LOCUS       XM_006712817            4181 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens ATP binding cassette subfamily B member 11
            (ABCB11), transcript variant X2, mRNA.
ACCESSION   XM_006712817
VERSION     XM_006712817.4
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_006712817.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4181
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..4181
                     /gene="ABCB11"
                     /gene_synonym="ABC16; BRIC2; BSEP; PFIC-2; PFIC2; PGY4;
                     SPGP"
                     /note="ATP binding cassette subfamily B member 11; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 14 ESTs, 3 long SRA reads, 3 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 6 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:8647"
                     /db_xref="HGNC:HGNC:42"
                     /db_xref="MIM:603201"
     CDS             128..4135
                     /gene="ABCB11"
                     /gene_synonym="ABC16; BRIC2; BSEP; PFIC-2; PFIC2; PGY4;
                     SPGP"
                     /codon_start=1
                     /product="bile salt export pump isoform X2"
                     /protein_id="XP_006712880.1"
                     /db_xref="GeneID:8647"
                     /db_xref="HGNC:HGNC:42"
                     /db_xref="MIM:603201"
                     /translation="MSDSVILRSIKKFGEENDGFESDKSCEWLFSLTASCTRRDNNDK
                     KSRLQDEKKGDGVRVGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVLLIFGTMTD
                     VFIDYDVELQELQIPGKACVNNTIVWTNSSLNQNMTNGTRCGLLNIESEMIKFASYYA
                     GIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSD
                     DINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLS
                     VSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGI
                     VMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASP
                     CLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVK
                     ILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWL
                     RDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLV
                     GEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTI
                     ISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQALNEED
                     IKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRK
                     DKDIPVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFS
                     IPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQ
                     DIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKL
                     SLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERR
                     FIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSY
                     VFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNF
                     QGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDP
                     DQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIA
                     AAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSA
                     LDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQ
                     KGAYYKLVTTGSPIS"
ORIGIN      
        1 agaatgatga aaaccgaggt tggaaaaggt tgtgaaacct tttaactctc cacagtggag
       61 tccattattt cctctggctt cctcaaattc atattcacag ggtcgttggc tgtgggttgc
      121 aattaccatg tctgactcag taattcttcg aagtataaag aaatttggag aggagaatga
      181 tggttttgag tcagataaat catgtgagtg gcttttttcc ctcactgcat cttgtacaag
      241 gagagataat aatgataaga aatcaaggtt acaagatgag aagaaaggtg atggcgttag
      301 agttggcttc tttcaattgt ttcggttttc ttcatcaact gacatttggc tgatgtttgt
      361 gggaagtttg tgtgcatttc tccatggaat agcccagcca ggcgtgctac tcatttttgg
      421 cacaatgaca gatgttttta ttgactacga cgttgagtta caagaactcc agattccagg
      481 aaaagcatgt gtgaataaca ccattgtatg gactaacagt tccctcaacc agaacatgac
      541 aaatggaaca cgttgtgggt tgctgaacat cgagagcgaa atgatcaaat ttgccagtta
      601 ctatgctgga attgctgtcg cagtacttat cacaggatat attcaaatat gcttttgggt
      661 cattgccgca gctcgtcaga tacagaaaat gagaaaattt tactttagga gaataatgag
      721 aatggaaata gggtggtttg actgcaattc agtgggggag ctgaatacaa gattctctga
