LOCUS       NM_172232               8252 bp    mRNA    linear   PRI 20-OCT-2024
DEFINITION  Homo sapiens ATP binding cassette subfamily A member 5 (ABCA5),
            transcript variant 2, mRNA.
ACCESSION   NM_172232
VERSION     NM_172232.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8252)
  AUTHORS   Palmer,M.A., Dias,I.H.K., Smart,E., Benatzy,Y. and Haslam,I.S.
  TITLE     Cholesterol homeostasis in hair follicle keratinocytes is disrupted
            by impaired ABCA5 activity
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1868 (9), 159361 (2023)
   PUBMED   37348644
  REMARK    GeneRIF: Cholesterol homeostasis in hair follicle keratinocytes is
            disrupted by impaired ABCA5 activity.
REFERENCE   2  (bases 1 to 8252)
  AUTHORS   Raza,R., Ullah,A., Haider,N., Krishin,J., Shah,M., Khan,F.U.,
            Abdullah, Hansen,T., Raza,S.I., Ahmad,W. and Basit,S.
  TITLE     Exome sequencing reveals the first intragenic deletion in ABCA5
            underlying autosomal recessive hypertrichosis
  JOURNAL   Clin Exp Dermatol 47 (6), 1137-1143 (2022)
   PUBMED   35150007
  REMARK    GeneRIF: Exome sequencing reveals the first intragenic deletion in
            ABCA5 underlying autosomal recessive hypertrichosis.
REFERENCE   3  (bases 1 to 8252)
  AUTHORS   Palmer,M.A., Smart,E. and Haslam,I.S.
  TITLE     Localisation and regulation of cholesterol transporters in the
            human hair follicle: mapping changes across the hair cycle
  JOURNAL   Histochem Cell Biol 155 (5), 529-545 (2021)
   PUBMED   33404706
  REMARK    GeneRIF: Localisation and regulation of cholesterol transporters in
            the human hair follicle: mapping changes across the hair cycle.
REFERENCE   4  (bases 1 to 8252)
  AUTHORS   Ray,A.G., Choudhury,K.R., Chakraborty,S., Chakravarty,D.,
            Chander,V., Jana,B., Siddiqui,K.N. and Bandyopadhyay,A.
  TITLE     Novel Mechanism of Cholesterol Transport by ABCA5 in Macrophages
            and Its Role in Dyslipidemia
  JOURNAL   J Mol Biol 432 (17), 4922-4941 (2020)
   PUBMED   32687853
  REMARK    GeneRIF: Novel Mechanism of Cholesterol Transport by ABCA5 in
            Macrophages and Its Role in Dyslipidemia.
REFERENCE   5  (bases 1 to 8252)
  AUTHORS   Fu,Y., Hsiao,J.H., Paxinos,G., Halliday,G.M. and Kim,W.S.
  TITLE     ABCA5 regulates amyloid-beta peptide production and is associated
            with Alzheimer's disease neuropathology
  JOURNAL   J Alzheimers Dis 43 (3), 857-869 (2015)
   PUBMED   25125465
  REMARK    GeneRIF: This report represents the first extensive expression and
            functional study of ABCA5 in the human brain and our data suggest a
            plausible function of ABCA5 in the brain as a cholesterol
            transporter associated with Abeta generation
REFERENCE   6  (bases 1 to 8252)
  AUTHORS   Hu,Y., Wang,M., Veverka,K., Garcia,F.U. and Stearns,M.E.
  TITLE     The ABCA5 protein: a urine diagnostic marker for prostatic
            intraepithelial neoplasia
  JOURNAL   Clin Cancer Res 13 (3), 929-938 (2007)
   PUBMED   17289887
  REMARK    GeneRIF: ABCA5 may have a role in prostatic intraepithelial
            neoplasia
REFERENCE   7  (bases 1 to 8252)
  AUTHORS   Kubo,Y., Sekiya,S., Ohigashi,M., Takenaka,C., Tamura,K., Nada,S.,
            Nishi,T., Yamamoto,A. and Yamaguchi,A.
  TITLE     ABCA5 resides in lysosomes, and ABCA5 knockout mice develop
            lysosomal disease-like symptoms
  JOURNAL   Mol Cell Biol 25 (10), 4138-4149 (2005)
   PUBMED   15870284
  REMARK    Erratum:[Mol Cell Biol. 2005 Jul;25(13):5786]
REFERENCE   8  (bases 1 to 8252)
  AUTHORS   Petry,F., Kotthaus,A. and Hirsch-Ernst,K.I.
