LOCUS       NM_001288985            6002 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens ATP binding cassette subfamily A member 8 (ABCA8),
            transcript variant 1, mRNA.
ACCESSION   NM_001288985 XM_005256939
VERSION     NM_001288985.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6002)
  AUTHORS   Yang,K., Li,X., Jiang,Z., Li,J., Deng,Q., He,J., Chen,J., Li,X.,
            Xu,S. and Jiang,Z.
  TITLE     Tumour suppressor ABCA8 inhibits malignant progression of
            colorectal cancer via Wnt/beta-catenin pathway
  JOURNAL   Dig Liver Dis 56 (5), 880-893 (2024)
   PUBMED   37968146
  REMARK    GeneRIF: Tumour suppressor ABCA8 inhibits malignant progression of
            colorectal cancer via Wnt/beta-catenin pathway.
REFERENCE   2  (bases 1 to 6002)
  AUTHORS   Lv,C., Yang,H., Yu,J. and Dai,X.
  TITLE     ABCA8 inhibits breast cancer cell proliferation by regulating the
            AMP activated protein kinase/mammalian target of rapamycin
            signaling pathway
  JOURNAL   Environ Toxicol 37 (6), 1423-1431 (2022)
   PUBMED   35191604
  REMARK    GeneRIF: ABCA8 inhibits breast cancer cell proliferation by
            regulating the AMP activated protein kinase/mammalian target of
            rapamycin signaling pathway.
REFERENCE   3  (bases 1 to 6002)
  AUTHORS   Guo,Y., Wang,Z.W., Su,W.H., Chen,J. and Wang,Y.L.
  TITLE     Prognostic Value and Immune Infiltrates of ABCA8 and FABP4 in
            Stomach Adenocarcinoma
  JOURNAL   Biomed Res Int 2020, 4145164 (2020)
   PUBMED   32685482
  REMARK    GeneRIF: Prognostic Value and Immune Infiltrates of ABCA8 and FABP4
            in Stomach Adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6002)
  AUTHORS   Cui,Y., Liang,S., Zhang,S., Zhang,C., Zhao,Y., Wu,D., Wang,J.,
            Song,R., Wang,J., Yin,D., Liu,Y., Pan,S., Liu,X., Wang,Y., Han,J.,
            Meng,F., Zhang,B., Guo,H., Lu,Z. and Liu,L.
  TITLE     ABCA8 is regulated by miR-374b-5p and inhibits proliferation and
            metastasis of hepatocellular carcinoma through the ERK/ZEB1 pathway
  JOURNAL   J Exp Clin Cancer Res 39 (1), 90 (2020)
   PUBMED   32430024
  REMARK    GeneRIF: ABCA8 is regulated by miR-374b-5p and inhibits
            proliferation and metastasis of hepatocellular carcinoma through
            the ERK/ZEB1 pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6002)
  AUTHORS   Sasaki,K., Tachikawa,M., Uchida,Y., Hirano,S., Kadowaki,F.,
            Watanabe,M., Ohtsuki,S. and Terasaki,T.
  TITLE     ATP-Binding Cassette Transporter A Subfamily 8 Is a Sinusoidal
            Efflux Transporter for Cholesterol and Taurocholate in Mouse and
            Human Liver
  JOURNAL   Mol Pharm 15 (2), 343-355 (2018)
   PUBMED   29300488
  REMARK    GeneRIF: Study results suggest that mABCA8b/ABCA8 functions as a
            sinusoidal efflux transporter for at least cholesterol and
            taurocholate in mouse and human liver.
REFERENCE   6  (bases 1 to 6002)
  AUTHORS   Kim,W.S., Weickert,C.S. and Garner,B.
  TITLE     Role of ATP-binding cassette transporters in brain lipid transport
            and neurological disease
  JOURNAL   J Neurochem 104 (5), 1145-1166 (2008)
   PUBMED   17973979
  REMARK    Review article
REFERENCE   7  (bases 1 to 6002)
  AUTHORS   Kim,W.S., Guillemin,G.J., Glaros,E.N., Lim,C.K. and Garner,B.
  TITLE     Quantitation of ATP-binding cassette subfamily-A transporter gene
            expression in primary human brain cells
  JOURNAL   Neuroreport 17 (9), 891-896 (2006)
   PUBMED   16738483
REFERENCE   8  (bases 1 to 6002)
  AUTHORS   Tsuruoka,S., Ishibashi,K., Yamamoto,H., Wakaumi,M., Suzuki,M.,
            Schwartz,G.J., Imai,M. and Fujimura,A.
