LOCUS       NM_000350               7328 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens ATP binding cassette subfamily A member 4 (ABCA4),
            transcript variant 1, mRNA.
ACCESSION   NM_000350
VERSION     NM_000350.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7328)
  AUTHORS   Cevik,S., Biswas,S.B., Ghosh,A. and Biswas-Fiss,E.E.
  TITLE     Virus-like particles as robust tools for functional assessment:
            Deciphering the pathogenicity of ABCA4 genetic variants of
            uncertain significance
  JOURNAL   J Biol Chem 300 (10), 107739 (2024)
   PUBMED   39222682
  REMARK    GeneRIF: Virus-like particles as robust tools for functional
            assessment: Deciphering the pathogenicity of ABCA4 genetic variants
            of uncertain significance.
REFERENCE   2  (bases 1 to 7328)
  AUTHORS   Scortecci,J.F., Garces,F.A., Mahto,J.K., Molday,L.L., Van
            Petegem,F. and Molday,R.S.
  TITLE     Structural and functional characterization of the
            nucleotide-binding domains of ABCA4 and their role in Stargardt
            disease
  JOURNAL   J Biol Chem 300 (9), 107666 (2024)
   PUBMED   39128720
  REMARK    GeneRIF: Structural and functional characterization of the
            nucleotide-binding domains of ABCA4 and their role in Stargardt
            disease.
REFERENCE   3  (bases 1 to 7328)
  AUTHORS   Chacon-Camacho,O.F., Xilotl-de Jesus,N., Calderon-Martinez,E.,
            Ordonez-Labastida,V., Neria-Gonzalez,M.I., Villafuerte-de la
            Cruz,R., Martinez-Rojas,A. and Zenteno,J.C.
  TITLE     Genotypic spectrum of ABCA4-associated retinal degenerations in 211
            unrelated Mexican patients: identification of 22 novel
            disease-causing variants
  JOURNAL   Mol Genet Genomics 299 (1), 79 (2024)
   PUBMED   39162841
  REMARK    GeneRIF: Genotypic spectrum of ABCA4-associated retinal
            degenerations in 211 unrelated Mexican patients: identification of
            22 novel disease-causing variants.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7328)
  AUTHORS   Corradi,Z., Dhaenens,C.M., Grunewald,O., Kocabas,I.S., Meunier,I.,
            Banfi,S., Karali,M., Cremers,F.P.M. and Hitti-Malin,R.J.
  TITLE     Novel and Recurrent Copy Number Variants in ABCA4-Associated
            Retinopathy
  JOURNAL   Int J Mol Sci 25 (11), 5940 (2024)
   PUBMED   38892127
  REMARK    GeneRIF: Novel and Recurrent Copy Number Variants in
            ABCA4-Associated Retinopathy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7328)
  AUTHORS   Allikmets,R., Wasserman,W.W., Hutchinson,A., Smallwood,P.,
            Nathans,J., Rogan,P.K., Schneider,T.D. and Dean,M.
  TITLE     Organization of the ABCR gene: analysis of promoter and splice
            junction sequences
  JOURNAL   Gene 215 (1), 111-122 (1998)
   PUBMED   9666097
REFERENCE   6  (bases 1 to 7328)
  AUTHORS   Azarian,S.M., Megarity,C.F., Weng,J., Horvath,D.H. and Travis,G.H.
  TITLE     The human photoreceptor rim protein gene (ABCR): genomic structure
            and primer set information for mutation analysis
  JOURNAL   Hum Genet 102 (6), 699-705 (1998)
   PUBMED   9703434
REFERENCE   7  (bases 1 to 7328)
  AUTHORS   Allikmets,R., Singh,N., Sun,H., Shroyer,N.F., Hutchinson,A.,
            Chidambaram,A., Gerrard,B., Baird,L., Stauffer,D., Peiffer,A.,
            Rattner,A., Smallwood,P., Li,Y., Anderson,K.L., Lewis,R.A.,
            Nathans,J., Leppert,M., Dean,M. and Lupski,J.R.
