LOCUS       NM_001089               6602 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens ATP binding cassette subfamily A member 3 (ABCA3),
            mRNA.
ACCESSION   NM_001089
VERSION     NM_001089.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6602)
  AUTHORS   Diesler,R., Legendre,M., Si-Mohamed,S., Brillet,P.Y., Wemeau,L.,
            Manali,E.D., Gagnadoux,F., Hirschi,S., Lorillon,G.,
            Reynaud-Gaubert,M., Bironneau,V., Blanchard,E., Bourdin,A.,
            Dominique,S., Justet,A., Macey,J., Marchand-Adam,S.,
            Morisse-Pradier,H., Nunes,H., Papiris,S.A., Traclet,J., Traore,I.,
            Crestani,B., Amselem,S., Nathan,N., Borie,R. and Cottin,V.
  CONSRTM   OrphaLung network
  TITLE     Similarities and differences of interstitial lung disease
            associated with pathogenic variants in SFTPC and ABCA3 in adults
  JOURNAL   Respirology 29 (4), 312-323 (2024)
   PUBMED   38345107
  REMARK    GeneRIF: Similarities and differences of interstitial lung disease
            associated with pathogenic variants in SFTPC and ABCA3 in adults.
REFERENCE   2  (bases 1 to 6602)
  AUTHORS   Anciuc-Crauciuc,M., Cucerea,M.C., Crauciuc,G.A., Tripon,F. and
            Banescu,C.V.
  TITLE     Evaluation of the Copy Number Variants and Single-Nucleotide
            Polymorphisms of ABCA3 in Newborns with Respiratory Distress
            Syndrome-A Pilot Study
  JOURNAL   Medicina (Kaunas) 60 (3), 419 (2024)
   PUBMED   38541145
  REMARK    GeneRIF: Evaluation of the Copy Number Variants and
            Single-Nucleotide Polymorphisms of ABCA3 in Newborns with
            Respiratory Distress Syndrome-A Pilot Study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6602)
  AUTHORS   El Demellawy,D., Kovesi,T., Gowans,R., Oltean,I., Huang,L.,
            White-Brown,A. and Sawyer,S.L.
  TITLE     Interstitial lung disease in a family with bi-allelic variants in
            ABCA3: non-specific interstitial pneumonitis pattern of injury
  JOURNAL   Pathology 56 (1), 104-107 (2024)
   PUBMED   37657992
  REMARK    GeneRIF: Interstitial lung disease in a family with bi-allelic
            variants in ABCA3: non-specific interstitial pneumonitis pattern of
            injury.
REFERENCE   4  (bases 1 to 6602)
  AUTHORS   Sun,Y.L., Hennessey,E.E., Heins,H., Yang,P., Villacorta-Martin,C.,
            Kwan,J., Gopalan,K., James,M., Emili,A., Cole,F.S., Wambach,J.A.
            and Kotton,D.N.
  TITLE     Human pluripotent stem cell modeling of alveolar type 2 cell
            dysfunction caused by ABCA3 mutations
  JOURNAL   J Clin Invest 134 (2), e164274 (2024)
   PUBMED   38226623
  REMARK    GeneRIF: Human pluripotent stem cell modeling of alveolar type 2
            cell dysfunction caused by ABCA3 mutations.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6602)
  AUTHORS   Al-Shumary,D.S., Al-Shammari,A.M. and Rasheed,M.N.
  TITLE     Increased Expression of the ABCA1 and ABCA3 Transporter Genes is
            Associated with Cisplatin Resistance in Breast Cancer Cells
  JOURNAL   Asian Pac J Cancer Prev 24 (11), 3969-3977 (2023)
   PUBMED   38019257
  REMARK    GeneRIF: Increased Expression of the ABCA1 and ABCA3 Transporter
            Genes is Associated with Cisplatin Resistance in Breast Cancer
            Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6602)
  AUTHORS   Mulugeta,S., Gray,J.M., Notarfrancesco,K.L., Gonzales,L.W.,
            Koval,M., Feinstein,S.I., Ballard,P.L., Fisher,A.B. and Shuman,H.