  TITLE     Functional analysis of ABCA8, a new drug transporter
  JOURNAL   Biochem Biophys Res Commun 298 (1), 41-45 (2002)
   PUBMED   12379217
  REMARK    GeneRIF: Functional analysis of the transport properties of ABCA8.
REFERENCE   9  (bases 1 to 6002)
  AUTHORS   Iida,A., Saito,S., Sekine,A., Mishima,C., Kitamura,Y., Kondo,K.,
            Harigae,S., Osawa,S. and Nakamura,Y.
  TITLE     Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13
            genes encoding human ATP-binding cassette transporters: ABCA4,
            ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2,
            ABCG4, ABCG5, and ABCG8
  JOURNAL   J Hum Genet 47 (6), 285-310 (2002)
   PUBMED   12111378
REFERENCE   10 (bases 1 to 6002)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC024003.1, BC130280.1,
            AB020629.1, AC015844.12 and AW590229.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001288985.1.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intracellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the ABC1 subfamily. Members of
            the ABC1 subfamily comprise the only major ABC subfamily found
            exclusively in multicellular eukaryotes. The encoded protein may
            regulate lipid metabolism and be involved in the formation and
            maintenance of myelin. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jan 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.231196.1,
                                           SRR1660807.261621.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000586539.6/ ENSP00000467271.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               BC024003.1         6-156
            152-1586            BC130280.1         1-1435
            1587-1587           AB020629.1         1385-1385
            1588-4581           BC130280.1         1437-4430
            4582-4582           AC015844.12        69927-69927
            4583-5516           AB020629.1         4261-5194
            5517-6002           AW590229.1         2-487               c
FEATURES             Location/Qualifiers
     source          1..6002
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q24.2"
     gene            1..6002
                     /gene="ABCA8"
                     /note="ATP binding cassette subfamily A member 8"
                     /db_xref="GeneID:10351"
                     /db_xref="HGNC:HGNC:38"
                     /db_xref="MIM:612505"
     exon            1..174
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            175..335
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            336..436
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     CDS             341..5206
                     /gene="ABCA8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ATP-binding cassette, sub-family A (ABC1), member 8;
                     ABC-type organic anion transporter ABCA8"
                     /codon_start=1
                     /product="ABC-type organic anion transporter ABCA8 isoform
                     1"
                     /protein_id="NP_001275914.1"
                     /db_xref="CCDS:CCDS74139.1"
                     /db_xref="GeneID:10351"
                     /db_xref="HGNC:HGNC:38"
                     /db_xref="MIM:612505"
                     /translation="MRKRKISVCQQTWALLCKNFLKKWRMKRESLMEWLNSLLLLLCL
                     YIYPHSHQVNDFSSLLTMDLGRVDTFNESRFSVVYTPVTNTTQQIMNKVASTPFLAGK
                     EVLGLPDEESIKEFTANYPEEIVRVTFTNTYSYHLKFLLGHGMPAKKEHKDHTAHCYE
                     TNEDVYCEVSVFWKEGFVALQAAINAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQS
                     GVITDLYLFSCIISFSSFIYYASVNVTRERKRMKALMTMMGLRDSAFWLSWGLLYAGF
                     IFIMALFLALVIRSTQFIILSGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVV
                     FLLTVFWGCLGFTSLYRHLPASLEWILSLLSPFAFMLGMAQLLHLDYDLNSNAFPHPS
                     DGSNLIVATNFMLAFDTCLYLALAIYFEKILPNEYGHRRPPLFFLKSSFWSQTQKTDH
                     VALEDEMDADPSFHDSFEQAPPEFQGKEAIRIRNVTKEYKGKPDKIEALKDLVFDIYE
