LOCUS       NM_004996               6504 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens ATP binding cassette subfamily C member 1 (ABCC1 blood
            group) (ABCC1), transcript variant 1, mRNA.
ACCESSION   NM_004996
VERSION     NM_004996.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6504)
  AUTHORS   Kok,C.Y., Igoor,S., Rao,R., Tsurusaki,S., Titus,T., MacLean,L.M.,
            Kadian,M., Skelton,R., Chong,J.J.H. and Kizana,E.
  TITLE     Overexpression of multidrug resistance-associated protein 1
            protects against cardiotoxicity by augmenting the doxorubicin
            efflux from cardiomyocytes
  JOURNAL   J Gene Med 26 (3), e3681 (2024)
   PUBMED   38484722
  REMARK    GeneRIF: Overexpression of multidrug resistance-associated protein
            1 protects against cardiotoxicity by augmenting the doxorubicin
            efflux from cardiomyocytes.
REFERENCE   2  (bases 1 to 6504)
  AUTHORS   Yahya,S.M.M., Nabih,H.K., Elsayed,G.H., Mohamed,S.I.A., Elfiky,A.M.
            and Salem,S.M.
  TITLE     Restoring microRNA-34a overcomes acquired drug resistance and
            disease progression in human breast cancer cell lines via
            suppressing the ABCC1 gene
  JOURNAL   Breast Cancer Res Treat 204 (1), 133-149 (2024)
   PUBMED   38057687
  REMARK    GeneRIF: Restoring microRNA-34a overcomes acquired drug resistance
            and disease progression in human breast cancer cell lines via
            suppressing the ABCC1 gene.
REFERENCE   3  (bases 1 to 6504)
  AUTHORS   Marjamaa,A., Gibbs,B., Kotrba,C. and Masamha,C.P.
  TITLE     The role and impact of alternative polyadenylation and miRNA
            regulation on the expression of the multidrug resistance-associated
            protein 1 (MRP-1/ABCC1) in epithelial ovarian cancer
  JOURNAL   Sci Rep 13 (1), 17476 (2023)
   PUBMED   37838788
  REMARK    GeneRIF: The role and impact of alternative polyadenylation and
            miRNA regulation on the expression of the multidrug
            resistance-associated protein 1 (MRP-1/ABCC1) in epithelial ovarian
            cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6504)
  AUTHORS   Zhang,L., Lu,X., Xu,Y., La,X., Tian,J., Li,A., Li,H., Wu,C., Xi,Y.,
            Song,G., Zhou,Z., Bai,W., An,L. and Li,Z.
  TITLE     Tumor-associated macrophages confer colorectal cancer
            5-fluorouracil resistance by promoting MRP1 membrane translocation
            via an intercellular CXCL17/CXCL22-CCR4-ATF6-GRP78 axis
  JOURNAL   Cell Death Dis 14 (9), 582 (2023)
   PUBMED   37658050
  REMARK    GeneRIF: Tumor-associated macrophages confer colorectal cancer
            5-fluorouracil resistance by promoting MRP1 membrane translocation
            via an intercellular CXCL17/CXCL22-CCR4-ATF6-GRP78 axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6504)
  AUTHORS   Grant,C.E., Kurz,E.U., Cole,S.P. and Deeley,R.G.
  TITLE     Analysis of the intron-exon organization of the human
            multidrug-resistance protein gene (MRP) and alternative splicing of
            its mRNA
  JOURNAL   Genomics 45 (2), 368-378 (1997)
   PUBMED   9344662
REFERENCE   6  (bases 1 to 6504)
  AUTHORS   Leier,I., Jedlitschky,G., Buchholz,U., Cole,S.P., Deeley,R.G. and
            Keppler,D.
  TITLE     The MRP gene encodes an ATP-dependent export pump for leukotriene
            C4 and structurally related conjugates
  JOURNAL   J Biol Chem 269 (45), 27807-27810 (1994)
   PUBMED   7961706
REFERENCE   7  (bases 1 to 6504)
  AUTHORS   Zaman,G.J., Flens,M.J., van Leusden,M.R., de Haas,M., Mulder,H.S.,
            Lankelma,J., Pinedo,H.M., Scheper,R.J., Baas,F., Broxterman,H.J. et
            al.
  TITLE     The human multidrug resistance-associated protein MRP is a plasma
            membrane drug-efflux pump
  JOURNAL   Proc Natl Acad Sci U S A 91 (19), 8822-8826 (1994)
   PUBMED   7916458
REFERENCE   8  (bases 1 to 6504)
  AUTHORS   Cole,S.P. and Deeley,R.G.
