LOCUS       NM_001288986            5826 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens ATP binding cassette subfamily A member 8 (ABCA8),
            transcript variant 3, mRNA.
ACCESSION   NM_001288986
VERSION     NM_001288986.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5826)
  AUTHORS   Yang,K., Li,X., Jiang,Z., Li,J., Deng,Q., He,J., Chen,J., Li,X.,
            Xu,S. and Jiang,Z.
  TITLE     Tumour suppressor ABCA8 inhibits malignant progression of
            colorectal cancer via Wnt/beta-catenin pathway
  JOURNAL   Dig Liver Dis 56 (5), 880-893 (2024)
   PUBMED   37968146
  REMARK    GeneRIF: Tumour suppressor ABCA8 inhibits malignant progression of
            colorectal cancer via Wnt/beta-catenin pathway.
REFERENCE   2  (bases 1 to 5826)
  AUTHORS   Lv,C., Yang,H., Yu,J. and Dai,X.
  TITLE     ABCA8 inhibits breast cancer cell proliferation by regulating the
            AMP activated protein kinase/mammalian target of rapamycin
            signaling pathway
  JOURNAL   Environ Toxicol 37 (6), 1423-1431 (2022)
   PUBMED   35191604
  REMARK    GeneRIF: ABCA8 inhibits breast cancer cell proliferation by
            regulating the AMP activated protein kinase/mammalian target of
            rapamycin signaling pathway.
REFERENCE   3  (bases 1 to 5826)
  AUTHORS   Guo,Y., Wang,Z.W., Su,W.H., Chen,J. and Wang,Y.L.
  TITLE     Prognostic Value and Immune Infiltrates of ABCA8 and FABP4 in
            Stomach Adenocarcinoma
  JOURNAL   Biomed Res Int 2020, 4145164 (2020)
   PUBMED   32685482
  REMARK    GeneRIF: Prognostic Value and Immune Infiltrates of ABCA8 and FABP4
            in Stomach Adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5826)
  AUTHORS   Cui,Y., Liang,S., Zhang,S., Zhang,C., Zhao,Y., Wu,D., Wang,J.,
            Song,R., Wang,J., Yin,D., Liu,Y., Pan,S., Liu,X., Wang,Y., Han,J.,
            Meng,F., Zhang,B., Guo,H., Lu,Z. and Liu,L.
  TITLE     ABCA8 is regulated by miR-374b-5p and inhibits proliferation and
            metastasis of hepatocellular carcinoma through the ERK/ZEB1 pathway
  JOURNAL   J Exp Clin Cancer Res 39 (1), 90 (2020)
   PUBMED   32430024
  REMARK    GeneRIF: ABCA8 is regulated by miR-374b-5p and inhibits
            proliferation and metastasis of hepatocellular carcinoma through
            the ERK/ZEB1 pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5826)
  AUTHORS   Sasaki,K., Tachikawa,M., Uchida,Y., Hirano,S., Kadowaki,F.,
            Watanabe,M., Ohtsuki,S. and Terasaki,T.
  TITLE     ATP-Binding Cassette Transporter A Subfamily 8 Is a Sinusoidal
            Efflux Transporter for Cholesterol and Taurocholate in Mouse and
            Human Liver
  JOURNAL   Mol Pharm 15 (2), 343-355 (2018)
   PUBMED   29300488
  REMARK    GeneRIF: Study results suggest that mABCA8b/ABCA8 functions as a
            sinusoidal efflux transporter for at least cholesterol and
            taurocholate in mouse and human liver.
REFERENCE   6  (bases 1 to 5826)
  AUTHORS   Kim,W.S., Weickert,C.S. and Garner,B.
  TITLE     Role of ATP-binding cassette transporters in brain lipid transport
            and neurological disease
  JOURNAL   J Neurochem 104 (5), 1145-1166 (2008)
   PUBMED   17973979
  REMARK    Review article
REFERENCE   7  (bases 1 to 5826)
  AUTHORS   Kim,W.S., Guillemin,G.J., Glaros,E.N., Lim,C.K. and Garner,B.
  TITLE     Quantitation of ATP-binding cassette subfamily-A transporter gene
            expression in primary human brain cells
  JOURNAL   Neuroreport 17 (9), 891-896 (2006)
   PUBMED   16738483
REFERENCE   8  (bases 1 to 5826)
  AUTHORS   Tsuruoka,S., Ishibashi,K., Yamamoto,H., Wakaumi,M., Suzuki,M.,
            Schwartz,G.J., Imai,M. and Fujimura,A.
