LOCUS       NM_080284               5321 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens ATP binding cassette subfamily A member 6 (ABCA6),
            mRNA.
ACCESSION   NM_080284
VERSION     NM_080284.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5321)
  AUTHORS   Pasello,M., Giudice,A.M., Cristalli,C., Manara,M.C., Mancarella,C.,
            Parra,A., Serra,M., Magagnoli,G., Cidre-Aranaz,F.,
            Grunewald,T.G.P., Bini,C., Lollini,P.L., Longhi,A., Donati,D.M. and
            Scotlandi,K.
  TITLE     ABCA6 affects the malignancy of Ewing sarcoma cells via
            cholesterol-guided inhibition of the IGF1R/AKT/MDM2 axis
  JOURNAL   Cell Oncol (Dordr) 45 (6), 1237-1251 (2022)
   PUBMED   36149602
  REMARK    GeneRIF: ABCA6 affects the malignancy of Ewing sarcoma cells via
            cholesterol-guided inhibition of the IGF1R/AKT/MDM2 axis.
            Erratum:[Cell Oncol (Dordr). 2022 Dec;45(6):1253. doi:
            10.1007/s13402-022-00735-z.. PMID: 36352194]
REFERENCE   2  (bases 1 to 5321)
  AUTHORS   He,B., Kang,S., Chen,Z., Liu,X., Wang,J., Li,X., Liu,X., Zheng,L.,
            Luo,M. and Wang,Y.
  TITLE     Hypercholesterolemia risk associated Abca6 does not regulate
            lipoprotein metabolism in mice or hamster
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1866 (11), 159006 (2021)
   PUBMED   34274505
  REMARK    GeneRIF: Hypercholesterolemia risk associated Abca6 does not
            regulate lipoprotein metabolism in mice or hamster.
REFERENCE   3  (bases 1 to 5321)
  AUTHORS   Breuss,M.W., Mamerto,A., Renner,T. and Waters,E.R.
  TITLE     The Evolution of the Mammalian ABCA6-like Genes: Analysis of
            Phylogenetic, Expression, and Population Genetic Data Reveals
            Complex Evolutionary Histories
  JOURNAL   Genome Biol Evol 12 (11), 2093-2106 (2020)
   PUBMED   32877505
  REMARK    GeneRIF: The Evolution of the Mammalian ABCA6-like Genes: Analysis
            of Phylogenetic, Expression, and Population Genetic Data Reveals
            Complex Evolutionary Histories.
REFERENCE   4  (bases 1 to 5321)
  AUTHORS   van Leeuwen,E.M., Karssen,L.C., Deelen,J., Isaacs,A.,
            Medina-Gomez,C., Mbarek,H., Kanterakis,A., Trompet,S., Postmus,I.,
            Verweij,N., van Enckevort,D.J., Huffman,J.E., White,C.C.,
            Feitosa,M.F., Bartz,T.M., Manichaikul,A., Joshi,P.K., Peloso,G.M.,
            Deelen,P., van Dijk,F., Willemsen,G., de Geus,E.J., Milaneschi,Y.,
            Penninx,B.W., Francioli,L.C., Menelaou,A., Pulit,S.L.,
            Rivadeneira,F., Hofman,A., Oostra,B.A., Franco,O.H., Mateo
            Leach,I., Beekman,M., de Craen,A.J., Uh,H.W., Trochet,H.,
            Hocking,L.J., Porteous,D.J., Sattar,N., Packard,C.J., Buckley,B.M.,
            Brody,J.A., Bis,J.C., Rotter,J.I., Mychaleckyj,J.C., Campbell,H.,
            Duan,Q., Lange,L.A., Wilson,J.F., Hayward,C., Polasek,O.,
            Vitart,V., Rudan,I., Wright,A.F., Rich,S.S., Psaty,B.M.,
            Borecki,I.B., Kearney,P.M., Stott,D.J., Adrienne Cupples,L.,
            Jukema,J.W., van der Harst,P., Sijbrands,E.J., Hottenga,J.J.,
            Uitterlinden,A.G., Swertz,M.A., van Ommen,G.J., de Bakker,P.I.,
            Eline Slagboom,P., Boomsma,D.I., Wijmenga,C. and van Duijn,C.M.
