LOCUS       NM_001606               8103 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ATP binding cassette subfamily A member 2 (ABCA2),
            transcript variant 1, mRNA.
ACCESSION   NM_001606
VERSION     NM_001606.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8103)
  AUTHORS   Inoue,Y., Tsuchida,N., Kim,C.A., de Oliveira Stephan,B.,
            Castro,M.A.A., Honjo,R.S., Bertola,D.R., Uchiyama,Y., Hamanaka,K.,
            Fujita,A., Koshimizu,E., Misawa,K., Miyatake,S., Mizuguchi,T. and
            Matsumoto,N.
  TITLE     Novel compound heterozygous ABCA2 variants cause IDPOGSA, a
            variable phenotypic syndrome with intellectual disability
  JOURNAL   J Hum Genet 69 (3-4), 163-167 (2024)
   PUBMED   38228874
  REMARK    GeneRIF: Novel compound heterozygous ABCA2 variants cause IDPOGSA,
            a variable phenotypic syndrome with intellectual disability.
REFERENCE   2  (bases 1 to 8103)
  AUTHORS   Shibata,Y., Matsumoto,N., Murase,R., Kubota,Y., Ishida,H.,
            Shimada,K. and Fujita,K.I.
  TITLE     A polymorphism in ABCA2 is associated with neutropenia induced by
            capecitabine in Japanese patients with colorectal cancer
  JOURNAL   Cancer Chemother Pharmacol 92 (6), 465-474 (2023)
   PUBMED   37653272
  REMARK    GeneRIF: A polymorphism in ABCA2 is associated with neutropenia
            induced by capecitabine in Japanese patients with colorectal
            cancer.
REFERENCE   3  (bases 1 to 8103)
  AUTHORS   Kim,M.S., Yang,S.H. and Kim,M.S.
  TITLE     Role of ABCA2 and its single nucleotide polymorphisms (4873T>A and
            4879G>C) in the regulation of multi-drug resistance in oral
            squamous carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 666, 1-9 (2023)
   PUBMED   37167718
  REMARK    GeneRIF: Role of ABCA2 and its single nucleotide polymorphisms
            (4873T>A and 4879G>C) in the regulation of multi-drug resistance in
            oral squamous carcinoma cells.
REFERENCE   4  (bases 1 to 8103)
  AUTHORS   Nedoszytko,B., Sobalska-Kwapis,M., Strapagiel,D., Lange,M.,
            Gorska,A., Elberink,J.N.G.O., van Doormaal,J., Slomka,M.,
            Kalinowski,L., Gruchala-Niedoszytko,M., Nowicki,R.J., Valent,P. and
            Niedoszytko,M.
  TITLE     Results from a Genome-Wide Association Study (GWAS) in Mastocytosis
            Reveal New Gene Polymorphisms Associated with WHO Subgroups
  JOURNAL   Int J Mol Sci 21 (15), 5506 (2020)
   PUBMED   32752121
  REMARK    GeneRIF: Results from a Genome-Wide Association Study (GWAS) in
            Mastocytosis Reveal New Gene Polymorphisms Associated with WHO
            Subgroups.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8103)
  AUTHORS   Sweeney,M.D., Zhao,Z., Montagne,A., Nelson,A.R. and Zlokovic,B.V.
  TITLE     Blood-Brain Barrier: From Physiology to Disease and Back
  JOURNAL   Physiol Rev 99 (1), 21-78 (2019)
   PUBMED   30280653
  REMARK    Review article
REFERENCE   6  (bases 1 to 8103)
  AUTHORS   Kaminski,W.E., Piehler,A., Pullmann,K., Porsch-Ozcurumez,M.,
            Duong,C., Bared,G.M., Buchler,C. and Schmitz,G.
  TITLE     Complete coding sequence, promoter region, and genomic structure of
            the human ABCA2 gene and evidence for sterol-dependent regulation
            in macrophages
  JOURNAL   Biochem Biophys Res Commun 281 (1), 249-258 (2001)
   PUBMED   11178988
REFERENCE   7  (bases 1 to 8103)
  AUTHORS   Zhao,L.X., Zhou,C.J., Tanaka,A., Nakata,M., Hirabayashi,T.,
            Amachi,T., Shioda,S., Ueda,K. and Inagaki,N.
