LOCUS       NM_001370497            5894 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens ATP binding cassette subfamily C member 11 (ABCC11),
            transcript variant 5, mRNA.
ACCESSION   NM_001370497 XM_017023795
VERSION     NM_001370497.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5894)
  AUTHORS   Toyoda,Y., Matsuo,H. and Takada,T.
  TITLE     Functional characterization of variants in human ABCC11, an
            axillary osmidrosis risk factor
  JOURNAL   Hum Cell 37 (4), 1070-1079 (2024)
   PUBMED   38750405
  REMARK    GeneRIF: Functional characterization of variants in human ABCC11,
            an axillary osmidrosis risk factor.
REFERENCE   2  (bases 1 to 5894)
  AUTHORS   Kutsuwada,Y., Yokota,K., Yoshida,K., Tsuda,H., Watanabe,K.,
            Matsumoto,A. and Iwamoto,S.
  TITLE     Association of HLA-DPB1, NLRP10, OVOL1, and ABCC11 with the
            axillary microbiome in a Japanese population
  JOURNAL   J Dermatol Sci 105 (2), 98-104 (2022)
   PUBMED   35078690
  REMARK    GeneRIF: Association of HLA-DPB1, NLRP10, OVOL1, and ABCC11 with
            the axillary microbiome in a Japanese population.
REFERENCE   3  (bases 1 to 5894)
  AUTHORS   Matsumoto,H., Sasai,H., Kawamoto,N., Katsuyama,M., Minamiyama,M.,
            Kuru,S., Fukao,T. and Ohnishi,H.
  CONSRTM   SMON research group members
  TITLE     Founder genetic variants of ABCC4 and ABCC11 in the Japanese
            population are not associated with the development of subacute
            myelo-optico-neuropathy (SMON)
  JOURNAL   Mol Genet Genomic Med 10 (1), e1845 (2022)
   PUBMED   34951141
  REMARK    GeneRIF: Founder genetic variants of ABCC4 and ABCC11 in the
            Japanese population are not associated with the development of
            subacute myelo-optico-neuropathy (SMON).
REFERENCE   4  (bases 1 to 5894)
  AUTHORS   Hara,S., Kusunoki,T., Nakagawa,H., Toyoda,Y., Nojiri,S., Kamiya,K.,
            Furukawa,M., Takata,Y., Okada,H., Anzai,T., Matsumoto,F. and
            Ikeda,K.
  TITLE     Association Between Earwax-Determinant Genotypes and Acquired
            Middle Ear Cholesteatoma in a Japanese Population
  JOURNAL   Otolaryngol Head Neck Surg 166 (1), 139-145 (2022)
   PUBMED   33722103
  REMARK    GeneRIF: Association Between Earwax-Determinant Genotypes and
            Acquired Middle Ear Cholesteatoma in a Japanese Population.
REFERENCE   5  (bases 1 to 5894)
  AUTHORS   Wang,Y., Li,J., Huang,J., Wu,C., Li,L. and Gong,P.
  TITLE     Mutation differences in circulating tumor DNAs from non-small cell
            lung cancer patients between Uygur and Han populations
  JOURNAL   Medicine (Baltimore) 100 (4), e24159 (2021)
   PUBMED   33530206
  REMARK    GeneRIF: Mutation differences in circulating tumor DNAs from
            non-small cell lung cancer patients between Uygur and Han
            populations.
REFERENCE   6  (bases 1 to 5894)
  AUTHORS   Lai,L. and Tan,T.M.
  TITLE     Role of glutathione in the multidrug resistance protein 4
            (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine
            analogues
  JOURNAL   Biochem J 361 (Pt 3), 497-503 (2002)
   PUBMED   11802779
REFERENCE   7  (bases 1 to 5894)
  AUTHORS   Yabuuchi,H., Shimizu,H., Takayanagi,S. and Ishikawa,T.
  TITLE     Multiple splicing variants of two new human ATP-binding cassette
            transporters, ABCC11 and ABCC12
  JOURNAL   Biochem Biophys Res Commun 288 (4), 933-939 (2001)
   PUBMED   11688999
  REMARK    GeneRIF: alternative splice variants and gene expression
REFERENCE   8  (bases 1 to 5894)
  AUTHORS   Bera,T.K., Lee,S., Salvatore,G., Lee,B. and Pastan,I.
