LOCUS       NM_019862               6327 bp    mRNA    linear   PRI 14-FEB-2025
DEFINITION  Homo sapiens ATP binding cassette subfamily C member 1 (ABCC1 blood
            group) (ABCC1), transcript variant 2, mRNA.
ACCESSION   NM_019862 XM_047434143
VERSION     NM_019862.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6327)
  AUTHORS   Kok,C.Y., Igoor,S., Rao,R., Tsurusaki,S., Titus,T., MacLean,L.M.,
            Kadian,M., Skelton,R., Chong,J.J.H. and Kizana,E.
  TITLE     Overexpression of multidrug resistance-associated protein 1
            protects against cardiotoxicity by augmenting the doxorubicin
            efflux from cardiomyocytes
  JOURNAL   J Gene Med 26 (3), e3681 (2024)
   PUBMED   38484722
  REMARK    GeneRIF: Overexpression of multidrug resistance-associated protein
            1 protects against cardiotoxicity by augmenting the doxorubicin
            efflux from cardiomyocytes.
REFERENCE   2  (bases 1 to 6327)
  AUTHORS   Yahya,S.M.M., Nabih,H.K., Elsayed,G.H., Mohamed,S.I.A., Elfiky,A.M.
            and Salem,S.M.
  TITLE     Restoring microRNA-34a overcomes acquired drug resistance and
            disease progression in human breast cancer cell lines via
            suppressing the ABCC1 gene
  JOURNAL   Breast Cancer Res Treat 204 (1), 133-149 (2024)
   PUBMED   38057687
  REMARK    GeneRIF: Restoring microRNA-34a overcomes acquired drug resistance
            and disease progression in human breast cancer cell lines via
            suppressing the ABCC1 gene.
REFERENCE   3  (bases 1 to 6327)
  AUTHORS   Marjamaa,A., Gibbs,B., Kotrba,C. and Masamha,C.P.
  TITLE     The role and impact of alternative polyadenylation and miRNA
            regulation on the expression of the multidrug resistance-associated
            protein 1 (MRP-1/ABCC1) in epithelial ovarian cancer
  JOURNAL   Sci Rep 13 (1), 17476 (2023)
   PUBMED   37838788
  REMARK    GeneRIF: The role and impact of alternative polyadenylation and
            miRNA regulation on the expression of the multidrug
            resistance-associated protein 1 (MRP-1/ABCC1) in epithelial ovarian
            cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6327)
  AUTHORS   Zhang,L., Lu,X., Xu,Y., La,X., Tian,J., Li,A., Li,H., Wu,C., Xi,Y.,
            Song,G., Zhou,Z., Bai,W., An,L. and Li,Z.
  TITLE     Tumor-associated macrophages confer colorectal cancer
            5-fluorouracil resistance by promoting MRP1 membrane translocation
            via an intercellular CXCL17/CXCL22-CCR4-ATF6-GRP78 axis
  JOURNAL   Cell Death Dis 14 (9), 582 (2023)
   PUBMED   37658050
  REMARK    GeneRIF: Tumor-associated macrophages confer colorectal cancer
            5-fluorouracil resistance by promoting MRP1 membrane translocation
            via an intercellular CXCL17/CXCL22-CCR4-ATF6-GRP78 axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6327)
  AUTHORS   Grant,C.E., Kurz,E.U., Cole,S.P. and Deeley,R.G.
  TITLE     Analysis of the intron-exon organization of the human
            multidrug-resistance protein gene (MRP) and alternative splicing of
            its mRNA
  JOURNAL   Genomics 45 (2), 368-378 (1997)
   PUBMED   9344662
REFERENCE   6  (bases 1 to 6327)
  AUTHORS   Leier,I., Jedlitschky,G., Buchholz,U., Cole,S.P., Deeley,R.G. and
            Keppler,D.
  TITLE     The MRP gene encodes an ATP-dependent export pump for leukotriene
            C4 and structurally related conjugates
  JOURNAL   J Biol Chem 269 (45), 27807-27810 (1994)
   PUBMED   7961706
REFERENCE   7  (bases 1 to 6327)
  AUTHORS   Zaman,G.J., Flens,M.J., van Leusden,M.R., de Haas,M., Mulder,H.S.,
            Lankelma,J., Pinedo,H.M., Scheper,R.J., Baas,F., Broxterman,H.J. et
            al.
  TITLE     The human multidrug resistance-associated protein MRP is a plasma
            membrane drug-efflux pump
  JOURNAL   Proc Natl Acad Sci U S A 91 (19), 8822-8826 (1994)
   PUBMED   7916458
REFERENCE   8  (bases 1 to 6327)
  AUTHORS   Cole,S.P. and Deeley,R.G.
