LOCUS       NM_001198934            5043 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens ATP binding cassette subfamily C member 10 (ABCC10),
            transcript variant MRP7, mRNA.
ACCESSION   NM_001198934
VERSION     NM_001198934.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5043)
  AUTHORS   Iqbal,J., Walsh,M.T. and Hussain,M.M.
  TITLE     ATP-Binding Cassette Transporter Family C Protein 10 Participates
            in the Synthesis and Efflux of Hexosylceramides in Liver Cells
  JOURNAL   Nutrients 14 (20), 4401 (2022)
   PUBMED   36297086
  REMARK    GeneRIF: ATP-Binding Cassette Transporter Family C Protein 10
            Participates in the Synthesis and Efflux of Hexosylceramides in
            Liver Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5043)
  AUTHORS   Hau,R.K., Klein,R.R., Wright,S.H. and Cherrington,N.J.
  TITLE     Localization of Xenobiotic Transporters Expressed at the Human
            Blood-Testis Barrier
  JOURNAL   Drug Metab Dispos 50 (6), 770-780 (2022)
   PUBMED   35307651
REFERENCE   3  (bases 1 to 5043)
  AUTHORS   Xiao,P., Liu,Y.K., Han,W., Hu,Y., Zhang,B.Y. and Liu,W.L.
  TITLE     Exosomal Delivery of FTO Confers Gefitinib Resistance to Recipient
            Cells through ABCC10 Regulation in an m6A-dependent Manner
  JOURNAL   Mol Cancer Res 19 (4), 726-738 (2021)
   PUBMED   33563765
  REMARK    GeneRIF: Exosomal Delivery of FTO Confers Gefitinib Resistance to
            Recipient Cells through ABCC10 Regulation in an m6A-dependent
            Manner.
REFERENCE   4  (bases 1 to 5043)
  AUTHORS   Sone,K., Oguri,T., Uemura,T., Takeuchi,A., Fukuda,S., Takakuwa,O.,
            Maeno,K., Fukumitsu,K., Kanemitsu,Y., Ohkubo,H., Takemura,M.,
            Ito,Y. and Niimi,A.
  TITLE     Genetic variation in the ATP binding cassette transporter ABCC10 is
            associated with neutropenia for docetaxel in Japanese lung cancer
            patients cohort
  JOURNAL   BMC Cancer 19 (1), 246 (2019)
   PUBMED   30890141
  REMARK    GeneRIF: In the cancer cell lines, only rs2125739 of ABCC10 gene
            was significantly associated with docetaxel cytotoxicity, and this
            was confirmed in the genome-edited cell line. In the non-small cell
            lung cancer (NSCLC) patients, there were no significant differences
            related to rs2125739 genotype in terms of response rate,
            progression free and overall survival. However, this SNP was
            associated with grade 3/4 neutropenia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5043)
  AUTHORS   Dabrowska,M. and Sirotnak,F.M.
  TITLE     E2F site in the essential promoter region does not confer S
            phase-specific transcription of the ABCC10 gene in human prostate
            cancer cells
  JOURNAL   Acta Biochim Pol 64 (2), 371-374 (2017)
   PUBMED   28612064
  REMARK    GeneRIF: It is thus inferred, that ABCC10 expression in CWR22Rv1
            cells is not S phase-specific but is primarily associated with cell
            proliferation.
REFERENCE   6  (bases 1 to 5043)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   7  (bases 1 to 5043)
  AUTHORS   Chen,Z.S., Hopper-Borge,E., Belinsky,M.G., Shchaveleva,I.,
            Kotova,E. and Kruh,G.D.
  TITLE     Characterization of the transport properties of human multidrug
            resistance protein 7 (MRP7, ABCC10)
  JOURNAL   Mol Pharmacol 63 (2), 351-358 (2003)
   PUBMED   12527806
  REMARK    GeneRIF: MRP7 has the facility for mediating the transport of
            conjugates such as E(2)17betaG indicates that it is a lipophilic
            anion transporter involved in phase III (cellular extrusion) of
            detoxification.
            GeneRIF: First study to describe ABCC10's ability to transport
            physiological substrates, confirming that this protein, with low
            identity to ABCC1, was indeed a efflux pump.
REFERENCE   8  (bases 1 to 5043)
  AUTHORS   Kao,H.H., Chang,M.S., Cheng,J.F. and Huang,J.D.