  TITLE     Cloning of human and rat ABCA5/Abca5 and detection of a human
            splice variant
  JOURNAL   Biochem Biophys Res Commun 300 (2), 343-350 (2003)
   PUBMED   12504089
  REMARK    GeneRIF: Cloning of ABCA5 and detection of a splice variant.
REFERENCE   9  (bases 1 to 8252)
  AUTHORS   Dean,M., Rzhetsky,A. and Allikmets,R.
  TITLE     The human ATP-binding cassette (ABC) transporter superfamily
  JOURNAL   Genome Res 11 (7), 1156-1166 (2001)
   PUBMED   11435397
  REMARK    Review article
REFERENCE   10 (bases 1 to 8252)
  AUTHORS   Allikmets,R., Gerrard,B., Hutchinson,A. and Dean,M.
  TITLE     Characterization of the human ABC superfamily: isolation and
            mapping of 21 new genes using the expressed sequence tags database
  JOURNAL   Hum Mol Genet 5 (10), 1649-1655 (1996)
   PUBMED   8894702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB096625.1, AJ275973.3,
            AC115085.4, AK058170.1, AC005495.2 and KF456324.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_172232.3.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intracellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            and White). This encoded protein is a member of the ABC1 subfamily.
            Members of the ABC1 subfamily comprise the only major ABC subfamily
            found exclusively in multicellular eukaryotes. This gene is
            clustered among 4 other ABC1 family members on 17q24, but neither
            the substrate nor the function of this gene is known. Alternative
            splicing of this gene results in several transcript variants;
            however, not all variants have been fully described. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) represents the shorter
            transcript variant. It contains a distinct 5' UTR compared to
            transcript variant 1, but encodes the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The extent of this RefSeq
            transcript is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.49939.1,
                                           SRR1803617.206054.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392676.8/ ENSP00000376443.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                DB096625.1         50-81
            33-2590             AJ275973.3         1-2558
            2591-2591           AC115085.4         128196-128196
            2592-4165           AJ275973.3         2560-4133
            4166-5215           AK058170.1         511-1560
            5216-7379           AC005495.2         165139-167302       c
            7380-7380           KF456324.1         197-197
            7381-8128           AC005495.2         164390-165137       c
            8129-8252           AC005495.2         164266-164389       c
FEATURES             Location/Qualifiers
     source          1..8252
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q24.3"
     gene            1..8252
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /note="ATP binding cassette subfamily A member 5"
                     /db_xref="GeneID:23461"
                     /db_xref="HGNC:HGNC:35"
                     /db_xref="MIM:612503"
     exon            1..82
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            83..199
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..5026
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /note="ATP-binding cassette A5; ATP-binding cassette,
                     sub-family A (ABC1), member 5"
                     /codon_start=1
                     /product="cholesterol transporter ABCA5"
                     /protein_id="NP_758424.1"
                     /db_xref="CCDS:CCDS11685.1"
                     /db_xref="GeneID:23461"
                     /db_xref="HGNC:HGNC:35"
                     /db_xref="MIM:612503"
                     /translation="MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLF
                     WLILISMMHPNKKYEEVPNIELNPMDKFTLSNLILGYTPVTNITSSIMQKVSTDHLPD
                     VIITEEYTNEKEMLTSSLSKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCS
                     KSCEAAQYWSSGFTVLQASIDAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPR
                     GVILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFL
                     MSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFV
                     TVAFGFIGLMIILIESFPKSLVWLFSPFCHCTFVIGIAQVMHLEDFNEGASFSNLTAG
                     PYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEEL
                     SEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQ
                     ITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQLDI
                     HFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLS
                     LGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADR
                     KAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCATESLSSLVKQHIPGATLLQQN
                     DQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQAD
                     YSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAALVSTMSLWKQQMYTIAKFHFFTLK
                     RESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIKLVPDLYFLKPGDKPHKYKTS
                     LLLQNSADSDISDLISFFTSQNIMVTMINDSDYVSVAPHSAALNVMHSEKDYVFAAVF
                     NSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTPFFQEITDIVFKIELYFQAALLGI
                     IVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLGSL
                     LAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAAL
                     ACIAITEITFFMGYTIATILHYAFCIIIPIYPLLGCLISFIKISWKNVRKNVDTYNPW
                     DRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPDNE
                     DEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYIS
                     FCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGY
                     CPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAG
                     IKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYME
                     EAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREIQY
                     IFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFV
                     ELTKEQEEEDNSCGTLNSTLWWERTQEDRVVF"
     exon            200..404
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            405..566
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            567..655
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            656..885
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1027
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1216
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1364
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1533
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1592
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1703
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1879
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1999
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2138
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2229
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2369
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2489
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2691
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2861
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..2989
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            2990..3127
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            3128..3241
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            3242..3412
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            3413..3526
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            3527..3661
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            3662..3736
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            3737..3828
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            3829..3955
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            3956..4073
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            4074..4165