  TITLE     Multidrug resistance-associated protein: sequence correction
  JOURNAL   Science 260 (5110), 879 (1993)
   PUBMED   8098549
  REMARK    Correction to:[Science. 1992 Dec 4;258(5088):1650-4. doi:
            10.1126/science.1360704.. PMID: 1360704]
REFERENCE   9  (bases 1 to 6504)
  AUTHORS   Cole,S.P., Bhardwaj,G., Gerlach,J.H., Mackie,J.E., Grant,C.E.,
            Almquist,K.C., Stewart,A.J., Kurz,E.U., Duncan,A.M. and Deeley,R.G.
  TITLE     Overexpression of a transporter gene in a multidrug-resistant human
            lung cancer cell line
  JOURNAL   Science 258 (5088), 1650-1654 (1992)
   PUBMED   1360704
  REMARK    Erratum:[Science. 1993 May 14;260(5110):879. doi:
            10.1126/science.8098549.. PMID: 8098549]
REFERENCE   10 (bases 1 to 6504)
  AUTHORS   Lam,B.K., Owen,W.F. Jr., Austen,K.F. and Soberman,R.J.
  TITLE     The identification of a distinct export step following the
            biosynthesis of leukotriene C4 by human eosinophils
  JOURNAL   J Biol Chem 264 (22), 12885-12889 (1989)
   PUBMED   2753893
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X78338.1, AC025778.8 and
            AC136624.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004996.3.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra-and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
            full transporter is a member of the MRP subfamily which is involved
            in multi-drug resistance. This protein functions as a multispecific
            organic anion transporter, with oxidized glutatione, cysteinyl
            leukotrienes, and activated aflatoxin B1 as substrates. This
            protein also transports glucuronides and sulfate conjugates of
            steroid hormones and bile salts. Alternatively spliced variants of
            this gene have been described but their full-length nature is
            unknown. [provided by RefSeq, Apr 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extend of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X78338.1, L05628.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399410.8/ ENSP00000382342.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1197              X78338.1           2-1198
            1198-1354           AC025778.8         144895-145051       c
            1355-1819           X78338.1           1356-1820
            1820-1960           AC025778.8         122606-122746       c
            1961-3979           X78338.1           1962-3980
            3980-4102           AC136624.3         171321-171443       c
            4103-5246           X78338.1           4104-5247
            5247-6504           AC136624.3         160203-161460       c
FEATURES             Location/Qualifiers
     source          1..6504
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.11"
     gene            1..6504
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /note="ATP binding cassette subfamily C member 1 (ABCC1
                     blood group)"
                     /db_xref="GeneID:4363"
                     /db_xref="HGNC:HGNC:51"
                     /db_xref="MIM:158343"
     exon            1..184
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..4732
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /EC_number="7.6.2.2"
                     /EC_number="7.6.2.3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     multidrug resistance-associated protein 1; leukotriene
                     C(4) transporter; LTC4 transporter; ATP-binding cassette
                     transporter variant ABCC1delta-ex13; ATP-binding cassette
                     transporter variant ABCC1delta-ex13&14; ATP-binding
                     cassette transporter variant ABCC1delta-ex25&26;
                     ATP-binding cassette, sub-family C (CFTR/MRP), member 1;
                     glutathione-S-conjugate-translocating ATPase ABCC1;
                     glutathione S-conjugate export pump"
                     /codon_start=1
                     /product="multidrug resistance-associated protein 1
                     isoform 1"
                     /protein_id="NP_004987.2"
                     /db_xref="CCDS:CCDS42122.1"
                     /db_xref="GeneID:4363"
                     /db_xref="HGNC:HGNC:51"