  TITLE     MRP8, a new member of ABC transporter superfamily, identified by
            EST database mining and gene prediction program, is highly
            expressed in breast cancer
  JOURNAL   Mol Med 7 (8), 509-516 (2001)
   PUBMED   11591886
REFERENCE   9  (bases 1 to 5894)
  AUTHORS   Tammur,J., Prades,C., Arnould,I., Rzhetsky,A., Hutchinson,A.,
            Adachi,M., Schuetz,J.D., Swoboda,K.J., Ptacek,L.J., Rosier,M.,
            Dean,M. and Allikmets,R.
  TITLE     Two new genes from the human ATP-binding cassette transporter
            superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome
            16q12
  JOURNAL   Gene 273 (1), 89-96 (2001)
   PUBMED   11483364
REFERENCE   10 (bases 1 to 5894)
  AUTHORS   Dean,M., Rzhetsky,A. and Allikmets,R.
  TITLE     The human ATP-binding cassette (ABC) transporter superfamily
  JOURNAL   Genome Res 11 (7), 1156-1166 (2001)
   PUBMED   11435397
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007600.6 and AC096996.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 9, 2019 this sequence version replaced XM_017023795.2.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra- and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC
            full transporter is a member of the MRP subfamily which is involved
            in multi-drug resistance. The product of this gene participates in
            physiological processes involving bile acids, conjugated steroids,
            and cyclic nucleotides. In addition, a SNP in this gene is
            responsible for determination of human earwax type. This gene and
            family member ABCC12 are determined to be derived by duplication
            and are both localized to chromosome 16q12.1. Multiple
            alternatively spliced transcript variants have been described for
            this gene. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF352582.1, SRR7346977.2318316.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356608.7/ ENSP00000349017.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               AC007600.6         10233-10458
            227-343             AC007600.6         25833-25949
            344-480             AC007600.6         27199-27335
            481-639             AC007600.6         29808-29966
            640-787             AC007600.6         33343-33490
            788-1021            AC007600.6         34941-35174
            1022-1195           AC007600.6         41485-41658
            1196-1343           AC007600.6         42428-42575
            1344-1492           AC007600.6         42743-42891
            1493-1600           AC007600.6         44222-44329
            1601-1852           AC007600.6         46573-46824
            1853-1924           AC096996.2         194325-194396       c
            1925-2049           AC096996.2         191313-191437       c
            2050-2122           AC096996.2         189128-189200       c
            2123-2326           AC096996.2         186176-186379       c
            2327-2461           AC096996.2         184041-184175       c
            2462-2558           AC096996.2         183871-183967       c
            2559-2648           AC096996.2         182132-182221       c
            2649-2752           AC096996.2         179779-179882       c
            2753-2950           AC096996.2         178420-178617       c
            2951-3177           AC096996.2         173101-173327       c
            3178-3315           AC096996.2         172853-172990       c
            3316-3502           AC096996.2         170340-170526       c
            3503-3592           AC096996.2         164497-164586       c
            3593-3782           AC096996.2         162824-163013       c
            3783-3942           AC096996.2         161158-161317       c
            3943-4021           AC096996.2         156789-156867       c
            4022-4135           AC096996.2         156005-156118       c
            4136-4300           AC096996.2         153396-153560       c
            4301-5894           AC096996.2         151673-153266       c
FEATURES             Location/Qualifiers
     source          1..5894
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q12.1"
     gene            1..5894
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /note="ATP binding cassette subfamily C member 11"
                     /db_xref="GeneID:85320"
