LOCUS       NM_012089               3869 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens ATP binding cassette subfamily B member 10 (ABCB10),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_012089
VERSION     NM_012089.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3869)
  AUTHORS   Do,Y., Yagi,M., Hirai,H., Miki,K., Fukahori,Y., Setoyama,D.,
            Yamamoto,M., Furukawa,T., Kunisaki,Y., Kang,D. and Uchiumi,T.
  TITLE     Cardiomyocyte-specific deletion of the mitochondrial transporter
            Abcb10 causes cardiac dysfunction via lysosomal-mediated
            ferroptosis
  JOURNAL   Biosci Rep 44 (5) (2024)
   PUBMED   38655715
  REMARK    GeneRIF: Cardiomyocyte-specific deletion of the mitochondrial
            transporter Abcb10 causes cardiac dysfunction via
            lysosomal-mediated ferroptosis.
REFERENCE   2  (bases 1 to 3869)
  AUTHORS   Miljkovic,M., Seguin,A., Jia,X., Cox,J.E., Catrow,J.L.,
            Bergonia,H., Phillips,J.D., Stephens,W.Z. and Ward,D.M.
  TITLE     Loss of the mitochondrial protein Abcb10 results in altered
            arginine metabolism in MEL and K562 cells and nutrient stress
            signaling through ATF4
  JOURNAL   J Biol Chem 299 (7), 104877 (2023)
   PUBMED   37269954
  REMARK    GeneRIF: Loss of the mitochondrial protein Abcb10 results in
            altered arginine metabolism in MEL and K562 cells and nutrient
            stress signaling through ATF4.
REFERENCE   3  (bases 1 to 3869)
  AUTHORS   Cao,S., Yang,Y., He,L., Hang,Y., Yan,X., Shi,H., Wu,J. and
            Ouyang,Z.
  TITLE     Cryo-EM structures of mitochondrial ABC transporter ABCB10 in apo
            and biliverdin-bound form
  JOURNAL   Nat Commun 14 (1), 2030 (2023)
   PUBMED   37041204
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3869)
  AUTHORS   Liu,J., Qiu,G., Wang,H., Li,N. and Liao,X.
  TITLE     CircRNA-ABCB10 promotes gastric cancer progression by sponging
            miR-1915-3p to upregulate RaC1
  JOURNAL   Dig Liver Dis 54 (7), 896-904 (2022)
   PUBMED   34987010
  REMARK    GeneRIF: CircRNA-ABCB10 promotes gastric cancer progression by
            sponging miR-1915-3p to upregulate RaC1.
REFERENCE   5  (bases 1 to 3869)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   6  (bases 1 to 3869)
  AUTHORS   Graf,S.A., Haigh,S.E., Corson,E.D. and Shirihai,O.S.
  TITLE     Targeting, import, and dimerization of a mammalian mitochondrial
            ATP binding cassette (ABC) transporter, ABCB10 (ABC-me)
  JOURNAL   J Biol Chem 279 (41), 42954-42963 (2004)
   PUBMED   15215243
  REMARK    GeneRIF: study of ABCB10 targeting, import, and dimerization
REFERENCE   7  (bases 1 to 3869)
  AUTHORS   Saito,S., Iida,A., Sekine,A., Miura,Y., Ogawa,C., Kawauchi,S.,
            Higuchi,S. and Nakamura,Y.
  TITLE     Three hundred twenty-six genetic variations in genes encoding nine
            members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the
            Japanese population
  JOURNAL   J Hum Genet 47 (1), 38-50 (2002)
   PUBMED   11829140
REFERENCE   8  (bases 1 to 3869)
  AUTHORS   Zhang,F., Hogue,D.L., Liu,L., Fisher,C.L., Hui,D., Childs,S. and
            Ling,V.
  TITLE     M-ABC2, a new human mitochondrial ATP-binding cassette membrane
            protein
  JOURNAL   FEBS Lett 478 (1-2), 89-94 (2000)
   PUBMED   10922475
REFERENCE   9  (bases 1 to 3869)
  AUTHORS   Zhang,F., Zhang,W., Liu,L., Fisher,C.L., Hui,D., Childs,S.,
            Dorovini-Zis,K. and Ling,V.