  TITLE     A photoreceptor cell-specific ATP-binding transporter gene (ABCR)
            is mutated in recessive Stargardt macular dystrophy
  JOURNAL   Nat Genet 15 (3), 236-246 (1997)
   PUBMED   9054934
  REMARK    Erratum:[Nat Genet. 1997 Sep;17(1):122. doi: 10.1038/ng0997-122a..
            PMID: 9288113]
REFERENCE   8  (bases 1 to 7328)
  AUTHORS   Martinez-Mir,A., Bayes,M., Vilageliu,L., Grinberg,D., Ayuso,C., del
            Rio,T., Garcia-Sandoval,B., Bussaglia,E., Baiget,M.,
            Gonzalez-Duarte,R. and Balcells,S.
  TITLE     A new locus for autosomal recessive retinitis pigmentosa (RP19)
            maps to 1p13-1p21
  JOURNAL   Genomics 40 (1), 142-146 (1997)
   PUBMED   9070931
REFERENCE   9  (bases 1 to 7328)
  AUTHORS   Allikmets,R., Gerrard,B., Hutchinson,A. and Dean,M.
  TITLE     Characterization of the human ABC superfamily: isolation and
            mapping of 21 new genes using the expressed sequence tags database
  JOURNAL   Hum Mol Genet 5 (10), 1649-1655 (1996)
   PUBMED   8894702
REFERENCE   10 (bases 1 to 7328)
  AUTHORS   Fahim,A.T., Daiger,S.P. and Weleber,R.G.
  TITLE     Nonsyndromic Retinitis Pigmentosa Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301590
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093579.2 and AC105278.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000350.2.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intracellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the ABC1 subfamily. Members of
            the ABC1 subfamily comprise the only major ABC subfamily found
            exclusively in multicellular eukaryotes. This protein is a
            retina-specific ABC transporter with N-retinylidene-PE as a
            substrate. It is expressed exclusively in retina photoreceptor
            cells, and the gene product mediates transport of an essental
            molecule, all-trans-retinal aldehyde (atRAL), across the
            photoreceptor cell membrane. Mutations in this gene are found in
            patients diagnosed with Stargardt disease, a form of juvenile-onset
            macular degeneration. Mutations in this gene are also associated
            with retinitis pigmentosa-19, cone-rod dystrophy type 3,
            early-onset severe retinal dystrophy, fundus flavimaculatus, and
            macular degeneration age-related 2. [provided by RefSeq, Sep 2019].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB210040.1, AF000148.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370225.4/ ENSP00000359245.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               AC093579.2         39620-39788
            170-263             AC093579.2         47702-47795
            264-405             AC093579.2         49189-49330
            406-545             AC093579.2         52052-52191
            546-673             AC093579.2         57626-57753
            674-871             AC093579.2         61777-61974
            872-961             AC093579.2         77327-77416
            962-1202            AC093579.2         80050-80290
            1203-1342           AC093579.2         81307-81446
            1343-1459           AC093579.2         82062-82178
            1460-1657           AC093579.2         82881-83078
            1658-1863           AC093579.2         97451-97656
            1864-2040           AC093579.2         98015-98191
            2041-2263           AC093579.2         100009-100231
            2264-2485           AC093579.2         103946-104167
            2486-2690           AC093579.2         105453-105657
            2691-2756           AC093579.2         109070-109135
            2757-2846           AC093579.2         111811-111900
            2847-3021           AC093579.2         113675-113849
            3022-3153           AC093579.2         116024-116155
            3154-3293           AC093579.2         117293-117432
            3294-3431           AC093579.2         117870-118007