  TITLE     Functional analysis of ABCA8, a new drug transporter
  JOURNAL   Biochem Biophys Res Commun 298 (1), 41-45 (2002)
   PUBMED   12379217
  REMARK    GeneRIF: Functional analysis of the transport properties of ABCA8.
REFERENCE   9  (bases 1 to 5826)
  AUTHORS   Iida,A., Saito,S., Sekine,A., Mishima,C., Kitamura,Y., Kondo,K.,
            Harigae,S., Osawa,S. and Nakamura,Y.
  TITLE     Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13
            genes encoding human ATP-binding cassette transporters: ABCA4,
            ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2,
            ABCG4, ABCG5, and ABCG8
  JOURNAL   J Hum Genet 47 (6), 285-310 (2002)
   PUBMED   12111378
REFERENCE   10 (bases 1 to 5826)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC024003.1, BC143972.1,
            AC015844.12, CK824290.1, AB020629.1 and AA448212.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001288986.1.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intracellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the ABC1 subfamily. Members of
            the ABC1 subfamily comprise the only major ABC subfamily found
            exclusively in multicellular eukaryotes. The encoded protein may
            regulate lipid metabolism and be involved in the formation and
            maintenance of myelin. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jan 2014].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and uses
            an alternate in-frame splice site in the central coding region,
            compared to variant 1. The encoded isoform (3) is shorter, compared
            to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC143972.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               BC024003.1         6-156
            152-861             BC143972.1         1-710
            862-4405            BC143972.1         712-4255
            4406-4406           AC015844.12        69927-69927
            4407-5063           BC143972.1         4257-4913
            5064-5544           CK824290.1         80-560
            5545-5823           AB020629.1         5399-5677
            5824-5826           AA448212.1         11-13               c
FEATURES             Location/Qualifiers
     source          1..5826
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q24.2"
     gene            1..5826
                     /gene="ABCA8"
                     /note="ATP binding cassette subfamily A member 8"
                     /db_xref="GeneID:10351"
                     /db_xref="HGNC:HGNC:38"
                     /db_xref="MIM:612505"
     exon            1..174
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            175..275
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..5030
                     /gene="ABCA8"
                     /note="isoform 3 is encoded by transcript variant 3;
                     ATP-binding cassette, sub-family A (ABC1), member 8;
                     ABC-type organic anion transporter ABCA8"
                     /codon_start=1
                     /product="ABC-type organic anion transporter ABCA8 isoform
                     3"
                     /protein_id="NP_001275915.1"
                     /db_xref="CCDS:CCDS74138.1"
                     /db_xref="GeneID:10351"
                     /db_xref="HGNC:HGNC:38"
                     /db_xref="MIM:612505"
                     /translation="MRKRKISVCQQTWALLCKNFLKKWRMKRESLMEWLNSLLLLLCL
                     YIYPHSHQVNDFSSLLTMDLGRVDTFNESRFSVVYTPVTNTTQQIMNKVASTPFLAGK
                     EVLGLPDEESIKEFTANYPEEIVRVTFTNTYSYHLKFLLGHGMPAKKEHKDHTAHCYE
                     TNEDVYCEVSVFWKEGFVALQAAINAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQS
                     GVITDLYLFSCIISFSSFIYYASVNVTRERKRMKALMTMMGLRDSAFWLSWGLLYAGF
                     IFIMALFLALVIRSTQFIILSGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVV
                     FLLTVFWGCLGFTSLYRHLPASLEWILSLLSPFAFMLGMAQLLHLDYDLNSNAFPHPS