  TITLE     Identification of LBM180, a lamellar body limiting membrane protein
            of alveolar type II cells, as the ABC transporter protein ABCA3
  JOURNAL   J Biol Chem 277 (25), 22147-22155 (2002)
   PUBMED   11940594
  REMARK    GeneRIF: Identification of LBM180, a lamellar body limiting
            membrane protein of alveolar type II cells, as the ABC transporter
            protein ABCA3
REFERENCE   7  (bases 1 to 6602)
  AUTHORS   Yamano,G., Funahashi,H., Kawanami,O., Zhao,L.X., Ban,N., Uchida,Y.,
            Morohoshi,T., Ogawa,J., Shioda,S. and Inagaki,N.
  TITLE     ABCA3 is a lamellar body membrane protein in human lung alveolar
            type II cells
  JOURNAL   FEBS Lett 508 (2), 221-225 (2001)
   PUBMED   11718719
REFERENCE   8  (bases 1 to 6602)
  AUTHORS   Connors,T.D., Van Raay,T.J., Petry,L.R., Klinger,K.W., Landes,G.M.
            and Burn,T.C.
  TITLE     The cloning of a human ABC gene (ABC3) mapping to chromosome
            16p13.3
  JOURNAL   Genomics 39 (2), 231-234 (1997)
   PUBMED   9027511
REFERENCE   9  (bases 1 to 6602)
  AUTHORS   Klugbauer,N. and Hofmann,F.
  TITLE     Primary structure of a novel ABC transporter with a chromosomal
            localization on the band encoding the multidrug
            resistance-associated protein
  JOURNAL   FEBS Lett 391 (1-2), 61-65 (1996)
   PUBMED   8706931
REFERENCE   10 (bases 1 to 6602)
  AUTHORS   Garcia,C.K. and Talbert,J.L.
  TITLE     Pulmonary Fibrosis Predisposition Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301408
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC106820.4, AC098805.2 and
            AC009065.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001089.2.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters.  ABC proteins transport various molecules across
            extra- and intracellular membranes.  ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White).  This protein is a member of the ABC1 subfamily.  Members
            of the ABC1 subfamily comprise the only major ABC subfamily found
            exclusively in multicellular eukaryotes.  The full transporter
            encoded by this gene may be involved in development of resistance
            to xenobiotics and engulfment during programmed cell death.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC151840.1, U78735.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301732.10/ ENSP00000301732.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AC106820.4         163239-163394
            157-363             AC106820.4         174113-174319
            364-668             AC106820.4         175210-175514
            669-748             AC098805.2         19699-19778
            749-1013            AC098805.2         19917-20181
            1014-1141           AC098805.2         21660-21787
            1142-1307           AC098805.2         22503-22668
            1308-1567           AC098805.2         26351-26610
            1568-1684           AC098805.2         28427-28543
            1685-1805           AC098805.2         28788-28908
            1806-1979           AC098805.2         37568-37741
            1980-2161           AC098805.2         42041-42222
            2162-2305           AC098805.2         46043-46186
            2306-2435           AC098805.2         46659-46788
            2436-2590           AC098805.2         47651-47805
            2591-2746           AC098805.2         48270-48425
            2747-2957           AC098805.2         48652-48862
            2958-3108           AC098805.2         50451-50601
            3109-3207           AC098805.2         53953-54051
            3208-3394           AC098805.2         56571-56757
            3395-3698           AC098805.2         57862-58165