  TITLE     Genomic structure, gene expression, and promoter analysis of human
            multidrug resistance-associated protein 7
  JOURNAL   J Biomed Sci 10 (1), 98-110 (2003)
   PUBMED   12566991
  REMARK    GeneRIF: The genomic organization and gene expression regulation of
            human multidrug resistance-associated protein 7 and a splicing
            variant MRP7A were identified
REFERENCE   9  (bases 1 to 5043)
  AUTHORS   Hopper,E., Belinsky,M.G., Zeng,H., Tosolini,A., Testa,J.R. and
            Kruh,G.D.
  TITLE     Analysis of the structure and expression pattern of MRP7 (ABCC10),
            a new member of the MRP subfamily
  JOURNAL   Cancer Lett 162 (2), 181-191 (2001)
   PUBMED   11146224
  REMARK    GeneRIF: First study to describe structure and expression pattern
            of this transporter.
REFERENCE   10 (bases 1 to 5043)
  AUTHORS   Allikmets,R., Gerrard,B., Hutchinson,A. and Dean,M.
  TITLE     Characterization of the human ABC superfamily: isolation and
            mapping of 21 new genes using the expressed sequence tags database
  JOURNAL   Hum Mol Genet 5 (10), 1649-1655 (1996)
   PUBMED   8894702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL359813.23, AK000002.1 and
            AY032599.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001198934.1.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra- and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This
            ABC full-transporter is a member of the MRP subfamily which is
            involved in multi-drug resistance. Multiple transcript variants
            encoding different isoforms have been found for this gene.[provided
            by RefSeq, Nov 2010].
            
            Transcript Variant: This variant (MRP7) encodes the longest isoform
            (MRP7).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000002.1, SRR9304715.254962.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372530.9/ ENSP00000361608.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AL359813.23        43090-43102
            14-5036             AK000002.1         1-5023
            5037-5041           AY032599.1         5080-5084
            5042-5043           AL359813.23        65975-65976
FEATURES             Location/Qualifiers
     source          1..5043
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..5043
                     /gene="ABCC10"
                     /gene_synonym="EST182763; MRP7; SIMRP7"
                     /note="ATP binding cassette subfamily C member 10"
                     /db_xref="GeneID:89845"
                     /db_xref="HGNC:HGNC:52"
                     /db_xref="MIM:612509"
     exon            1..217
                     /gene="ABCC10"
                     /gene_synonym="EST182763; MRP7; SIMRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            218..389
                     /gene="ABCC10"
                     /gene_synonym="EST182763; MRP7; SIMRP7"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..4707
                     /gene="ABCC10"
                     /gene_synonym="EST182763; MRP7; SIMRP7"
                     /EC_number="7.6.2.2"
                     /EC_number="7.6.2.3"
                     /note="isoform MRP7 is encoded by transcript variant MRP7;
                     multidrug resistance-associated protein 7; ATP-binding
                     cassette sub-family C member 10; ATP-binding cassette,
                     sub-family C (CFTR/MRP), member 10"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family C member 10
                     isoform MRP7"
                     /protein_id="NP_001185863.1"
                     /db_xref="CCDS:CCDS56430.1"
                     /db_xref="GeneID:89845"
                     /db_xref="HGNC:HGNC:52"
                     /db_xref="MIM:612509"
                     /translation="MERLLAQLCGSSAAWPLPLWEGDTTGHCFTQLVLSALPHALLAV
                     LSACYLGTPRSPDYILPCSPGWRLRLAASFLLSVFPLLDLLPVALPPGAGPGPIGLEV
