aggctaatga accgtttttc caaggatatg gacgagctgg atgtgaggct
     3241 gccgtttcac gcagagaact ttctgcagca gttttttatg gtggtgttta ttctcgtgat
     3301 cttggctgct gtgtttcctg ctgtcctttt agtcgtggcc agccttgctg taggcttctt
     3361 cattctgtta cgcattttcc acagaggagt ccaggagctc aagaaggtgg agaatgtcag
     3421 ccggtcaccc tggttcaccc acatcacctc ctccatgcag ggcctgggca tcattcacgc
     3481 ctatggcaag aaggagagct gcatcaccta tcacctcctc tactttaact gtgctctcag
     3541 gtggtttgcg ctgagaatgg atgtcctcat gaacatcctt accttcactg tggccttgtt
     3601 ggtgaccctg agtttctcct ccatcagtac ttcatccaaa ggcctgtcat tgtcatacat
     3661 catccagctg agcggactgc tccaagtgtg tgtgcgaacg ggaacagaga cgcaagccaa
     3721 attcacctcc gtggagctgc tcagggaata catttcgacc tgtgttcctg aatgcactca
     3781 tcccctcaaa gtggggacct gtcccaagga ctggcccagc cgtggggaga tcaccttcag
     3841 agactatcag atgagataca gagacaacac cccccttgtt ctcgacagcc tgaacttgaa
     3901 catacaaagt gggcagacag tcgggattgt tggaagaaca ggttccggaa agtcatcgtt
     3961 aggaatggct ttgtttcgtc tggtggagcc agccagtggc acaatcttta ttgatgaggt
     4021 ggatatctgc attctcagct tggaagacct cagaaccaag ctgactgtga tcccacagga
     4081 tcctgtcctg tttgtaggta cagtaaggta caacttggat ccctttgaga gtcacaccga
     4141 tgagatgctc tggcaggttc tggagagaac attcatgaga gacacaataa tgaaactccc
     4201 agaaaaatta caggcagaag tcacagaaaa tggagaaaac ttctcagtag gggaacgtca
     4261 gctgctttgt gtggcccgag ctcttctccg taattcaaag atcattctcc ttgatgaagc
     4321 caccgcctct atggactcca agactgacac cctggttcag aacaccatca aagatgcctt
     4381 caagggctgc actgtgctga ccatcgccca ccgcctcaac acagttctca actgcgatca
     4441 cgtcctggtt atggaaaatg ggaaggtgat tgagtttgac aagcctgaag tccttgcaga
     4501 gaagccagat tctgcatttg cgatgttact agcagcagaa gtcagattgt agaggtcctg
     4561 gcggctgatt ctagaggagg aagaggctct gtgagatgaa taggaggagt cttcaggagg
     4621 aggggctgtc ctctccgcag gcagccctgg tcttcagccc ctcccatcca cggagtgagc
     4681 tggggctgaa gttgtcccca ctgccatact cagtccatgt caccccactt ggtgggcttg
     4741 gggttggttc tgggtggtga accggggcag acccagctaa tggattaaaa aactgccctt
     4801 cacctcccaa atccccaagg gttcctcatg tgttttcacc aaaaccaccc cagtgcctga
     4861 gattgaaaat attgtaactt tcagttagaa atcagccaca ataaacaaca tgggaaaatg
     4921 ccttaggatg gagtttgcaa ggtttccttg cccattatca gaaggaaaaa gagcagaatt
     4981 ttcttctcgt ttaaccccac tcacttccat cttgactggg tgacaagtgg taatgacaca
     5041 gatttgtagc gtgaaagact gaatacagtg tttggccaaa aattttttta aaaatcatat
     5101 tatatgtttc aattgatctg ttagaataac caagaaaaca aaatgctgga gtttctctat
     5161 aaatgacact tttatatctt ctttattcgt cgttaaaacg cggtaggaaa ttaccctgaa
     5221 atgtcgcctt gcaattattt cactgaagat attccaattt ccatactatt tcctccaata