  TITLE     Multidrug resistance-associated protein: sequence correction
  JOURNAL   Science 260 (5110), 879 (1993)
   PUBMED   8098549
  REMARK    Correction to:[Science. 1992 Dec 4;258(5088):1650-4. doi:
            10.1126/science.1360704.. PMID: 1360704]
REFERENCE   9  (bases 1 to 6327)
  AUTHORS   Cole,S.P., Bhardwaj,G., Gerlach,J.H., Mackie,J.E., Grant,C.E.,
            Almquist,K.C., Stewart,A.J., Kurz,E.U., Duncan,A.M. and Deeley,R.G.
  TITLE     Overexpression of a transporter gene in a multidrug-resistant human
            lung cancer cell line
  JOURNAL   Science 258 (5088), 1650-1654 (1992)
   PUBMED   1360704
  REMARK    Erratum:[Science. 1993 May 14;260(5110):879. doi:
            10.1126/science.8098549.. PMID: 8098549]
REFERENCE   10 (bases 1 to 6327)
  AUTHORS   Lam,B.K., Owen,W.F. Jr., Austen,K.F. and Soberman,R.J.
  TITLE     The identification of a distinct export step following the
            biosynthesis of leukotriene C4 by human eosinophils
  JOURNAL   J Biol Chem 264 (22), 12885-12889 (1989)
   PUBMED   2753893
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC130651.2, AC025778.8,
            KC877577.1 and AC136624.3.
            
            On or before Jul 29, 2022 this sequence version replaced
            XM_047434143.1, NM_019862.2.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra-and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
            full transporter is a member of the MRP subfamily which is involved
            in multi-drug resistance. This protein functions as a multispecific
            organic anion transporter, with oxidized glutatione, cysteinyl
            leukotrienes, and activated aflatoxin B1 as substrates. This
            protein also transports glucuronides and sulfate conjugates of
            steroid hormones and bile salts. Alternatively spliced variants of
            this gene have been described but their full-length nature is
            unknown. [provided by RefSeq, Apr 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372080.4094890.1,
                                           SRR14038197.2214759.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               AC130651.2         116895-117078
            185-361             AC025778.8         182916-183092       c
            362-487             AC025778.8         181007-181132       c
            488-625             AC025778.8         176280-176417       c
            626-751             AC025778.8         174287-174412       c
            752-813             AC025778.8         157738-157799       c
            814-945             AC025778.8         154305-154436       c
            946-1176            AC025778.8         146228-146458       c
            1177-1354           AC025778.8         144895-145072       c
            1355-1516           AC025778.8         142605-142766       c
            1517-1609           AC025778.8         138092-138184       c
            1610-1813           AC025778.8         134613-134816       c
            1814-1960           AC025778.8         122606-122752       c
            1961-2048           AC025778.8         119179-119266       c
            2049-2124           AC025778.8         114507-114582       c
            2125-2251           AC025778.8         111430-111556       c
            2252-2419           AC025778.8         103917-104084       c
            2420-2510           AC025778.8         100413-100503       c
            2511-2603           KC877577.1         1-93
            2604-2694           AC136624.3         200539-200629       c
            2695-2830           AC136624.3         196383-196518       c
            2831-3038           AC136624.3         191674-191881       c
            3039-3349           AC136624.3         188180-188490       c
            3350-3549           AC136624.3         181082-181281       c
            3550-3676           AC136624.3         178341-178467       c
            3677-3778           AC136624.3         177345-177446       c
            3779-3925           AC136624.3         171321-171467       c
            3926-4084           AC136624.3         168748-168906       c
            4085-4251           AC136624.3         166612-166778       c
            4252-4446           AC136624.3         164698-164892       c
            4447-6327           AC136624.3         160203-162083       c
FEATURES             Location/Qualifiers
     source          1..6327
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.11"
     gene            1..6327
