LOCUS       NM_212533               8146 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens ATP binding cassette subfamily A member 2 (ABCA2),
            transcript variant 2, mRNA.
ACCESSION   NM_212533
VERSION     NM_212533.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8146)
  AUTHORS   Inoue,Y., Tsuchida,N., Kim,C.A., de Oliveira Stephan,B.,
            Castro,M.A.A., Honjo,R.S., Bertola,D.R., Uchiyama,Y., Hamanaka,K.,
            Fujita,A., Koshimizu,E., Misawa,K., Miyatake,S., Mizuguchi,T. and
            Matsumoto,N.
  TITLE     Novel compound heterozygous ABCA2 variants cause IDPOGSA, a
            variable phenotypic syndrome with intellectual disability
  JOURNAL   J Hum Genet 69 (3-4), 163-167 (2024)
   PUBMED   38228874
  REMARK    GeneRIF: Novel compound heterozygous ABCA2 variants cause IDPOGSA,
            a variable phenotypic syndrome with intellectual disability.
REFERENCE   2  (bases 1 to 8146)
  AUTHORS   Shibata,Y., Matsumoto,N., Murase,R., Kubota,Y., Ishida,H.,
            Shimada,K. and Fujita,K.I.
  TITLE     A polymorphism in ABCA2 is associated with neutropenia induced by
            capecitabine in Japanese patients with colorectal cancer
  JOURNAL   Cancer Chemother Pharmacol 92 (6), 465-474 (2023)
   PUBMED   37653272
  REMARK    GeneRIF: A polymorphism in ABCA2 is associated with neutropenia
            induced by capecitabine in Japanese patients with colorectal
            cancer.
REFERENCE   3  (bases 1 to 8146)
  AUTHORS   Kim,M.S., Yang,S.H. and Kim,M.S.
  TITLE     Role of ABCA2 and its single nucleotide polymorphisms (4873T>A and
            4879G>C) in the regulation of multi-drug resistance in oral
            squamous carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 666, 1-9 (2023)
   PUBMED   37167718
  REMARK    GeneRIF: Role of ABCA2 and its single nucleotide polymorphisms
            (4873T>A and 4879G>C) in the regulation of multi-drug resistance in
            oral squamous carcinoma cells.
REFERENCE   4  (bases 1 to 8146)
  AUTHORS   Nedoszytko,B., Sobalska-Kwapis,M., Strapagiel,D., Lange,M.,
            Gorska,A., Elberink,J.N.G.O., van Doormaal,J., Slomka,M.,
            Kalinowski,L., Gruchala-Niedoszytko,M., Nowicki,R.J., Valent,P. and
            Niedoszytko,M.
  TITLE     Results from a Genome-Wide Association Study (GWAS) in Mastocytosis
            Reveal New Gene Polymorphisms Associated with WHO Subgroups
  JOURNAL   Int J Mol Sci 21 (15), 5506 (2020)
   PUBMED   32752121
  REMARK    GeneRIF: Results from a Genome-Wide Association Study (GWAS) in
            Mastocytosis Reveal New Gene Polymorphisms Associated with WHO
            Subgroups.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8146)
  AUTHORS   Sweeney,M.D., Zhao,Z., Montagne,A., Nelson,A.R. and Zlokovic,B.V.
  TITLE     Blood-Brain Barrier: From Physiology to Disease and Back
  JOURNAL   Physiol Rev 99 (1), 21-78 (2019)
   PUBMED   30280653
  REMARK    Review article
REFERENCE   6  (bases 1 to 8146)
  AUTHORS   Kaminski,W.E., Piehler,A., Pullmann,K., Porsch-Ozcurumez,M.,
            Duong,C., Bared,G.M., Buchler,C. and Schmitz,G.
  TITLE     Complete coding sequence, promoter region, and genomic structure of
            the human ABCA2 gene and evidence for sterol-dependent regulation
            in macrophages
  JOURNAL   Biochem Biophys Res Commun 281 (1), 249-258 (2001)
   PUBMED   11178988
REFERENCE   7  (bases 1 to 8146)
  AUTHORS   Zhao,L.X., Zhou,C.J., Tanaka,A., Nakata,M., Hirabayashi,T.,
            Amachi,T., Shioda,S., Ueda,K. and Inagaki,N.
