LOCUS       NM_019112               6815 bp    mRNA    linear   PRI 03-DEC-2024
DEFINITION  Homo sapiens ATP binding cassette subfamily A member 7 (ABCA7),
            mRNA.
ACCESSION   NM_019112
VERSION     NM_019112.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6815)
  AUTHORS   Tayran,H., Yilmaz,E., Bhattarai,P., Min,Y., Wang,X., Ma,Y.,
            Wang,N., Jeong,I., Nelson,N., Kassara,N., Cosacak,M.I., Dogru,R.M.,
            Reyes-Dumeyer,D., Stenersen,J.M., Reddy,J.S., Qiao,M., Flaherty,D.,
            Gunasekaran,T.I., Yang,Z., Jurisch-Yaksi,N., Teich,A.F.,
            Kanekiyo,T., Tosto,G., Vardarajan,B.N., Is,O., Ertekin-Taner,N.,
            Mayeux,R. and Kizil,C.
  TITLE     ABCA7-dependent induction of neuropeptide Y is required for
            synaptic resilience in Alzheimer's disease through BDNF/NGFR
            signaling
  JOURNAL   Cell Genom 4 (9), 100642 (2024)
   PUBMED   39216475
  REMARK    GeneRIF: ABCA7-dependent induction of neuropeptide Y is required
            for synaptic resilience in Alzheimer's disease through BDNF/NGFR
            signaling.
REFERENCE   2  (bases 1 to 6815)
  AUTHORS   Gialama,V., Siokas,V., Liampas,I., Tsouris,Z., Stamati,P.,
            Aslanidou,P., Provatas,A., Tsimourtou,V., Xiromerisiou,G.,
            Bogdanos,D.P. and Dardiotis,E.
  TITLE     Alzheimer's Disease and Effects of ABCA7 Polymorphisms: A Review
  JOURNAL   J Integr Neurosci 23 (9), 164 (2024)
   PUBMED   39344232
  REMARK    GeneRIF: Alzheimer's Disease and Effects of ABCA7 Polymorphisms: A
            Review.
            Review article
REFERENCE   3  (bases 1 to 6815)
  AUTHORS   Kawatani,K., Holm,M.L., Starling,S.C., Martens,Y.A., Zhao,J.,
            Lu,W., Ren,Y., Li,Z., Jiang,P., Jiang,Y., Baker,S.K., Wang,N.,
            Roy,B., Parsons,T.M., Perkerson,R.B. 3rd, Bao,H., Han,X., Bu,G. and
            Kanekiyo,T.
  TITLE     ABCA7 deficiency causes neuronal dysregulation by altering
            mitochondrial lipid metabolism
  JOURNAL   Mol Psychiatry 29 (3), 809-819 (2024)
   PUBMED   38135757
  REMARK    GeneRIF: ABCA7 deficiency causes neuronal dysregulation by altering
            mitochondrial lipid metabolism.
REFERENCE   4  (bases 1 to 6815)
  AUTHORS   Duchateau,L., Kuukali,F., De Roeck,A., Wittens,M.M.J.,
            Temmerman,J., Weets,I., Timmers,M., Engelborghs,S., Bjerke,M. and
            Sleegers,K.
  TITLE     CSF biomarker analysis of ABCA7 mutation carriers suggests altered
            APP processing and reduced inflammatory response
  JOURNAL   Alzheimers Res Ther 15 (1), 195 (2023)
   PUBMED   37946268
  REMARK    GeneRIF: CSF biomarker analysis of ABCA7 mutation carriers suggests
            altered APP processing and reduced inflammatory response.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6815)
  AUTHORS   Wiener,J.P., Desire,S., Garliyev,V., Lyssenko Iii,N., Pratico,D.
            and Lyssenko,N.N.
  TITLE     Down-Regulation of ABCA7 in Human Microglia, Astrocyte and THP-1
            Cell Lines by Cholesterol Depletion, IL-1beta and TNFalpha, or PMA
  JOURNAL   Cells 12 (17), 2143 (2023)
   PUBMED   37681876
  REMARK    GeneRIF: Down-Regulation of ABCA7 in Human Microglia, Astrocyte and
            THP-1 Cell Lines by Cholesterol Depletion, IL-1beta and TNFalpha,
            or PMA.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6815)
  AUTHORS   Tanaka,A.R., Ikeda,Y., Abe-Dohmae,S., Arakawa,R., Sadanami,K.,
            Kidera,A., Nakagawa,S., Nagase,T., Aoki,R., Kioka,N., Amachi,T.,
            Yokoyama,S. and Ueda,K.