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /note="ATP binding cassette subfamily C member 1 (ABCC1
                     blood group)"
                     /db_xref="GeneID:4363"
                     /db_xref="HGNC:HGNC:51"
                     /db_xref="MIM:158343"
     exon            1..184
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..4555
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /EC_number="7.6.2.2"
                     /EC_number="7.6.2.3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     multidrug resistance-associated protein 1; leukotriene
                     C(4) transporter; LTC4 transporter; ATP-binding cassette
                     transporter variant ABCC1delta-ex13; ATP-binding cassette
                     transporter variant ABCC1delta-ex13&14; ATP-binding
                     cassette transporter variant ABCC1delta-ex25&26;
                     ATP-binding cassette, sub-family C (CFTR/MRP), member 1;
                     glutathione-S-conjugate-translocating ATPase ABCC1;
                     glutathione S-conjugate export pump"
                     /codon_start=1
                     /product="multidrug resistance-associated protein 1
                     isoform 2"
                     /protein_id="NP_063915.2"
                     /db_xref="CCDS:CCDS45427.1"
                     /db_xref="GeneID:4363"
                     /db_xref="HGNC:HGNC:51"
                     /db_xref="MIM:158343"
                     /translation="MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCF
                     YLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFL
                     APVFLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTA
                     LKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSR
                     ITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVV
                     YSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAI
                     HDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSG
                     MRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQ
                     VILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEI
                     LNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFA
                     VYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEE
                     LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGC
                     GKSSLLSALLAEMDKVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVD
                     AHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLA
                     RDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLS
                     SSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLF
                     ISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVF
                     GYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPE
                     VIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVS
                     RSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLEC
                     VGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVER
                     LKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGE
                     KVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVL
                     FSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQL
                     VCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYT
                     RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV"
     exon            185..361
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            362..487
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            488..625
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            626..751
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            752..813
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            814..945
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1176
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1354
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1516
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1609
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1813
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1960
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2048
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2124
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2251
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2419
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2603