  TITLE     Characterization of ABCB9, an ATP binding cassette protein
            associated with lysosomes
  JOURNAL   J Biol Chem 275 (30), 23287-23294 (2000)
   PUBMED   10748049
REFERENCE   10 (bases 1 to 3869)
  AUTHORS   Allikmets,R., Gerrard,B., Glavac,D., Ravnik-Glavac,M.,
            Jenkins,N.A., Gilbert,D.J., Copeland,N.G., Modi,W. and Dean,M.
  TITLE     Characterization and mapping of three new mammalian ATP-binding
            transporter genes from an EST database
  JOURNAL   Mamm Genome 6 (2), 114-117 (1995)
   PUBMED   7766993
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121990.34, AF216833.1,
            AB013380.1 and BC064930.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012089.2.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters.  ABC proteins transport various molecules across
            extra- and intra-cellular membranes.  ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White).  This protein is a member of the MDR/TAP subfamily.
            Members of the MDR/TAP subfamily are involved in multidrug
            resistance.  The function of this mitochondrial protein is unknown.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB013380.1, AF216833.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000344517.5/
                                                  ENSP00000355637.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AL121990.34        72711-72722         c
            13-22               AF216833.1         1-10
            23-1871             AB013380.1         1-1849
            1872-3499           BC064930.1         1855-3482
            3500-3869           AB013380.1         3500-3869
FEATURES             Location/Qualifiers
     source          1..3869
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.13"
     gene            1..3869
                     /gene="ABCB10"
                     /gene_synonym="EST20237; M-ABC2; MTABC2"
                     /note="ATP binding cassette subfamily B member 10"
                     /db_xref="GeneID:23456"
                     /db_xref="HGNC:HGNC:41"
                     /db_xref="MIM:605454"
     exon            1..572
                     /gene="ABCB10"
                     /gene_synonym="EST20237; M-ABC2; MTABC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..2272
                     /gene="ABCB10"
                     /gene_synonym="EST20237; M-ABC2; MTABC2"
                     /note="ATP-binding cassette transporter 10; ABC
                     transporter 10 protein; mitochondrial ATP-binding cassette
                     2; ATP-binding cassette, sub-family B (MDR/TAP), member
                     10; ABC-me protein; ABC-mitochondrial erythroid protein"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family B member 10,
                     mitochondrial"
                     /protein_id="NP_036221.2"
                     /db_xref="CCDS:CCDS1580.1"
                     /db_xref="GeneID:23456"
                     /db_xref="HGNC:HGNC:41"
                     /db_xref="MIM:605454"
                     /translation="MRGPPAWPLRLLEPPSPAEPGRLLPVACVWAAASRVPGSLSPFT
                     GLRPARLWGAGPALLWGVGAARRWRSGCRGGGPGASRGVLGLARLLGLWARGPGSCRC
                     GAFAGPGAPRLPRARFPGGPAAAAWAGDEAWRRGPAAPPGDKGRLRPAAAGLPEARKL
                     LGLAYPERRRLAAAVGFLTMSSVISMSAPFFLGKIIDVIYTNPTVDYSDNLTRLCLGL
                     SAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLS
                     SDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGR
                     YLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEA
                     FARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSS
                     FYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVP
                     IFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWL
                     RSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFN
                     TVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDG
                     RTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQSFISA"
     exon            573..773
                     /gene="ABCB10"
                     /gene_synonym="EST20237; M-ABC2; MTABC2"
                     /inference="alignment:Splign:2.1.0"
     exon            774..976
                     /gene="ABCB10"
                     /gene_synonym="EST20237; M-ABC2; MTABC2"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1111
                     /gene="ABCB10"
                     /gene_synonym="EST20237; M-ABC2; MTABC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1258
                     /gene="ABCB10"
                     /gene_synonym="EST20237; M-ABC2; MTABC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1394
                     /gene="ABCB10"
                     /gene_synonym="EST20237; M-ABC2; MTABC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1490
                     /gene="ABCB10"
                     /gene_synonym="EST20237; M-ABC2; MTABC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1700
                     /gene="ABCB10"
                     /gene_synonym="EST20237; M-ABC2; MTABC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1780
                     /gene="ABCB10"
                     /gene_synonym="EST20237; M-ABC2; MTABC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1961
                     /gene="ABCB10"
                     /gene_synonym="EST20237; M-ABC2; MTABC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2005
                     /gene="ABCB10"
                     /gene_synonym="EST20237; M-ABC2; MTABC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2040
                     /gene="ABCB10"
                     /gene_synonym="EST20237; M-ABC2; MTABC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..3869
                     /gene="ABCB10"
                     /gene_synonym="EST20237; M-ABC2; MTABC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3847..3852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCB10"
                     /gene_synonym="EST20237; M-ABC2; MTABC2"
                     /note="hexamer: ATTAAA"
     polyA_site      3869
                     /gene="ABCB10"
                     /gene_synonym="EST20237; M-ABC2; MTABC2"
                     /note="major polyA site"
ORIGIN      
        1 gggctttgcg cgcgcctggc cggcgggctg aggcgtacgg gtcgcacgca gcgccatgcg
       61 aggcccccct gcctggccgc tgcggctgct cgagccaccg agccctgccg agccaggtcg
      121 gctcctgccg gtagcctgcg tgtgggccgc ggccagccgc gttcccgggt ccctatcgcc
      181 gttcactggc ctgaggccgg cgcggctatg gggcgcgggg cccgcgctgc tctggggcgt
      241 tggagccgcg cgccgctgga ggagcggctg ccggggcggg ggtccgggcg cctcgcgggg
      301 cgtcctgggc ctcgcgcggc tcctggggct gtgggctcgc ggccccggca gctgcaggtg
      361 cggggctttt gccgggccag gcgctcctcg gctcccgcgc gcccggttcc cgggcggtcc
      421 cgcagccgct gcctgggcag gggacgaggc ctggcggcgc gggccggcgg cgcctcccgg
      481 ggacaagggg cggctgcgcc ccgcagcggc cggactcccg gaggcccgga agctcctggg
      541 gctggcgtac cctgagcgcc ggaggctggc agctgcggtt ggatttctca cgatgtccag
      601 tgttatctcc atgtctgccc ctttcttcct ggggaagatc attgatgtca tctataccaa
      661 ccccactgtg gactacagcg acaacctgac ccgcctctgc ctagggctca gtgccgtgtt
      721 tctgtgtggt gctgccgcca atgccattcg tgtctacctc atgcaaactt caggtcagcg
      781 cattgtgaat aggctgagaa cttcattatt ctcctccatt ctgaggcagg aggttgcttt
      841 ctttgacaag actcgcacag gagaattgat taaccgcctc tcatcagaca ctgcactcct