  TITLE     Human ABCA1 contains a large amino-terminal extracellular domain
            homologous to an epitope of Sjogren's Syndrome
  JOURNAL   Biochem Biophys Res Commun 283 (5), 1019-1025 (2001)
   PUBMED   11355874
REFERENCE   7  (bases 1 to 6815)
  AUTHORS   Broccardo,C., Osorio,J., Luciani,M.F., Schriml,L.M., Prades,C.,
            Shulenin,S., Arnould,I., Naudin,L., Lafargue,C., Rosier,M.,
            Jordan,B., Mattei,M.G., Dean,M., Denefle,P. and Chimini,G.
  TITLE     Comparative analysis of the promoter structure and genomic
            organization of the human and mouse ABCA7 gene encoding a novel
            ABCA transporter
  JOURNAL   Cytogenet Cell Genet 92 (3-4), 264-270 (2001)
   PUBMED   11435699
REFERENCE   8  (bases 1 to 6815)
  AUTHORS   Kaminski,W.E., Piehler,A. and Schmitz,G.
  TITLE     Genomic organization of the human cholesterol-responsive ABC
            transporter ABCA7: tandem linkage with the minor histocompatibility
            antigen HA-1 gene
  JOURNAL   Biochem Biophys Res Commun 278 (3), 782-789 (2000)
   PUBMED   11095984
REFERENCE   9  (bases 1 to 6815)
  AUTHORS   Niwa,M., Maruyama,H., Fujimoto,T., Dohi,K. and Maruyama,I.N.
  TITLE     Affinity selection of cDNA libraries by lambda phage surface
            display
  JOURNAL   Gene 256 (1-2), 229-236 (2000)
   PUBMED   11054552
REFERENCE   10 (bases 1 to 6815)
  AUTHORS   Kaminski,W.E., Orso,E., Diederich,W., Klucken,J., Drobnik,W. and
            Schmitz,G.
  TITLE     Identification of a novel human sterol-sensitive ATP-binding
            cassette transporter (ABCA7)
  JOURNAL   Biochem Biophys Res Commun 273 (2), 532-538 (2000)
   PUBMED   10873640
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC405492.1, AF250238.1,
            AF328787.1, CD629701.1, AK097344.1 and BU675136.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 7, 2019 this sequence version replaced NM_019112.3.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra- and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
            protein is a member of the ABC1 subfamily. Members of the ABC1
            subfamily comprise the only major ABC subfamily found exclusively
            in multicellular eukaryotes. This full transporter has been
            detected predominantly in myelo-lymphatic tissues with the highest
            expression in peripheral leukocytes, thymus, spleen, and bone
            marrow. The function of this protein is not yet known; however, the
            expression pattern suggests a role in lipid homeostasis in cells of
            the immune system. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF328787.1, AF250238.1 [ECO:0000331]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000263094.11/ ENSP00000263094.6
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-563               DC405492.1         5-567
            564-1159            AF250238.1         337-932
            1160-4806           AF328787.1         1049-4695
            4807-4902           CD629701.1         89-184
            4903-6211           AF328787.1         4792-6100
            6212-6812           AK097344.1         1279-1879
            6813-6815           BU675136.1         16-18               c
FEATURES             Location/Qualifiers
     source          1..6815
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..6815
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /note="ATP binding cassette subfamily A member 7"
                     /db_xref="GeneID:10347"
                     /db_xref="HGNC:HGNC:37"
                     /db_xref="MIM:605414"
     exon            1..90
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            91..293
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..6668
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /EC_number="7.6.2.1"
                     /note="autoantigen SS-N; macrophage ABC transporter;