                     /db_xref="MIM:158343"
                     /translation="MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCF
                     YLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFL
                     APVFLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTA
                     LKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSR
                     ITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVV
                     YSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAI
                     HDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSG
                     MRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQ
                     VILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEI
                     LNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFA
                     VYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEE
                     LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGC
                     GKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSV
                     IQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAV
                     DAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELL
                     ARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQL
                     SSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGL
                     FISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAV
                     FGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIP
                     EVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESV
                     SRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLE
                     CVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVE
                     RLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGG
                     EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPV
                     LFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQ
                     LVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDY
                     TRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV"
     exon            185..361
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            362..487
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            488..625
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            626..751
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            752..813
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            814..945
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1176
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1354
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1516
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1609
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1813
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1960
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2048
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2124
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2251
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2428
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2596
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2780
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2781..2871
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2872..3007
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3008..3215
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3216..3526
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3527..3726
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3727..3853
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3854..3955
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3956..4102
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4103..4261
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4262..4428
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4429..4623
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4624..6504
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5899
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /note="major polyA site"
     regulatory      6481..6486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /note="hexamer: AGTAAA"
     polyA_site      6504
                     /gene="ABCC1"
                     /gene_synonym="ABC29; ABCC; DFNA77; GS-X; MRP; MRP1"
                     /note="major polyA site"
ORIGIN      
        1 gccgccgccg ccgccgccag cgctagcgcc agcagccggg cccgatcacc cgccgcccgg
       61 tgcccgccgc cgcccgcgcc agcaaccggg cccgatcacc cgccgcccgg tgcccgccgc
      121 cgcccgcgcc accggcatgg cgctccgggg cttctgcagc gccgatggct ccgacccgct
      181 ctgggactgg aatgtcacgt ggaataccag caaccccgac ttcaccaagt gctttcagaa
      241 cacggtcctc gtgtgggtgc cttgttttta cctctgggcc tgtttcccct tctacttcct
      301 ctatctctcc cgacatgacc gaggctacat tcagatgaca cctctcaaca aaaccaaaac
      361 tgccttggga tttttgctgt ggatcgtctg ctgggcagac ctcttctact ctttctggga
      421 aagaagtcgg ggcatattcc tggccccagt gtttctggtc agcccaactc tcttgggcat
      481 caccatgctg cttgctacct ttttaattca gctggagagg aggaagggag ttcagtcttc
      541 agggatcatg ctcactttct ggctggtagc cctagtgtgt gccctagcca tcctgagatc
      601 caaaattatg acagccttaa aagaggatgc ccaggtggac ctgtttcgtg acatcacttt
      661 ctacgtctac ttttccctct tactcattca gctcgtcttg tcctgtttct cagatcgctc
      721 acccctgttc tcggaaacca tccacgaccc taatccctgc ccagagtcca gcgcttcctt
      781 cctgtcgagg atcaccttct ggtggatcac agggttgatt gtccggggct accgccagcc
      841 cctggagggc agtgacctct ggtccttaaa caaggaggac acgtcggaac aagtcgtgcc
      901 tgttttggta aagaactgga agaaggaatg cgccaagact aggaagcagc cggtgaaggt
      961 tgtgtactcc tccaaggatc ctgcccagcc gaaagagagt tccaaggtgg atgcgaatga
     1021 ggaggtggag gctttgatcg tcaagtcccc acagaaggag tggaacccct ctctgtttaa
     1081 ggtgttatac aagacctttg ggccctactt cctcatgagc ttcttcttca aggccatcca
     1141 cgacctgatg atgttttccg ggccgcagat cttaaagttg ctcatcaagt tcgtgaatga
     1201 cacgaaggcc ccagactggc agggctactt ctacaccgtg ctgctgtttg tcactgcctg
     1261 cctgcagacc ctcgtgctgc accagtactt ccacatctgc ttcgtcagtg gcatgaggat
     1321 caagaccgct gtcattgggg ctgtctatcg gaaggccctg gtgatcacca attcagccag
     1381 aaaatcctcc acggtcgggg agattgtcaa cctcatgtct gtggacgctc agaggttcat
     1441 ggacttggcc acgtacatta acatgatctg gtcagccccc ctgcaagtca tccttgctct
     1501 ctacctcctg tggctgaatc tgggcccttc cgtcctggct ggagtggcgg tgatggtcct
     1561 catggtgccc gtcaatgctg tgatggcgat gaagaccaag acgtatcagg tggcccacat
     1621 gaagagcaaa gacaatcgga tcaagctgat gaacgaaatt ctcaatggga tcaaagtgct
     1681 aaagctttat gcctgggagc tggcattcaa ggacaaggtg ctggccatca ggcaggagga
     1741 gctgaaggtg ctgaagaagt ctgcctacct gtcagccgtg ggcaccttca cctgggtctg
     1801 cacgcccttt ctggtggcct tgtgcacatt tgccgtctac gtgaccattg acgagaacaa
     1861 catcctggat gcccagacag ccttcgtgtc tttggccttg ttcaacatcc tccggtttcc
     1921 cctgaacatt ctccccatgg tcatcagcag catcgtgcag gcgagtgtct ccctcaaacg
     1981 cctgaggatc tttctctccc atgaggagct ggaacctgac agcatcgagc gacggcctgt
     2041 caaagacggc gggggcacga acagcatcac cgtgaggaat gccacattca cctgggccag
     2101 gagcgaccct cccacactga atggcatcac cttctccatc cccgaaggtg ctttggtggc
     2161 cgtggtgggc caggtgggct gcggaaagtc gtccctgctc tcagccctct tggctgagat
     2221 ggacaaagtg gaggggcacg tggctatcaa gggctccgtg gcctatgtgc cacagcaggc
     2281 ctggattcag aatgattctc tccgagaaaa catccttttt ggatgtcagc tggaggaacc
     2341 atattacagg tccgtgatac aggcctgtgc cctcctccca gacctggaaa tcctgcccag
     2401 tggggatcgg acagagattg gcgagaaggg cgtgaacctg tctgggggcc agaagcagcg
     2461 cgtgagcctg gcccgggccg tgtactccaa cgctgacatt tacctcttcg atgatcccct
     2521 ctcagcagtg gatgcccatg tgggaaaaca catctttgaa aatgtgattg gccccaaggg
     2581 gatgctgaag aacaagacgc ggatcttggt cacgcacagc atgagctact tgccgcaggt
     2641 ggacgtcatc atcgtcatga gtggcggcaa gatctctgag atgggctcct accaggagct
     2701 gctggctcga gacggcgcct tcgctgagtt cctgcgtacc tatgccagca cagagcagga
     2761 gcaggatgca gaggagaacg gggtcacggg cgtcagcggt ccagggaagg aagcaaagca
     2821 aatggagaat ggcatgctgg tgacggacag tgcagggaag caactgcaga gacagctcag
     2881 cagctcctcc tcctatagtg gggacatcag caggcaccac aacagcaccg cagaactgca
     2941 gaaagctgag gccaagaagg aggagacctg gaagctgatg gaggctgaca aggcgcagac
     3001 agggcaggtc aagctttccg tgtactggga ctacatgaag gccatcggac tcttcatctc
     3061 cttcctcagc atcttccttt tcatgtgtaa ccatgtgtcc gcgctggctt ccaactattg
     3121 gctcagcctc tggactgatg accccatcgt caacgggact caggagcaca cgaaagtccg