  CONSRTM   Genome of The Netherlands Consortium
  TITLE     Genome of The Netherlands population-specific imputations identify
            an ABCA6 variant associated with cholesterol levels
  JOURNAL   Nat Commun 6, 6065 (2015)
   PUBMED   25751400
  REMARK    GeneRIF: A rare missense variant in ABCA6 (rs77542162,
            p.Cys1359Arg, frequency 0.034), found in a Dutch population, is
            predicted to be deleterious with respect to blood cholesterol
            levels.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5321)
  AUTHORS   Baecklund,F., Foo,J.N., Bracci,P., Darabi,H., Karlsson,R.,
            Hjalgrim,H., Rosenquist,R., Adami,H.O., Glimelius,B., Melbye,M.,
            Conde,L., Liu,J., Humphreys,K., Skibola,C.F. and Smedby,K.E.
  TITLE     A comprehensive evaluation of the role of genetic variation in
            follicular lymphoma survival
  JOURNAL   BMC Med Genet 15, 113 (2014)
   PUBMED   25294155
  REMARK    GeneRIF: Results suggest a possible role for multidrug resistance
            genes ABCA10 and ABCA6 in follicular lymphoma survival and add to
            the evidence that genetic variation in CD46 and IL8 may have
            prognostic implications follicular lymphoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5321)
  AUTHORS   Hosgood,H.D. 3rd, Menashe,I., Shen,M., Yeager,M., Yuenger,J.,
            Rajaraman,P., He,X., Chatterjee,N., Caporaso,N.E., Zhu,Y.,
            Chanock,S.J., Zheng,T. and Lan,Q.
  TITLE     Pathway-based evaluation of 380 candidate genes and lung cancer
            susceptibility suggests the importance of the cell cycle pathway
  JOURNAL   Carcinogenesis 29 (10), 1938-1943 (2008)
   PUBMED   18676680
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5321)
  AUTHORS   Kaminski,W.E., Wenzel,J.J., Piehler,A., Langmann,T. and Schmitz,G.
  TITLE     ABCA6, a novel a subclass ABC transporter
  JOURNAL   Biochem Biophys Res Commun 285 (5), 1295-1301 (2001)
   PUBMED   11478798
REFERENCE   8  (bases 1 to 5321)
  AUTHORS   Dean,M., Rzhetsky,A. and Allikmets,R.
  TITLE     The human ATP-binding cassette (ABC) transporter superfamily
  JOURNAL   Genome Res 11 (7), 1156-1166 (2001)
   PUBMED   11435397
  REMARK    Review article
REFERENCE   9  (bases 1 to 5321)
  AUTHORS   Klucken,J., Buchler,C., Orso,E., Kaminski,W.E.,
            Porsch-Ozcurumez,M., Liebisch,G., Kapinsky,M., Diederich,W.,
            Drobnik,W., Dean,M., Allikmets,R. and Schmitz,G.
  TITLE     ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a
            regulator of macrophage cholesterol and phospholipid transport
  JOURNAL   Proc Natl Acad Sci U S A 97 (2), 817-822 (2000)
   PUBMED   10639163
REFERENCE   10 (bases 1 to 5321)
  AUTHORS   Allikmets,R., Gerrard,B., Hutchinson,A. and Dean,M.
  TITLE     Characterization of the human ABC superfamily: isolation and
            mapping of 21 new genes using the expressed sequence tags database
  JOURNAL   Hum Mol Genet 5 (10), 1649-1655 (1996)
   PUBMED   8894702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005495.2 and AC005922.1.
            
            On Nov 25, 2018 this sequence version replaced NM_080284.2.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intracellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            and White). This encoded protein is a member of the ABC1 subfamily.