                     ATP-binding cassette sub-family A member 7; ATP-binding
                     cassette, sub-family A (ABC1), member 7"
                     /codon_start=1
                     /product="phospholipid-transporting ATPase ABCA7"
                     /protein_id="NP_061985.2"
                     /db_xref="CCDS:CCDS12055.1"
                     /db_xref="GeneID:10347"
                     /db_xref="HGNC:HGNC:37"
                     /db_xref="MIM:605414"
                     /translation="MAFWTQLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRH
                     SHPPLEHHECHFPNKPLPSAGTVPWLQGLICNVNNTCFPQLTPGEEPGRLSNFNDSLV
                     SRLLADARTVLGGASAHRTLAGLGKLIATLRAARSTAQPQPTKQSPLEPPMLDVAELL
                     TSLLRTESLGLALGQAQEPLHSLLEAAEDLAQELLALRSLVELRALLQRPRGTSGPLE
                     LLSEALCSVRGPSSTVGPSLNWYEASDLMELVGQEPESALPDSSLSPACSELIGALDS
                     HPLSRLLWRRLKPLILGKLLFAPDTPFTRKLMAQVNRTFEELTLLRDVREVWEMLGPR
                     IFTFMNDSSNVAMLQRLLQMQDEGRRQPRPGGRDHMEALRSFLDPGSGGYSWQDAHAD
                     VGHLVGTLGRVTECLSLDKLEAAPSEAALVSRALQLLAEHRFWAGVVFLGPEDSSDPT
                     EHPTPDLGPGHVRIKIRMDIDVVTRTNKIRDRFWDPGPAADPLTDLRYVWGGFVYLQD
                     LVERAAVRVLSGANPRAGLYLQQMPYPCYVDDVFLRVLSRSLPLFLTLAWIYSVTLTV
                     KAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVLKLGDILPYSH
                     PGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYVLCVAWRDRLP
                     AGGRVAASLLSPVAFGFGCESLALLEEQGEGAQWHNVGTRPTADVFSLAQVSGLLLLD
                     AALYGLATWYLEAVCPGQYGIPEPWNFPFRRSYWCGPRPPKSPAPCPTPLDPKVLVEE
                     APPGLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSG
                     LFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAA
                     VVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDP
                     ASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLG
                     SGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQHWVPG
                     ARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEIFLKV
                     VEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETDQGSG
                     PDAVGRVQGWALTRQQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIVPP
                     FGHYPALRLSPTMYGAQVSFFSEDAPGDPGRARLLEALLQEAGLEEPPVQHSSHRFSA
                     PEVPAEVAKVLASGNWTPESPSPACQCSRPGARRLLPDCPAAAGGPPPPQAVTGSGEV
                     VQNLTGRNLSDFLVKTYPRLVRQGLKTKKWVNEVRYGGFSLGGRDPGLPSGQELGRSV
                     EELWALLSPLPGGALDRVLKNLTAWAHSLDAQDSLKIWFNNKGWHSMVAFVNRASNAI
                     LRAHLPPGPARHAHSITTLNHPLNLTKEQLSEGALMASSVDVLVSICVVFAMSFVPAS
                     FTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLIFLAFQQRAY
                     VAPANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMATFV
                     LELFSDQKLQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDRQFQSPLR
                     WEVVGKNLLAMVIQGPLFLLFTLLLQHRSQLLPQPRVRSLPLLGEEDEDVARERERVV
                     QGATQGDVLVLRNLTKVYRGQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTG
                     DTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEA
                     QVAQTAGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDP
                     SARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRF
                     AAGHTLTLRVPAARSQPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGEL
                     AVHGAEHGVEDFSVSQTMLEEVFLYFSKDQGKDEDTEEQKEAGVGVDPAPGLQHPKRV
                     SQFLDDPSTAETVL"
     exon            294..387
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            388..529
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            530..642
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            643..725
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            726..806