                     LAGCVAAVAWISHSLALWVLAHSPHGHSRGPLALALVALLPAPALVLTVLWHCQRGTL
                     LPPLLPGPMARLCLLILQLAALLAYALGWAAPGGPREPWAQEPLLPEDQEPEVAEDGE
                     SWLSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPTYLARVFQAHWQEGARLWRA
                     LYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQEPLSHGLLYALGLAGGA
                     VLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPSRPPTGEALNLLGTDSERLL
                     NFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIATRIMASNQE
                     MLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIKYLDAACVY
                     LWAALPVVISIVIFITYVLMGHQLTATKVFTALALVRMLILPLNNFPWVINGLLEAKV
                     SLDRIQLFLDLPNHNPQAYYSPDPPAEPSTVLELHGALFSWDPVGTSLETFISHLEVK
                     KGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQFATIRD
                     NILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAV
                     YQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADAVLLME
                     AGRLIRAGPPSEILPLVQAVPKAWAENGQESDSATAQSVQNPEKTKEGLEEEQSTSGR
                     LLQEESKKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQATRNAADWWLSHWISQLK
                     AENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYA
                     TIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSS
                     DVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRAS
                     SRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSA
                     TMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSS
                     FTQTEAMLVSVERLEEYTCDLPQEPQGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNA
                     LDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLR
                     SQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSMGGLDGELGEG
                     GRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTI
                     AHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSSQQGVPASLGGP"
     exon            390..1608
                     /gene="ABCC10"
                     /gene_synonym="EST182763; MRP7; SIMRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1836
                     /gene="ABCC10"
                     /gene_synonym="EST182763; MRP7; SIMRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1993
                     /gene="ABCC10"
                     /gene_synonym="EST182763; MRP7; SIMRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2103
                     /gene="ABCC10"
                     /gene_synonym="EST182763; MRP7; SIMRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2183
                     /gene="ABCC10"
                     /gene_synonym="EST182763; MRP7; SIMRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2355
                     /gene="ABCC10"
                     /gene_synonym="EST182763; MRP7; SIMRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2454
                     /gene="ABCC10"
                     /gene_synonym="EST182763; MRP7; SIMRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2455..2644
                     /gene="ABCC10"
                     /gene_synonym="EST182763; MRP7; SIMRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2722
                     /gene="ABCC10"
                     /gene_synonym="EST182763; MRP7; SIMRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..2917
                     /gene="ABCC10"
                     /gene_synonym="EST182763; MRP7; SIMRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3068
                     /gene="ABCC10"
                     /gene_synonym="EST182763; MRP7; SIMRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            3069..3258
                     /gene="ABCC10"
                     /gene_synonym="EST182763; MRP7; SIMRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            3259..3602
                     /gene="ABCC10"