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2694
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2830
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..3038
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3039..3349
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3350..3549
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3550..3676
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3677..3778
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3779..3925
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3926..4084
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4085..4251
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4252..4446
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4447..6327
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5722
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /note="major polyA site"
     regulatory      6304..6309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /note="hexamer: AGTAAA"
     polyA_site      6327
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /note="major polyA site"
ORIGIN      
        1 gccgccgccg ccgccgccag cgctagcgcc agcagccggg cccgatcacc cgccgcccgg
       61 tgcccgccgc cgcccgcgcc agcaaccggg cccgatcacc cgccgcccgg tgcccgccgc
      121 cgcccgcgcc accggcatgg cgctccgggg cttctgcagc gccgatggct ccgacccgct
      181 ctgggactgg aatgtcacgt ggaataccag caaccccgac ttcaccaagt gctttcagaa
      241 cacggtcctc gtgtgggtgc cttgttttta cctctgggcc tgtttcccct tctacttcct
      301 ctatctctcc cgacatgacc gaggctacat tcagatgaca cctctcaaca aaaccaaaac
      361 tgccttggga tttttgctgt ggatcgtctg ctgggcagac ctcttctact ctttctggga
      421 aagaagtcgg ggcatattcc tggccccagt gtttctggtc agcccaactc tcttgggcat
      481 caccatgctg cttgctacct ttttaattca gctggagagg aggaagggag ttcagtcttc
      541 agggatcatg ctcactttct ggctggtagc cctagtgtgt gccctagcca tcctgagatc
      601 caaaattatg acagccttaa aagaggatgc ccaggtggac ctgtttcgtg acatcacttt
      661 ctacgtctac ttttccctct tactcattca gctcgtcttg tcctgtttct cagatcgctc
      721 acccctgttc tcggaaacca tccacgaccc taatccctgc ccagagtcca gcgcttcctt
      781 cctgtcgagg atcaccttct ggtggatcac agggttgatt gtccggggct accgccagcc
      841 cctggagggc agtgacctct ggtccttaaa caaggaggac acgtcggaac aagtcgtgcc
      901 tgttttggta aagaactgga agaaggaatg cgccaagact aggaagcagc cggtgaaggt
      961 tgtgtactcc tccaaggatc ctgcccagcc gaaagagagt tccaaggtgg atgcgaatga
     1021 ggaggtggag gctttgatcg tcaagtcccc acagaaggag tggaacccct ctctgtttaa
     1081 ggtgttatac aagacctttg ggccctactt cctcatgagc ttcttcttca aggccatcca
     1141 cgacctgatg atgttttccg ggccgcagat cttaaagttg ctcatcaagt tcgtgaatga
     1201 cacgaaggcc ccagactggc agggctactt ctacaccgtg ctgctgtttg tcactgcctg
     1261 cctgcagacc ctcgtgctgc accagtactt ccacatctgc ttcgtcagtg gcatgaggat
     1321 caagaccgct gtcattgggg ctgtctatcg gaaggccctg gtgatcacca attcagccag
     1381 aaaatcctcc acggtcgggg agattgtcaa cctcatgtct gtggacgctc agaggttcat
     1441 ggacttggcc acgtacatta acatgatctg gtcagccccc ctgcaagtca tccttgctct
     1501 ctacctcctg tggctgaatc tgggcccttc cgtcctggct ggagtggcgg tgatggtcct
     1561 catggtgccc gtcaatgctg tgatggcgat gaagaccaag acgtatcagg tggcccacat
     1621 gaagagcaaa gacaatcgga tcaagctgat gaacgaaatt ctcaatggga tcaaagtgct
     1681 aaagctttat gcctgggagc tggcattcaa ggacaaggtg ctggccatca ggcaggagga
     1741 gctgaaggtg ctgaagaagt ctgcctacct gtcagccgtg ggcaccttca cctgggtctg
     1801 cacgcccttt ctggtggcct tgtgcacatt tgccgtctac gtgaccattg acgagaacaa
     1861 catcctggat gcccagacag ccttcgtgtc tttggccttg ttcaacatcc tccggtttcc
     1921 cctgaacatt ctccccatgg tcatcagcag catcgtgcag gcgagtgtct ccctcaaacg
     1981 cctgaggatc tttctctccc atgaggagct ggaacctgac agcatcgagc gacggcctgt
     2041 caaagacggc gggggcacga acagcatcac cgtgaggaat gccacattca cctgggccag
     2101 gagcgaccct cccacactga atggcatcac cttctccatc cccgaaggtg ctttggtggc
     2161 cgtggtgggc caggtgggct gcggaaagtc gtccctgctc tcagccctct tggctgagat
     2221 ggacaaagtg gaggggcacg tggctatcaa gggcgtgaac ctgtctgggg gccagaagca
     2281 gcgcgtgagc ctggcccggg ccgtgtactc caacgctgac atttacctct tcgatgatcc
     2341 cctctcagca gtggatgccc atgtgggaaa acacatcttt gaaaatgtga ttggccccaa
     2401 ggggatgctg aagaacaaga cgcggatctt ggtcacgcac agcatgagct acttgccgca
     2461 ggtggacgtc atcatcgtca tgagtggcgg caagatctct gagatgggct cctaccagga
     2521 gctgctggct cgagacggcg ccttcgctga gttcctgcgt acctatgcca gcacagagca
     2581 ggagcaggat gcagaggaga acggggtcac gggcgtcagc ggtccaggga aggaagcaaa
     2641 gcaaatggag aatggcatgc tggtgacgga cagtgcaggg aagcaactgc agagacagct