            Members of the ABC1 subfamily comprise the only major ABC subfamily
            found exclusively in multicellular eukaryotes. This gene is
            clustered among 4 other ABC1 family members on 17q24 and may play a
            role in macrophage lipid homeostasis. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY028898.1, SRR1803614.264573.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284425.7/ ENSP00000284425.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               AC005495.2         61700-61850         c
            152-292             AC005495.2         60563-60703         c
            293-497             AC005495.2         57251-57455         c
            498-656             AC005495.2         56047-56205         c
            657-760             AC005495.2         54594-54697         c
            761-987             AC005495.2         53596-53822         c
            988-1129            AC005495.2         49565-49706         c
            1130-1315           AC005495.2         48574-48759         c
            1316-1463           AC005495.2         44843-44990         c
            1464-1632           AC005495.2         43194-43362         c
            1633-1691           AC005495.2         37853-37911         c
            1692-1802           AC005495.2         35331-35441         c
            1803-1978           AC005495.2         34717-34892         c
            1979-2098           AC005495.2         33573-33692         c
            2099-2237           AC005495.2         33177-33315         c
            2238-2328           AC005495.2         32138-32228         c
            2329-2468           AC005495.2         30756-30895         c
            2469-2585           AC005495.2         27651-27767         c
            2586-2769           AC005495.2         25983-26166         c
            2770-2936           AC005495.2         25417-25583         c
            2937-3070           AC005495.2         22790-22923         c
            3071-3208           AC005495.2         20752-20889         c
            3209-3316           AC005495.2         17875-17982         c
            3317-3490           AC005495.2         16583-16756         c
            3491-3604           AC005495.2         16195-16308         c
            3605-3724           AC005495.2         11098-11217         c
            3725-3802           AC005495.2         9420-9497           c
            3803-3894           AC005495.2         8122-8213           c
            3895-4015           AC005495.2         7308-7428           c
            4016-4133           AC005495.2         6573-6690           c
            4134-4225           AC005495.2         5580-5671           c
            4226-4380           AC005495.2         4983-5137           c
            4381-4456           AC005495.2         4387-4462           c
            4457-4551           AC005495.2         4216-4310           c
            4552-4671           AC005495.2         3167-3286           c
            4672-4812           AC005495.2         2828-2968           c
            4813-4892           AC005922.1         901-980
            4893-4948           AC005922.1         2781-2836
            4949-5321           AC005922.1         2972-3344
FEATURES             Location/Qualifiers
     source          1..5321
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q24.2-q24.3"
     gene            1..5321
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /note="ATP binding cassette subfamily A member 6"
                     /db_xref="GeneID:23460"
                     /db_xref="HGNC:HGNC:36"
                     /db_xref="MIM:612504"
     exon            1..151
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            152..292
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..5050
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /note="ATP-binding cassette A6; ABC transporter ABCA6;
                     ATP-binding cassette, sub-family A (ABC1), member 6"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family A member 6"