                     /gene_synonym="EST182763; MRP7; SIMRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            3603..3772
                     /gene="ABCC10"
                     /gene_synonym="EST182763; MRP7; SIMRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            3773..3933
                     /gene="ABCC10"
                     /gene_synonym="EST182763; MRP7; SIMRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            3934..4187
                     /gene="ABCC10"
                     /gene_synonym="EST182763; MRP7; SIMRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            4188..4333
                     /gene="ABCC10"
                     /gene_synonym="EST182763; MRP7; SIMRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            4334..4431
                     /gene="ABCC10"
                     /gene_synonym="EST182763; MRP7; SIMRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            4432..4544
                     /gene="ABCC10"
                     /gene_synonym="EST182763; MRP7; SIMRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            4545..5043
                     /gene="ABCC10"
                     /gene_synonym="EST182763; MRP7; SIMRP7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5017..5022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCC10"
                     /gene_synonym="EST182763; MRP7; SIMRP7"
                     /note="hexamer: ATTAAA"
     polyA_site      5043
                     /gene="ABCC10"
                     /gene_synonym="EST182763; MRP7; SIMRP7"
                     /note="major polyA site"
ORIGIN      
        1 agcatatggg cgtggcgaat agcgccggct aggtcttcca acctctaggt ggggtgccag
       61 ccggggcggg cccagcaccc cggccgggca gtactttttt tttttttgca tacaccagtt
      121 ctcaggatat cggaatccgg tgcacagcag cttcttcagg tttgaggttc cggatgcctg
      181 ggggcggaga aacgggaggg gaaaaacaga tggcaaggtg aggcgtccat ggaacgactt
      241 ctggcccagc tgtgcggcag cagcgcagcg tggccgctcc cgctgtggga gggggacacc
      301 acaggccact gcttcaccca gctggtgctc agcgccctgc cccacgcgct cctcgccgtg
      361 ctcagtgcct gttacttggg caccccgagg agtccagatt acatcctacc ctgcagtcct
      421 ggatggcgcc tccgacttgc agcttccttc ctgctttccg tcttcccgct gctagacctt
      481 cttccagttg ctttgccacc aggggcaggc ccaggaccca tagggctaga ggtgttggca
      541 gggtgcgtgg cagctgtggc ctggatcagc cacagcctgg ccctgtgggt gttggcacat
      601 tcccctcatg gccactcccg gggtcccttg gccttggccc tggtagcctt gctgccagct
      661 ccagccctag tgctgaccgt gttgtggcat tgccagcgag gcacacttct gcccccactt
      721 ctcccagggc ccatggcccg cctatgcttg ctcatcctgc agctggctgc actcttggcc
      781 tatgcactgg gatgggcagc tcctggggga ccacgagaac cctgggctca ggagcccctc
      841 ctgcccgagg atcaagaacc tgaggtggct gaagatgggg agagttggct gtcacgcttt
      901 tcctatgcct ggctggcacc cttgctggcc cgtggggcct gtggagagct ccggcagcct
      961 caggacattt gccgcctccc ccacagactg cagccaacct acctggctcg tgtcttccag
     1021 gcacactggc aggagggggc acggctgtgg agggccttgt atggggcctt tggacggtgc
     1081 tatctggcac ttggactgct gaagctggtg gggaccatgt tgggattctc agggcccctg
     1141 ttgctctccc tactggtggg cttcctggaa gaggggcagg agccactaag ccacggcctg
     1201 ctctatgctc tggggctagc cggtggggct gtgctgggtg ctgtgctgca gaatcagtat
     1261 gggtatgagg tatataaggt aacacttcag gcacgggggg ctgtgctgaa catcctgtac
     1321 tgcaaggctt tacagctggg gcccagccgc cctcctactg gggaggccct gaacctacta
     1381 ggcactgact ctgaacggct gcttaacttt gctgggagct tccatgaagc ctggggcctg
     1441 cccctgcaac tggccatcac cctctacctg ctgtaccagc aggtaggcgt ggccttcgtg
     1501 ggtggtctca tcttggcact gctgctggta cccgtcaaca aagtgattgc cacccgcatc
     1561 atggccagca accaggaaat gctacagcac aaggatgcgc gggttaagct tgtgacagag
     1621 ctgctgagtg gcattcgggt catcaagttc tgcgggtggg agcaggcact gggagcccga
     1681 gtagaggcct gccgggctcg agagctgggg cgactccggg tcatcaaata cctggatgcg
     1741 gcctgtgtat acctgtgggc tgccctaccg gttgtcatct ccatcgttat cttcatcacc
     1801 tatgtcctca tggggcacca gctcactgcc accaaggtgt tcacggccct ggcactggtg
     1861 cgaatgctca ttcttcctct caacaacttc ccttgggtga tcaatggtct cctggaggcc