            3432-3625           AC093579.2         119366-119559
            3626-3710           AC093579.2         120641-120725
            3711-3916           AC093579.2         123418-123623
            3917-3965           AC093579.2         123980-124028
            3966-4231           AC093579.2         128725-128990
            4232-4356           AC093579.2         129648-129772
            4357-4455           AC093579.2         130242-130340
            4456-4642           AC093579.2         131137-131323
            4643-4737           AC093579.2         135720-135814
            4738-4770           AC093579.2         137350-137382
            4771-4876           AC093579.2         138817-138922
            4877-4951           AC093579.2         139054-139128
            4952-5121           AC093579.2         139359-139528
            5122-5299           AC093579.2         141009-141186
            5300-5415           AC093579.2         144914-145029
            5416-5563           AC093579.2         146078-146225
            5564-5687           AC093579.2         149383-149506
            5688-5817           AC093579.2         149839-149968
            5818-5938           AC093579.2         151897-152017
            5939-6001           AC093579.2         152471-152533
            6002-6108           AC093579.2         153028-153134
            6109-6250           AC093579.2         155186-155327
            6251-6385           AC105278.2         104790-104924
            6386-6489           AC105278.2         105677-105780
            6490-6582           AC105278.2         105854-105946
            6583-6832           AC105278.2         108672-108921
            6833-6919           AC105278.2         110587-110673
            6920-7328           AC105278.2         113540-113948
FEATURES             Location/Qualifiers
     source          1..7328
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.1"
     gene            1..7328
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /note="ATP binding cassette subfamily A member 4"
                     /db_xref="GeneID:24"
                     /db_xref="HGNC:HGNC:34"
                     /db_xref="MIM:601691"
     exon            1..169
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..6925
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /EC_number="7.6.2.1"
                     /note="isoform 1 is encoded by transcript variant 1; ATP
                     binding cassette transporter; ATP-binding transporter,
                     retina-specific; ATP-binding cassette transporter,
                     retinal-specific; retinal-specific ATP-binding cassette
                     transporter; photoreceptor rim protein; retinal-specific
                     phospholipid-transporting ATPase ABCA4; retina-specific
                     ABC transporter; RIM protein; RIM ABC transporter;
                     stargardt disease protein; ATP-binding cassette sub-family
                     A member 4; ATP-binding cassette, sub-family A (ABC1),
                     member 4; RIM proteinv"
                     /codon_start=1
                     /product="retinal-specific phospholipid-transporting
                     ATPase ABCA4 isoform 1"
                     /protein_id="NP_000341.2"
                     /db_xref="CCDS:CCDS747.1"
                     /db_xref="GeneID:24"
                     /db_xref="HGNC:HGNC:34"
                     /db_xref="MIM:601691"
                     /translation="MGFVRQIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRN
                     ANPLYSHHECHFPNKAMPSAGMLPWLQGIFCNVNNPCFQSPTPGESPGIVSNYNNSIL
                     ARVYRDFQELLMNAPESQHLGRIWTELHILSQFMDTLRTHPERIAGRGIRIRDILKDE
                     ETLTLFLIKNIGLSDSVVYLLINSQVRPEQFAHGVPDLALKDIACSEALLERFIIFSQ
                     RRGAKTVRYALCSLSQGTLQWIEDTLYANVDFFKLFRVLPTLLDSRSQGINLRSWGGI