  TITLE     Cloning, characterization and tissue distribution of the rat
            ATP-binding cassette (ABC) transporter ABC2/ABCA2
  JOURNAL   Biochem J 350 Pt 3 (Pt 3), 865-872 (2000)
   PUBMED   10970803
REFERENCE   8  (bases 1 to 8146)
  AUTHORS   Klucken,J., Buchler,C., Orso,E., Kaminski,W.E.,
            Porsch-Ozcurumez,M., Liebisch,G., Kapinsky,M., Diederich,W.,
            Drobnik,W., Dean,M., Allikmets,R. and Schmitz,G.
  TITLE     ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a
            regulator of macrophage cholesterol and phospholipid transport
  JOURNAL   Proc Natl Acad Sci U S A 97 (2), 817-822 (2000)
   PUBMED   10639163
REFERENCE   9  (bases 1 to 8146)
  AUTHORS   Allikmets,R., Gerrard,B., Glavac,D., Ravnik-Glavac,M.,
            Jenkins,N.A., Gilbert,D.J., Copeland,N.G., Modi,W. and Dean,M.
  TITLE     Characterization and mapping of three new mammalian ATP-binding
            transporter genes from an EST database
  JOURNAL   Mamm Genome 6 (2), 114-117 (1995)
   PUBMED   7766993
REFERENCE   10 (bases 1 to 8146)
  AUTHORS   Luciani,M.F., Denizot,F., Savary,S., Mattei,M.G. and Chimini,G.
  TITLE     Cloning of two novel ABC transporters mapping on human chromosome 9
  JOURNAL   Genomics 21 (1), 150-159 (1994)
   PUBMED   8088782
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL807752.10, BM921499.1,
            BC029282.1, BF516223.1, AF178941.1, DB168116.1, BE273611.1,
            AL525193.3 and BM474929.1.
            
            On May 31, 2019 this sequence version replaced NM_212533.2.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intracellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the ABC1 subfamily. Members of
            the ABC1 subfamily comprise the only major ABC subfamily found
            exclusively in multicellular eukaryotes. This protein is highly
            expressed in brain tissue and may play a role in macrophage lipid
            metabolism and neural development. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding region compared to variant 1. The resulting isoform (b) is
            longer and has a distinct N-terminus compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               AL807752.10        98775-98884         c
            111-811             BM921499.1         67-767
            812-2099            BC029282.1         778-2065
            2100-2526           BF516223.1         8-434
            2527-5611           AF178941.1         2437-5521
            5612-6123           DB168116.1         80-591
            6124-6829           AF178941.1         6034-6739
            6830-7415           BE273611.1         54-639
            7416-7819           AL525193.3         272-675             c
            7820-8146           BM474929.1         173-499
FEATURES             Location/Qualifiers
     source          1..8146
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..8146
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /note="ATP binding cassette subfamily A member 2"
                     /db_xref="GeneID:20"
                     /db_xref="HGNC:HGNC:32"
                     /db_xref="MIM:600047"
     exon            1..206
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..7451
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /note="isoform b is encoded by transcript variant 2;
                     ATP-binding cassette, sub-family A, member 2; ATP-binding
                     cassette 2; ATP-binding cassette transporter 2;