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            4166..4341
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            4342..4417
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            4418..4512
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            4513..4632
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            4633..4782
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            4783..4862
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            4863..4918
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     exon            4919..8252
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5196..5201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /note="hexamer: AATAAA"
     polyA_site      5222
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /note="major polyA site"
     regulatory      5893..5898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /note="hexamer: AATAAA"
     polyA_site      5913
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
     regulatory      6026..6031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /note="hexamer: AATAAA"
     polyA_site      6052
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
     regulatory      8101..8106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /note="hexamer: AATAAA"
     polyA_site      8126
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
     regulatory      8221..8226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
                     /note="hexamer: ATTAAA"
     polyA_site      8252
                     /gene="ABCA5"
                     /gene_synonym="ABC13; DEL17q24; EST90625; HTC3; HTGH"
ORIGIN      
        1 acagatccca gctgggtcac ccgcactgag tcaacagact gagcgcgtcc aggcctgaca
       61 gctctgcggc tcgggccctg aggtttattc agaaaacatg tccactgcaa ttagggaggt
      121 aggagtttgg agacagacca gaacacttct actgaagaat tacttaatta aatgcagaac
      181 caaaaagagt agtgttcagg aaattctttt tccactattt tttttatttt ggttaatatt
      241 aattagcatg atgcatccaa ataagaaata tgaagaagtg cctaatatag aactcaatcc
      301 tatggacaag tttactcttt ctaatctaat tcttggatat actccagtga ctaatattac
      361 aagcagcatc atgcagaaag tgtctactga tcatctacct gatgtcataa ttactgaaga
      421 atatacaaat gaaaaagaaa tgttaacatc cagtctctct aagccgagca actttgtagg
      481 tgtggttttc aaagactcca tgtcctatga acttcgtttt tttcctgata tgattccagt
      541 atcttctatt tatatggatt caagagctgg ctgttcaaaa tcatgtgagg ctgctcagta
      601 ctggtcctca ggtttcacag ttttacaagc atccatagat gctgccatta tacagttgaa
      661 gaccaatgtt tctctttgga aggagctgga gtcaactaaa gctgttatta tgggagaaac
      721 tgctgttgta gaaatagata cctttccccg aggagtaatt ttaatatacc tagttatagc
      781 attttcacct tttggatact ttttggcaat tcatatcgta gcagaaaaag aaaaaaaaat
      841 aaaagaattt ttaaagataa tgggacttca tgatactgcc ttttggcttt cctgggttct
      901 tctatataca agtttaattt ttcttatgtc ccttcttatg gcagtcattg cgacagcttc
      961 tttgttattt cctcaaagta gcagcattgt gatatttctg ctttttttcc tttatggatt
     1021 atcatctgta ttttttgctt taatgctgac acctcttttt aaaaaatcaa aacatgtggg
     1081 aatagttgaa ttttttgtta ctgtggcttt tggatttatt ggccttatga taatcctcat
     1141 agaaagtttt cccaaatcgt tagtgtggct tttcagtcct ttctgtcact gtacttttgt
     1201 gattggtatt gcacaggtca tgcatttaga agattttaat gaaggtgctt cattttcaaa
     1261 tttgactgca ggcccatatc ctctaattat tacaattatc atgctcacac ttaatagtat
     1321 attctatgtc ctcttggctg tctatcttga tcaagtcatt ccaggggaat ttggcttacg
     1381 gagatcatct ttatattttc tgaagccttc atattggtca aagagcaaaa gaaattatga
     1441 ggagttatca gagggcaatg ttaatggaaa tattagtttt agtgaaatta ttgagccagt
     1501 ttcttcagaa tttgtaggaa aagaagccat aagaattagt ggtattcaga agacatacag
     1561 aaagaagggt gaaaatgtgg aggctttgag aaatttgtca tttgacatat atgagggtca
     1621 gattactgcc ttacttggcc acagtggaac aggaaagagt acattgatga atattctttg
     1681 tggactctgc ccaccttctg atgggtttgc atctatatat ggacacagag tctcagaaat
     1741 agatgaaatg tttgaagcaa gaaaaatgat tggcatttgt ccacagttag atatacactt
     1801 tgatgttttg acagtagaag aaaatttatc aattttggct tcaatcaaag ggataccagc
