LOCUS       XM_011512078            4974 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens ATP binding cassette subfamily B member 11
            (ABCB11), transcript variant X1, mRNA.
ACCESSION   XM_011512078
VERSION     XM_011512078.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011512078.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4974
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..4974
                     /gene="ABCB11"
                     /gene_synonym="ABC16; BRIC2; BSEP; PFIC-2; PFIC2; PGY4;
                     SPGP"
                     /note="ATP binding cassette subfamily B member 11; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 15 ESTs, 3 long SRA reads, 3 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 2 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:8647"
                     /db_xref="HGNC:HGNC:42"
                     /db_xref="MIM:603201"
     CDS             128..4195
                     /gene="ABCB11"
                     /gene_synonym="ABC16; BRIC2; BSEP; PFIC-2; PFIC2; PGY4;
                     SPGP"
                     /codon_start=1
                     /product="bile salt export pump isoform X1"
                     /protein_id="XP_011510380.1"
                     /db_xref="GeneID:8647"
                     /db_xref="HGNC:HGNC:42"
                     /db_xref="MIM:603201"
                     /translation="MSDSVILRSIKKFGEENDGFESDKSCEWLFSLTASCTRRGENKS
                     RTSWSSFKEQKKISNNNNDKKSRLQDEKKGDGVRVGFFQLFRFSSSTDIWLMFVGSLC
                     AFLHGIAQPGVLLIFGTMTDVFIDYDVELQELQIPGKACVNNTIVWTNSSLNQNMTNG
                     TRCGLLNIESEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMR
                     MEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLT
                     LVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKRE
                     VERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGT
                     LVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRI
                     KGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDP
                     CEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAA
                     KEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALD
                     NESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKG
                     VYFTLVTLQSQGNQALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYL
                     VHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAAV
                     NGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAK
                     SGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIV
                     NSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQ
                     ITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIAN
                     SASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQL
                     LDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFV
                     GSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSI
                     MDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIA
                     IARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADII
                     AVMAQGVVIEKGTHEELMAQKGAYYKLVTTGSPIS"
