LOCUS       NM_001163941            5350 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens ATP binding cassette subfamily B member 5 (ABCB5),
            transcript variant 1, mRNA.
ACCESSION   NM_001163941
VERSION     NM_001163941.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5350)
  AUTHORS   Aadithi,M.G., Divya,B., Nandhini,G., Rajkumar,K., Ramesh Kumar,A.
            and Sarangarajan,R.
  TITLE     Evaluation of ABCB5 immunostained epithelial stem cells in oral
            squamous cell carcinoma, inflammatory gingival hyperplasia and
            normal mucosa
  JOURNAL   Biotech Histochem 99 (1), 44-48 (2024)
   PUBMED   38073314
  REMARK    GeneRIF: Evaluation of ABCB5 immunostained epithelial stem cells in
            oral squamous cell carcinoma, inflammatory gingival hyperplasia and
            normal mucosa.
REFERENCE   2  (bases 1 to 5350)
  AUTHORS   Gerard,L., Duvivier,L., Fourrez,M., Salazar,P., Sprimont,L.,
            Xia,D., Ambudkar,S.V., Gottesman,M.M. and Gillet,J.P.
  TITLE     Identification of two novel heterodimeric ABC transporters in
            melanoma: ABCB5beta/B6 and ABCB5beta/B9
  JOURNAL   J Biol Chem 300 (2), 105594 (2024)
   PUBMED   38145744
  REMARK    GeneRIF: Identification of two novel heterodimeric ABC transporters
            in melanoma: ABCB5beta/B6 and ABCB5beta/B9.
REFERENCE   3  (bases 1 to 5350)
  AUTHORS   Szatmari,P. and Ducza,E.
  TITLE     Changes in Expression and Function of Placental and Intestinal P-gp
            and BCRP Transporters during Pregnancy
  JOURNAL   Int J Mol Sci 24 (17), 13089 (2023)
   PUBMED   37685897
  REMARK    GeneRIF: Changes in Expression and Function of Placental and
            Intestinal P-gp and BCRP Transporters during Pregnancy.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5350)
  AUTHORS   Dieter,K., Niebergall-Roth,E., Daniele,C., Fluhr,S., Frank,N.Y.,
            Ganss,C., Kiritsi,D., McGrath,J.A., Tolar,J., Frank,M.H. and
            Kluth,M.A.
  TITLE     ABCB5+ mesenchymal stromal cells facilitate complete and durable
            wound closure in recessive dystrophic epidermolysis bullosa
  JOURNAL   Cytotherapy 25 (7), 782-788 (2023)
   PUBMED   36868990
  REMARK    GeneRIF: ABCB5[+] mesenchymal stromal cells facilitate complete and
            durable wound closure in recessive dystrophic epidermolysis
            bullosa.
            Erratum:[Cytotherapy. 2023 Sep;25(9):1016. doi:
            10.1016/j.jcyt.2023.06.001.. PMID: 37517864]
REFERENCE   5  (bases 1 to 5350)
  AUTHORS   Domdey,M., Kluth,M.A., Masslo,C., Ganss,C., Frank,M.H., Frank,N.Y.,
            Coroneo,M.T., Cursiefen,C. and Notara,M.
  TITLE     Consecutive dosing of UVB irradiation induces loss of ABCB5
            expression and activation of EMT and fibrosis proteins in limbal
            epithelial cells similar to pterygium epithelium
  JOURNAL   Stem Cell Res 64, 102936 (2022)
   PUBMED   36242878
  REMARK    GeneRIF: Consecutive dosing of UVB irradiation induces loss of
            ABCB5 expression and activation of EMT and fibrosis proteins in
            limbal epithelial cells similar to pterygium epithelium.
REFERENCE   6  (bases 1 to 5350)
  AUTHORS   Frank,N.Y., Margaryan,A., Huang,Y., Schatton,T., Waaga-Gasser,A.M.,
            Gasser,M., Sayegh,M.H., Sadee,W. and Frank,M.H.