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            807..1017
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1157
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1274
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1442
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1672
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1849
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..2072
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2294
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2496
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2607
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2779
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2780..2911
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3051
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            3052..3189
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            3190..3374
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            3375..3447
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            3448..3650
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            3651..3699
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            3700..3804
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            3805..3953
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            3954..4078
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            4079..4177
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            4178..4432
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            4433..4465
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            4466..4643
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            4644..4813
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            4814..4991
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            4992..5107
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            5108..5252
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            5253..5376
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            5377..5506
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            5507..5627
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            5628..5690
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            5691..5797
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            5798..5939
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            5940..6074
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            6075..6178
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            6179..6271
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            6272..6512
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     exon            6513..6815
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6778..6783
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /note="hexamer: AATAAA"
     polyA_site      6815
                     /gene="ABCA7"
                     /gene_synonym="ABCA-SSN; ABCX; AD9"
                     /note="major polyA site"
ORIGIN      
        1 aagctcagcg cacttggctt aaggggcggc gcgctccctg cctgctgctg ggcggaggga
       61 aggcggcaag agctgcggag cccctggaag agcttccagg aaccctgcgc tgtgggataa
      121 aggaatgagg ttcagaaagg ggcagggagt tgcccgcagc cgcaccgcac gtcttcagcc
      181 cgaccgttgt cctgacctct ctgtcccgtc ccctgcccag tctcaccatg gccttctgga
      241 cacagctgat gctgctgctc tggaagaatt tcatgtatcg ccggagacag ccggtccagc
      301 tcctggtcga attgctgtgg cctctcttcc tcttcttcat cctggtggct gttcgccact
      361 cccacccgcc cctggagcac catgaatgcc acttcccaaa caagccactg ccatcggcgg
      421 gcaccgtgcc ctggctccag ggtctcatct gtaatgtgaa caacacctgc tttccgcagc
      481 tgacaccggg cgaggagccc gggcgcctga gcaacttcaa cgactccctg gtctcccggc
      541 tgctagccga tgcccgcact gtgctgggag gggccagtgc ccacaggacg ctggctggcc