                     /protein_id="NP_525023.2"
                     /db_xref="CCDS:CCDS11683.1"
                     /db_xref="GeneID:23460"
                     /db_xref="HGNC:HGNC:36"
                     /db_xref="MIM:612504"
                     /translation="MNMKQKSVYQQTKALLCKNFLKKWRMKRESLLEWGLSILLGLCI
                     ALFSSSMRNVQFPGMAPQNLGRVDKFNSSSLMVVYTPISNLTQQIMNKTALAPLLKGT
                     SVIGAPNKTHMDEILLENLPYAMGIIFNETFSYKLIFFQGYNSPLWKEDFSAHCWDGY
                     GEFSCTLTKYWNRGFVALQTAINTAIIEITTNHPVMEELMSVTAITMKTLPFITKNLL
                     HNEMFILFFLLHFSPLVYFISLNVTKERKKSKNLMKMMGLQDSAFWLSWGLIYAGFIF
                     IISIFVTIIITFTQIIVMTGFMVIFILFFLYGLSLVALVFLMSVLLKKAVLTNLVVFL
                     LTLFWGCLGFTVFYEQLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGVIFPDPSGD
                     SYTMIATFSMLLLDGLIYLLLALYFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKV
                     IEKEIDAEHPSDDYFEPVAPEFQGKEAIRIRNVKKEYKGKSGKVEALKGLLFDIYEGQ
                     ITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNV
                     QFDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLT
                     FGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADHVILFSTQSMDEADILADR
                     KVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRNEICNPEQITSFITHHIPDAKLKTEN
                     KEKLVYTLPLERTNTFPDLFSDLDKCSDQGVTGYDISMSTLNEVFMKLEGQSTIEQDF
                     EQVEMIRDSESLNEMELAHSSFSEMQTAVSDMGLWRMQVFAMARLRFLKLKRQTKVLL
                     TLLLVFGIAIFPLIVENIMYAMLNEKIDWEFKNELYFLSPGQLPQEPRTSLLIINNTE
                     SNIEDFIKSLKHQNILLEVDDFENRNGTDGLSYNGAIIVSGKQKDYRFSVVCNTKRLH
                     CFPILMNIISNGLLQMFNHTQHIRIESSPFPLSHIGLWTGLPDGSFFLFLVLCSISPY
                     ITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSFFILILLLMYLIFYIENMQYL
                     LITSQIVFALVIVTPGYAASLVFFIYMISFIFRKRRKNSGLWSFYFFFASTIMFSITL
                     INHFDLSILITTMVLVPSYTLLGFKTFLEVRDQEHYREFPEANFELSATDFLVCFIPY
                     FQTLLFVFVLRCMELKCGKKRMRKDPVFRISPQSRDAKPNPEEPIDEDEDIQTERIRT
                     ATALTTSILDEKPVIIASCLHKEYAGQKKSCFSKRKKKIAARNISFCVQEGEILGLLG
                     PNGAGKSSSIRMISGITKPTAGEVELKGCSSVLGHLGYCPQENVLWPMLTLREHLEVY
                     AAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLL
                     DEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLAEAEALCDRVAIMVSGRLRCI
                     GSIQHLKNKLGKDYILELKVKETSQVTLVHTEILKLFPQAAGQERYSSLLTYKLPVAD
                     VYPLSQTFHKLEAVKHNFNLEEYSLSQCTLEKVFLELSKEQEVGNFDEEIDTTMRWKL
                     LPHSDEP"
     exon            293..497
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            498..656
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            657..760
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            761..987
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1129
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1315
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1463
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1632
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1691
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1802
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1978
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2098
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2237
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2328
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2468
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2585
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2769
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2936
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..3070
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..3208
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            3209..3316
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            3317..3490
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            3491..3604
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            3605..3724