                     LSDMSPRIQEFIHRPSMQDLLWVTRPLMQNGGPETFTKLMGILSDLLCGYPEGGGSRV
                     LSFNWYEDNNYKAFLGIDSTRKDPIYSYDRRTTSFCNALIQSLESNPLTKIAWRAAKP
                     LLMGKILYTPDSPAARRILKNANSTFEELEHVRKLVKAWEEVGPQIWYFFDNSTQMNM
                     IRDTLGNPTVKDFLNRQLGEEGITAEAILNFLYKGPRESQADDMANFDWRDIFNITDR
                     TLRLVNQYLECLVLDKFESYNDETQLTQRALSLLEENMFWAGVVFPDMYPWTSSLPPH
                     VKYKIRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYIWGGFAYLQDMVEQGITRSQV
                     QAEAPVGIYLQQMPYPCFVDDSFMIILNRCFPIFMVLAWIYSVSMTVKSIVLEKELRL
                     KETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHGRILHYSDPFILFLFLLAF
                     STATIMLCFLLSTFFSKASLAAACSGVIYFTLYLPHILCFAWQDRMTAELKKAVSLLS
                     PVAFGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSMQMMLLDAAVYGLLAWY
                     LDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPLTEETEDPEHPEGIH
                     DSFFEREHPGWVPGVCVKNLVKIFEPCGRPAVDRLNITFYENQITAFLGHNGAGKTTT
                     LSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQL
                     KGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEP
                     TSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLF
                     LKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQVLDGD
                     VNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGLSSF
                     GISDTPLEEIFLKVTEDSDSGPLFAGGAQQKRENVNPRHPCLGPREKAGQTPQDSNVC
                     SPGAPAAHPEGQPPPEPECPGPQLNTGTQLVLQHVQALLVKRFQHTIRSHKDFLAQIV
                     LPATFVFLALMLSIVIPPFGEYPALTLHPWIYGQQYTFFSMDEPGSEQFTVLADVLLN
                     KPGFGNRCLKEGWLPEYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTRE
                     KLTMLPECPEGAGGLPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKFWV
                     NEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGGPITREASKEIPDFLKHLE
                     TEDNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQL
                     SEITVLTTSVDAVVAICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVT
                     NFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFL
                     FDVPSTAYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLG
                     RGLIDLALSQAVTDVYARFGEEHSANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHF
                     FLSQWIAEPTKEPIVDEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSSPAVDRL
                     CVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGY
                     CPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTYSGG
                     NKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEE
                     CEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQ
                     GNFPGSVQRERHYNMLQFQVSSSSLARIFQLLLSHKDSLLIEEYSVTQTTLDQVFVNF
                     AKQQTESHDLPLHPRAAGASRQAQD"
     exon            170..263
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            264..405
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            406..545
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..673
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            674..871
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            872..961
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1202
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1342
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1459
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1657
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1863
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2040
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2263
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2485
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2690
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2756
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2846
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..3021