      781 tgatattaat aaaatcaatg atgccatagc tgaccaaatg gcccttttca ttcagcgcat
      841 gacctcgacc atctgtggtt tcctgttggg atttttcagg ggttggaaac tgaccttggt
      901 tattatttct gtcagccctc tcattgggat tggagcagcc accattggtc tgagtgtgtc
      961 caagtttacg gactatgagc tgaaggccta tgccaaagca ggggtggtgg ctgatgaagt
     1021 catttcatca atgagaacag tggctgcttt tggtggtgag aaaagagagg ttgaaaggta
     1081 tgagaaaaat cttgtgttcg cccagcgttg gggaattaga aaaggaatag tgatgggatt
     1141 ctttactgga ttcgtgtggt gtctcatctt tttgtgttat gcactggcct tctggtacgg
     1201 ctccacactt gtcctggatg aaggagaata tacaccagga acccttgtcc agattttcct
     1261 cagtgtcata gtaggagctt taaatcttgg caatgcctct ccttgtttgg aagcctttgc
     1321 aactggacgt gcagcagcca ccagcatttt tgagacaata gacaggaaac ccatcattga
     1381 ctgcatgtca gaagatggtt acaagttgga tcgaatcaag ggtgaaattg aattccataa
     1441 tgtgaccttc cattatcctt ccagaccaga ggtgaagatt ctaaatgacc tcaacatggt
     1501 cattaaacca ggggaaatga cagctctggt aggacccagt ggagctggaa aaagtacagc
     1561 actgcaactc attcagcgat tctatgaccc ctgtgaagga atggtgaccg tggatggcca
     1621 tgacattcgc tctcttaaca ttcagtggct tagagatcag attgggatag tggagcaaga
     1681 gccagttctg ttctctacca ccattgcaga aaatattcgc tatggcagag aagatgcaac
     1741 aatggaagac atagtccaag ctgccaagga ggccaatgcc tacaacttca tcatggacct
     1801 gccacagcaa tttgacaccc ttgttggaga aggaggaggc cagatgagtg gtggccagaa
     1861 acaaagggta gctatcgcca gagccctcat ccgaaatccc aagattctgc ttttggacat
     1921 ggccacctca gctctggaca atgagagtga agccatggtg caagaagtgc tgagtaagat
     1981 tcagcatggg cacacaatca tttcagttgc tcatcgcttg tctacggtca gagctgcaga
     2041 taccatcatt ggttttgaac atggcactgc agtggaaaga gggacccatg aagaattact
     2101 ggaaaggaaa ggtgtttact tcactctagt gactttgcaa agccagggaa atcaagctct
     2161 taatgaagag gacataaagg atgcaactga agatgacatg cttgcgagga cctttagcag
     2221 agggagctac caggatagtt taagggcttc catccggcaa cgctccaagt ctcagctttc
     2281 ttacctggtg cacgaacctc cattagctgt tgtagatcat aagtctacct atgaagaaga
     2341 tagaaaggac aaggacattc ctgtgcagga agaagttgaa cctgccccag ttaggaggat
     2401 tctgaaattc agtgctccag aatggcccta catgctggta gggtctgtgg gtgcagctgt
     2461 gaacgggaca gtcacaccct tgtatgcctt tttattcagc cagattcttg ggactttttc
     2521 aattcctgat aaagaggaac aaaggtcaca gatcaatggt gtgtgcctac tttttgtagc
     2581 aatgggctgt gtatctcttt tcacccaatt tctacaggga tatgcctttg ctaaatctgg
     2641 ggagctccta acaaaaaggc tacgtaaatt tggtttcagg gcaatgctgg ggcaagatat
     2701 tgcctggttt gatgacctca gaaatagccc tggagcattg acaacaagac ttgctacaga
     2761 tgcttcccaa gttcaagggg ctgccggctc tcagatcggg atgatagtca attccttcac
     2821 taacgtcact gtggccatga tcattgcctt ctcctttagc tggaagctga gcctggtcat
     2881 cttgtgcttc ttccccttct tggctttatc aggagccaca cagaccagga tgttgacagg
     2941 atttgcctct cgagataagc aggccctgga gatggtggga cagattacaa atgaagccct
     3001 cagtaacatc cgcactgttg ctggaattgg aaaggagagg cggttcattg aagcacttga
     3061 gactgagctg gagaagccct tcaagacagc cattcagaaa gccaatattt acggattctg
     3121 ctttgccttt gcccagtgca tcatgtttat tgcgaattct gcttcctaca gatatggagg
     3181 ttacttaatc tccaatgagg ggctccattt cagctatgtg ttcagggtga tctctgcagt
     3241 tgtactgagt gcaacagctc ttggaagagc cttctcttac accccaagtt atgcaaaagc
     3301 taaaatatca gctgcacgct tttttcaact gctggaccga caacccccaa tcagtgtata
     3361 caatactgca ggtgaaaaat gggacaactt ccaggggaag attgattttg ttgattgtaa
     3421 atttacatat ccttctcgac ctgactcgca agttctgaat ggtctctcag tgtcgattag
     3481 tccagggcag acactggcgt ttgttgggag cagtggatgt ggcaaaagca ctagcattca
     3541 gctgttggaa cgtttctatg atcctgatca agggaaggtg atgatagatg gtcatgacag
     3601 caaaaaagta aatgtccagt tcctccgctc aaacattgga attgtttccc aggaaccagt
     3661 gttgtttgcc tgtagcataa tggacaatat caagtatgga gacaacacca aagaaattcc
     3721 catggaaaga gtcatagcag ctgcaaaaca ggctcagctg catgattttg tcatgtcact
     3781 cccagagaaa tatgaaacta acgttgggtc ccaggggtct caactctcta gaggggagaa
     3841 acaacgcatt gctattgctc gggccattgt acgagatcct aaaatcttgc tactagatga
     3901 agccacttct gccttagaca cagaaagtga aaagacggtg caggttgctc tagacaaagc
     3961 cagagagggt cggacctgca ttgtcattgc ccatcgcttg tccaccatcc agaacgcgga
     4021 tatcattgct gtcatggcac agggggtggt gattgaaaag gggacccatg aagaactgat
     4081 ggcccaaaaa ggagcctact acaaactagt caccactgga tcccccatca gttgacccaa
     4141 tgcaagaatc tcagacacac atgacgcacc agttacaggg g
//