     1861 caacaatata atacaagaag tgcagaaggt tttactagat ttagacatgc agactatcaa
     1921 agataaccaa gctaaaaaat taagtggtgg tcaaaaaaga aagctgtcat taggaattgc
     1981 tgttcttggg aacccaaaga tactgctgct agatgaacca acagctggaa tggacccctg
     2041 ttctcgacat attgtatgga atcttttaaa atacagaaaa gccaatcggg tgacagtgtt
     2101 cagtactcat ttcatggatg aagctgacat tcttgcagat aggaaagctg tgatatcaca
     2161 aggaatgctg aaatgtgttg gttcttcaat gttcctcaaa agtaaatggg ggatcggcta
     2221 ccgcctgagc atgtacatag acaaatattg tgccacagaa tctctttctt cactggttaa
     2281 acaacatata cctggagcta ctttattaca acagaatgac caacaacttg tgtatagctt
     2341 gcctttcaag gacatggaca aattttcagg tttgttttct gccctagaca gtcattcaaa
     2401 tttgggtgtc atttcttatg gtgtttccat gacgactttg gaagacgtat ttttaaagct
     2461 agaagttgaa gcagaaattg accaagcaga ttatagtgta tttactcagc agccactgga
     2521 ggaagaaatg gattcaaaat cttttgatga aatggaacag agcttactta ttctttctga
     2581 aaccaaggct gctctagtga gcaccatgag cctttggaaa caacagatgt atacaatagc
     2641 aaagtttcat ttctttacct tgaaacgtga aagtaaatca gtgagatcag tgttgcttct
     2701 gcttttaatt tttttcacag ttcagatttt tatgtttttg gttcatcact cttttaaaaa
     2761 tgctgtggtt cccatcaaac ttgttccaga cttatatttt ctaaaacctg gagacaaacc
     2821 acataaatac aaaacaagtc tgcttcttca aaattctgct gactcagata tcagtgatct
     2881 tattagcttt ttcacaagcc agaacataat ggtgacgatg attaatgaca gtgactatgt
     2941 atccgtggct ccccatagtg cggctttaaa tgtgatgcat tcagaaaagg actatgtttt
     3001 tgcagctgtt ttcaacagta ctatggttta ttctttacct atattagtga atatcattag
     3061 taactactat ctttatcatt taaatgtgac tgaaaccatc cagatctgga gtaccccatt
     3121 ctttcaagaa attactgata tagtttttaa aattgagctg tattttcaag cagctttgct
     3181 tggaatcatt gttactgcaa tgccacctta ctttgccatg gaaaatgcag agaatcataa
     3241 gatcaaagct tatactcaac ttaaactttc aggtcttttg ccatctgcat attggattgg
     3301 acaagctgtt gttgatatcc ccttattttt tatcattctt attttgatgc taggaagctt
     3361 attggcattt cattatggat tatattttta tactgtaaag ttccttgctg tggttttttg
     3421 ccttattggt tatgttccat cagttattct gttcacttat attgcttctt tcacctttaa
     3481 gaaaatttta aataccaaag aattttggtc atttatctat tctgtggcag cgttggcttg
     3541 tattgcaatc actgaaataa ctttctttat gggatacaca attgcaacta ttcttcatta
     3601 tgccttttgt atcatcattc caatctatcc acttctaggt tgcctgattt ctttcataaa
     3661 gatttcttgg aagaatgtac gaaaaaatgt ggacacctat aatccatggg ataggctttc
     3721 agtagctgtt atatcgcctt acctgcagtg tgtactgtgg attttcctct tacaatacta
     3781 tgagaaaaaa tatggaggca gatcaataag aaaagatccc tttttcagaa acctttcaac
     3841 gaagtctaaa aataggaagc ttccagaacc accagacaat gaggatgaag atgaagatgt
     3901 caaagctgaa agactaaagg tcaaagagct gatgggttgc cagtgttgtg aggagaaacc
     3961 atccattatg gtcagcaatt tgcataaaga atatgatgac aagaaagatt ttcttctttc
     4021 aagaaaagta aagaaagtgg caactaaata catctctttc tgtgtgaaaa aaggagagat
     4081 cttaggacta ttgggtccaa atggtgctgg caaaagcaca attattaata ttctggttgg
     4141 tgatattgaa ccaacttcag gccaggtatt tttaggagat tattcttcag agacaagtga
     4201 agatgatgat tcactgaagt gtatgggtta ctgtcctcag ataaaccctt tgtggccaga
     4261 tactacattg caggaacatt ttgaaattta tggagctgtc aaaggaatga gtgcaagtga
     4321 catgaaagaa gtcataagtc gaataacaca tgcacttgat ttaaaagaac atcttcagaa
     4381 gactgtaaag aaactacctg caggaatcaa acgaaagttg tgttttgctc taagtatgct
     4441 agggaatcct cagattactt tgctagatga accatctaca ggtatggatc ccaaagccaa
     4501 acagcacatg tggcgagcaa ttcgaactgc atttaaaaac agaaagcggg ctgctattct
     4561 gaccactcac tatatggagg aggcagaggc tgtctgtgat cgagtagcta tcatggtgtc
     4621 tgggcagtta agatgtatcg gaacagtaca acatctaaag agtaaatttg gaaaaggcta
     4681 ctttttggaa attaaattga aggactggat agaaaaccta gaagtagacc gccttcaaag
     4741 agaaattcag tatattttcc caaatgcaag ccgtcaggaa agtttttctt ctattttggc
     4801 ttataaaatt cctaaggaag atgttcagtc cctttcacaa tcttttttta agctggaaga
     4861 agctaaacat gcttttgcca ttgaagaata tagcttttct caagcaacat tggaacaggt
     4921 ttttgtagaa ctcactaaag aacaagagga ggaagataat agttgtggaa ctttaaacag
     4981 cacactttgg tgggaacgaa cacaagaaga tagagtagta ttttgaattt gtattgttcg