            3699-3972           AC098805.2         59224-59497
            3973-4177           AC098805.2         60545-60749
            4178-4397           AC098805.2         61193-61412
            4398-4556           AC098805.2         61754-61912
            4557-4729           AC098805.2         62833-63005
            4730-4858           AC098805.2         64682-64810
            4859-5053           AC098805.2         64970-65164
            5054-5241           AC098805.2         67061-67248
            5242-5412           AC098805.2         67733-67903
            5413-5603           AC098805.2         68122-68312
            5604-5677           AC098805.2         68521-68594
            5678-6602           AC009065.8         607-1531
FEATURES             Location/Qualifiers
     source          1..6602
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..6602
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /note="ATP binding cassette subfamily A member 3"
                     /db_xref="GeneID:21"
                     /db_xref="HGNC:HGNC:33"
                     /db_xref="MIM:601615"
     exon            1..156
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            157..363
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            364..668
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            669..748
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             695..5809
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /EC_number="7.6.2.2"
                     /EC_number="7.6.2.1"
                     /note="ABC transporter 3; ATP-binding cassette sub-family
                     A member 3; ABC-C transporter; ATP-binding cassette
                     transporter 3; ATP-binding cassette, sub-family A (ABC1),
                     member 3; xenobiotic-transporting ATPase ABCA3"
                     /codon_start=1
                     /product="phospholipid-transporting ATPase ABCA3"
                     /protein_id="NP_001080.2"
                     /db_xref="CCDS:CCDS10466.1"
                     /db_xref="GeneID:21"
                     /db_xref="HGNC:HGNC:33"
                     /db_xref="MIM:601615"
                     /translation="MAVLRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLRL
                     KIQSENVPNATIYPGQSIQELPLFFTFPPPGDTWELAYIPSHSDAAKTVTETVRRALV
                     INMRVRGFPSEKDFEDYIRYDNCSSSVLAAVVFEHPFNHSKEPLPLAVKYHLRFSYTR
                     RNYMWTQTGSFFLKETEGWHTTSLFPLFPNPGPREPTSPDGGEPGYIREGFLAVQHAV
                     DRAIMEYHADAATRQLFQRLTVTIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTAL
                     TIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPN
                     VAVLSRSDPSLVLAFLLCFAISTISFSFMVSTFFSKANMAAAFGGFLYFFTYIPYFFV
                     APRYNWMTLSQKLCSCLLSNVAMAMGAQLIGKFEAKGMGIQWRDLLSPVNVDDDFCFG
                     QVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMPSYWCGKPRAVAGKEEEDS
                     DPEKALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQITVLLG
                     HNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQIRKSLGLCPQHDILFDNLTVA
                     EHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALIAG
                     SKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRIAIMAKGE
                     LQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLVHHHVPNATLESSAGAELSFIL
                     PRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFLRVGKLVDSSMDIQAIQLPA
                     LQYQHERRASDWAVDSNLCGAMDPSDGIGALIEEERTAVKLNTGLALHCQQFWAMFLK
                     KAAYSWREWKMVAAQVLVPLTCVTLALLAINYSSELFDDPMLRLTLGEYGRTVVPFSV
                     PGTSQLGQQLSEHLKDALQAEGQEPREVLGDLEEFLIFRASVEGGGFNERCLVAASFR
                     DVGERTVVNALFNNQAYHSPATALAVVDNLLFKLLCGPHASIVVSNFPQPRSALQAAK
                     DQFNEGRKGFDIALNLLFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVASFWLSAL
                     LWDLISFLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFFL
                     GAATAYTRLTIFNILSGIATFLMVTIMRIPAVKLEELSKTLDHVFLVLPNHCLGMAVS
                     SFYENYETRRYCTSSEVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLIL
                     LFLIETNLLQRLRGILCALRRRRTLTELYTRMPVLPEDQDVADERTRILAPSPDSLLH
                     TPLIIKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLT
                     SGDAFVGGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGAC
                     VENTLRGLLLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRL
                     LWDTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYS
                     LRAKVQSEGQQEALEEFKAFVDLTFPGSVLEDEHQGMVHYHLPGRDLSWAKVFGILEK
                     AKEKYGVDDYSVSQISLEQVFLSFAHLQPPTAEEGR"
     exon            749..1013
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1141
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1307
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1567
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1684
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1805
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1979
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2161
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2305
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2435
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2590
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2746
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..2957
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2958..3108
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3109..3207
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3208..3394
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3395..3698
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3699..3972
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3973..4177
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4178..4397
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4398..4556
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4557..4729
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4730..4858
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4859..5053
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            5054..5241
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            5242..5412
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            5413..5603
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            5604..5677
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            5678..6602
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6582..6587
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /note="hexamer: AATAAA"
     polyA_site      6602
                     /gene="ABCA3"
                     /gene_synonym="ABC-C; ABC3; EST111653; LBM180; SMDP3"
                     /note="major polyA site"
ORIGIN      
        1 agtagcgggt tgcaggcgca ccctcccctc cagggcggcc acgcagctgt cagtgccgcc
       61 gccactgcga ggctggagcg gagcccgggt ggccgaggga ggggaccccg cgagagggcc
      121 gcgcgccggc cgccgccgcc ccggcgccca ggctcggtgc tggagagtca tgcctgtgag
      181 ccctgggcac ctcctgatgt cctgcgaggt cacggtgttc ccaaacctca gggttgccct
      241 gccccactcc agaggctctc aggccccacc ccggagccct ctgtgcggag ccgcctcctc
      301 ctggccagtt ccccagtagt cctgaaggga gacctgctgt gtggagcctc ttctgggacc
      361 cagccatgag tgtggagctg agcaactgaa cctgaaactc ttccactgtg agtcaaggag
      421 gcttttccgc acatgaagga cgctgagcgg gaaggactcc tctctgcctg cagttgtagc
      481 gagtggacca gcaccagggg ctctctagac tgcccctcct ccatcgcctt ccctgcctct
      541 ccaggacaga gcagccacgt ctgcacacct cgccctcttt acactcagtt ttcagagcac