                     /db_xref="HGNC:HGNC:14639"
                     /db_xref="MIM:607040"
     exon            1..226
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            227..343
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..4393
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /EC_number="7.6.2.2"
                     /EC_number="7.6.2.3"
                     /note="isoform a is encoded by transcript variant 5;
                     multi-resistance protein 8; ATP-binding cassette
                     transporter MRP8; ATP-binding cassette protein C11;
                     ATP-binding cassette transporter sub-family C member 11;
                     ATP-binding cassette sub-family C member 11; multidrug
                     resistance-associated protein 8; ATP-binding cassette,
                     sub-family C (CFTR/MRP), member 11"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family C member 11
                     isoform a"
                     /protein_id="NP_001357426.1"
                     /db_xref="CCDS:CCDS10732.1"
                     /db_xref="GeneID:85320"
                     /db_xref="HGNC:HGNC:14639"
                     /db_xref="MIM:607040"
                     /translation="MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWS
                     QQERNPEAPGRAAVPPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTP
                     LMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQR
                     TRLIFDALLGICFCIASVLGPILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSL
                     SFSSSWIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVC
                     YGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEV
                     SDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFI
                     IPTVATAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMR
                     FKKFFLQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMT
                     RPRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEG
                     SVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDM
                     TEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLR
                     GKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSD
                     MLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQEEEMEEGSLSWRVYHHYIQ
                     AAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADN
                     PQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTI
                     PIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVI
                     CFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTD
                     AQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIVLQLA
                     SSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDY
                     HMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGV
                     DICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAISK
                     FPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTI
                     REAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATAT
                     SSLR"
     exon            344..480
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            481..639
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            640..787
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            788..1021
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1195
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1343
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1492
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1600
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1852
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1924
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2049
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2122
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2326
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2461
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2558
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2648
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..2752
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2950
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            2951..3177