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3022..3153
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3154..3293
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3294..3431
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3432..3625
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3626..3710
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3711..3916
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3917..3965
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            3966..4231
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4232..4356
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4357..4455
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4456..4642
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4643..4737
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4738..4770
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4771..4876
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4877..4951
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            4952..5121
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            5122..5299
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            5300..5415
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            5416..5563
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            5564..5687
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            5688..5817
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            5818..5938
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            5939..6001
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            6002..6108
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            6109..6250
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            6251..6385
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            6386..6489
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            6490..6582
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            6583..6832
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            6833..6919
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     exon            6920..7328
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7298..7303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /note="hexamer: AATAAA"
     polyA_site      7328
                     /gene="ABCA4"
                     /gene_synonym="ABC10; ABCR; ARMD2; CORD3; FFM; RMP; RP19;
                     STGD; STGD1"
                     /note="major polyA site"
ORIGIN      
        1 ggacacagcg tccggagcca gaggcgctct taacggcgtt tatgtccttt gctgtctgag
       61 gggcctcagc tctgaccaat ctggtcttcg tgtggtcatt agcatgggct tcgtgagaca
      121 gatacagctt ttgctctgga agaactggac cctgcggaaa aggcaaaaga ttcgctttgt
      181 ggtggaactc gtgtggcctt tatctttatt tctggtcttg atctggttaa ggaatgccaa
      241 cccactctac agccatcatg aatgccattt ccccaacaag gcgatgccct cagcaggaat
      301 gctgccgtgg ctccagggga tcttctgcaa tgtgaacaat ccctgttttc aaagccccac
      361 cccaggagaa tctcctggaa ttgtgtcaaa ctataacaac tccatcttgg caagggtata
      421 tcgagatttt caagaactcc tcatgaatgc accagagagc cagcaccttg gccgtatttg
      481 gacagagcta cacatcttgt cccaattcat ggacaccctc cggactcacc cggagagaat
      541 tgcaggaaga ggaatacgaa taagggatat cttgaaagat gaagaaacac tgacactatt
      601 tctcattaaa aacatcggcc tgtctgactc agtggtctac cttctgatca actctcaagt
      661 ccgtccagag cagttcgctc atggagtccc ggacctggcg ctgaaggaca tcgcctgcag
      721 cgaggccctc ctggagcgct tcatcatctt cagccagaga cgcggggcaa agacggtgcg
      781 ctatgccctg tgctccctct cccagggcac cctacagtgg atagaagaca ctctgtatgc
      841 caacgtggac ttcttcaagc tcttccgtgt gcttcccaca ctcctagaca gccgttctca
      901 aggtatcaat ctgagatctt ggggaggaat attatctgat atgtcaccaa gaattcaaga
      961 gtttatccat cggccgagta tgcaggactt gctgtgggtg accaggcccc tcatgcagaa
     1021 tggtggtcca gagaccttta caaagctgat gggcatcctg tctgacctcc tgtgtggcta