      601 gtttctccta tttcctgcgg gttgcagcgc ctacttgaac ttactcagac cacctacttc
      661 tctagcagca ctgggcgtcc ctttcagcaa gacgatggct gtgctcaggc agctggcgct
      721 cctcctctgg aagaactaca ccctgcagaa gcggaaggtc ctggtgacgg tcctggaact
      781 cttcctgcca ttgctgtttt ctgggatcct catctggctc cgcttgaaga ttcagtcgga
      841 aaatgtgccc aacgccacca tctacccggg ccagtccatc caggagctgc ctctgttctt
      901 caccttccct ccgccaggag acacctggga gcttgcctac atcccttctc acagtgacgc
      961 tgccaagacc gtcactgaga cagtgcgcag ggcacttgtg atcaacatgc gagtgcgcgg
     1021 ctttccctcc gagaaggact ttgaggacta cattaggtac gacaactgct cgtccagcgt
     1081 gctggccgcc gtggtcttcg agcacccctt caaccacagc aaggagcccc tgccgctggc
     1141 ggtgaaatat cacctacggt tcagttacac acggagaaat tacatgtgga cccaaacagg
     1201 ctcctttttc ctgaaagaga cagaaggctg gcacactact tcccttttcc cgcttttccc
     1261 aaacccagga ccaagggaac ctacatcccc tgatggcgga gaacctgggt acatccggga
     1321 aggcttcctg gccgtgcagc atgctgtgga ccgggccatc atggagtacc atgccgatgc
     1381 cgccacacgc cagctgttcc agagactgac ggtgaccatc aagaggttcc cgtacccgcc
     1441 gttcatcgca gaccccttcc tcgtggccat ccagtaccag ctgcccctgc tgctgctgct
     1501 cagcttcacc tacaccgcgc tcaccattgc ccgtgctgtc gtgcaggaga aggaaaggag
     1561 gctgaaggag tacatgcgca tgatggggct cagcagctgg ctgcactgga gtgcctggtt
     1621 cctcttgttc ttcctcttcc tcctcatcgc cgcctccttc atgaccctgc tcttctgtgt
     1681 caaggtgaag ccaaatgtag ccgtgctgtc ccgcagcgac ccctccctgg tgctcgcctt
     1741 cctgctgtgc ttcgccatct ctaccatctc cttcagcttc atggtcagca ccttcttcag
     1801 caaagccaac atggcagcag ccttcggagg cttcctctac ttcttcacct acatccccta
     1861 cttcttcgtg gcccctcggt acaactggat gactctgagc cagaagctct gctcctgcct
     1921 cctgtctaat gtcgccatgg caatgggagc ccagctcatt gggaaatttg aggcgaaagg
     1981 catgggcatc cagtggcgag acctcctgag tcccgtcaac gtggacgacg acttctgctt
     2041 cgggcaggtg ctggggatgc tgctgctgga ctctgtgctc tatggcctgg tgacctggta
     2101 catggaggcc gtcttcccag ggcagttcgg cgtgcctcag ccctggtact tcttcatcat
     2161 gccctcctat tggtgtggga agccaagggc ggttgcaggg aaggaggaag aagacagtga
     2221 ccccgagaaa gcactcagaa acgagtactt tgaagccgag ccagaggacc tggtggcggg
     2281 gatcaagatc aagcacctgt ccaaggtgtt cagggtggga aataaggaca gggcggccgt
     2341 cagagacctg aacctcaacc tgtacgaggg acagatcacc gtcctgctgg gccacaacgg
     2401 tgccgggaag accaccaccc tctccatgct cacaggtctc tttcccccca ccagtggacg
     2461 ggcatacatc agcgggtatg aaatttccca ggacatggtt cagatccgga agagcctggg
     2521 cctgtgcccg cagcacgaca tcctgtttga caacttgaca gtcgcagagc acctttattt
     2581 ctacgcccag ctgaagggcc tgtcacgtca gaagtgccct gaagaagtca agcagatgct
     2641 gcacatcatc ggcctggagg acaagtggaa ctcacggagc cgcttcctga gcgggggcat
     2701 gaggcgcaag ctctccatcg gcatcgccct catcgcaggc tccaaggtgc tgatactgga
     2761 cgagcccacc tcgggcatgg acgccatctc caggagggcc atctgggatc ttcttcagcg
     2821 gcagaaaagt gaccgcacca tcgtgctgac cacccacttc atggacgagg ctgacctgct
     2881 gggagaccgc atcgccatca tggccaaggg ggagctgcag tgctgcgggt cctcgctgtt
     2941 cctcaagcag aaatacggtg ccggctatca catgacgctg gtgaaggagc cgcactgcaa
     3001 cccggaagac atctcccagc tggtccacca ccacgtgccc aacgccacgc tggagagcag
     3061 cgctggggcc gagctgtctt tcatccttcc cagagagagc acgcacaggt ttgaaggtct
     3121 ctttgctaaa ctggagaaga agcagaaaga gctgggcatt gccagctttg gggcatccat
     3181 caccaccatg gaggaagtct tccttcgggt cgggaagctg gtggacagca gtatggacat
     3241 ccaggccatc cagctccctg ccctgcagta ccagcacgag aggcgcgcca gcgactgggc
     3301 tgtggacagc aacctctgtg gggccatgga cccctccgac ggcattggag ccctcatcga
     3361 ggaggagcgc accgctgtca agctcaacac tgggctcgcc ctgcactgcc agcaattctg
     3421 ggccatgttc ctgaagaagg ccgcatacag ctggcgcgag tggaaaatgg tggcggcaca
     3481 ggtcctggtg cctctgacct gcgtcaccct ggccctcctg gccatcaact actcctcgga
     3541 gctcttcgac gaccccatgc tgaggctgac cttgggcgag tacggcagaa ccgtcgtgcc