     1921 aaagtgtcct tggaccggat ccagcttttc ctcgaccttc caaaccacaa cccccaggcc
     1981 tactacagcc cagatccccc tgcagagcca tctacagtat tggagctgca tggagccttg
     2041 ttctcctggg acccagttgg aaccagcctg gagaccttca tcagtcatct cgaagtgaaa
     2101 aagggtatgc tggtgggcat cgtggggaag gtcggctgtg ggaagagctc cctgctggct
     2161 gccatcgctg gagagctcca caggctgcgt gggcatgtgg cagtgcgggg gctgtccaag
     2221 ggctttggcc tggccaccca ggaaccctgg atccagtttg ccaccatccg agacaacatc
     2281 ctctttggga agacatttga tgcacagctg tacaaggagg tgctagaagc ctgcgccctc
     2341 aatgatgacc tcagtatcct gcctgctgga gaccagacag aggtggggga gaagggtgtc
     2401 acccttagcg gaggacagcg tgcccggatt gcccttgctc gtgctgtcta ccaggaaaag
     2461 gagctctatc tcctcgatga ccctctggcc gctgtggatg cagatgtggc caaccacctg
     2521 ctgcacaggt gcatcctggg catgctgagc tacaccacac ggctgctctg cacccaccgc
     2581 actgagtacc tggagagggc tgacgcggtg ctgctgatgg aggccgggcg cctcatccgg
     2641 gctggacctc cctctgagat tctgccactg gtacaagctg tccccaaagc ctgggctgag
     2701 aatggacaag agtctgactc agccacagcc cagtcagtac agaacccaga gaaaacaaag
     2761 gaggggctgg aggaggagca gagcacatct ggtcgcctgc tgcaggaaga aagcaagaag
     2821 gagggcgccg tggccttgca cgtgtaccaa gcttactgga aggccgtggg ccagggcttg
     2881 gccttagcca tcctcttctc tctgcttctc atgcaagcca cgcggaacgc tgctgactgg
     2941 tggctctccc actggatctc tcagctgaag gctgagaata gctcccagga ggcgcaaccc
     3001 tccaccagcc cagcttctat ggggctcttc tctccgcagc tgctcctctt ttcccctgga
     3061 aacctctaca tcccagtgtt cccactgccc aaagctgccc ccaatggctc ctcagacatc
     3121 cgtttctacc tcaccgtgta tgcgaccatt gctggtgtaa attccctctg cacccttctc
     3181 cgggcagtgc tctttgcagc aggcaccctt caagcagctg ccactctgca tcgccgcctg
     3241 ctgcatcgag tccttatggc accagtgact ttcttcaatg ccacacccac gggccggatc
     3301 ctaaaccgct tctcctctga tgtggcctgt gcggatgaca gcctgccctt catcctcaac
     3361 atcctcctgg ccaacgcggc aggcctgctg gggctcctgg ccgtgctggg ctctggcctg
     3421 ccctggctgc tgctcctgct gccgcctttg agcatcatgt actatcacgt gcagcgccac
     3481 tacagggcct cctcacggga gctgcggcgc ctgggcagcc tcaccctgtc tccactgtat
     3541 agccatctgg ccgatacctt ggctggcctc tctgtgctcc gggccacagg ggccacctac
     3601 aggtttgagg aggagaacct gcgactcctt gagctaaacc agaggtgcca gtttgccacc
     3661 agtgccacaa tgcagtggct ggacattcgg ctacagctca tgggggcggc agtggtcagc
     3721 gctatcgcag gcatcgctct ggtgcagcac cagcagggcc tcgctaaccc agggctggtg
     3781 ggcttgtcgc tgtcttatgc cctgtccctg acgggcctgc tctcgggcct ggtgagcagc
     3841 ttcacacaga cagaggccat gctggtgagc gtcgagcggc tggaagagta cacctgtgac
     3901 ctgccccagg aaccccaggg ccagccactg cagctgggca ccggctggct gacccagggg
     3961 ggcgtggagt tccaggacgt ggtgttggcg taccggccag ggctgccgaa tgccctggat
     4021 ggagtgacct tctgcgtgca gcctggagag aagttgggca tcgtgggccg cacaggctcc
     4081 ggcaagtctt ccctgttgtt ggtgctcttc cggctgctag agcccagttc agggcgagtg
     4141 ctgctggacg gcgtggacac cagccagctg gagctggccc agctcagatc ccagttggct
     4201 atcatccccc aggagccctt tttgttcagt gggactgttc gggaaaacct ggacccccag
     4261 ggcctacata aggacagggc cttgtggcag gccctgaagc agtgccacct gagtgaggtg
     4321 attacatcca tgggtggtct ggatggtgag ctgggtgagg ggggccggag cttatctctt
     4381 gggcagaggc agctgttgtg tttggccagg gctctcctca cagatgccaa gatcctgtgt
     4441 atcgatgagg ccacagcaag tgtggaccag aagacagacc agctgctcca gcagaccatc
     4501 tgcaaacgct ttgccaacaa gacagtgctg accattgccc ataggctcaa cacgatcctg
     4561 aactcagacc gggtgctggt gctacaagcg gggagagtgg tagagctgga ctccccggcc
     4621 accctgcgca accagcccca ctccctgttc cagcagctgc tgcagagcag ccagcaggga
     4681 gtccctgcct cactcggagg tccctgagcc caatcccaca ccctgcagag ttctcccctc
     4741 tctctgatcc aggccgggcc tatacagagg tgctggctgc ttgtttacat tctcctctgg
     4801 ggctctacct ctccacactt ccccagaagg gaaaagggca ccctggatta ctctttggaa
     4861 atcactcctt ggtgggcagc atcctgaggc ttccccagaa ccaggcctct gctctggccc
     4921 tcttgcatct ggaacgccag gtgggttttt ctggcatagg agcccacttg cattttcata
     4981 gttttatttg ataaaattcc atcttacatt ctgtgtatta aaaaaataat atttctggtg
     5041 tga
//