                     ATP-binding cassette, sub-family A (ABC1), member 2"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family A member 2
                     isoform b"
                     /protein_id="NP_997698.1"
                     /db_xref="CCDS:CCDS94539.1"
                     /db_xref="GeneID:20"
                     /db_xref="HGNC:HGNC:32"
                     /db_xref="MIM:600047"
                     /translation="MGRKTSRVQQGPPRSPACSAHGERSWGLEFPPFRWLLGIAGRTH
                     LAALPPFQWVLAFEIFIPLVLFFILLGLRQKKPTISVKEVSFYTAAPLTSAGILPVMQ
                     SLCPDGQRDEFGFLQYANSTVTQLLERLDRVVEEGNLFDPARPSLGSELEALRQHLEA
                     LSAGPGTSGSHLDRSTVSSFSLDSVARNPQELWRFLTQNLSLPNSTAQALLAARVDPP
                     EVYHLLFGPSSALDSQSGLHKGQEPWSRLGGNPLFRMEELLLAPALLEQLTCTPGSGE
                     LGRILTVPESQKGALQGYRDAVCSGQAAARARRFSGLSAELRNQLDVAKVSQQLGLDA
                     PNGSDSSPQAPPPRRLQALLGDLLDAQKVLQDVDVLSALALLLPQGACTGRTPGPPAS
                     GAGGAANGTGAGAVMGPNATAEEGAPSAAALATPDTLQGQCSAFVQLWAGLQPILCGN
                     NRTIEPEALRRGNMSSLGFTSKEQRNLGLLVHLMTSNPKILYAPAGSEVDRVILKANE
                     TFAFVGNVTHYAQVWLNISAEIRSFLEQGRLQQHLRWLQQYVAELRLHPEALNLSLDE
                     LPPALRQDNFSLPSGMALLQQLDTIDNAACGWIQFMSKVSVDIFKGFPDEESIVNYTL
                     NQAYQDNVTVFASVIFQTRKDGSLPPHVHYKIRQNSSFTEKTNEIRRAYWRPGPNTGG
                     RFYFLYGFVWIQDMMERAIIDTFVGHDVVEPGSYVQMFPYPCYTRDDFLFVIEHMMPL
                     CMVISWVYSVAMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTAL
                     TAILKYGQVLMHSHVVIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSY
                     VPYMYVAIREEVAHDKITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQS
                     PVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGR
                     TEAWEWSWPWARTPRLSVMEEDQACAMESRRFEETRGMEEEPTHLPLVVCVDKLTKVY
                     KDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRT
                     EMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNK
                     RHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRT
                     ILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQ
                     EPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFE
                     RLFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRKDVLPGAE
                     GPASGEGHAGNLARCSELTQSQASLQSASSVGSARGDEGAGYTDVYGDYRPLFDNPQD
                     PDNVSLQEVEAEALSRVGQGSRKLDGGWLKVRQFHGLLVKRFHCARRNSKALFSQILL
                     PAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNYTQPRGNFIPYANEERREYRLRLSP
                     DASPQQLVSTFRLPSGVGATCVLKSPANGSLGPTLNLSSGESRLLAARFFDSMCLESF
                     TQGLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVSLPPTAGPEMWTSAPSLPRLVREP
                     VRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITGHNVSEYLLFTSDRFRLHRYG
                     AITFGNVLKSIPASFGTRAPPMVRKIAVRRAAQVFYNNKGYHSMPTYLNSLNNAILRA
                     NLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLLQGTDVVIAIFIIVAMSFVPASFVV
                     FLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSP
                     TNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLLQL
                     FEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMKSPFEW
                     DIVTRGLVAMAVEGVVGFLLTIMCQYNFLRRPQRMPVSTKPVEDDVDVASERQRVLRG
                     DADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLT
                     GDESTTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISW
                     KDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMD