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            3725..3802
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            3803..3894
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            3895..4015
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            4016..4133
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            4134..4225
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            4226..4380
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            4381..4456
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            4457..4551
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            4552..4671
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            4672..4812
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            4813..4892
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            4893..4948
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     exon            4949..5321
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5084..5089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /note="hexamer: TATAAA"
     polyA_site      5108
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
     regulatory      5299..5304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /note="hexamer: AATAAA"
     polyA_site      5321
                     /gene="ABCA6"
                     /gene_synonym="EST155051"
                     /note="major polyA site"
ORIGIN      
        1 agaaaccagg ctgtgtaaga gctgctggag taggcaccca tttaaagaaa aaatgaagaa
       61 gcagcaataa agaagttgta atcgttacct agacaaacag agaactggtt ttgacagtgt
      121 ttctagagtg ctttttatta ttttcctgac agttgtgttc caccatgatt actttctcct
      181 tcagcgaata ggctaaatga atatgaaaca gaaaagcgtg tatcagcaaa ccaaagcact
      241 tctgtgcaag aattttctta agaaatggag gatgaaaaga gagagcttat tggaatgggg
      301 cctctcaata cttctaggac tgtgtattgc tctgttttcc agttccatga gaaatgtcca
      361 gtttcctgga atggctcctc agaatctggg aagggtagat aaatttaata gctcttcttt
      421 aatggttgtg tatacaccaa tatctaattt aacccagcag ataatgaata aaacagcact
      481 tgctcctctt ttgaaaggaa caagtgtcat tggggcacca aataaaacac acatggacga
      541 aatacttctg gaaaatttac catatgctat gggaatcatc tttaatgaaa ctttctctta
      601 taagttaata tttttccagg gatataacag tccactttgg aaagaagatt tctcagctca
      661 ttgctgggat ggatatggtg agttttcatg tacattgacc aaatactgga atagaggatt
      721 tgtggcttta caaacagcta ttaatactgc cattatagaa atcacaacca atcaccctgt
      781 gatggaggag ttgatgtcag ttactgctat aactatgaag acattacctt tcataactaa
      841 aaatcttctt cacaatgaga tgtttatttt attcttcttg cttcatttct ccccacttgt
      901 atattttata tcactcaatg taacaaaaga gagaaaaaag tctaagaatt tgatgaaaat
      961 gatgggtctc caagattcag cattctggct ctcctggggt ctaatctatg ctggcttcat
     1021 ctttattatt tccatattcg ttacaattat cataacattc acccaaatta tagtcatgac
     1081 tggcttcatg gtcatattta tactcttttt tttatatggc ttatctttgg tagctttggt
     1141 gttcctgatg agtgtgctgt taaagaaagc tgtcctcacc aatttggttg tgtttctcct
     1201 taccctcttt tggggatgtc tgggattcac tgtattttat gaacaacttc cttcatctct
     1261 ggagtggatt ttgaatattt gtagcccttt tgcctttact actggaatga ttcagattat
     1321 caaactggat tataacttga atggtgtaat ttttcctgac ccttcaggag actcatatac
     1381 aatgatagca actttttcta tgttgctttt ggatggtctc atctacttgc tattggcatt
     1441 atactttgac aaaattttac cctatggaga tgagcgccat tattctcctt tatttttctt
     1501 gaattcatca tcttgtttcc aacaccaaag gactaatgct aaggttattg agaaagaaat
     1561 cgatgctgag catccctctg atgattattt tgaaccagta gctcctgaat tccaaggaaa
     1621 agaagccatc agaatcagaa atgttaagaa ggaatataaa ggaaaatctg gaaaagtgga
     1681 agcattgaaa ggcttgctct ttgacatata tgaaggtcaa atcacggcaa tcctgggtca
     1741 cagtggagct ggcaaatctt cactgctaaa tattcttaat ggattgtctg ttccaacaga
     1801 aggatcagtt accatctata ataaaaatct ctctgaaatg caagacttgg aggaaatcag
     1861 aaagataact ggcgtctgtc ctcaattcaa tgttcaattt gacatactca ccgtgaagga
     1921 aaacctcagc ctgtttgcta aaataaaagg gattcatcta aaggaagtgg aacaagaggt
     1981 acaacgaata ttattggaat tggacatgca aaacattcaa gataaccttg ctaaacattt
     2041 aagtgaagga cagaaaagaa agctgacttt tgggattacc attttaggag atcctcaaat