  TITLE     ABCB5-mediated doxorubicin transport and chemoresistance in human
            malignant melanoma
  JOURNAL   Cancer Res 65 (10), 4320-4333 (2005)
   PUBMED   15899824
  REMARK    GeneRIF: ABCB5 mediates chemoresistance in stem cell
            phenotype-expressing human malignant melanoma cells.
REFERENCE   7  (bases 1 to 5350)
  AUTHORS   Chen,K.G., Szakacs,G., Annereau,J.P., Rouzaud,F., Liang,X.J.,
            Valencia,J.C., Nagineni,C.N., Hooks,J.J., Hearing,V.J. and
            Gottesman,M.M.
  TITLE     Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB
            5beta) of the ATP-binding cassette transporter gene ABCB 5 in
            melanoma cells and melanocytes
  JOURNAL   Pigment Cell Res 18 (2), 102-112 (2005)
   PUBMED   15760339
  REMARK    GeneRIF: expression of ABCB 5alpha/beta might possibly provide two
            novel molecular markers for differential diagnosis of melanomas and
            constitute potential molecular targets for therapy of melanomas
REFERENCE   8  (bases 1 to 5350)
  AUTHORS   Huang,Y., Anderle,P., Bussey,K.J., Barbacioru,C., Shankavaram,U.,
            Dai,Z., Reinhold,W.C., Papp,A., Weinstein,J.N. and Sadee,W.
  TITLE     Membrane transporters and channels: role of the transportome in
            cancer chemosensitivity and chemoresistance
  JOURNAL   Cancer Res 64 (12), 4294-4301 (2004)
   PUBMED   15205344
REFERENCE   9  (bases 1 to 5350)
  AUTHORS   Frank,N.Y., Pendse,S.S., Lapchak,P.H., Margaryan,A., Shlain,D.,
            Doeing,C., Sayegh,M.H. and Frank,M.H.
  TITLE     Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a
            novel human ATP-binding cassette transporter
  JOURNAL   J Biol Chem 278 (47), 47156-47165 (2003)
   PUBMED   12960149
  REMARK    GeneRIF: ABCB5 P-glycoprotein functions include:  Regulation of
            progenitor cell fusion; Regulation of cell membrane potential;
            Rhodamine-123 transport.
REFERENCE   10 (bases 1 to 5350)
  AUTHORS   Allikmets,R., Gerrard,B., Hutchinson,A. and Dean,M.
  TITLE     Characterization of the human ABC superfamily: isolation and
            mapping of 21 new genes using the expressed sequence tags database
  JOURNAL   Hum Mol Genet 5 (10), 1649-1655 (1996)
   PUBMED   8894702
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB353947.1, BC104894.1 and AY230001.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001163941.1.
            
            Summary: ABCB5 belongs to the ATP-binding cassette (ABC)
            transporter superfamily of integral membrane proteins. These
            proteins participate in ATP-dependent transmembrane transport of
            structurally diverse molecules ranging from small ions, sugars, and
            peptides to more complex organic molecules (Chen et al., 2005
            [PubMed 15760339]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY230001.1, AB353947.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000404938.7/ ENSP00000384881.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3099              AB353947.1         46-3144
            3100-3100           BC104894.1         1869-1869
            3101-5139           AB353947.1         3146-5184
            5140-5350           AY230001.1         5078-5288
FEATURES             Location/Qualifiers
     source          1..5350
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21.1"
     gene            1..5350
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /note="ATP binding cassette subfamily B member 5"
                     /db_xref="GeneID:340273"
                     /db_xref="HGNC:HGNC:46"
                     /db_xref="MIM:611785"
     exon            1..171
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     exon            172..245