                     DGSNLIVATNFMLAFDTCLYLALAIYFEKILPNEYGHRRPPLFFLKSSFWSQTQKTDH
                     VALEDEMDADPSFHDSFEQAPPEFQGKEAIRIRNVTKEYKGKPDKIEALKDLVFDIYE
                     GQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQS
                     NVQFDFLTVRENLRLFAKIKGILPQEVDKEIQRVLLELEMKNIQDVLAQNLSGGQKRK
                     LTFGIAILGDPQIFLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILA
                     DRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLNEICVEENITSLVKQHIPDAKLSA
                     KSEGKLIYTLPLERTNKFPELYKDLDSYPDLGIENYGVSMTTLNEVFLKLEGKSTINE
                     SDIAILGEVQAEKADDTERLVEMEQVLSSLNKMRKTIGGVALWRQQICAIARVRLLKL
                     KHERKALLALLLILMAGFCPLLVEYTMVKIYQNSYTWELSPHLYFLAPGQQPHDPLTQ
                     LLIINKTGASIDDFIQSVEHQNIALEVDAFGTRNGTDDPSYNGAITVCCNEKNYSFSL
                     ACNAKRLNCFPVLMDIVSNGLLGMVKPSVHIRTERSTFLENGQDNPIGFLAYIMFWLV
                     LTSSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSLYFLVFVFIYLMS
                     YISNFEDMLLTIIHIIQIPCAVGYSFSLIFMTYVISFIFRKGRKNSGIWSFCFYVVTV
                     FSVAGFAFSIFESDIPFIFTFLIPPATMIGCLFLSSHLLFSSLFSEERMDVQPFLVFL
                     IPFLHFIIFLFTLRCLEWKFGKKSMRKDPFFSSDVCQNPEEPEGEDEDVQMERVRTAN
                     ALNSTNFDEKPVIIASCLRKEYAGKRKGCFSKRKNKIATRNVSFCVRKGEVLGLLGHN
                     GAGKSTSIKVITGDTKPTAGQVLLKGSGGGDALEFLGYCPQENALWPNLTVRQHLEVY
                     AAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIKRKLCFVLSILGNPSVVLL
                     DEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCI
                     GSIQHLKSKFGKDYLLEMKVKNLAQVEPLHAEILRLFPQAARQERYSSLMVYKLPVED
                     VQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDFEEDFDPSVKWKL
                     LPQEEP"
     exon            276..480
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            481..645
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            646..749
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            750..976
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1118
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1304
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1452
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1621
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1680
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1791
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1967
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2087
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2226
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2317
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2457
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2577
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            2578..2776
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2943
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            2944..3077
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..3215
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            3216..3323
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            3324..3494
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            3495..3608
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            3609..3728
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            3729..3794
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            3795..3886
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            3887..3992
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            3993..4110
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            4111..4202
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            4203..4363
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            4364..4439
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            4440..4534
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            4535..4654