     polyA_site      4974
                     /gene="ABCB11"
                     /gene_synonym="ABC16; BRIC2; BSEP; PFIC-2; PFIC2; PGY4;
                     SPGP"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 agaatgatga aaaccgaggt tggaaaaggt tgtgaaacct tttaactctc cacagtggag
       61 tccattattt cctctggctt cctcaaattc atattcacag ggtcgttggc tgtgggttgc
      121 aattaccatg tctgactcag taattcttcg aagtataaag aaatttggag aggagaatga
      181 tggttttgag tcagataaat catgtgagtg gcttttttcc ctcactgcat cttgtacaag
      241 gagaggtgag aacaaaagta ggacaagctg gtcaagtttc aaggagcaga aaaaaatcag
      301 caacaataat aatgataaga aatcaaggtt acaagatgag aagaaaggtg atggcgttag
      361 agttggcttc tttcaattgt ttcggttttc ttcatcaact gacatttggc tgatgtttgt
      421 gggaagtttg tgtgcatttc tccatggaat agcccagcca ggcgtgctac tcatttttgg
      481 cacaatgaca gatgttttta ttgactacga cgttgagtta caagaactcc agattccagg
      541 aaaagcatgt gtgaataaca ccattgtatg gactaacagt tccctcaacc agaacatgac
      601 aaatggaaca cgttgtgggt tgctgaacat cgagagcgaa atgatcaaat ttgccagtta
      661 ctatgctgga attgctgtcg cagtacttat cacaggatat attcaaatat gcttttgggt
      721 cattgccgca gctcgtcaga tacagaaaat gagaaaattt tactttagga gaataatgag
      781 aatggaaata gggtggtttg actgcaattc agtgggggag ctgaatacaa gattctctga
      841 tgatattaat aaaatcaatg atgccatagc tgaccaaatg gcccttttca ttcagcgcat
      901 gacctcgacc atctgtggtt tcctgttggg atttttcagg ggttggaaac tgaccttggt
      961 tattatttct gtcagccctc tcattgggat tggagcagcc accattggtc tgagtgtgtc
     1021 caagtttacg gactatgagc tgaaggccta tgccaaagca ggggtggtgg ctgatgaagt
     1081 catttcatca atgagaacag tggctgcttt tggtggtgag aaaagagagg ttgaaaggta
     1141 tgagaaaaat cttgtgttcg cccagcgttg gggaattaga aaaggaatag tgatgggatt
     1201 ctttactgga ttcgtgtggt gtctcatctt tttgtgttat gcactggcct tctggtacgg
     1261 ctccacactt gtcctggatg aaggagaata tacaccagga acccttgtcc agattttcct
     1321 cagtgtcata gtaggagctt taaatcttgg caatgcctct ccttgtttgg aagcctttgc
     1381 aactggacgt gcagcagcca ccagcatttt tgagacaata gacaggaaac ccatcattga
     1441 ctgcatgtca gaagatggtt acaagttgga tcgaatcaag ggtgaaattg aattccataa
     1501 tgtgaccttc cattatcctt ccagaccaga ggtgaagatt ctaaatgacc tcaacatggt
     1561 cattaaacca ggggaaatga cagctctggt aggacccagt ggagctggaa aaagtacagc
     1621 actgcaactc attcagcgat tctatgaccc ctgtgaagga atggtgaccg tggatggcca
     1681 tgacattcgc tctcttaaca ttcagtggct tagagatcag attgggatag tggagcaaga
     1741 gccagttctg ttctctacca ccattgcaga aaatattcgc tatggcagag aagatgcaac
     1801 aatggaagac atagtccaag ctgccaagga ggccaatgcc tacaacttca tcatggacct
     1861 gccacagcaa tttgacaccc ttgttggaga aggaggaggc cagatgagtg gtggccagaa
     1921 acaaagggta gctatcgcca gagccctcat ccgaaatccc aagattctgc ttttggacat
     1981 ggccacctca gctctggaca atgagagtga agccatggtg caagaagtgc tgagtaagat
     2041 tcagcatggg cacacaatca tttcagttgc tcatcgcttg tctacggtca gagctgcaga
     2101 taccatcatt ggttttgaac atggcactgc agtggaaaga gggacccatg aagaattact
     2161 ggaaaggaaa ggtgtttact tcactctagt gactttgcaa agccagggaa atcaagctct
     2221 taatgaagag gacataaagg atgcaactga agatgacatg cttgcgagga cctttagcag
     2281 agggagctac caggatagtt taagggcttc catccggcaa cgctccaagt ctcagctttc
     2341 ttacctggtg cacgaacctc cattagctgt tgtagatcat aagtctacct atgaagaaga