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..3966
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /EC_number="7.6.2.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ATP-binding cassette sub-family B member 5; P-glycoprotein
                     ABCB5; ATP-binding cassette protein; ABCB5 P-gp;
                     ATP-binding cassette, sub-family B (MDR/TAP), member 5"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family B member 5
                     isoform 1"
                     /protein_id="NP_001157413.1"
                     /db_xref="CCDS:CCDS55090.1"
                     /db_xref="GeneID:340273"
                     /db_xref="HGNC:HGNC:46"
                     /db_xref="MIM:611785"
                     /translation="MENSERAEEMQENYQRNGTAEEQPKLRKEAVGSIEIFRFADGLD
                     ITLMILGILASLVNGACLPLMPLVLGEMSDNLISGCLVQTNTTNYQNCTQSQEKLNED
                     MTLLTLYYVGIGVAALIFGYIQISLWIITAARQTKRIRKQFFHSVLAQDIGWFDSCDI
                     GELNTRMTDDIDKISDGIGDKIALLFQNMSTFSIGLAVGLVKGWKLTLVTLSTSPLIM
                     ASAAACSRMVISLTSKELSAYSKAGAVAEEVLSSIRTVIAFRAQEKELQRYTQNLKDA
                     KDFGIKRTIASKVSLGAVYFFMNGTYGLAFWYGTSLILNGEPGYTIGTVLAVFFSVIH
                     SSYCIGAAVPHFETFAIARGAAFHIFQVIDKKPSIDNFSTAGYKPESIEGTVEFKNVS
                     FNYPSRPSIKILKGLNLRIKSGETVALVGLNGSGKSTVVQLLQRLYDPDDGFIMVDEN
                     DIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIM
                     EFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAA
                     LEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQD
                     IKKADEQMESMTYSTERKTNSLPLHSVKSIKSDFIDKAEESTQSKEISLPEVSLLKIL
                     KLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIYSMIFV
                     ILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTIL
                     AIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIET
                     AAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKK
                     AQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETL
                     VLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDV
                     FILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQW
                     LRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYN
                     TQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTG
                     RTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQSVQ"
     exon            246..300
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     exon            301..451
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     exon            452..506
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     exon            507..698
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     exon            699..870
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     exon            871..995
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1173
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1287
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1398
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1524
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1728
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1899
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2061
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2202
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2346
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2451
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     exon            2452..2529
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2613
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..2817