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            3178..3315
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            3316..3502
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            3503..3592
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            3593..3782
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            3783..3942
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            3943..4021
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            4022..4135
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            4136..4300
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     exon            4301..5894
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4737..4742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /note="hexamer: TATAAA"
     polyA_site      4757
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /note="major polyA site"
     regulatory      5684..5689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /note="hexamer: AATAAA"
     polyA_site      5706
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
     regulatory      5869..5874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
                     /note="hexamer: CATAAA"
     polyA_site      5894
                     /gene="ABCC11"
                     /gene_synonym="EWWD; MRP8; WW"
ORIGIN      
        1 gcacactaac gtgcagaaag ggactgtact actcaaaacc accaaggaag tggcagaggt
       61 aagtcaacat ctaatcctgc cactctgtgt ggcaaagaac gctgggagca aattacttct
      121 gctgctcttt gaaggctgtg ccagcgtcac ctggatagcg caaaggaaac aagagaaagg
      181 aacagagccc ctcttctggc ctctgggcta ccatacagaa aagcagaatt ggcaggaact
      241 gaaaatgact aggaagagga catactgggt gcccaactct tctggtggcc tcgtgaatcg
      301 tggcatcgac ataggcgatg acatggtttc aggacttatt tataaaacct atactctcca
      361 agatggcccc tggagtcagc aagagagaaa tcctgaggct ccagggaggg cagctgtccc
      421 accgtggggg aagtatgatg ctgccttgag aaccatgatt cccttccgtc ccaagccgag
      481 gtttcctgcc ccccagcccc tggacaatgc tggcctgttc tcctacctca ccgtgtcatg
      541 gctcaccccg ctcatgatcc aaagcttacg gagtcgctta gatgagaaca ccatccctcc
      601 actgtcagtc catgatgcct cagacaaaaa tgtccaaagg cttcaccgcc tttgggaaga
      661 agaagtctca aggcgaggga ttgaaaaagc ttcagtgctt ctggtgatgc tgaggttcca
      721 gagaacaagg ttgattttcg atgcacttct gggcatctgc ttctgcattg ccagtgtact
      781 cgggccaata ttgattatac caaagatcct ggaatattca gaagagcagt tggggaatgt
      841 tgtccatgga gtgggactct gctttgccct ttttctctcc gaatgtgtga agtctctgag
      901 tttctcctcc agttggatca tcaaccaacg cacagccatc aggttccgag cagctgtttc
      961 ctcctttgcc tttgagaagc tcatccaatt taagtctgta atacacatca cctcaggaga
     1021 ggccatcagc ttcttcaccg gtgatgtaaa ctacctgttt gaaggggtgt gctatggacc
     1081 cctagtactg atcacctgcg catcgctggt catctgcagc atttcttcct acttcattat
     1141 tggatacact gcatttattg ccatcttatg ctatctcctg gttttcccac tggcggtatt
     1201 catgacaaga atggctgtga aggctcagca tcacacatct gaggtcagcg accagcgcat
     1261 ccgtgtgacc agtgaagttc tcacttgcat taagctgatt aaaatgtaca catgggagaa
     1321 accatttgca aaaatcattg aagacctaag aaggaaggaa aggaaactat tggagaagtg
     1381 cgggcttgtc cagagcctga caagtataac cttgttcatc atccccacag tggccacagc
     1441 ggtctgggtt ctcatccaca catccttaaa gctgaaactc acagcgtcaa tggccttcag
     1501 catgctggcc tccttgaatc tccttcggct gtcagtgttc tttgtgccta ttgcagtcaa
     1561 aggtctcacg aattccaagt ctgcagtgat gaggttcaag aagtttttcc tccaggagag
     1621 ccctgttttc tatgtccaga cattacaaga ccccagcaaa gctctggtct ttgaggaggc
     1681 caccttgtca tggcaacaga cctgtcccgg gatcgtcaat ggggcactgg agctggagag
     1741 gaacgggcat gcttctgagg ggatgaccag gcctagagat gccctcgggc cagaggaaga
     1801 agggaacagc ctgggcccag agttgcacaa gatcaacctg gtggtgtcca aggggatgat
     1861 gttaggggtc tgcggcaaca cggggagtgg taagagcagc ctgttgtcag ccatcctgga
     1921 ggagatgcac ttgctcgagg gctcggtggg ggtgcaggga agcctggcct atgtccccca
     1981 gcaggcctgg atcgtcagcg ggaacatcag ggagaacatc ctcatgggag gcgcatatga
     2041 caaggcccga tacctccagg tgctccactg ctgctccctg aatcgggacc tggaacttct
     2101 gccctttgga gacatgacag agattggaga gcggggcctc aacctctctg gggggcagaa
     2161 acagaggatc agcctggccc gcgccgtcta ttccgaccgt cagatctacc tgctggacga
     2221 ccccctgtct gctgtggacg cccacgtggg gaagcacatt tttgaggagt gcattaagaa
     2281 gacactcagg gggaagacgg tcgtcctggt gacccaccag ctgcagtact tagaattttg
     2341 tggccagatc attttgttgg aaaatgggaa aatctgtgaa aatggaactc acagtgagtt