     2401 tagaaaggac aaggacattc ctgtgcagga agaagttgaa cctgccccag ttaggaggat
     2461 tctgaaattc agtgctccag aatggcccta catgctggta gggtctgtgg gtgcagctgt
     2521 gaacgggaca gtcacaccct tgtatgcctt tttattcagc cagattcttg ggactttttc
     2581 aattcctgat aaagaggaac aaaggtcaca gatcaatggt gtgtgcctac tttttgtagc
     2641 aatgggctgt gtatctcttt tcacccaatt tctacaggga tatgcctttg ctaaatctgg
     2701 ggagctccta acaaaaaggc tacgtaaatt tggtttcagg gcaatgctgg ggcaagatat
     2761 tgcctggttt gatgacctca gaaatagccc tggagcattg acaacaagac ttgctacaga
     2821 tgcttcccaa gttcaagggg ctgccggctc tcagatcggg atgatagtca attccttcac
     2881 taacgtcact gtggccatga tcattgcctt ctcctttagc tggaagctga gcctggtcat
     2941 cttgtgcttc ttccccttct tggctttatc aggagccaca cagaccagga tgttgacagg
     3001 atttgcctct cgagataagc aggccctgga gatggtggga cagattacaa atgaagccct
     3061 cagtaacatc cgcactgttg ctggaattgg aaaggagagg cggttcattg aagcacttga
     3121 gactgagctg gagaagccct tcaagacagc cattcagaaa gccaatattt acggattctg
     3181 ctttgccttt gcccagtgca tcatgtttat tgcgaattct gcttcctaca gatatggagg
     3241 ttacttaatc tccaatgagg ggctccattt cagctatgtg ttcagggtga tctctgcagt
     3301 tgtactgagt gcaacagctc ttggaagagc cttctcttac accccaagtt atgcaaaagc
     3361 taaaatatca gctgcacgct tttttcaact gctggaccga caacccccaa tcagtgtata
     3421 caatactgca ggtgaaaaat gggacaactt ccaggggaag attgattttg ttgattgtaa
     3481 atttacatat ccttctcgac ctgactcgca agttctgaat ggtctctcag tgtcgattag
     3541 tccagggcag acactggcgt ttgttgggag cagtggatgt ggcaaaagca ctagcattca
     3601 gctgttggaa cgtttctatg atcctgatca agggaaggtg atgatagatg gtcatgacag
     3661 caaaaaagta aatgtccagt tcctccgctc aaacattgga attgtttccc aggaaccagt
     3721 gttgtttgcc tgtagcataa tggacaatat caagtatgga gacaacacca aagaaattcc
     3781 catggaaaga gtcatagcag ctgcaaaaca ggctcagctg catgattttg tcatgtcact
     3841 cccagagaaa tatgaaacta acgttgggtc ccaggggtct caactctcta gaggggagaa
     3901 acaacgcatt gctattgctc gggccattgt acgagatcct aaaatcttgc tactagatga
     3961 agccacttct gccttagaca cagaaagtga aaagacggtg caggttgctc tagacaaagc
     4021 cagagagggt cggacctgca ttgtcattgc ccatcgcttg tccaccatcc agaacgcgga
     4081 tatcattgct gtcatggcac agggggtggt gattgaaaag gggacccatg aagaactgat
     4141 ggcccaaaaa ggagcctact acaaactagt caccactgga tcccccatca gttgacccaa
     4201 tgcaagaatc tcagacacac atgacgcacc agttacaggg gttgtttttt ctttaaagaa
     4261 gaatgttaat attttacttt tacagtcatt ttcctacatc ggaatccaag ctaatttcta
     4321 atggccttcc ataataattc tgctttagat gtgtatacag aaaatgaaag aaactagggt
     4381 ccatatgagg gaaaacccaa tgtcaagtgg cagctcagcc accactcagt gcttctctgt
     4441 gcaggagcca gtcctgatta atatgtggga attagtgaga catcagggag taagtgacac
     4501 tttgaactcc tcaagggcag agaactgtct ttcatttttg aaccctcggt gtacacagag
     4561 gcgggtctat aacaggcaat caacaaacgt ttcttgagct agaccaaggt cagatttgaa
     4621 aagaacagaa ggactgaaga ccagctgtgt ttcttaacta aatttgtctt tcaagtgaaa
     4681 ccagcttcct tcatctctaa ggctaaggat agggaaaggg tggatgctct caggctgagg
     4741 gaggcagaaa gggaaagtat tagcatgagc tttccagtta gggctgttga tttatgcttt
     4801 aacttcagag tgagtgtagg ggtggtgatg ctaccattac tgtgaggacc taccagtgtg
     4861 gctggagcag ggactctctc ccaggccttt tactcctcag cacctccctg catactgatt
     4921 gttgttttta gtttctgtga aattatattc atgaaatgaa aatagcgcat ttta
//