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     exon            2818..2918
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..3059
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     exon            3060..3216
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     exon            3217..3414
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     exon            3415..3621
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     exon            3622..3768
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
     exon            3769..5350
                     /gene="ABCB5"
                     /gene_synonym="ABCB5alpha; ABCB5beta; EST422562"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcacttcca aaatccacaa gccagactag aaggctggaa attctggcaa aaaattgata
       61 ccttgtatct gaaagcttta tcctatcctc ttcagaagac ttcagtcttt tctcttaagg
      121 acttcaactg actggatggg gcccactcaa aacagcatct aaggaattaa aaagaagtaa
      181 attgtaaata agatggaaaa ttcagaaaga gctgaagaaa tgcaagaaaa ttatcagaga
      241 aatggaactg cagaagaaca gccaaaactg agaaaggaag cagttggatc tattgagata
      301 ttccgctttg ctgatggact ggacatcaca ctcatgatcc tgggtatact ggcatcactg
      361 gtcaatggag cctgccttcc tttaatgcca ctggttttag gagaaatgag tgataacctt
      421 attagtggat gtctagtcca aactaacaca acaaattatc agaactgtac tcagtctcaa
      481 gagaagctga atgaagatat gactctgttg accctgtatt atgttggaat aggtgttgct
      541 gccttgattt ttggttacat acagatttcc ttgtggatta taactgcagc acgacagacc
      601 aagaggattc gaaaacagtt ttttcattca gttttggcac aggacatcgg ctggtttgat
      661 agctgtgaca tcggtgaact taacactcgc atgacagatg acattgacaa aatcagtgat
      721 ggtattggag ataagattgc tctgttgttt caaaacatgt ctactttttc gattggcctg
      781 gcagttggtt tggtgaaggg ctggaaactc accctagtga ctctatccac gtctcctctt
      841 ataatggctt cagcggcagc atgttctagg atggtcatct cattgaccag taaggaatta
      901 agtgcctatt ccaaagctgg ggctgtggca gaagaagtct tgtcatcaat ccgaacagtc
      961 atagccttta gggcccagga gaaagaactt caaaggtata cacagaatct caaagatgca
     1021 aaggattttg gcataaaaag gactatagct tcaaaagtgt ctcttggtgc tgtgtacttc
     1081 tttatgaatg gaacctatgg acttgctttt tggtatggaa cctccttgat tcttaatgga
     1141 gaacctggat ataccatcgg gactgttctt gctgttttct ttagtgtaat ccatagcagt
     1201 tattgcattg gagcagcagt ccctcacttt gaaaccttcg caatagcccg aggagctgcc
     1261 tttcatattt tccaggttat tgataagaaa cccagtatag ataacttttc cacagctgga
     1321 tataaacctg aatccataga aggaactgtg gaatttaaaa atgtttcttt caattatcca
     1381 tcaagaccat ctatcaagat tctgaaaggt ctgaatctca gaattaagtc tggagagaca
     1441 gtcgccttgg tcggtctcaa tggcagtggg aagagtacgg tagtccagct tctgcagagg
     1501 ttatatgatc cggatgatgg ctttatcatg gtggatgaga atgacatcag agctttaaat
     1561 gtgcggcatt atcgagacca tattggagtg gttagtcaag agcctgtttt gttcgggacc
     1621 accatcagta acaatatcaa gtatggacga gatgatgtga ctgatgaaga gatggagaga
     1681 gcagcaaggg aagcaaatgc gtatgatttt atcatggagt ttcctaataa atttaataca
     1741 ttggtagggg aaaaaggagc tcaaatgagt ggagggcaga aacagaggat cgcaattgct
     1801 cgtgccttag ttcgaaaccc caagattctg attttagatg aggctacgtc tgccctggat
     1861 tcagaaagca agtcagctgt tcaagctgca ctggagaagg cgagcaaagg tcggactaca
     1921 atcgtggtag cacaccgact ttctactatt cgaagtgcag atttgattgt gaccctaaag
     1981 gatggaatgc tggcggagaa aggagcacat gctgaactaa tggcaaaacg aggtctatat
     2041 tattcacttg tgatgtcaca ggatattaaa aaagctgatg aacagatgga gtcaatgaca
     2101 tattctactg aaagaaagac caactcactt cctctgcact ctgtgaagag catcaagtca
     2161 gacttcattg acaaggctga ggaatccacc caatctaaag agataagtct tcctgaagtc
     2221 tctctattaa aaattttaaa gttaaacaag cctgaatggc cttttgtggt tctggggaca
     2281 ttggcttctg ttctaaatgg aactgttcat ccagtatttt ccatcatctt tgcaaaaatt
     2341 ataaccatgt ttggaaataa tgataaaacc acattaaagc atgatgcaga aatttattcc