      601 tagggaagct gatcgccacg ctgagggctg cacgcagcac ggcccagcct caaccaacca
      661 agcagtctcc actggaacca cccatgctgg atgtcgcgga gctgctgacg tcactgctgc
      721 gcacggaatc cctggggttg gcactgggcc aagcccagga gcccttgcac agcttgttgg
      781 aggccgctga ggacctggcc caggagctcc tggcgctgcg cagcctggtg gagcttcggg
      841 cactgctgca gagaccccga gggaccagcg gccccctgga gttgctgtca gaggccctct
      901 gcagtgtcag gggacctagc agcacagtgg gcccctccct caactggtac gaggctagtg
      961 acctgatgga gctggtgggg caggagccag aatccgccct gccagacagc agcctgagcc
     1021 ccgcctgctc ggagctgatt ggagccctgg acagccaccc gctgtcccgc ctgctctgga
     1081 gacgcctgaa gcctctgatc ctcgggaagc tactctttgc accagataca ccttttaccc
     1141 ggaagctcat ggcccaggtg aaccggacct tcgaggagct caccctgctg agggatgtcc
     1201 gggaggtgtg ggagatgctg ggaccccgga tcttcacctt catgaacgac agttccaatg
     1261 tggccatgct gcagcggctc ctgcagatgc aggatgaagg aagaaggcag cccagacctg
     1321 gaggccggga ccacatggag gccctgcgat cctttctgga ccctgggagc ggtggctaca
     1381 gctggcagga cgcacacgct gatgtggggc acctggtggg cacgctgggc cgagtgacgg
     1441 agtgcctgtc cttggacaag ctggaggcgg caccctcaga ggcagccctg gtgtcgcggg
     1501 ccctgcaact gctcgcggaa catcgattct gggccggcgt cgtcttcttg ggacctgagg
     1561 actcttcaga ccccacagag cacccaaccc cagacctggg ccccggccac gtgcgcatca
     1621 aaatccgcat ggacattgac gtggtcacga ggaccaataa gatcagggac aggttttggg
     1681 accctggccc agccgcggac cccctgaccg acctgcgcta cgtgtggggc ggcttcgtgt
     1741 acctgcaaga cctggtggag cgtgcagccg tccgcgtgct cagcggcgcc aacccccggg
     1801 ccggcctcta cctgcagcag atgccctatc cgtgctatgt ggacgacgtg ttcctgcgtg
     1861 tgctgagccg gtcgctgccg ctcttcctga cgctggcctg gatctactcc gtgacactga
     1921 cagtgaaggc cgtggtgcgg gagaaggaga cgcggctgcg ggacaccatg cgcgccatgg
     1981 ggctcagccg cgcggtgctc tggctaggct ggttcctcag ctgcctcggg cccttcctgc
     2041 tcagcgccgc actgctggtt ctggtgctca agctgggaga catcctcccc tacagccacc
     2101 cgggcgtggt cttcctgttc ttggcagcct tcgcggtggc cacggtgacc cagagcttcc
     2161 tgctcagcgc cttcttctcc cgcgccaacc tggctgcggc ctgcggcggc ctggcctact
     2221 tctccctcta cctgccctac gtgctgtgtg tggcttggcg ggaccggctg cccgcgggtg
     2281 gccgcgtggc cgcgagcctg ctgtcgcccg tggccttcgg cttcggctgc gagagcctgg
     2341 ctctgctgga ggagcagggc gagggcgcgc agtggcacaa cgtgggcacc cggcctacgg
     2401 cagacgtctt cagcctggcc caggtctctg gccttctgct gctggacgcg gcgctctacg
     2461 gcctcgccac ctggtacctg gaagctgtgt gcccaggcca gtacgggatc cctgaaccat
     2521 ggaattttcc ttttcggagg agctactggt gcggacctcg gccccccaag agtccagccc
     2581 cttgccccac cccgctggac ccaaaggtgc tggtagaaga ggcaccgccc ggcctgagtc
     2641 ctggcgtctc cgttcgcagc ctggagaagc gctttcctgg aagcccgcag ccagccctgc
     2701 gggggctcag cctggacttc taccagggcc acatcaccgc cttcctgggc cacaacgggg
     2761 ccggcaagac caccaccctg tccatcttga gtggcctctt cccacccagt ggtggctctg
     2821 ccttcatcct gggccacgac gtccgctcca gcatggccgc catccggccc cacctgggcg
     2881 tctgtcctca gtacaacgtg ctgtttgaca tgctgaccgt ggacgagcac gtctggttct
     2941 atgggcggct gaagggtctg agtgccgctg tagtgggccc cgagcaggac cgtctgctgc
     3001 aggatgtggg gctggtctcc aagcagagtg tgcagactcg ccacctctct ggtgggatgc
     3061 aacggaagct gtccgtggcc attgcctttg tgggcggctc ccaagttgtt atcctggacg
     3121 agcctacggc tggcgtggat cctgcttccc gccgcggtat ttgggagctg ctgctcaaat
     3181 accgagaagg tcgcacgctg atcctctcca cccaccacct ggatgaggca gagctgctgg
     3241 gagaccgtgt ggccgtggtg gcaggtggcc gcttgtgctg ctgtggctcc ccactcttcc
     3301 tgcgccgtca cctgggctcc ggctactacc tgacgctggt gaaggcccgc ctgcccctga
     3361 ccaccaatga gaaggctgac actgacatgg agggcagtgt ggacaccagg caggaaaaga
     3421 agaatggcag ccagggcagc agagtcggca ctcctcagct gctggccctg gtacagcact
     3481 gggtgcccgg ggcacggctg gtggaggagc tgccacacga gctggtgctg gtgctgccct
     3541 acacgggtgc ccatgacggc agcttcgcca cactcttccg agagctagac acgcggctgg
     3601 cggagctgag gctcactggc tacgggatct ccgacaccag cctcgaggag atcttcctga
     3661 aggtggtgga ggagtgtgct gcggacacag atatggagga tggcagctgc gggcagcacc