      901 ggggcgctca gtgactgaaa acctctcaga tgggctcagg gccggggccc aggcttccgt
      961 aggcatcagt atgatgtttt ttgtctcacc taatctggcc acctttgttt tgagcgtggt
     1021 gcctccagtg tcaatcattg ctgtaattta tgggcgatat ctacggaaac tgaccaaagt
     1081 cactcaggat tccctggcac aagccactca gctagctgag gaacgtattg gaaatgtaag
     1141 aactgttcga gcttttggga aagaaatgac tgaaatcgag aaatatgcca gcaaagtgga
     1201 ccatgtaatg cagttagcaa ggaaagaggc attcgcccgg gctggtttct ttggagcaac
     1261 tgggctctcc ggaaacctga tcgtgctttc tgtcctgtac aaaggagggc tgctgatggg
     1321 cagtgcccac atgaccgtgg gtgaactctc ttccttccta atgtatgctt tctgggttgg
     1381 aataagcatt ggaggtctga gctctttcta ctcggagctg atgaaaggac tgggtgcagg
     1441 ggggcgcctc tgggagctcc tggagagaga gcccaagctg ccttttaacg agggggtcat
     1501 cttaaatgag aaaagcttcc agggtgcttt ggagtttaag aacgtgcatt ttgcctatcc
     1561 agctcgccca gaggtgccca tatttcagga tttcagcctt tccattccgt caggatctgt
     1621 cacggcactg gttggcccaa gtggttctgg caaatcaaca gtgctttcac tcctgctgag
     1681 gttgtacgac cctgcttctg gaactattag tcttgatggc catgacatcc gtcagctaaa
     1741 cccagtgtgg ctgagatcca aaattgggac agtgagtcag gaacccattt tgttttcttg
     1801 ctctattgct gagaacattg cttatggtgc tgatgaccct tcctctgtga ccgctgagga
     1861 aatccagaga gtggctgaag tggccaatgc agtggccttc atccggaatt tcccccaagg
     1921 gttcaacact gtggttggag aaaagggtgt tctcctctca ggtgggcaga aacagcggat
     1981 tgcgattgcc cgtgctctgc taaagaatcc caaaattctt ctcctagatg aagcaaccag
     2041 tgcgctggat gccgaaaatg agtaccttgt tcaagaagct ctagatcgac tgatggatgg
     2101 aagaacggtg ttagttattg cccatcgtct gtccaccatt aagaatgcta atatggttgc
     2161 tgttcttgac caaggaaaaa ttactgaata tggaaaacat gaagagctgc tttcaaaacc
     2221 aaatgggata tacagaaaac taatgaacaa acaaagtttt atttcagcat aaggaagcaa
     2281 ttactggtaa acaatatgag actttaatgc aaaacagtgt tgcagaaaaa aaactcagag
     2341 actatgaaat acataaacca tatatcaagt tatttgaaaa atacctattt ttttccaaag
     2401 tgtgtaaaag attgttttga aacgtacctg ttctcaagat ctttttattc agagttttaa
     2461 taattgtaac tttttaaatg tctatagcac tgaagttatt ttcaggtttt gtattttctt
     2521 ttcttgtgga atattttaat taatatagca tggcacctca ttttcttttg cctgctgtta
     2581 aagattgaag ctattgtcaa atgacaactt taaaaaggca attataaata aaaagcctga
     2641 ttattttagg ccagtttacc aatcactgtg taattcttct ggtagtattc tacctacttt
     2701 taagtctaat tttacagata gaataatgga aattgaaaat ttaacccttt attccgataa
     2761 tctcatgaag caaacctaac tatttaacat cagctggaaa gaagggaaca tttatattgc
     2821 ccatctcctg tgtcttcaaa ggtgtgagag ctgaggaata tgtgttccta tgggaactat
     2881 gtttgaatat gtgcagtttt caacattttg gcacatgaaa gcctgacaag tttttaaaag
     2941 ggcagaagct ttattttttg aacaggaaaa catgtttttt aaattcacat gtttgtatga
     3001 gtacttttgc gaagcaaggc atgaactgct aggtattatt aagaatgaat gatttttgca
     3061 tttaagttgt ttgaaggcat gtattttgaa aaatatctgt tacaaattta taatttcaag
     3121 acaaattgaa tcttatttta taatactttt ggaatttcat taataaggct aaaatttgag
     3181 gaatataact aattttcagc cttaagacat ttaagtttgg aagtccttgc tattcaacag
     3241 aataacaaga aaacttcaga atgtatcact ctcctgaaaa gaagatatta ataagccctt
     3301 ttatttatgg ttatagtttt atttatagtc tcaaaattcc taaagcaatg ctacaaccat
     3361 tgaatttgcc atattttgta tcagtgctgt taatttgctg ttgcctcaag aaaaagtgct
     3421 ttttctccat ggatgaggct agaccctaag aagtaattaa gtcaatgtaa atcaaatgga
     3481 agttttccca tgaactaagc atttattagt tccctgatta gactggaaga agaaaccact
     3541 atttcatgaa aagcatggaa tattatattt tattgttcat aattaatgaa taaaattgat
     3601 atgaatgaat atagtgttct ttgaattagt aaacagtaca tctgtgacaa tcatttttaa
     3661 caagctctac ttgtgttctt tataaagtgt gattttcaga aagcaaacaa cacaattaca
     3721 aggttgaatc tgaggaaaat aatccttgtg ccatagaagt atttacgaaa ttgcatttca
     3781 ttgttatgtt ttattttctg atacatgatg ttcaatttta tctttaggta atattttata
     3841 tcatagatta aaatttatag tgaacttta
//