     1081 ccccgaggga ggtggctctc gggtgctctc cttcaactgg tatgaagaca ataactataa
     1141 ggcctttctg gggattgact ccacaaggaa ggatcctatc tattcttatg acagaagaac
     1201 aacatccttt tgtaatgcat tgatccagag cctggagtca aatcctttaa ccaaaatcgc
     1261 ttggagggcg gcaaagcctt tgctgatggg aaaaatcctg tacactcctg attcacctgc
     1321 agcacgaagg atactgaaga atgccaactc aacttttgaa gaactggaac acgttaggaa
     1381 gttggtcaaa gcctgggaag aagtagggcc ccagatctgg tacttctttg acaacagcac
     1441 acagatgaac atgatcagag ataccctggg gaacccaaca gtaaaagact ttttgaatag
     1501 gcagcttggt gaagaaggta ttactgctga agccatccta aacttcctct acaagggccc
     1561 tcgggaaagc caggctgacg acatggccaa cttcgactgg agggacatat ttaacatcac
     1621 tgatcgcacc ctccgcctgg tcaatcaata cctggagtgc ttggtcctgg ataagtttga
     1681 aagctacaat gatgaaactc agctcaccca acgtgccctc tctctactgg aggaaaacat
     1741 gttctgggcc ggagtggtat tccctgacat gtatccctgg accagctctc taccacccca
     1801 cgtgaagtat aagatccgaa tggacataga cgtggtggag aaaaccaata agattaaaga
     1861 caggtattgg gattctggtc ccagagctga tcccgtggaa gatttccggt acatctgggg
     1921 cgggtttgcc tatctgcagg acatggttga acaggggatc acaaggagcc aggtgcaggc
     1981 ggaggctcca gttggaatct acctccagca gatgccctac ccctgcttcg tggacgattc
     2041 tttcatgatc atcctgaacc gctgtttccc tatcttcatg gtgctggcat ggatctactc
     2101 tgtctccatg actgtgaaga gcatcgtctt ggagaaggag ttgcgactga aggagacctt
     2161 gaaaaatcag ggtgtctcca atgcagtgat ttggtgtacc tggttcctgg acagcttctc
     2221 catcatgtcg atgagcatct tcctcctgac gatattcatc atgcatggaa gaatcctaca
     2281 ttacagcgac ccattcatcc tcttcctgtt cttgttggct ttctccactg ccaccatcat
     2341 gctgtgcttt ctgctcagca ccttcttctc caaggccagt ctggcagcag cctgtagtgg
     2401 tgtcatctat ttcaccctct acctgccaca catcctgtgc ttcgcctggc aggaccgcat
     2461 gaccgctgag ctgaagaagg ctgtgagctt actgtctccg gtggcatttg gatttggcac
     2521 tgagtacctg gttcgctttg aagagcaagg cctggggctg cagtggagca acatcgggaa
     2581 cagtcccacg gaaggggacg aattcagctt cctgctgtcc atgcagatga tgctccttga
     2641 tgctgctgtc tatggcttac tcgcttggta ccttgatcag gtgtttccag gagactatgg
     2701 aaccccactt ccttggtact ttcttctaca agagtcgtat tggcttggcg gtgaagggtg
     2761 ttcaaccaga gaagaaagag ccctggaaaa gaccgagccc ctaacagagg aaacggagga
     2821 tccagagcac ccagaaggaa tacacgactc cttctttgaa cgtgagcatc cagggtgggt
     2881 tcctggggta tgcgtgaaga atctggtaaa gatttttgag ccctgtggcc ggccagctgt
     2941 ggaccgtctg aacatcacct tctacgagaa ccagatcacc gcattcctgg gccacaatgg
     3001 agctgggaaa accaccacct tgtccatcct gacgggtctg ttgccaccaa cctctgggac
     3061 tgtgctcgtt gggggaaggg acattgaaac cagcctggat gcagtccggc agagccttgg
     3121 catgtgtcca cagcacaaca tcctgttcca ccacctcacg gtggctgagc acatgctgtt
     3181 ctatgcccag ctgaaaggaa agtcccagga ggaggcccag ctggagatgg aagccatgtt
     3241 ggaggacaca ggcctccacc acaagcggaa tgaagaggct caggacctat caggtggcat
     3301 gcagagaaag ctgtcggttg ccattgcctt tgtgggagat gccaaggtgg tgattctgga
     3361 cgaacccacc tctggggtgg acccttactc gagacgctca atctgggatc tgctcctgaa
     3421 gtatcgctca ggcagaacca tcatcatgtc cactcaccac atggacgagg ccgacctcct
     3481 tggggaccgc attgccatca ttgcccaggg aaggctctac tgctcaggca ccccactctt
     3541 cctgaagaac tgctttggca caggcttgta cttaaccttg gtgcgcaaga tgaaaaacat
     3601 ccagagccaa aggaaaggca gtgaggggac ctgcagctgc tcgtctaagg gtttctccac
     3661 cacgtgtcca gcccacgtcg atgacctaac tccagaacaa gtcctggatg gggatgtaaa
     3721 tgagctgatg gatgtagttc tccaccatgt tccagaggca aagctggtgg agtgcattgg
     3781 tcaagaactt atcttccttc ttccaaataa gaacttcaag cacagagcat atgccagcct
     3841 tttcagagag ctggaggaga cgctggctga ccttggtctc agcagttttg gaatttctga
     3901 cactcccctg gaagagattt ttctgaaggt cacggaggat tctgattcag gacctctgtt
     3961 tgcgggtggc gctcagcaga aaagagaaaa cgtcaacccc cgacacccct gcttgggtcc
     4021 cagagagaag gctggacaga caccccagga ctccaatgtc tgctccccag gggcgccggc
     4081 tgctcaccca gagggccagc ctcccccaga gccagagtgc ccaggcccgc agctcaacac
     4141 ggggacacag ctggtcctcc agcatgtgca ggcgctgctg gtcaagagat tccaacacac