     5041 gtctgcttac tgggacttct ttctttttca cttaatttta actttggttt aaaaagtttt
     5101 ttattggaat ggtaactgga gaaccaagaa cgcacttgaa atttttctaa gctccttaat
     5161 tgaaatgctg tggttgtgtg ttttgctttt ctttaaataa aacgtatgta taattaagtg
     5221 aagctgcatg tttgtattga agtatattga actatatagt ttgtatgtca tctttttcac
     5281 cattcagaaa cagtgcttct gaatttgtga tttaaaggaa ttgtaataga atagttttat
     5341 ttttaagtta tctttaagtt tatgccatct tcttaaataa gtacgtaatg ttccaatcta
     5401 aataaaaaac taattcataa ctaatgcata gaaaagatac ataaagcaat gtgaaagttt
     5461 cttgcttctc ctttttaatt tctaaaaaag ccactttgaa tggaagttgt catccgtaaa
     5521 agctgaagtg taagcactag gaaatctcaa tatagagatt tgaggaaagt tatatccact
     5581 aggtggcagt cattgatcat aataagtgaa atgagccctt gttctagtac atgattttag
     5641 gcttaggtaa ttaggtatgt gaaattacat ttctttaatt taaagtaaaa ttcagaaggt
     5701 tttagttatt ataattaaag gaagactgtg tgtagaatct tacgtaatag tctgattctt
     5761 tgactctgtg gctagaatga cagttatcta tggaggtggt agaattaagc catacctttt
     5821 ccttcatcac tcttggaaca tataaatttt ttgtcatctt ccttgcaaag ggcacattta
     5881 attttgttct tgaataaaat attttattgg gtatttgttt ttattggtaa actttagtga
     5941 atctcttcta taaaattgta agtagatcag tgtgtagatt tatttagtaa cttacctcat
     6001 tgactttgga acatggtagg atatgaataa actctttcaa gggttaaatt aagaattgta
     6061 agtgcagtgc gcctatttct ttttaataag aaccagaatt tcatttttga tagagttaaa
     6121 ggcatggcta atattttctt agaaatactt ccttgtacaa cccatgtatt ggctcaaggt
     6181 ataaaatagt gtaaataatg ctagttgaca ttacatttca accaaatgaa agtattaact
     6241 tcataaaaca aatatattga gagtgtgatt attgtattag acaacaacaa cagcaatgac
     6301 agaaggattt ggtactgaat tactttaaat aagcaaaacc tttcagtggc attattcatt
     6361 ctttaatgta ggcaaaattt aatgaacttt tagctttatt gtgtaataag acatctgtga
     6421 ttttaggctc tagcagtgga tttaaaagtg ttctttctcg gtacaaagta cgtggctgat
     6481 attttccccc attgctgggg gcagttgcta tacactttcc taaagtatat ataatgttca
     6541 cataaatacc cagggacctc ttttttggga tgtgcttttg taattatgtg taaccttgaa
     6601 tacttaagtt tagtaaaagc aacaaaatta tatctatagt ttactaaggc agtcacgaaa
     6661 aagcatagtt ttttttagaa cctgaccatc ctaagaaagt tatgtcatct gaagatagag
     6721 catgactaat gaagaaaatt acctgctttt gcacgtagat ttggtaactt tcactttaca
     6781 tttgtgaatg tgtaattggt gcaaagtaaa ttttttttcc tgcaaagtga aagttgagta
     6841 gtcacaatca tgttatttat tttgttcatt tagttacttt gcttttaatg tatatgaata
     6901 catgctcttg taaacaattt taaaagacat tcaaattttt ttttagtttt tatatactca
     6961 gaatatattt tggttgttaa attaaattat gttccctttt tcacagtaac aaaatctgac
     7021 tcaggagaaa tataacttaa ttcttaggaa aacaagggta agtgagctgg aaagcaaagg
     7081 aggcaaaaag tgaaatatat ttatttacag tgtacagttc atgtttatga acatactaat
     7141 tttaaaatgt cttaaattac tgatctcaaa acttttttct atgtcagtac agataaataa
     7201 ataaatatac atattaggca aaagcaacat caccaacctt atatttccca ttcatggtca
     7261 aattttcaaa ggaaagtaaa agctgagctt tactgagtga gtgtttactg actaataagg
     7321 caagaaaaaa catgatgagt gtactttaca tcttactttt gtgggctctt aatttttttt
     7381 tctagtttgt tttcagtaaa gacagtgggt tttctttaaa ataatttttt tcttttaaat
     7441 ttgcacaaat tatcttaggt cagtattttg gttttaatca ttaaaacatt tttagagtaa
     7501 tgtaatttaa caaatatttt aagtgattat gtttccagaa atggattctt tggagagaac
     7561 tcggatgact atcagttttg gccctgtaag atcgtggaga tctgtaagat agatacttat
     7621 ataacttaca taaaatatat ataatatatt acttatataa cttatataac tagctattat
     7681 tttatataac taactataat atgacaaatc ctttgctagt agtactaaca acgttttata
     7741 ggagcacaat taattttact taggataagt gttgttatta ttgtttttat tgttgttctg
     7801 ttagttactc aaaacttcat tctaattgtg ccctgagttt gttaaaatac catactgtat
     7861 ttttgtgtaa catgtaaata ggcattaatt tttgagaaat agaaatgttt atccttaatg
     7921 tatttttaat ttgctaacat tgatttttta ttttctttcc tgaaatagct tatttcctaa
     7981 aatgaaagaa tttattctca gatgaataat ttttatatca gctattctta tcaggtaaaa
     8041 gtttaattat tttttattta taatatatgt aagcaattct caatgctgct ctttaagaaa
     8101 aataaatatg attatattaa taataagctt taagagttga aaatttaaga caagtcattt
     8161 tgtatactga agtgaattct ttgttattta gtgctgataa ttgaataatg agtagctcat
     8221 attaaaaatg atgcaaaaac ctggcactaa aa
//