     2401 atgatattcg tcattttggg tgttatttgc tttgtcagtt atttcatgca gggattattt
     2461 tacggcagag caggggaaat tttaacgatg agattaagac acttggcctt caaagccatg
     2521 ttatatcagg atattgcctg gtttgatgaa aaggaaaaca gcacaggagg cttgacaaca
     2581 atattagcca tagatatagc acaaattcaa ggagcaacag gttccaggat tggcgtctta
     2641 acacaaaatg caactaacat gggactttca gttatcattt cctttatata tggatgggag
     2701 atgacattcc tgattctgag tattgctcca gtacttgccg tgacaggaat gattgaaacc
     2761 gcagcaatga ctggatttgc caacaaagat aagcaagaac ttaagcatgc tggaaagata
     2821 gcaactgaag ctttggagaa tatacgtact atagtgtcat taacaaggga aaaagccttc
     2881 gagcaaatgt atgaagagat gcttcagact caacacagaa atacctcgaa gaaagcacag
     2941 attattggaa gctgttatgc attcagccat gcctttatat attttgccta tgcggcaggg
     3001 tttcgatttg gagcctattt aattcaagct ggacgaatga ccccagaggg catgttcata
     3061 gtttttactg caattgcata tggagctatg gccatcggag aaacgctcgt tttggctcct
     3121 gaatattcca aagccaaatc gggggctgcg catctgtttg ccttgttgga aaagaaacca
     3181 aatatagaca gccgcagtca agaagggaaa aagccagaca catgtgaagg gaatttagag
     3241 tttcgagaag tctctttctt ctatccatgt cgcccagatg ttttcatcct ccgtggctta
     3301 tccctcagta ttgagcgagg aaagacagta gcatttgtgg ggagcagcgg ctgtgggaaa
     3361 agcacttctg ttcaacttct gcagagactt tatgaccccg tgcaaggaca agtgctgttt
     3421 gatggtgtgg atgcaaaaga attgaatgta cagtggctcc gttcccaaat agcaatcgtt
     3481 cctcaagagc ctgtgctctt caactgcagc attgctgaga acatcgccta tggtgacaac
     3541 agccgtgtgg tgccattaga tgagatcaaa gaagccgcaa atgcagcaaa tatccattct
     3601 tttattgaag gtctccctga gaaatacaac acacaagttg gactgaaagg agcacagctt
     3661 tctggcggcc agaaacaaag actagctatt gcaagggctc ttctccaaaa acccaaaatt
     3721 ttattgttgg atgaggccac ttcagccctc gataatgaca gtgagaaggt ggttcagcat
     3781 gcccttgata aagccaggac gggaaggaca tgcctagtgg tcactcacag gctctctgca
     3841 attcagaacg cagatttgat agtggttctg cacaatggaa agataaagga acaaggaact
     3901 catcaagagc tcctgagaaa tcgagacata tattttaagt tagtgaatgc acagtcagtg
     3961 cagtgatgct gttgaggtag cacatatttt gatgttcgtg taatgcaaag aaggagtact
     4021 taataattac ttggcaagct ttgatctctt ttattgcata tatcaatacc tagaatcatg
     4081 ctactcaagt acatacatgt tctattcaca caccatctga ccttcagatt tttaaaagga
     4141 agcaaaaatt tgcttatttc atgtaagtga aataatgctt atatccttca ctttataaaa
     4201 ctattctagc acatttgctt gtaaagcagt tttctacaag gtgaatttat ttcccatcaa
     4261 cttctgctat aaaatcggaa atatgtttcc agggggaata ttatccaatt aaccatgttg
     4321 aaggttttag caaaggcagt gtaagataga gtggggcctg tagcattgca gggagagtgt
     4381 ctttcacttg gaattttgtt ttgcagcaca tattacagta gttttgctag tcccttttct
     4441 ccagaccgta gggatttctc tcaataagta ttcactattt ctctaaattt tattctattt
     4501 ttttgttgag cagggaatag aaaggattac gatgtaaaat ttctgggagg attaggtagc
     4561 tatctcctac ttcaccagta agtgaagtgc ctcacatgag ccatcccaaa gattcattat
     4621 tccaaacctt gggtttggca gtataagtca caggcctacc tgtttatgaa aacttactta
     4681 cttaaaataa gagctacttt tgggccgggt gcggtggctc acgcctgtaa tcccagaact
     4741 ttgggaggcc gaggagggcg gatcacttga ggtcaggagt tcgagaccag cctggccaac
     4801 atggtgaaac cccgtctcta ctaaaaacac aaaaattagc caatcttggt ggcgggcacc
     4861 tggaatccca gctacttggg aggctgaggc aggagaatca tttgaaccta ggaggcagag
     4921 gttgcagtga gccgagatct caccactgca ctccagcctg cgcaacagag cgagactcca
     4981 tctcaaaaaa taataaataa gagctaattt tattgtgggt gaaaattttt aaacgtcttt
     5041 ctctataata aaataatttc cttaaatttt atatatactt tatcatatat aatgtgtgaa
     5101 tgattttaaa gttctgtgta aataacaata ttggtaaaat gagttacatt ttcaacttac
     5161 ttaaatatgt aatgtcacct ggtgatttta tctttattct tcagtgtatt ttcttccatt
     5221 tacacattta gctagcctcc ctaaagtgta ctctaccaat aattgaaatc ttgttaaaca
     5281 aaattaaaac catttatata ttatgctgct ttctttaaaa tgcaaaataa aaataagatt
     5341 ggggacttga
//