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            4655..4795
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            4796..4875
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            4876..4931
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            4932..5826
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5799..5804
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCA8"
                     /note="hexamer: AATAAA"
     polyA_site      5826
                     /gene="ABCA8"
                     /note="major polyA site"
ORIGIN      
        1 ataacctcca ctctgaaagc agtcttcaca gaaacttttc acagaagtca aatagttaaa
       61 gcaaattcta gatacatggt agagaccagg agaaaatatg aataactttc ttctaaacaa
      121 ggagctcagt ggataaacca tacctctaga ttccttgctt ccattttccc agaaacaaga
      181 tgaggaagag aaagatcagt gtgtgtcaac aaacttgggc cttattatgc aagaactttc
      241 ttaaaaaatg gagaatgaaa agagagtcct taatggaatg gctgaattca ttgctcctac
      301 tactttgttt gtatatatat cctcatagtc atcaagtaaa tgatttttct tcactgctta
      361 ccatggacct gggacgggta gatacattta atgaatccag attttctgtt gtatacacac
      421 ctgtcaccaa cacgacccaa cagataatga ataaagtagc ctctactccc ttcctggcag
      481 gtaaagaggt cttgggactg ccagatgagg aaagtattaa agaattcaca gcaaattatc
      541 ctgaagaaat agtaagagtc acctttacta atacatactc atatcatttg aagttcttgc
      601 taggacatgg aatgccagca aagaaggagc acaaggacca tacagctcat tgttatgaaa
      661 caaatgaaga tgtttactgt gaagtttcag tattttggaa ggaaggtttt gtggctcttc
      721 aagctgccat taatgctgct attatagaaa tcacaacaaa tcactcagtg atggaggagc
      781 tgatgtcagt tactggaaaa aatatgaaga tgcattcctt cattggtcaa tcaggagtta
      841 taactgattt gtaccttttt tcctgcatta tttcattttc ctcattcatt tactatgcat
      901 ctgttaatgt cacaagagag aggaaaagga tgaaggcctt gatgacaatg atgggtcttc
      961 gggattcagc gttctggctc tcctggggtt tgctctatgc tggtttcatc ttcattatgg
     1021 cccttttctt ggcacttgtt ataagatcta cccagtttat cattttgtct ggcttcatgg
     1081 tagtcttcag cctctttctc ctgtatggat tatctttggt agctttggct ttcttaatga
     1141 gcatcttggt aaagaaatct ttcctcaccg gcctggtcgt gttcctcctc actgtctttt
     1201 gggggtgtct ggggttcaca tcactgtaca gacaccttcc tgcatccttg gagtggattt
     1261 taagcttgct tagtcccttt gccttcatgc ttggaatggc ccagctttta cacttggact
     1321 atgatttgaa ttctaatgca tttcctcatc catcggacgg ctcaaatctc attgtagcaa
     1381 caaatttcat gttggcattt gacacttgcc tctatctggc attggcgatt tactttgaaa
     1441 aaattttgcc aaatgaatat ggacatcgac gtccaccttt gtttttcctg aagtcctcat
     1501 tttggtctca aacacaaaag actgatcacg tggcccttga agatgaaatg gatgccgatc
     1561 cttcatttca tgactctttt gaacaagcgc ctccagaatt ccaagggaaa gaagccatca
     1621 gaatcagaaa tgttacaaaa gaatataaag gaaagcctga taaaatagaa gccttgaaag
     1681 atctggtatt tgacatttac gaaggccaaa tcactgcaat acttggtcac agtggagctg
     1741 gaaagtcaac actgctaaac attcttagtg ggttgtctgt tcccaccaaa ggttcagtca
     1801 ccatctataa caataagctt tcagaaatgg ctgacctaga aaatctcagc aagctgaccg
     1861 gagtttgtcc acaatccaat gtgcaatttg acttcctcac tgtaagagaa aacctcagac
     1921 tctttgctaa aataaaaggg attctgccac aagaagtgga taaagagata caaagggttc
     1981 tgctggaatt ggaaatgaaa aatattcagg atgttcttgc tcaaaactta agtggtggac
     2041 agaaaagaaa gctaaccttt gggattgcca ttttaggaga tcctcagatt ttcctgttgg
     2101 atgaaccaac tgctggattg gatccctttt caagacacca agtatggaac cttctgaaag
     2161 aacgcaaaac agaccgcgtg atcctcttca gtacccagtt catggatgag gccgacatcc
     2221 tggcggacag gaaagtattt ctctcccaag ggaagctaaa gtgcgcgggc tcttctttgt
     2281 ttctaaagaa gaaatggggg attggatatc acttaagctt gcagttaaat gaaatatgtg
     2341 ttgaggaaaa cataacatca cttgttaaac agcacatccc tgatgccaaa ttatcagcca
     2401 aaagcgaagg aaaacttatt tatacattac ccttagaaag aacaaataaa tttccagaac
     2461 tttacaagga tcttgatagc tatcctgacc taggaattga gaattatggt gtttccatga
     2521 caactttgaa tgaagtattc ctgaagctag aaggaaaatc tacaattaat gaatcggaca
     2581 ttgctatttt gggagaagta caagcggaaa aagctgacga cactgaaagg cttgttgaga
     2641 tggaacaagt cctctcttca cttaacaaga tgagaaagac aataggtggt gtggctctct