     3721 tatgcacagg cattgctggc ctagacgtaa ccctacggct caagatgccg ccacaggaga
     3781 cagcgctgga gaacggggaa ccagctgggt cagccccaga gactgaccag ggctctgggc
     3841 cagacgccgt gggccgggta cagggctggg cactgacccg ccagcagctc caggccctgc
     3901 ttctcaagcg ctttctgctt gcccgccgca gccgccgcgg cctgttcgcc cagatcgtgc
     3961 tgcctgccct ctttgtgggc ctggccctcg tgttcagcct catcgtgcct cctttcgggc
     4021 actacccggc tctgcggctc agtcccacca tgtacggtgc tcaggtgtcc ttcttcagtg
     4081 aggacgcccc aggggaccct ggacgtgccc ggctgctcga ggcgctgctg caggaggcag
     4141 gactggagga gcccccagtg cagcatagct cccacaggtt ctcggcacca gaagttcctg
     4201 ctgaagtggc caaggtcttg gccagtggca actggacccc agagtctcca tccccagcct
     4261 gccagtgtag ccggcccggt gcccggcgcc tgctgcccga ctgcccggct gcagctggtg
     4321 gtccccctcc gccccaggca gtgaccggct ctggggaagt ggttcagaac ctgacaggcc
     4381 ggaacctgtc tgacttcctg gtcaagacct acccgcgcct ggtgcgccag ggcctgaaga
     4441 ctaagaagtg ggtgaatgag gtcagatacg gaggcttctc gctggggggc cgagacccag
     4501 gcctgccctc gggccaagag ttgggccgct cagtggagga gttgtgggcg ctgctgagtc
     4561 ccctgcctgg cggggccctc gaccgtgtcc tgaaaaacct cacagcctgg gctcacagcc
     4621 tggatgctca ggacagtctc aagatctggt tcaacaacaa aggctggcac tccatggtgg
     4681 cctttgtcaa ccgagccagc aacgcaatcc tccgtgctca cctgccccca ggcccggccc
     4741 gccacgccca cagcatcacc acactcaacc accccttgaa cctcaccaag gagcagctgt
     4801 ctgagggtgc actgatggcc tcctcggtgg acgtcctcgt ctccatctgt gtggtctttg
     4861 ccatgtcctt tgtcccggcc agcttcactc ttgtcctcat tgaggagcga gtcacccgag
     4921 ccaagcacct gcagctcatg gggggcctgt cccccaccct ctactggctt ggcaactttc
     4981 tctgggacat gtgtaactac ttggtgccag catgcatcgt ggtgctcatc tttctggcct
     5041 tccagcagag ggcatatgtg gcccctgcca acctgcctgc tctcctgctg ttgctactac
     5101 tgtatggctg gtcgatcaca ccgctcatgt acccagcctc cttcttcttc tccgtgccca
     5161 gcacagccta tgtggtgctc acctgcataa acctctttat tggcatcaat ggaagcatgg
     5221 ccacctttgt gcttgagctc ttctctgatc agaagctgca ggaggtgagc cggatcttga
     5281 aacaggtctt ccttatcttc ccccacttct gcttgggccg ggggctcatt gacatggtgc
     5341 ggaaccaggc catggctgat gcctttgagc gcttgggaga caggcagttc cagtcacccc
     5401 tgcgctggga ggtggtcggc aagaacctct tggccatggt gatacagggg cccctcttcc
     5461 ttctcttcac actactgctg cagcaccgaa gccaactcct gccacagccc agggtgaggt
     5521 ctctgccact cctgggagag gaggacgagg atgtagcccg tgaacgggag cgggtggtcc
     5581 aaggagccac ccagggggat gtgttggtgc tgaggaactt gaccaaggta taccgtgggc
     5641 agaggatgcc agctgttgac cgcttgtgcc tggggattcc ccctggtgag tgttttgggc
     5701 tgctgggtgt gaatggagca gggaagacgt ccacgtttcg catggtgacg ggggacacat
     5761 tggccagcag gggcgaggct gtgctggcag gccacagcgt ggcccgggaa cccagtgctg
     5821 cgcacctcag catgggatac tgccctcaat ccgatgccat ctttgagctg ctgacgggcc
     5881 gcgagcacct ggagctgctt gcgcgcctgc gcggtgtccc ggaggcccag gttgcccaga
     5941 ccgctggctc gggcctggcg cgtctgggac tctcatggta cgcagaccgg cctgcaggca
     6001 cctacagcgg agggaacaaa cgcaagctgg cgacggccct ggcgctggtt ggggacccag
     6061 ccgtggtgtt tctggacgag ccgaccacag gcatggaccc cagcgcgcgg cgcttccttt
     6121 ggaacagcct tttggccgtg gtgcgggagg gccgttcagt gatgctcacc tcccatagca
     6181 tggaggagtg tgaagcgctc tgctcgcgcc tggccatcat ggtgaatggg cggttccgct
     6241 gcctgggcag cccgcaacat ctcaagggca gattcgcggc gggtcacaca ctgaccctgc
     6301 gggtgcccgc cgcaaggtcc cagccggcag cggccttcgt ggcggccgag ttccctgggg
     6361 cggagctgcg cgaggcacat ggaggccgcc tgcgcttcca gctgccgccg ggagggcgct
     6421 gcgccctggc gcgcgtcttt ggagagctgg cggtgcacgg cgcagagcac ggcgtggagg
     6481 acttttccgt gagccagacg atgctggagg aggtattctt gtacttctcc aaggaccagg
     6541 ggaaggacga ggacaccgaa gagcagaagg aggcaggagt gggagtggac cccgcgccag
     6601 gcctgcagca ccccaaacgc gtcagccagt tcctcgatga ccctagcact gccgagactg
     6661 tgctctgagc ctccctcccc tgcggggccg cggggaggcc ctgggaatgg caagggcaag
     6721 gtagagtgcc taggagccct ggactcaggc tggcagaggg gctggtgccc tggagaaaat
     6781 aaagagaagg ctggagagaa gccgtggtgg tgaaa
//