                     PKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNR
                     FGDGYMITVRTKSSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSK
                     MEQVSGVLGIEDYSVSQTTLDNVFVNFAKKQSDNLEQQETEPPSALQSPLGCLLSLLR
                     PRSAPTELRALVADEPEDLDTEDEGLISFEEERAQLSFNTDTLC"
     exon            207..300
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            301..303
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            304..415
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            416..579
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            580..707
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            708..818
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            819..1037
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1405
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1565
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1694
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1862
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1959
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2133
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2236
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2351
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2542
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2693
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..2898
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2899..3063
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            3064..3244
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            3245..3457
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            3458..3654
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            3655..3837
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            3838..4022
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            4023..4143
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            4144..4380
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            4381..4587
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            4588..4690
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            4691..5007
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            5008..5221
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            5222..5327
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            5328..5439
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            5440..5500
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            5501..5675
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            5676..5791
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            5792..5939
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            5940..6063
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            6064..6196
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            6197..6314
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            6315..6493
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            6494..6635
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            6636..6770
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            6771..6874
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            6875..6967
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            6968..7070
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            7071..7208
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            7209..7415
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            7416..8146
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8128..8133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /note="hexamer: AATAAA"
     polyA_site      8146
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /note="major polyA site"
ORIGIN      
        1 agaaccgcct gatcccgaac tccctgtgca gagaccagac tcgcccgaat atggggagaa
       61 aaacgagccg cgtgcagcag gggccgcctc ggtcccctgc ctgctccgct cacggcgagc
      121 gttcctgggg cctcgagttt ccccccttcc gctggctgct cggaatcgcg ggacggaccc
      181 acctggccgc cctgcctccc ttccagtggg tcctggcctt cgagatcttc atccccctgg
      241 tgctgttctt tatcctgctg gggctgcgac agaagaagcc caccatctcc gtgaaggaag
      301 tctccttcta cacagcggcg cccctgacgt ctgccggcat cctgcctgtc atgcaatcgc
      361 tgtgcccgga cggccagcga gacgagttcg gcttcctgca gtacgccaac tccacggtca
      421 cgcagctgct tgagcgcctg gaccgcgtgg tggaggaagg caacctgttt gacccagcgc
      481 ggcccagcct gggctcagag ctcgaggccc tacgccagca tctggaggcc ctcagtgcgg
      541 gcccgggcac ctcggggagc cacctggaca gatccacagt gtcttccttc tctctggact
      601 cggtggccag aaacccgcag gagctctggc gtttcctgac gcaaaacttg tcgctgccca
      661 atagcacggc ccaagcactc ttggccgccc gtgtggaccc gcccgaggtc taccacctgc
      721 tctttggtcc ctcatctgcc ctggattcac agtctggcct ccacaagggt caggagccct
      781 ggagccgcct agggggcaat cccctgttcc ggatggagga gctgctgctg gctcctgccc
      841 tcctggagca gctcacctgc acgccgggct cgggggagct gggccggatc ctcactgtgc
      901 ctgagagtca gaagggagcc ctgcagggct accgggatgc tgtctgcagt gggcaggctg
      961 ctgcgcgtgc caggcgcttc tctgggctgt ctgctgagct ccggaaccag ctggacgtgg
     1021 ccaaggtctc ccagcagctg ggcctggatg cccccaacgg ctcggactcc tcgccacagg
     1081 cgccaccccc acggaggctg caggcgcttc tgggggacct gctggatgcc cagaaggttc
     1141 tgcaggatgt ggatgtcctg tcggccctgg ccctgctact gccccagggt gcctgcactg
     1201 gccggacccc cggaccccca gccagtggtg cgggtggggc ggccaatggc actggggcag
     1261 gggcagtcat gggccccaac gccaccgctg aggagggcgc accctctgct gcagcactgg
     1321 ccaccccgga cacgctgcag ggccagtgct cagccttcgt acagctctgg gccggcctgc
     1381 agcccatctt gtgtggcaac aaccgcacca ttgaacccga ggcgctgcgg cggggcaaca
     1441 tgagctccct gggcttcacg agcaaggagc agcggaacct gggcctcctc gtgcacctca
     1501 tgaccagcaa ccccaaaatc ctgtacgcgc ctgcgggctc tgaggtcgac cgcgtcatcc
     1561 tcaaggccaa cgagactttt gcttttgtgg gcaacgtgac tcactatgcc caggtctggc
     1621 tcaacatctc ggcggagatc cgcagcttcc tggagcaggg caggctgcag caacacctgc
     1681 gctggctgca gcagtatgta gcagagctgc ggctgcaccc cgaggcactg aacctgtcac
     1741 tggatgagct gccgccggcc ctgagacagg acaacttctc gctgcccagt ggcatggccc
     1801 tcctgcagca gctggatacc attgacaacg cggcctgcgg ctggatccag ttcatgtcca
     1861 aggtgagcgt ggacatcttc aagggcttcc ccgacgagga gagcattgtc aactacaccc
     1921 tcaaccaggc ctaccaggac aacgtcactg tttttgccag tgtgatcttc cagacccgga
     1981 aggacggctc gctcccgcct cacgtgcact acaagatccg ccagaactcc agcttcaccg
     2041 agaaaaccaa cgagatccgc cgcgcctact ggcggcctgg gcccaatact ggcggccgct
     2101 tctacttcct ctacggcttc gtctggatcc aggacatgat ggagcgcgcc atcatcgaca
     2161 cttttgtggg gcacgatgtg gtggagccag gcagctacgt gcagatgttc ccctacccct
     2221 gctacacacg cgatgacttc ctgtttgtca ttgagcacat gatgccgctg tgcatggtga
     2281 tctcctgggt ctactccgtg gccatgacca tccagcacat cgtggcggag aaggagcacc
     2341 ggctcaagga ggtgatgaag accatgggcc tgaacaacgc ggtgcactgg gtggcctggt
     2401 tcatcaccgg ctttgtgcag ctgtccatct ccgtgacagc actcaccgcc atcctgaagt
     2461 acggccaggt gcttatgcac agccacgtgg tcatcatctg gctcttcctg gcagtctacg