                     GQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQS
                     NVQFDFLTVRENLRLFAKIKGILPQEVDKEIQRVLLELEMKNIQDVLAQNLSGGQKRK
                     LTFGIAILGDPQIFLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILA
                     DRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLNEICVEENITSLVKQHIPDAKLSA
                     KSEGKLIYTLPLERTNKFPELYKDLDSYPDLGIENYGVSMTTLNEVFLKLEGKSTINE
                     SDIAILGEVQAEKADDTERLVEMEQVLSSLNKMRKTIGGVALWRQQICAIARVRLLKL
                     KHERKALLALLLILMAGFCPLLVEYTMVKIYQNSYTWELSPHLYFLAPGQQPHDPLTQ
                     LLIINKTGASIDDFIQSVEHQNIALEVDAFGTRNGTDDPSYNGAITVCCNEKNYSFSL
                     ACNAKRLNCFPVLMDIVSNGLLGMVKPSVHIRTERSTFLENGQDNPIGFLAYIMFWLV
                     LTSSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSLYFLVFVFIYLMS
                     YISNFEDMLLTIIHIIQIPCAVGYSFSLIFMTYVISFIFRKGRKNSGIWSFCFYVVTV
                     FSVAGFAFSIFESDIPFIFTFLIPPATMIGCLFLSSHLLFSSLFSEERMDVQPFLVFL
                     IPFLHFIIFLFTLRCLEWKFGKKSMRKDPFFRISPRSSDVCQNPEEPEGEDEDVQMER
                     VRTANALNSTNFDEKPVIIASCLRKEYAGKRKGCFSKRKNKIATRNVSFCVRKGEVLG
                     LLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGDALEFLGYCPQENALWPNLTVRQ
                     HLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIKRKLCFVLSILGNP
                     SVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSG
                     RLRCIGSIQHLKSKFGKDYLLEMKVKNLAQVEPLHAEILRLFPQAARQERYSSLMVYK
                     LPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDFEEDFDPS
                     VKWKLLPQEEP"
     exon            437..641
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            642..806
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            807..910
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1137
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1279
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1465
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1613
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1782
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1841
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1952
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2128
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2248
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2387
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..2478
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..2618
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            2619..2738
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2937
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            2938..3104
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3238
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            3239..3376
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            3377..3484
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            3485..3655
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            3656..3769
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            3770..3889
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            3890..3955
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            3956..4047
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            4048..4168
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            4169..4286
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            4287..4378
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            4379..4539
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            4540..4615
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            4616..4710
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            4711..4830
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            4831..4971
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            4972..5051