     4201 catccgcagc cacaaggact tcctggcgca gatcgtgctc ccggctacct ttgtgttttt
     4261 ggctctgatg ctttctattg ttatccctcc ttttggcgaa taccccgctt tgacccttca
     4321 cccctggata tatgggcagc agtacacctt cttcagcatg gatgaaccag gcagtgagca
     4381 gttcacggta cttgcagacg tcctcctgaa taagccaggc tttggcaacc gctgcctgaa
     4441 ggaagggtgg cttccggagt acccctgtgg caactcaaca ccctggaaga ctccttctgt
     4501 gtccccaaac atcacccagc tgttccagaa gcagaaatgg acacaggtca acccttcacc
     4561 atcctgcagg tgcagcacca gggagaagct caccatgctg ccagagtgcc ccgagggtgc
     4621 cgggggcctc ccgccccccc agagaacaca gcgcagcacg gaaattctac aagacctgac
     4681 ggacaggaac atctccgact tcttggtaaa aacgtatcct gctcttataa gaagcagctt
     4741 aaagagcaaa ttctgggtca atgaacagag gtatggagga atttccattg gaggaaagct
     4801 cccagtcgtc cccatcacgg gggaagcact tgttgggttt ttaagcgacc ttggccggat
     4861 catgaatgtg agcgggggcc ctatcactag agaggcctct aaagaaatac ctgatttcct
     4921 taaacatcta gaaactgaag acaacattaa ggtgtggttt aataacaaag gctggcatgc
     4981 cctggtcagc tttctcaatg tggcccacaa cgccatctta cgggccagcc tgcctaagga
     5041 caggagcccc gaggagtatg gaatcaccgt cattagccaa cccctgaacc tgaccaagga
     5101 gcagctctca gagattacag tgctgaccac ttcagtggat gctgtggttg ccatctgcgt
     5161 gattttctcc atgtccttcg tcccagccag ctttgtcctt tatttgatcc aggagcgggt
     5221 gaacaaatcc aagcacctcc agtttatcag tggagtgagc cccaccacct actgggtgac
     5281 caacttcctc tgggacatca tgaattattc cgtgagtgct gggctggtgg tgggcatctt
     5341 catcgggttt cagaagaaag cctacacttc tccagaaaac cttcctgccc ttgtggcact
     5401 gctcctgctg tatggatggg cggtcattcc catgatgtac ccagcatcct tcctgtttga
     5461 tgtccccagc acagcctatg tggctttatc ttgtgctaat ctgttcatcg gcatcaacag
     5521 cagtgctatt accttcatct tggaattatt tgagaataac cggacgctgc tcaggttcaa
     5581 cgccgtgctg aggaagctgc tcattgtctt cccccacttc tgcctgggcc ggggcctcat
     5641 tgaccttgca ctgagccagg ctgtgacaga tgtctatgcc cggtttggtg aggagcactc
     5701 tgcaaatccg ttccactggg acctgattgg gaagaacctg tttgccatgg tggtggaagg
     5761 ggtggtgtac ttcctcctga ccctgctggt ccagcgccac ttcttcctct cccaatggat
     5821 tgccgagccc actaaggagc ccattgttga tgaagatgat gatgtggctg aagaaagaca
     5881 aagaattatt actggtggaa ataaaactga catcttaagg ctacatgaac taaccaagat
     5941 ttatccaggc acctccagcc cagcagtgga caggctgtgt gtcggagttc gccctggaga
     6001 gtgctttggc ctcctgggag tgaatggtgc cggcaaaaca accacattca agatgctcac
     6061 tggggacacc acagtgacct caggggatgc caccgtagca ggcaagagta ttttaaccaa
     6121 tatttctgaa gtccatcaaa atatgggcta ctgtcctcag tttgatgcaa ttgatgagct
     6181 gctcacagga cgagaacatc tttaccttta tgcccggctt cgaggtgtac cagcagaaga
     6241 aatcgaaaag gttgcaaact ggagtattaa gagcctgggc ctgactgtct acgccgactg
     6301 cctggctggc acgtacagtg ggggcaacaa gcggaaactc tccacagcca tcgcactcat
     6361 tggctgccca ccgctggtgc tgctggatga gcccaccaca gggatggacc cccaggcacg
     6421 ccgcatgctg tggaacgtca tcgtgagcat catcagagaa gggagggctg tggtcctcac
     6481 atcccacagc atggaagaat gtgaggcact gtgtacccgg ctggccatca tggtaaaggg
     6541 cgcctttcga tgtatgggca ccattcagca tctcaagtcc aaatttggag atggctatat
     6601 cgtcacaatg aagatcaaat ccccgaagga cgacctgctt cctgacctga accctgtgga
     6661 gcagttcttc caggggaact tcccaggcag tgtgcagagg gagaggcact acaacatgct
     6721 ccagttccag gtctcctcct cctccctggc gaggatcttc cagctcctcc tctcccacaa
     6781 ggacagcctg ctcatcgagg agtactcagt cacacagacc acactggacc aggtgtttgt
     6841 aaattttgct aaacagcaga ctgaaagtca tgacctccct ctgcaccctc gagctgctgg
     6901 agccagtcga caagcccagg actgatcttt cacaccgctc gttcctgcag ccagaaagga
     6961 actctgggca gctggaggcg caggagcctg tgcccatatg gtcatccaaa tggactggcc
     7021 agcgtaaatg accccactgc agcagaaaac aaacacacga ggagcatgca gcgaattcag
     7081 aaagaggtct ttcagaagga aaccgaaact gacttgctca cctggaacac ctgatggtga
     7141 aaccaaacaa atacaaaatc cttctccaga ccccagaact agaaaccccg ggccatccca
     7201 ctagcagctt tggcctccat attgctctca tttcaagcag atctgctttt ctgcatgttt
     7261 gtctgtgtgt ctgcgttgtg tgtgattttc atggaaaaat aaaatgcaaa tgcactcatc
     7321 acaaacta
//