     2401 aatgcagaaa aaggggaaat atgcccaact tatccagaag atgcacaagg aagccacttc
     2461 ggacatgttg caggacacag caaagatagc agagaagcca aaggtagaaa gtcaggctct
     2521 ggccacctcc ctggaagagt ctctcaacgg aaatgctgtg ccggagcatc agctcacaca
     2581 ggaggaggag atggaagaag gctccttgag ttggagggtc taccaccact acatccaggc
     2641 agctggaggt tacatggtct cttgcataat tttcttcttc gtggtgctga tcgtcttctt
     2701 aacgatcttc agcttctggt ggctgagcta ctggttggag cagggctcgg ggaccaatag
     2761 cagccgagag agcaatggaa ccatggcaga cctgggcaac attgcagaca atcctcaact
     2821 gtccttctac cagctggtgt acgggctcaa cgccctgctc ctcatctgtg tgggggtctg
     2881 ctcctcaggg attttcacca aggtcacgag gaaggcatcc acggccctgc acaacaagct
     2941 cttcaacaag gttttccgct gccccatgag tttctttgac accatcccaa taggccggct
     3001 tttgaactgc ttcgcagggg acttggaaca gctggaccag ctcttgccca tcttttcaga
     3061 gcagttcctg gtcctgtcct taatggtgat cgccgtcctg ttgattgtca gtgtgctgtc
     3121 tccatatatc ctgttaatgg gagccataat catggttatt tgcttcattt attatatgat
     3181 gttcaagaag gccatcggtg tgttcaagag actggagaac tatagccggt ctcctttatt
     3241 ctcccacatc ctcaattctc tgcaaggcct gagctccatc catgtctatg gaaaaactga
     3301 agacttcatc agccagttta agaggctgac tgatgcgcag aataactacc tgctgttgtt
     3361 tctatcttcc acacgatgga tggcattgag gctggagatc atgaccaacc ttgtgacctt
     3421 ggctgttgcc ctgttcgtgg cttttggcat ttcctccacc ccctactcct ttaaagtcat
     3481 ggctgtcaac atcgtgctgc agctggcgtc cagcttccag gccactgccc ggattggctt
     3541 ggagacagag gcacagttca cggctgtaga gaggatactg cagtacatga agatgtgtgt
     3601 ctcggaagct cctttacaca tggaaggcac aagttgtccc caggggtggc cacagcatgg
     3661 ggaaatcata tttcaggatt atcacatgaa atacagagac aacacaccca ccgtgcttca
     3721 cggcatcaac ctgaccatcc gcggccacga agtggtgggc atcgtgggaa ggacgggctc
     3781 tgggaagtcc tccttgggca tggctctctt ccgcctggtg gagcccatgg caggccggat
     3841 tctcattgac ggcgtggaca tttgcagcat cggcctggag gacttgcggt ccaagctctc
     3901 agtgatccct caagatccag tgctgctctc aggaaccatc agattcaacc tagatccctt
     3961 tgaccgtcac actgaccagc agatctggga tgccttggag aggacattcc tgaccaaggc
     4021 catctcaaag ttccccaaaa agctgcatac agatgtggtg gaaaacggtg gaaacttctc
     4081 tgtgggggag aggcagctgc tctgcattgc cagggctgtg cttcgcaact ccaagatcat
     4141 ccttatcgat gaagccacag cctccattga catggagaca gacaccctga tccagcgcac
     4201 aatccgtgaa gccttccagg gctgcaccgt gctcgtcatt gcccaccgtg tcaccactgt
     4261 gctgaactgt gaccacatcc tggttatggg caatgggaag gtggtagaat ttgatcggcc
     4321 ggaggtactg cggaagaagc ctgggtcatt gttcgcagcc ctcatggcca cagccacttc
     4381 ttcactgaga taaggagatg tggagacttc atggaggctg gcagctgagc tcagaggttc
     4441 acacaggtgc agcttcgagg cccacagtct gcgaccttct tgtttggaga tgagaacttc
     4501 tcctggaagc aggggtaaat gtaggggggg tggggattgc tggatggaaa ccctggaata
     4561 ggctacttga tggctctcaa gaccttagaa ccccagaacc atctaagaca tgggattcag
     4621 tgatcatgtg gttctccttt taacttacat gctgaataat tttataataa ggtaaaagct
     4681 tatagttttc tgatctgtgt tagaagtgtt gcaaatgctg tactgacttt gtaaaatata
     4741 aaactaagga aaactcactt tctttgttct gcttcctttc gtttcttttc tttttgtttt
     4801 tttagacagg gtcttgctct gttgcccagg ctggagcgca gtggcgcaat ctcagctcac
     4861 tgtagcctct gcctcccagg ttcaagcaat tctcctgcct cagcctcctg aatagctagg
     4921 attacaagca tgtgccacca tgactggcta atttttgtat ttttagtaga ggcggggttt
     4981 caccatgttg gccaggctga tctcaagtga tccgcttgcc ttggcctccc aaagtgctga
     5041 ggttatgggc atgaaccact gcacccagcc atcttcattc tgctttttac gttagctagt
     5101 acttattcag ttgcaaggaa cagagactcc ctcaaactaa ctttggaaaa aaaaaagagt
     5161 ttgttggtct tgtaacagaa agatacagaa aaagttcaag gttgggtgcc ggaatgaaag
     5221 gatgcctgtt ttgaggtctc tgtttctctt ctcctagctc tgctttcctt tgtttggctt
     5281 cactttctaa cttcctcttg cctcatggtg gcaatatggt tgcctgcagc tccaggttca
     5341 cgtcctacac actctgcacc ccccaggtct tcttgcctca atgattccag ggtgaaatct
     5401 cactgggcca gcttgggtca tgtgcttgtt cctgatcaat catgtgctag gctgttggca
     5461 tactgtgatt tgccaggcct gagccacatg cccatatttg ggcctgggga tgggatttgc
     5521 tgccctagat catgtagact gagaatagaa gaggttgttt caccaaagta aaattgtgcc
     5581 tgagggaaga atggatatgg atgctggcca ggccccagat agcagctgtc tactatgatt
     5641 gtttactgaa gagcagcata acttacaacg tatgacaact gaaaataaaa taatttgttt
     5701 tctctctttc ttgttctcac tcccccaccc tccacatgtg gttacagaca aatagaaaag
     5761 gcaatcattt tcaacttact tctggggaga ccttgttgtt gggggaaata tgtttcaaag
     5821 tactttcctt tttattccag attatgatgt ctgattttca aaaaatgcca taaaaaatca
     5881 atttagtaaa ccaa
//