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            5052..5107
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     exon            5108..6002
                     /gene="ABCA8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5975..5980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCA8"
                     /note="hexamer: AATAAA"
     polyA_site      6002
                     /gene="ABCA8"
                     /note="major polyA site"
ORIGIN      
        1 ataacctcca ctctgaaagc agtcttcaca gaaacttttc acagaagtca aatagttaaa
       61 gcaaattcta gatacatggt agagaccagg agaaaatatg aataactttc ttctaaacaa
      121 ggagctcagt ggataaacca tacctctaga ttccttgctt ccattttccc agaagttttg
      181 gtagcaggat gatgttggcc tcataatgtg agttagagag gagtccctct ttttcgactg
      241 tttggaattg tttcagaagg aatgctacca gctcctcttg taccactggt agaattcagc
      301 tgtgaatctg tctggtcctg ggcttttttt gattgacaag atgaggaaga gaaagatcag
      361 tgtgtgtcaa caaacttggg ccttattatg caagaacttt cttaaaaaat ggagaatgaa
      421 aagagagtcc ttaatggaat ggctgaattc attgctccta ctactttgtt tgtatatata
      481 tcctcatagt catcaagtaa atgatttttc ttcactgctt accatggacc tgggacgggt
      541 agatacattt aatgaatcca gattttctgt tgtatacaca cctgtcacca acacgaccca
      601 acagataatg aataaagtag cctctactcc cttcctggca ggtaaagagg tcttgggact
      661 gccagatgag gaaagtatta aagaattcac agcaaattat cctgaagaaa tagtaagagt
      721 cacctttact aatacatact catatcattt gaagttcttg ctaggacatg gaatgccagc
      781 aaagaaggag cacaaggacc atacagctca ttgttatgaa acaaatgaag atgtttactg
      841 tgaagtttca gtattttgga aggaaggttt tgtggctctt caagctgcca ttaatgctgc
      901 tattatagaa atcacaacaa atcactcagt gatggaggag ctgatgtcag ttactggaaa
      961 aaatatgaag atgcattcct tcattggtca atcaggagtt ataactgatt tgtacctttt
     1021 ttcctgcatt atttcatttt cctcattcat ttactatgca tctgttaatg tcacaagaga
     1081 gaggaaaagg atgaaggcct tgatgacaat gatgggtctt cgggattcag cgttctggct
     1141 ctcctggggt ttgctctatg ctggtttcat cttcattatg gcccttttct tggcacttgt
     1201 tataagatct acccagttta tcattttgtc tggcttcatg gtagtcttca gcctctttct
     1261 cctgtatgga ttatctttgg tagctttggc tttcttaatg agcatcttgg taaagaaatc
     1321 tttcctcacc ggcctggtcg tgttcctcct cactgtcttt tgggggtgtc tggggttcac
     1381 atcactgtac agacaccttc ctgcatcctt ggagtggatt ttaagcttgc ttagtccctt
     1441 tgccttcatg cttggaatgg cccagctttt acacttggac tatgatttga attctaatgc
     1501 atttcctcat ccatcggacg gctcaaatct cattgtagca acaaatttca tgttggcatt
     1561 tgacacttgc ctctatctgg cattggcgat ttactttgaa aaaattttgc caaatgaata
     1621 tggacatcga cgtccacctt tgtttttcct gaagtcctca ttttggtctc aaacacaaaa
     1681 gactgatcac gtggcccttg aagatgaaat ggatgccgat ccttcatttc atgactcttt
     1741 tgaacaagcg cctccagaat tccaagggaa agaagccatc agaatcagaa atgttacaaa
     1801 agaatataaa ggaaagcctg ataaaataga agccttgaaa gatctggtat ttgacattta
     1861 cgaaggccaa atcactgcaa tacttggtca cagtggagct ggaaagtcaa cactgctaaa
     1921 cattcttagt gggttgtctg ttcccaccaa aggttcagtc accatctata acaataagct
     1981 ttcagaaatg gctgacctag aaaatctcag caagctgacc ggagtttgtc cacaatccaa
     2041 tgtgcaattt gacttcctca ctgtaagaga aaacctcaga ctctttgcta aaataaaagg
     2101 gattctgcca caagaagtgg ataaagagat acaaagggtt ctgctggaat tggaaatgaa
     2161 aaatattcag gatgttcttg ctcaaaactt aagtggtgga cagaaaagaa agctaacctt
     2221 tgggattgcc attttaggag atcctcagat tttcctgttg gatgaaccaa ctgctggatt
     2281 ggatcccttt tcaagacacc aagtatggaa ccttctgaaa gaacgcaaaa cagaccgcgt
     2341 gatcctcttc agtacccagt tcatggatga ggccgacatc ctggcggaca ggaaagtatt
     2401 tctctcccaa gggaagctaa agtgcgcggg ctcttctttg tttctaaaga agaaatgggg
     2461 gattggatat cacttaagct tgcagttaaa tgaaatatgt gttgaggaaa acataacatc
     2521 acttgttaaa cagcacatcc ctgatgccaa attatcagcc aaaagcgaag gaaaacttat
     2581 ttatacatta cccttagaaa gaacaaataa atttccagaa ctttacaagg atcttgatag
     2641 ctatcctgac ctaggaattg agaattatgg tgtttccatg acaactttga atgaagtatt
     2701 cctgaagcta gaaggaaaat ctacaattaa tgaatcggac attgctattt tgggagaagt
     2761 acaagcggaa aaagctgacg acactgaaag gcttgttgag atggaacaag tcctctcttc