     3601 cttctcagtt cccgggacct cccagctggg tcagcagctg tcagagcatc tgaaagacgc
     3661 actgcaggct gagggacagg agccccgcga ggtgctcggt gacctggagg agttcttgat
     3721 cttcagggct tctgtggagg ggggcggctt taatgagcgg tgccttgtgg cagcgtcctt
     3781 cagagatgtg ggagagcgca cggtcgtcaa cgccttgttc aacaaccagg cgtaccactc
     3841 tccagccact gccctggccg tcgtggacaa ccttctgttc aagctgctgt gcgggcctca
     3901 cgcctccatt gtggtctcca acttccccca gccccggagc gccctgcagg ctgccaagga
     3961 ccagtttaac gagggccgga agggattcga cattgccctc aacctgctct tcgccatggc
     4021 attcttggcc agcacgttct ccatcctggc ggtcagcgag agggccgtgc aggccaagca
     4081 tgtgcagttt gtgagtggag tccacgtggc cagtttctgg ctctctgctc tgctgtggga
     4141 cctcatctcc ttcctcatcc ccagtctgct gctgctggtg gtgtttaagg ccttcgacgt
     4201 gcgtgccttc acgcgggacg gccacatggc tgacaccctg ctgctgctcc tgctctacgg
     4261 ctgggccatc atccccctca tgtacctgat gaacttcttc ttcttggggg cggccactgc
     4321 ctacacgagg ctgaccatct tcaacatcct gtcaggcatc gccaccttcc tgatggtcac
     4381 catcatgcgc atcccagctg taaaactgga agaactttcc aaaaccctgg atcacgtgtt
     4441 cctggtgctg cccaaccact gtctggggat ggcagtcagc agtttctacg agaactacga
     4501 gacgcggagg tactgcacct cctccgaggt cgccgcccac tactgcaaga aatataacat
     4561 ccagtaccag gagaacttct atgcctggag cgccccgggg gtcggccggt ttgtggcctc
     4621 catggccgcc tcagggtgcg cctacctcat cctgctcttc ctcatcgaga ccaacctgct
     4681 tcagagactc aggggcatcc tctgcgccct ccggaggagg cggacactga cagaattata
     4741 cacccggatg cctgtgcttc ctgaggacca agatgtagcg gacgagagga cccgcatcct
     4801 ggcccccagt ccggactccc tgctccacac acctctgatt atcaaggagc tctccaaggt
     4861 gtacgagcag cgggtgcccc tcctggccgt ggacaggctc tccctcgcgg tgcagaaagg
     4921 ggagtgcttc ggcctgctgg gcttcaatgg agccgggaag accacgactt tcaaaatgct
     4981 gaccggggag gagagcctca cttctgggga tgcctttgtc gggggtcaca gaatcagctc
     5041 tgatgtcgga aaggtgcggc agcggatcgg ctactgcccg cagtttgatg ccttgctgga
     5101 ccacatgaca ggccgggaga tgctggtcat gtacgctcgg ctccggggca tccctgagcg
     5161 ccacatcggg gcctgcgtgg agaacactct gcggggcctg ctgctggagc cacatgccaa
     5221 caagctggtc aggacgtaca gtggtggtaa caagcggaag ctgagcaccg gcatcgccct
     5281 gatcggagag cctgctgtca tcttcctgga cgagccgtcc actggcatgg accccgtggc
     5341 ccggcgcctg ctttgggaca ccgtggcacg agcccgagag tctggcaagg ccatcatcat
     5401 cacctcccac agcatggagg agtgtgaggc cctgtgcacc cggctggcca tcatggtgca
     5461 ggggcagttc aagtgcctgg gcagccccca gcacctcaag agcaagttcg gcagcggcta
     5521 ctccctgcgg gccaaggtgc agagtgaagg gcaacaggag gcgctggagg agttcaaggc
     5581 cttcgtggac ctgacctttc caggcagcgt cctggaagat gagcaccaag gcatggtcca
     5641 ttaccacctg ccgggccgtg acctcagctg ggcgaaggtt ttcggtattc tggagaaagc
     5701 caaggaaaag tacggcgtgg acgactactc cgtgagccag atctcgctgg aacaggtctt
     5761 cctgagcttc gcccacctgc agccgcccac cgcagaggag gggcgatgag gggtggcggc
     5821 tgtctcgcca tcaggcaggg acaggacggg caagcagggc ccatcttaca tcctctctct
     5881 ccaagtttat ctcatccttt atttttaatc acttttttct atgatggata tgaaaaattc
     5941 aaggcagtat gcacagaatg gacgagtgca gcccagccct catgcccagg atcagcatgc
     6001 gcatctccat gtctgcatac tctggagttc actttcccag agctggggca ggccgggcag
     6061 tctgcgggca agctccgggg tctctgggtg gagagctgac ccaggaaggg ctgcagctga
     6121 gctgggggtt gaatttctcc aggcactccc tggagagagg acccagtgac ttgtccaagt
     6181 ttacacacga cactaatctc ccctggggag gaagcgggaa gccagccagg ttgaactgta
     6241 gcgaggcccc caggccgcca ggaatggacc atgcagatca ctgtcagtgg agggaagctg
     6301 ctgactgtga ttaggtgctg gggtcttagc gtccagcgca gcccgggggc atcctggagg
     6361 ctctgctcct tagggcatgg tagtcaccgc gaagccgggc accgtcccac agcatctcct
     6421 agaagcagcc ggcacaggag ggaaggtggc caggctcgaa gcagtctctg tttccagcac
     6481 tgcaccctca ggaagtcgcc cgccccagga cacgcaggga ccaccctaag ggctgggtgg
     6541 ctgtctcaag gacacattga atacgttgtg accatccaga aaataaatgc tgaggggaca
     6601 ca
//