     2521 cggtggccac catcatgttc tgcttcctgg tgtctgtgct gtactccaag gccaagctgg
     2581 cctcggcctg cggtggcatc atctacttcc tgagctacgt gccctacatg tacgtggcga
     2641 tccgagagga ggtggcgcat gataagatca cggccttcga gaagtgcatc gcgtccctca
     2701 tgtccacgac ggcctttggt ctgggctcta agtacttcgc gctgtatgag gtggccggcg
     2761 tgggcatcca gtggcacacc ttcagccagt ccccggtgga gggggacgac ttcaacttgc
     2821 tcctggctgt caccatgctg atggtggacg ccgtggtcta tggcatcctc acgtggtaca
     2881 ttgaggctgt gcacccaggc atgtacgggc tgccccggcc ctggtacttc ccactgcaga
     2941 agtcctactg gctgggcagt gggcggacag aagcctggga gtggagctgg ccgtgggcac
     3001 gcaccccccg cctcagtgtc atggaggagg accaggcctg tgccatggag agccggcgct
     3061 ttgaggagac ccgtggcatg gaggaggagc ccacccacct gcctctggtt gtctgcgtgg
     3121 acaaactcac caaggtctac aaggacgaca agaagctggc cctgaacaag ctgagcctga
     3181 acctctacga gaaccaggtg gtctccttct tgggccacaa cggggcgggc aagaccacca
     3241 ccatgtccat cctgaccggc ctgttccctc caacgtcggg ttccgccacc atctacgggc
     3301 acgacatccg cacggagatg gatgagatcc gcaagaacct gggcatgtgc ccgcagcaca
     3361 atgtgctctt tgaccggctc acggtggagg aacacctctg gttctactca cggctcaaga
     3421 gcatggctca ggaggagatc cgcagagaga tggacaagat gatcgaggac ctggagctct
     3481 ccaacaaacg gcactcactg gtgcagacat tgtcgggtgg catgaagcgc aagctgtccg
     3541 tggccatcgc cttcgtgggc ggctctcgcg ccatcatcct ggacgagccc acggcgggcg
     3601 tggaccccta cgcgcgccgc gccatctggg acctcatcct gaagtacaag ccaggccgca
     3661 ccatccttct gtccacccac cacatggatg aggctgacct gcttggggac cgcattgcca
     3721 tcatctccca tgggaagctc aagtgctgcg gctccccgct cttcctcaag ggcacctatg
     3781 gcgacgggta ccgcctcacg ctggtcaagc ggcccgccga gccggggggc ccccaagagc
     3841 cagggctggc atccagcccc ccaggtcggg ccccgctgag cagctgctcc gagctccagg
     3901 tgtcccagtt catccgcaag catgtggcct cctgcctgct ggtctcagac acaagcacgg
     3961 agctctccta catcctgccc agcgaggccg ccaagaaggg ggctttcgag cgcctcttcc
     4021 agcacctgga gcgcagcctg gatgcactgc acctcagcag cttcgggctg atggacacga
     4081 ccctggagga agtgttcctc aaggtgtcgg aggaggatca gtcgctggag aacagtgagg
     4141 ccgatgtgaa ggagtccagg aaggatgtgc tccctggggc ggagggcccg gcgtctgggg
     4201 agggtcacgc tggcaatctg gcccggtgct cggagctgac ccagtcgcag gcatcgctgc
     4261 agtcggcgtc atctgtgggc tctgcccgtg gcgacgaggg agctggctac accgacgtct
     4321 atggcgacta ccgccccctc tttgataacc cacaggaccc agacaatgtc agcctgcaag
     4381 aggtggaggc agaggccctg tcgagggtcg gccagggcag ccgcaagctg gacggcgggt
     4441 ggctgaaggt gcgccagttc cacgggctgc tggtcaaacg cttccactgc gcccgccgca
     4501 actccaaggc actcttctcc cagatcttgc tgccagcctt cttcgtctgc gtggccatga
     4561 ccgtggccct gtccgtcccg gagattggtg atctgccccc gctggtcctg tcaccttccc
     4621 agtaccacaa ctacacccag ccccgtggca atttcatccc ctacgccaac gaggagcgcc
     4681 gcgagtaccg gctgcggcta tcgcccgacg ccagccccca gcagctcgtg agcacgttcc
     4741 ggctgccgtc gggggtgggt gccacctgcg tgctcaagtc tcccgccaac ggctcgctgg
     4801 ggcccacgtt gaacctgagc agcggggagt cgcgcctgct ggcggctcgg ttcttcgaca
     4861 gcatgtgtct ggagtccttc acacaggggc tgccactgtc caatttcgtg ccacccccac
     4921 cctcgcccgc cccatctgac tcgccagcgt ccccggatga ggacctgcag gcctggaacg
     4981 tctccctgcc gcccaccgct gggccagaaa tgtggacgtc ggcaccctcc ctgccgcgcc
     5041 tggtacggga gcccgtccgc tgcacctgct ctgcgcaggg caccggcttc tcctgcccca
     5101 gcagtgtggg cgggcacccg ccccagatgc gggtggtcac aggcgacatc ctgaccgaca
     5161 tcaccggcca caatgtctct gagtacctgc tcttcacctc cgaccgcttc cgactgcacc
     5221 ggtatggggc catcaccttt ggaaacgtcc tgaagtccat cccagcctca tttggcacca
     5281 gggccccacc catggtgcgg aagatcgcgg tgcgcagggc tgcccaggtt ttctacaaca