     2101 tttgctttta gatgaaccaa ctactggatt ggatcccttt tccagagatc aagtgtggag
     2161 cctcctgaga gagcgtagag cagatcatgt gatccttttc agtacccagt ccatggatga
     2221 ggctgacatc ctggctgata gaaaagtgat catgtccaat gggagactga agtgtgcagg
     2281 ttcttctatg tttttgaaaa gaaggtgggg tcttggatat cacctaagtt tacataggaa
     2341 tgaaatatgt aacccagaac aaataacatc cttcattact catcacatcc ccgatgctaa
     2401 attaaaaaca gaaaacaaag aaaagcttgt atatactttg ccactggaaa ggacaaatac
     2461 atttccagat cttttcagtg atctggataa gtgttctgac cagggagtga caggttatga
     2521 catttccatg tcaactctaa atgaagtctt tatgaaactg gaaggacagt caactatcga
     2581 acaagatttc gaacaagtgg agatgataag agactcagaa agcctcaatg aaatggagct
     2641 ggctcactct tccttctctg aaatgcagac agctgtgagt gacatgggcc tctggagaat
     2701 gcaagtcttt gccatggcac ggctccgttt cttaaagtta aaacgtcaaa ctaaagtgtt
     2761 attgacccta ttattggtat ttggaatcgc aatattccct ttgattgttg aaaatataat
     2821 gtatgctatg ttaaatgaaa agatcgattg ggaatttaaa aacgaattgt attttctctc
     2881 tcctggacaa cttccccagg aaccccgtac cagcctgttg atcatcaata acacagaatc
     2941 aaatattgaa gattttataa aatcactgaa gcatcaaaat atacttttgg aagtagatga
     3001 ctttgaaaac agaaatggta ctgatggcct ctcatacaat ggagctatca tagtttctgg
     3061 taaacaaaag gattatagat tttcagttgt gtgtaatacc aagagattgc actgttttcc
     3121 aattcttatg aatattatca gcaatgggct acttcaaatg tttaatcaca cacaacatat
     3181 tcgaattgag tcaagcccat ttcctcttag ccacatagga ctctggactg ggttgccgga
     3241 tggttccttt ttcttatttt tggttctatg tagcatttct ccttatatca ccatgggcag
     3301 catcagtgat tacaagaaaa atgctaagtc ccagctatgg atttcaggcc tctacacttc
     3361 tgcttactgg tgtgggcagg cactagtgga cgtcagcttc ttcattttaa ttctcctttt
     3421 aatgtattta attttctaca tagaaaacat gcagtacctt cttattacaa gccaaattgt
     3481 gtttgctttg gttatagtta ctcctggtta tgcagcttct cttgtcttct tcatatatat
     3541 gatatcattt atttttcgca aaaggagaaa aaacagtggc ctttggtcat tttacttctt
     3601 ttttgcctcc accatcatgt tttccatcac tttaatcaat cattttgacc taagtatatt
     3661 gattaccacc atggtattgg ttccttcata taccttgctt ggatttaaaa cttttttgga
     3721 agtgagagac caggagcact acagagaatt tccagaggca aattttgaat tgagtgccac
     3781 tgattttcta gtctgcttca taccctactt tcagactttg ctattcgttt ttgttctaag
     3841 atgcatggaa ctaaaatgtg gaaagaaaag aatgcgaaaa gatcctgttt tcagaatttc
     3901 cccccaaagt agagatgcta agccaaatcc agaagaaccc atagatgaag atgaagatat
     3961 tcaaacagaa agaataagaa cagccactgc tctgaccact tcaatcttag atgagaaacc
     4021 tgttataatt gccagctgtc tacacaaaga atatgcaggc cagaagaaaa gttgcttttc
     4081 aaagaggaag aagaaaatag cagcaagaaa tatctctttc tgtgttcaag aaggtgaaat
     4141 tttgggattg ctaggaccca atggtgctgg aaaaagttca tctattagaa tgatatctgg
     4201 gatcacaaag ccaactgctg gagaggtgga actgaaaggc tgcagttcag ttttgggcca
     4261 cctggggtac tgccctcaag agaacgtgct gtggcccatg ctgacgttga gggaacacct
     4321 ggaggtgtat gctgccgtca aggggctcag gaaagcggac gcgaggctcg ccatcgcaag
     4381 attagtgagt gctttcaaac tgcatgagca gctgaatgtt cctgtgcaga aattaacagc
     4441 aggaatcacg agaaagttgt gttttgtgct gagcctcctg ggaaactcac ctgtcttgct
     4501 cctggatgaa ccatctacgg gcatagaccc cacagggcag cagcaaatgt ggcaggcaat
     4561 ccaggcagtc gttaaaaaca cagagagagg tgtcctcctg accacccata acctggctga
     4621 ggcggaagcc ttgtgtgacc gtgtggccat catggtgtct ggaaggctta gatgcattgg
     4681 ctccatccaa cacctgaaaa acaaacttgg caaggattac attctagagc taaaagtgaa
     4741 ggaaacgtct caagtgactt tggtccacac tgagattctg aagcttttcc cacaggctgc
     4801 agggcaggaa aggtattcct ctttgttaac ctataagctg cccgtggcag acgtttaccc
     4861 tctatcacag acctttcaca aattagaagc agtgaagcat aactttaacc tggaagaata
     4921 cagcctttct cagtgcacac tggagaaggt attcttagag ctttctaaag aacaggaagt
     4981 aggaaatttt gatgaagaaa ttgatacaac aatgagatgg aaactcctcc ctcattcaga
     5041 tgaaccttaa aacctcaaac ctagtaattt tttgttgatc tcctataaac tcatgtttta
     5101 tgtaataatt aatagtatgt ttaattttaa agatcattta aaattaacat caggtatatt
     5161 ttgtaaattt agttaacaaa tacataaatt ttaaaattat tcttcctctc aaacataggg
     5221 gtgatagcaa acctgtgata aaggcaatac aaaatattag taaagtcacc caaagagtca
     5281 ggcactgggt attgtggaaa taaaactata taaacttaga a
//