     5281 gacccttgtt gccttctccc ttcactcagt aatgaacctt cacagtcgct taccaaacaa
     5341 aaagctttct ctccaacctg gaggctggtt ctgatggaag cagtaaagat gtattcccag
     5401 cagccccagg agtgagcgct gctaactcat ggtgacattt gggaaaaaaa tatttataga
     5461 aaatccagca agctcttgtg tagtagccgc caaggggcac gctgggagtt ctggctgttt
     5521 ttcattcatc aggaatgaag gccccatgag gttccctggg cctgctttcc aggccccagg
     5581 ctgagctcta aatgtagctc agggcagtgt ggtcagcaaa gcttccagac cacaaccccc
     5641 caccccactt cccttgtaag tgttggtcac gtacttgctt ccccagacgt ggaggaagga
     5701 gtgcctggca cctggaagca ctcgggaaac acttgtggca gccatgaatg acagcatcta
     5761 atgaactcgc tgaaacacag ctgtggagcc tggcggacac ccctcccagg tgtgtgtgca
     5821 tgttaagagc ttaatctgga tttctggcca aaaagccaac agccagcaat tcaagggctg
     5881 ggcatgtgag gttaacctcc aaccgattat tctccagccc tcctccggcc aggcctgggc
     5941 aggggtctac ccaaccagcg gggaggtgag cacacctggc cttaggtaga gcttataacc
     6001 tggcaactgc atgaaagccc tggcccagca gcttggcagc aatggatcct gccctcagca
     6061 gagggtgcac taagacatgt ggctgagaag gacgtgagcc agggggttcc ttctgtgggc
     6121 agctccaggc caagtgtgga tctctctgtg aagggacaca gtgtatcttt gcctgatctg
     6181 agctttcccc catggtgcat gaccctgact gaaggtcatt aaacccacat ccacagcgtt
     6241 ctgagcagct gctcccagct gagtgtgggc atcaccttta tggacataag ataacttccc
     6301 caatatgaca agcagactgg gcagtctgtg ctggccatgg gaatccatga cagttgtgca
     6361 atgtcaggga gggatgcttt actttctacc aactggacac cagccagata atcagtctgt
     6421 gatttcaaga ggtggtgttt tcatgaggac agaggataga ctacaatgat ccctgctgct
     6481 ccttcagatg cattgagaga tgaatcacct cctatgactc cttttctgcc cacactcgct
     6541 ttggtttact ctggcagaag aagaacaccg acattgatcc tgatgtctac tgagaccttg
     6601 cagtgtgcca ggactgtgac aagcattttt tccatgaatt atttcactga atcctcatct
     6661 caccccatga gatgggattt gaggctcact gaggttagta acttatctac agatgcccag
     6721 gaaggaaggg acagagatag ggcttgaacc ctaaccagtc tggctccaca ggccctgctc
     6781 ccaacccctt cacaacaaag cccctccagt cctttcccct tggcctgttg caaggacagt
     6841 gatggtcatc agtatcatcc ctgggggaga gtgacttctg agggtttggc tgtttgcatg
     6901 tataagacac gaaaccatct tagcaaaccc ctctcccacc ccaacccctt gctatcactg
     6961 ccatgtcagc caaggggaga ctatgtagaa taatagtagc catttagcca aattcctcaa
     7021 agcacaggct taggttatta aatcctgaac atatccctgt ggggtaggtg tctgctatga
     7081 tctgaacatt gtgttccccc aaaatcctcc tgttgaaaca taatcctcag tgtgacagta
     7141 tagaggtagg gcctttagga ggtgattaat taggtcatga gggtggagac ctcatgaata
     7201 ggattggctc tcttataaaa gagacttggg gaagcttgtt caccccttcc tccatgtgag
     7261 gacacataga aggcatcatc tgtgaggaat gggccctcac tcaacaccaa atctgttggc
     7321 acctcgacca tggatttccc agcgtccaga actgtgagca ataaatttct gttgtttata
     7381 aatta
//