     2701 ggcgacagca aatctgcgca attgcaaggg ttcgcttgtt aaagttaaag catgaaagaa
     2761 aagctctttt agcactgcta ttaattctaa tggctggatt ttgccctctt cttgtggagt
     2821 ataccatggt gaaaatatat caaaacagtt acacctggga actttctcct catttgtatt
     2881 tccttgctcc tggacaacaa ccacatgacc ctctcactca actactgatc atcaataaaa
     2941 caggggcaag cattgatgac tttatacagt ctgtggagca ccagaacata gctttagaag
     3001 tggatgcatt tggaactaga aatggcacag atgacccatc ttataatgga gccatcacag
     3061 tgtgttgtaa tgaaaagaat tacagctttt cgttagcatg caatgccaaa agattgaatt
     3121 gcttcccagt tcttatggac attgttagta atgggctact tggaatggtt aaaccatcag
     3181 tacatatccg aactgaaaga agtacatttt tggagaatgg acaggacaat ccaatcggat
     3241 tcctggcata tatcatgttc tggctggttt taacatcgag ttgcccacct tacattgcca
     3301 tgagcagcat cgatgattat aagaacagag ctcggtccca gctacggatt tccggactct
     3361 ccccttctgc ttactggttt gggcaggcgc tggtggatgt ttccctgtac ttcttggtct
     3421 tcgtttttat atatttaatg agctacattt caaacttcga agacatgcta cttacaataa
     3481 ttcatattat tcaaatccca tgtgctgttg gttattcctt ttccctcatc ttcatgacat
     3541 acgtgatttc cttcatcttt cgcaagggga gaaaaaatag tggcatttgg tcattttgtt
     3601 tctatgttgt cactgtattc tctgtggctg gatttgcgtt cagtatcttc gaaagtgata
     3661 ttccatttat cttcactttt ttaataccac ctgccacaat gattggctgt ttgttcttat
     3721 cttctcatct tctcttttct tctctctttt ctgaagaacg aatggatgta cagccatttc
     3781 tggtattcct aattcctttc cttcatttta tcatttttct ttttactctt cgatgtctgg
     3841 aatggaagtt tggaaagaaa tcaatgagaa aggatccttt ctttagtagt gatgtgtgtc
     3901 aaaatccaga agaaccagaa ggagaggatg aagatgttca gatggaaaga gtgagaacag
     3961 caaatgcctt gaattctact aattttgatg agaagccagt catcattgcc agctgtctac
     4021 gcaaggagta tgcagggaag aggaaaggct gtttttccaa gaggaagaat aagatagcca
     4081 cgagaaatgt ctccttctgt gttagaaaag gtgaagtttt aggattatta ggacacaatg
     4141 gagctggtaa aagcacatcc attaaggtga taactggaga cacaaaacca actgctggac
     4201 aagtgctact gaaagggagc ggtggagggg atgccctgga gttcctgggg tactgccctc
     4261 aggagaacgc gctgtggccc aacctgacag tgaggcagca cctggaggtg tacgccgccg
     4321 tgaaagggct gaggaaaggg gatgctgagg ttgccatcac acggttagtg gatgcgctca
     4381 agctgcagga ccagctgaag tctcccgtga agaccttgtc agagggaata aagagaaagc
     4441 tgtgctttgt cctgagcata ctggggaacc cgtcagtggt gcttctggat gagccgtcga
     4501 ccgggatgga ccccgagggg cagcagcaaa tgtggcaggc catccgggcc acctttagaa
     4561 acacggaaag gggtgccctc ctaaccaccc actacatggc agaggctgag gccgtgtgtg
     4621 accgagtggc catcatggta tctgggaggt tgagatgtat cggttccatc caacacctga
     4681 aaagcaaatt tggcaaagat tacctgctgg agatgaaggt gaagaacctg gcacaagtgg
     4741 agcccctcca tgcagagatc ctgaggcttt tcccccaggc tgctcggcag gaaaggtact
     4801 cctctctgat ggtttataag ttgccagtgg aagatgtgca acctttagcc caagctttct
     4861 tcaaattaga gaaggttaaa cagagctttg acctagagga gtacagcctc tcacagtcta
     4921 ccctggagca ggttttcctg gagctctcca aggagcagga gctgggtgat tttgaggagg
     4981 attttgatcc ctcagtgaag tggaagctcc tcccccagga agagccttaa aaccccaaat
     5041 tctgtgttcc tgtttaaacc cgtggttttt tttaaataca tttattttta tagcagcaat
     5101 gttctatttt tagaaactat attataagta cagaaatggt tctccgtgtg gtgggaggag
     5161 gaggttcggg tgctgggtaa gtgccatgtc agtgtggaca gaggcatttg actaagccaa
     5221 cctcctctca cagcctctgt atctctgcag gccatactgg ttccattgtt ctgtataata
     5281 ctgaataaat aaatttactt ttacatgatc gtataagttt ctagataaga taaacaaatt
     5341 ttgtttaaat ttttttaata aaaatcttaa aacacttttt ttctaaccta gactgagaaa
     5401 ttcatgttta cttttctagg tgtatgatac tttgtaaagt tgatactttc ctaagaattt
     5461 aacatgtcat atttttgaaa tagatttaag tgtgcttctt attgctaaaa atactaaatg
     5521 tcatgggtca tagtatctga tatcaatatc gttgataaca tatccacagg taacaccatg
     5581 atgtaggcat aaatggaaaa caaaaaccct actatttcaa atatattgta cttttttatt
     5641 tctgtaagcc aactgtgtgc cattttcact ggacttttaa atctagactt tagtgatgtc
     5701 tacattgtaa atgatctttt gtggatattt gtcacttggt ttcagaaagt tcacaaatgt
     5761 agcaacagct cacatgactg agtaggtaga aaatgtgaaa taaatctcat atatatagtt
     5821 ttgaaa
//