     5341 acaagggcta tcacagcatg cccacctacc tcaacagcct caacaacgcc atcctgcgtg
     5401 ccaacctgcc caagagcaag ggcaacccgg cggcttacgg catcaccgtc accaaccacc
     5461 ccatgaataa gaccagcgcc agcctctccc tggattacct gctgcagggc acggatgtcg
     5521 tcatcgccat cttcatcatc gtggccatgt ccttcgtgcc ggccagcttc gttgtcttcc
     5581 tcgtggccga gaagtccacc aaggccaagc acctgcagtt tgtcagcggc tgcaacccca
     5641 tcatctactg gctggcgaac tacgtgtggg acatgctcaa ctacctggtc cccgctacct
     5701 gctgtgtcat catcctgttt gtgttcgacc tgccggccta cacgtcgccc accaacttcc
     5761 ctgccgtcct ctccctcttc ctgctctatg ggtggtccat cacgcccatc atgtacccgg
     5821 cctccttctg gttcgaggtc cccagctccg cctacgtgtt cctcattgtc atcaatctct
     5881 tcatcggcat caccgccacc gtggccacct tcctgctaca gctcttcgag cacgacaagg
     5941 acctgaaggt tgtcaacagt tacctgaaaa gctgcttcct cattttcccc aactacaacc
     6001 tgggccacgg gctcatggag atggcctaca acgagtacat caacgagtac tacgccaaga
     6061 ttggccagtt tgacaagatg aagtccccgt tcgagtggga cattgtcacc cgcggactgg
     6121 tggccatggc ggttgagggc gtcgtgggct tcctcctgac catcatgtgc cagtacaact
     6181 tcctgcggcg gccacagcgc atgcctgtgt ctaccaagcc tgtggaggat gatgtggacg
     6241 tggccagtga gcggcagcga gtgctccggg gagacgccga caatgacatg gtcaagattg
     6301 agaacctgac caaggtctac aagtcccgga agattggccg tatcctggcc gttgaccgcc
     6361 tgtgcctggg tgtgcgtcct ggcgagtgct tcgggctcct gggcgtcaac ggtgcgggca
     6421 agaccagcac cttcaagatg ctgaccggcg acgagagcac gacggggggc gaggccttcg
     6481 tcaatggaca cagcgtgctg aaggagctgc tccaggtgca gcagagcctc ggctactgcc
     6541 cgcagtgtga cgcgctgttc gacgagctca cggcccggga gcacctgcag ctgtacacgc
     6601 ggctgcgtgg gatctcctgg aaggacgagg cccgggtggt gaagtgggct ctggagaagc
     6661 tggagctgac caagtacgca gacaagccgg ctggcaccta cagcggcggc aacaagcgga
     6721 agctctccac ggccatcgcc ctcattgggt acccagcctt catcttcctg gacgagccca
     6781 ccacaggcat ggaccccaag gcccggcgct tcctctggaa cctcatcctt gacctcatca
     6841 agacagggcg ttcagtggtg ctgacatcac acagcatgga ggagtgcgag gcgctgtgca
     6901 cgcggctggc catcatggtg aacggtcgcc tgcggtgcct gggcagcatc cagcacctga
     6961 agaaccggtt tggagatggc tacatgatca cggtgcggac caagagcagc cagagtgtga
     7021 aggacgtggt gcggttcttc aaccgcaact tcccggaagc catgctcaag gagcggcacc
     7081 acacaaaggt gcagtaccag ctcaagtcgg agcacatctc gctggcccag gtgttcagca
     7141 agatggagca ggtgtctggc gtgctgggca tcgaggacta ctcggtcagc cagaccacac
     7201 tggacaatgt gttcgtgaac tttgccaaga agcagagtga caacctggag cagcaggaga
     7261 cggagccgcc atccgcactg cagtcccctc tcggctgctt gctcagcctg ctccggcccc
     7321 ggtctgcccc cacggagctc cgggcacttg tggcagacga gcccgaggac ctggacacgg
     7381 aggacgaggg cctcatcagc ttcgaggagg agcgggccca gctgtccttc aacacggaca
     7441 cgctctgctg accacccaga gctgggccag ggaggacacg ctccactgac cacccagagc
     7501 tgggccaggg actcaacaat ggggacagaa gtcccccagt gcctgccagg gcctggagtg
     7561 gaggttcagg accaaggggc ttctggtcct ccagcccctg tactcggcca tgccctgtgg
     7621 tcactgcggt tgccgcccct aattgtgcca aaggctgacc cggcccgggc tgcgtacacc
     7681 cttgccctgc tttgccttaa agcctcgggg tctgcccggc ccctcgcccc tgcctggcac
     7741 tgctcaccgc ccaaggcgac gccggctgga ccaggcactg ctggcctttc tcctgcccgg
     7801 cctcggaacc agcttttctc tcttacgatg aaggctgatg ccgagagcgg gctgtgggcg
     7861 gagctgggtc agtcccgtat ttattttgct ttgagaagag gctcctctgg ccctgctctc
     7921 ctgcagggag gtggctgtcc tgcgggaagc catcagcttg ggccagctgg caggtggcag
     7981 gaatggagaa gctgaccctg ctggccaggc aaggggccag acccccccca acccccagct
     8041 gccatcgctc tcccacccag cttggccccc tgcccgccca cctccctggg agccgggcct
     8101 gtacatagcg cacagatgtt tgttttaaat aaataaacaa aatgtc
//