     2701 cagcagctcc tcctcctata gtggggacat cagcaggcac cacaacagca ccgcagaact
     2761 gcagaaagct gaggccaaga aggaggagac ctggaagctg atggaggctg acaaggcgca
     2821 gacagggcag gtcaagcttt ccgtgtactg ggactacatg aaggccatcg gactcttcat
     2881 ctccttcctc agcatcttcc ttttcatgtg taaccatgtg tccgcgctgg cttccaacta
     2941 ttggctcagc ctctggactg atgaccccat cgtcaacggg actcaggagc acacgaaagt
     3001 ccggctgagc gtctatggag ccctgggcat ttcacaaggg atcgccgtgt ttggctactc
     3061 catggccgtg tccatcgggg ggatcttggc ttcccgctgt ctgcacgtgg acctgctgca
     3121 cagcatcctg cggtcaccca tgagcttctt tgagcggacc cccagtggga acctggtgaa
     3181 ccgcttctcc aaggagctgg acacagtgga ctccatgatc ccggaggtca tcaagatgtt
     3241 catgggctcc ctgttcaacg tcattggtgc ctgcatcgtt atcctgctgg ccacgcccat
     3301 cgccgccatc atcatcccgc cccttggcct catctacttc ttcgtccaga ggttctacgt
     3361 ggcttcctcc cggcagctga agcgcctcga gtcggtcagc cgctccccgg tctattccca
     3421 tttcaacgag accttgctgg gggtcagcgt cattcgagcc ttcgaggagc aggagcgctt
     3481 catccaccag agtgacctga aggtggacga gaaccagaag gcctattacc ccagcatcgt
     3541 ggccaacagg tggctggccg tgcggctgga gtgtgtgggc aactgcatcg ttctgtttgc
     3601 tgccctgttt gcggtgatct ccaggcacag cctcagtgct ggcttggtgg gcctctcagt
     3661 gtcttactca ttgcaggtca ccacgtactt gaactggctg gttcggatgt catctgaaat
     3721 ggaaaccaac atcgtggccg tggagaggct caaggagtat tcagagactg agaaggaggc
     3781 gccctggcaa atccaggaga cagctccgcc cagcagctgg ccccaggtgg gccgagtgga
     3841 attccggaac tactgcctgc gctaccgaga ggacctggac ttcgttctca ggcacatcaa
     3901 tgtcacgatc aatgggggag aaaaggtcgg catcgtgggg cggacgggag ctgggaagtc
     3961 gtccctgacc ctgggcttat ttcggatcaa cgagtctgcc gaaggagaga tcatcatcga
     4021 tggcatcaac atcgccaaga tcggcctgca cgacctccgc ttcaagatca ccatcatccc
     4081 ccaggaccct gttttgtttt cgggttccct ccgaatgaac ctggacccat tcagccagta
     4141 ctcggatgaa gaagtctgga cgtccctgga gctggcccac ctgaaggact tcgtgtcagc
     4201 ccttcctgac aagctagacc atgaatgtgc agaaggcggg gagaacctca gtgtcgggca
     4261 gcgccagctt gtgtgcctag cccgggccct gctgaggaag acgaagatcc ttgtgttgga
     4321 tgaggccacg gcagccgtgg acctggaaac ggacgacctc atccagtcca ccatccggac
     4381 acagttcgag gactgcaccg tcctcaccat cgcccaccgg ctcaacacca tcatggacta
     4441 cacaagggtg atcgtcttgg acaaaggaga aatccaggag tacggcgccc catcggacct
     4501 cctgcagcag agaggtcttt tctacagcat ggccaaagac gccggcttgg tgtgagcccc
     4561 agagctggca tatctggtca gaactgcagg gcctatatgc cagcgcccag ggaggagtca
     4621 gtacccctgg taaaccaagc ctcccacact gaaaccaaaa cataaaaacc aaacccagac
     4681 aaccaaaaca tattcaaagc agcagccacc gccatccggt cccctgcctg gaactggctg
     4741 tgaagaccca ggagagacag agatgcgaac cacccaaaac acgcacaccc tgcccctggt
     4801 gccctgagac agacacacag cctcacgccc ccaggaatgc aagtggtttc ctggtgcttc
     4861 ccacggagga gttttggcag ccagacttct ggaggaattg gttgtataga agatcctagt
     4921 gaccaaattc agcctactgc ctcggatctc tccagccgaa gtctgtggac tgcaagtctt
     4981 tgagatgctt ctggctccca tcacctctaa catccttgtc tgggtctacc aggaacgctt
     5041 catttccttg gggctgcagt tttgtggttg aggggcctgg agaaaatcat tttctcccct
     5101 tggcagtgtc ccagggccct ggatggtcct cttaccaaca tctggtcttc caggcactca
     5161 aaagctggga accagcatct cagcgccagc tctaccagtt ctcgttttgg gccagaggca
     5221 gcctctgcac tcccacgcct gtcctcctgg aagggacctg gttggactaa cggctaacct
     5281 ggacctggaa ctgtagggcc aggggattgt ctcagggccg acgttccacc tggggcttcc
     5341 ctccccaccc accccgactc caggctttcc cttttttctt ttgttcaaca ttgtaagaac
     5401 aatcaatgct gttattactg ttcccaccat gattgatgtg gggtaaatat taaggagatg
     5461 gcctcatggg aatttgacct tgactagaaa tagagactga gagtgagcaa ccagctggaa
     5521 ggtactatgc cagtcctagc agaaaaatgt gttaggggcc tggcccaaag cagtgttggt
     5581 tgcttacagt gttgattgat tttgttcttt tttcttacca cctcttttct ttccctctca
     5641 tggtacctgc tcatggttat gaagctttca aagtaaagaa cacgaaatac ctcccaagta
     5701 ttaccagtgg gtaccaaaaa aatgtcccct tgagtctttt ccttgttttt agatgttaat
     5761 tctctccctt ggcatccggt tagcccccca gggggggcag cattgtggag aacttgatat
     5821 ttagttactg atgctcttcc aggacacgaa aagaacccat ctttgaatat caatgatttt
     5881 ttttttttaa gtactgttcc ggggagaaaa acagtctcaa aacttgaact tcttgggaat
     5941 agaagtgttg ggctgagaag taacattccc aggaaatagt gagaagctcg ccctgtgttt
     6001 gaaaccgtgt tggtctctgt gttcctggaa gaaaacaggg aagcagcatc ttttaaagcc
     6061 tgttctttaa ggtgtctcgt tagagcccaa agtggaatcc ggaaggcagc cagagctgag
     6121 gctgccccaa gactcagact tgctaagaat tacgccgccg acttcaaacc cagagagcat
     6181 ctttctttta ggcgaaaacg catatattta ttttttgtaa gttataccat tctttcacat
     6241 tagataaact aagttttggg ggatcctttt gtaatgactt acactggaaa tgcgaacatt
     6301 tgcagtaaaa aaatatatat atatcta
//