     3181 gctgagcgtc tatggagccc tgggcatttc acaagggatc gccgtgtttg gctactccat
     3241 ggccgtgtcc atcgggggga tcttggcttc ccgctgtctg cacgtggacc tgctgcacag
     3301 catcctgcgg tcacccatga gcttctttga gcggaccccc agtgggaacc tggtgaaccg
     3361 cttctccaag gagctggaca cagtggactc catgatcccg gaggtcatca agatgttcat
     3421 gggctccctg ttcaacgtca ttggtgcctg catcgttatc ctgctggcca cgcccatcgc
     3481 cgccatcatc atcccgcccc ttggcctcat ctacttcttc gtccagaggt tctacgtggc
     3541 ttcctcccgg cagctgaagc gcctcgagtc ggtcagccgc tccccggtct attcccattt
     3601 caacgagacc ttgctggggg tcagcgtcat tcgagccttc gaggagcagg agcgcttcat
     3661 ccaccagagt gacctgaagg tggacgagaa ccagaaggcc tattacccca gcatcgtggc
     3721 caacaggtgg ctggccgtgc ggctggagtg tgtgggcaac tgcatcgttc tgtttgctgc
     3781 cctgtttgcg gtgatctcca ggcacagcct cagtgctggc ttggtgggcc tctcagtgtc
     3841 ttactcattg caggtcacca cgtacttgaa ctggctggtt cggatgtcat ctgaaatgga
     3901 aaccaacatc gtggccgtgg agaggctcaa ggagtattca gagactgaga aggaggcgcc
     3961 ctggcaaatc caggagacag ctccgcccag cagctggccc caggtgggcc gagtggaatt
     4021 ccggaactac tgcctgcgct accgagagga cctggacttc gttctcaggc acatcaatgt
     4081 cacgatcaat gggggagaaa aggtcggcat cgtggggcgg acgggagctg ggaagtcgtc
     4141 cctgaccctg ggcttatttc ggatcaacga gtctgccgaa ggagagatca tcatcgatgg
     4201 catcaacatc gccaagatcg gcctgcacga cctccgcttc aagatcacca tcatccccca
     4261 ggaccctgtt ttgttttcgg gttccctccg aatgaacctg gacccattca gccagtactc
     4321 ggatgaagaa gtctggacgt ccctggagct ggcccacctg aaggacttcg tgtcagccct
     4381 tcctgacaag ctagaccatg aatgtgcaga aggcggggag aacctcagtg tcgggcagcg
     4441 ccagcttgtg tgcctagccc gggccctgct gaggaagacg aagatccttg tgttggatga
     4501 ggccacggca gccgtggacc tggaaacgga cgacctcatc cagtccacca tccggacaca
     4561 gttcgaggac tgcaccgtcc tcaccatcgc ccaccggctc aacaccatca tggactacac
     4621 aagggtgatc gtcttggaca aaggagaaat ccaggagtac ggcgccccat cggacctcct
     4681 gcagcagaga ggtcttttct acagcatggc caaagacgcc ggcttggtgt gagccccaga
     4741 gctggcatat ctggtcagaa ctgcagggcc tatatgccag cgcccaggga ggagtcagta
     4801 cccctggtaa accaagcctc ccacactgaa accaaaacat aaaaaccaaa cccagacaac
     4861 caaaacatat tcaaagcagc agccaccgcc atccggtccc ctgcctggaa ctggctgtga
     4921 agacccagga gagacagaga tgcgaaccac ccaaaacacg cacaccctgc ccctggtgcc
     4981 ctgagacaga cacacagcct cacgccccca ggaatgcaag tggtttcctg gtgcttccca
     5041 cggaggagtt ttggcagcca gacttctgga ggaattggtt gtatagaaga tcctagtgac
     5101 caaattcagc ctactgcctc ggatctctcc agccgaagtc tgtggactgc aagtctttga
     5161 gatgcttctg gctcccatca cctctaacat ccttgtctgg gtctaccagg aacgcttcat
     5221 ttccttgggg ctgcagtttt gtggttgagg ggcctggaga aaatcatttt ctccccttgg
     5281 cagtgtccca gggccctgga tggtcctctt accaacatct ggtcttccag gcactcaaaa
     5341 gctgggaacc agcatctcag cgccagctct accagttctc gttttgggcc agaggcagcc
     5401 tctgcactcc cacgcctgtc ctcctggaag ggacctggtt ggactaacgg ctaacctgga
     5461 cctggaactg tagggccagg ggattgtctc agggccgacg ttccacctgg ggcttccctc
     5521 cccacccacc ccgactccag gctttccctt ttttcttttg ttcaacattg taagaacaat
     5581 caatgctgtt attactgttc ccaccatgat tgatgtgggg taaatattaa ggagatggcc
     5641 tcatgggaat ttgaccttga ctagaaatag agactgagag tgagcaacca gctggaaggt
     5701 actatgccag tcctagcaga aaaatgtgtt aggggcctgg cccaaagcag tgttggttgc
     5761 ttacagtgtt gattgatttt gttctttttt cttaccacct cttttctttc cctctcatgg
     5821 tacctgctca tggttatgaa gctttcaaag taaagaacac gaaatacctc ccaagtatta
     5881 ccagtgggta ccaaaaaaat gtccccttga gtcttttcct tgtttttaga tgttaattct
     5941 ctcccttggc atccggttag ccccccaggg ggggcagcat tgtggagaac ttgatattta
     6001 gttactgatg ctcttccagg acacgaaaag aacccatctt tgaatatcaa tgattttttt
     6061 tttttaagta ctgttccggg gagaaaaaca gtctcaaaac ttgaacttct tgggaataga
     6121 agtgttgggc tgagaagtaa cattcccagg aaatagtgag aagctcgccc tgtgtttgaa
     6181 accgtgttgg tctctgtgtt cctggaagaa aacagggaag cagcatcttt taaagcctgt
     6241 tctttaaggt gtctcgttag agcccaaagt ggaatccgga aggcagccag agctgaggct
     6301 gccccaagac tcagacttgc taagaattac gccgccgact tcaaacccag agagcatctt
     6361 tcttttaggc gaaaacgcat atatttattt tttgtaagtt ataccattct ttcacattag
     6421 ataaactaag ttttggggga tccttttgta atgacttaca ctggaaatgc gaacatttgc
     6481 agtaaaaaaa tatatatata tcta
//