     2821 acttaacaag atgagaaaga caataggtgg tgtggctctc tggcgacagc aaatctgcgc
     2881 aattgcaagg gttcgcttgt taaagttaaa gcatgaaaga aaagctcttt tagcactgct
     2941 attaattcta atggctggat tttgccctct tcttgtggag tataccatgg tgaaaatata
     3001 tcaaaacagt tacacctggg aactttctcc tcatttgtat ttccttgctc ctggacaaca
     3061 accacatgac cctctcactc aactactgat catcaataaa acaggggcaa gcattgatga
     3121 ctttatacag tctgtggagc accagaacat agctttagaa gtggatgcat ttggaactag
     3181 aaatggcaca gatgacccat cttataatgg agccatcaca gtgtgttgta atgaaaagaa
     3241 ttacagcttt tcgttagcat gcaatgccaa aagattgaat tgcttcccag ttcttatgga
     3301 cattgttagt aatgggctac ttggaatggt taaaccatca gtacatatcc gaactgaaag
     3361 aagtacattt ttggagaatg gacaggacaa tccaatcgga ttcctggcat atatcatgtt
     3421 ctggctggtt ttaacatcga gttgcccacc ttacattgcc atgagcagca tcgatgatta
     3481 taagaacaga gctcggtccc agctacggat ttccggactc tccccttctg cttactggtt
     3541 tgggcaggcg ctggtggatg tttccctgta cttcttggtc ttcgttttta tatatttaat
     3601 gagctacatt tcaaacttcg aagacatgct acttacaata attcatatta ttcaaatccc
     3661 atgtgctgtt ggttattcct tttccctcat cttcatgaca tacgtgattt ccttcatctt
     3721 tcgcaagggg agaaaaaata gtggcatttg gtcattttgt ttctatgttg tcactgtatt
     3781 ctctgtggct ggatttgcgt tcagtatctt cgaaagtgat attccattta tcttcacttt
     3841 tttaatacca cctgccacaa tgattggctg tttgttctta tcttctcatc ttctcttttc
     3901 ttctctcttt tctgaagaac gaatggatgt acagccattt ctggtattcc taattccttt
     3961 ccttcatttt atcatttttc tttttactct tcgatgtctg gaatggaagt ttggaaagaa
     4021 atcaatgaga aaggatcctt tctttagaat ttctccaaga agtagtgatg tgtgtcaaaa
     4081 tccagaagaa ccagaaggag aggatgaaga tgttcagatg gaaagagtga gaacagcaaa
     4141 tgccttgaat tctactaatt ttgatgagaa gccagtcatc attgccagct gtctacgcaa
     4201 ggagtatgca gggaagagga aaggctgttt ttccaagagg aagaataaga tagccacgag
     4261 aaatgtctcc ttctgtgtta gaaaaggtga agttttagga ttattaggac acaatggagc
     4321 tggtaaaagc acatccatta aggtgataac tggagacaca aaaccaactg ctggacaagt
     4381 gctactgaaa gggagcggtg gaggggatgc cctggagttc ctggggtact gccctcagga
     4441 gaacgcgctg tggcccaacc tgacagtgag gcagcacctg gaggtgtacg ccgccgtgaa
     4501 agggctgagg aaaggggatg ctgaggttgc catcacacgg ttagtggatg cgctcaagct
     4561 gcaggaccag ctgaagtctc ccgtgaagac cttgtcagag ggaataaaga gaaagctgtg
     4621 ctttgtcctg agcatactgg ggaacccgtc agtggtgctt ctggatgagc cgtcgaccgg
     4681 gatggacccc gaggggcagc agcaaatgtg gcaggccatc cgggccacct ttagaaacac
     4741 ggaaaggggt gccctcctaa ccacccacta catggcagag gctgaggccg tgtgtgaccg
     4801 agtggccatc atggtatctg ggaggttgag atgtatcggt tccatccaac acctgaaaag
     4861 caaatttggc aaagattacc tgctggagat gaaggtgaag aacctggcac aagtggagcc
     4921 cctccatgca gagatcctga ggcttttccc ccaggctgct cggcaggaaa ggtactcctc
     4981 tctgatggtt tataagttgc cagtggaaga tgtgcaacct ttagcccaag ctttcttcaa
     5041 attagagaag gttaaacaga gctttgacct agaggagtac agcctctcac agtctaccct
     5101 ggagcaggtt ttcctggagc tctccaagga gcaggagctg ggtgattttg aggaggattt
     5161 tgatccctca gtgaagtgga agctcctccc ccaggaagag ccttaaaacc ccaaattctg
     5221 tgttcctgtt taaacccgtg gtttttttta aatacattta tttttatagc agcaatgttc
     5281 tatttttaga aactatatta taagtacaga aatggttctc cgtgtggtgg gaggaggagg
     5341 ttcgggtgct gggtaagtgc catgtcagtg tggacagagg catttgacta agccaacctc
     5401 ctctcacagc ctctgtatct ctgcaggcca tactggttcc attgttctgt ataatactga
     5461 ataaataaat ttacttttac atgatcgtat aagtttctag ataagataaa caaattttgt
     5521 ttaaattttt ttaataaaaa tcttaaaaca ctttttttct aacctagact gagaaattca
     5581 tgtttacttt tctaggtgta tgatactttg taaagttgat actttcctaa gaatttaaca
     5641 tgtcatattt ttgaaataga tttaagtgtg cttcttattg ctaaaaatac taaatgtcat
     5701 gggtcatagt atctgatatc aatatcgttg ataacatatc cacaggtaac accatgatgt
     5761 aggcataaat ggaaaacaaa aaccctacta tttcaaatat attgtacttt tttatttctg
     5821 taagccaact gtgtgccatt ttcactggac ttttaaatct agactttagt gatgtctaca
     5881 ttgtaaatga tcttttgtgg atatttgtca cttggtttca gaaagttcac aaatgtagca
     5941 acagctcaca tgactgagta ggtagaaaat gtgaaataaa tctcatatat atagttttga
     6001 aa
//