  TITLE     Cloning, characterization and tissue distribution of the rat
            ATP-binding cassette (ABC) transporter ABC2/ABCA2
  JOURNAL   Biochem J 350 Pt 3 (Pt 3), 865-872 (2000)
   PUBMED   10970803
REFERENCE   8  (bases 1 to 8103)
  AUTHORS   Klucken,J., Buchler,C., Orso,E., Kaminski,W.E.,
            Porsch-Ozcurumez,M., Liebisch,G., Kapinsky,M., Diederich,W.,
            Drobnik,W., Dean,M., Allikmets,R. and Schmitz,G.
  TITLE     ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a
            regulator of macrophage cholesterol and phospholipid transport
  JOURNAL   Proc Natl Acad Sci U S A 97 (2), 817-822 (2000)
   PUBMED   10639163
REFERENCE   9  (bases 1 to 8103)
  AUTHORS   Allikmets,R., Gerrard,B., Glavac,D., Ravnik-Glavac,M.,
            Jenkins,N.A., Gilbert,D.J., Copeland,N.G., Modi,W. and Dean,M.
  TITLE     Characterization and mapping of three new mammalian ATP-binding
            transporter genes from an EST database
  JOURNAL   Mamm Genome 6 (2), 114-117 (1995)
   PUBMED   7766993
REFERENCE   10 (bases 1 to 8103)
  AUTHORS   Luciani,M.F., Denizot,F., Savary,S., Mattei,M.G. and Chimini,G.
  TITLE     Cloning of two novel ABC transporters mapping on human chromosome 9
  JOURNAL   Genomics 21 (1), 150-159 (1994)
   PUBMED   8088782
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL807752.10, CD676110.1,
            BM921499.1, BC029282.1, BF516223.1, AF178941.1, DB168116.1,
            BE273611.1, AL525193.3 and BM474929.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001606.4.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intracellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the ABC1 subfamily. Members of
            the ABC1 subfamily comprise the only major ABC subfamily found
            exclusively in multicellular eukaryotes. This protein is highly
            expressed in brain tissue and may play a role in macrophage lipid
            metabolism and neural development. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the predominant isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341511.11/ ENSP00000344155.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AL807752.10        98153-98199         c
            48-641              CD676110.1         37-630
            642-768             BM921499.1         641-767
            769-2056            BC029282.1         778-2065
            2057-2483           BF516223.1         8-434
            2484-5568           AF178941.1         2437-5521
            5569-6080           DB168116.1         80-591
            6081-6786           AF178941.1         6034-6739
            6787-7372           BE273611.1         54-639
            7373-7776           AL525193.3         272-675             c
            7777-8103           BM474929.1         173-499
FEATURES             Location/Qualifiers
     source          1..8103
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..8103
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /note="ATP binding cassette subfamily A member 2"
                     /db_xref="GeneID:20"
                     /db_xref="HGNC:HGNC:32"
                     /db_xref="MIM:600047"
     exon            1..163
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..7408
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /note="isoform a is encoded by transcript variant 1;
                     ATP-binding cassette, sub-family A, member 2; ATP-binding
                     cassette 2; ATP-binding cassette transporter 2;
                     ATP-binding cassette, sub-family A (ABC1), member 2"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family A member 2
                     isoform a"
                     /protein_id="NP_001597.2"
                     /db_xref="CCDS:CCDS43909.1"
                     /db_xref="GeneID:20"
                     /db_xref="HGNC:HGNC:32"
                     /db_xref="MIM:600047"
                     /translation="MGFLHQLQLLLWKNVTLKRRSPWVLAFEIFIPLVLFFILLGLRQ
                     KKPTISVKEVSFYTAAPLTSAGILPVMQSLCPDGQRDEFGFLQYANSTVTQLLERLDR
                     VVEEGNLFDPARPSLGSELEALRQHLEALSAGPGTSGSHLDRSTVSSFSLDSVARNPQ
                     ELWRFLTQNLSLPNSTAQALLAARVDPPEVYHLLFGPSSALDSQSGLHKGQEPWSRLG
                     GNPLFRMEELLLAPALLEQLTCTPGSGELGRILTVPESQKGALQGYRDAVCSGQAAAR
                     ARRFSGLSAELRNQLDVAKVSQQLGLDAPNGSDSSPQAPPPRRLQALLGDLLDAQKVL
                     QDVDVLSALALLLPQGACTGRTPGPPASGAGGAANGTGAGAVMGPNATAEEGAPSAAA
                     LATPDTLQGQCSAFVQLWAGLQPILCGNNRTIEPEALRRGNMSSLGFTSKEQRNLGLL
                     VHLMTSNPKILYAPAGSEVDRVILKANETFAFVGNVTHYAQVWLNISAEIRSFLEQGR
                     LQQHLRWLQQYVAELRLHPEALNLSLDELPPALRQDNFSLPSGMALLQQLDTIDNAAC
                     GWIQFMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGSLPPHVHY
                     KIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLYGFVWIQDMMERAIIDTFVGHDVVE
                     PGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMK
                     TMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAVATI
                     MFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMST
                     TAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDAVVYGILTWYI
                     EAVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESR
                     RFEETRGMEEEPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAG
                     KTTTMSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWF
                     YSRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAII
                     LDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCG
                     SPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQFIRKHV
                     ASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEEVFL
                     KVSEEDQSLENSEADVKESRKDVLPGAEGPASGEGHAGNLARCSELTQSQASLQSASS
                     VGSARGDEGAGYTDVYGDYRPLFDNPQDPDNVSLQEVEAEALSRVGQGSRKLDGGWLK
                     VRQFHGLLVKRFHCARRNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQ
                     YHNYTQPRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGS
                     LGPTLNLSSGESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQ
                     AWNVSLPPTAGPEMWTSAPSLPRLVREPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTG
                     DILTDITGHNVSEYLLFTSDRFRLHRYGAITFGNVLKSIPASFGTRAPPMVRKIAVRR
                     AAQVFYNNKGYHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSL
                     DYLLQGTDVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYV
                     WDMLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEV
                     PSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGL
                     MEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMAVEGVVGFLLTIMCQYNFLR
                     RPQRMPVSTKPVEDDVDVASERQRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDRL
                     CLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKELLQVQQSLGY
                     CPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYADKPAGTYSGG
                     NKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEE
                     CEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVRFFNRNFPE
                     AMLKERHHTKVQYQLKSEHISLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFAKK
                     QSDNLEQQETEPPSALQSPLGCLLSLLRPRSAPTELRALVADEPEDLDTEDEGLISFE
                     EERAQLSFNTDTLC"
     exon            164..257
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            258..260
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            261..372
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            373..536
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            537..664
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            665..775
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            776..994
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1362
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1522
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1651
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1819
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1916
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2090
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2193
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2308
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2499
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2650
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2855
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2856..3020
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3201
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            3202..3414
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            3415..3611
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            3612..3794
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            3795..3979
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            3980..4100
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            4101..4337
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            4338..4544
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            4545..4647
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            4648..4964
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            4965..5178
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            5179..5284
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            5285..5396
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            5397..5457
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            5458..5632
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            5633..5748
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            5749..5896
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            5897..6020
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            6021..6153
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            6154..6271
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            6272..6450
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            6451..6592
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            6593..6727
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            6728..6831
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            6832..6924
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            6925..7027
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            7028..7165
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            7166..7372
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            7373..8103
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8085..8090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /note="hexamer: AATAAA"
     polyA_site      8103
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgggcga tgcccagcgg cgcggcgggc tgcggggccc ggcggggcgc gcagaggagc
       61 gggccgcggc gctgaggcgg cggagcgtgg ccccgccatg ggcttcctgc accagctgca
      121 gctgctgctc tggaagaacg tgacgctcaa acgccggagc ccgtgggtcc tggccttcga
      181 gatcttcatc cccctggtgc tgttctttat cctgctgggg ctgcgacaga agaagcccac
      241 catctccgtg aaggaagtct ccttctacac agcggcgccc ctgacgtctg ccggcatcct
      301 gcctgtcatg caatcgctgt gcccggacgg ccagcgagac gagttcggct tcctgcagta
      361 cgccaactcc acggtcacgc agctgcttga gcgcctggac cgcgtggtgg aggaaggcaa
      421 cctgtttgac ccagcgcggc ccagcctggg ctcagagctc gaggccctac gccagcatct
      481 ggaggccctc agtgcgggcc cgggcacctc ggggagccac ctggacagat ccacagtgtc
      541 ttccttctct ctggactcgg tggccagaaa cccgcaggag ctctggcgtt tcctgacgca
      601 aaacttgtcg ctgcccaata gcacggccca agcactcttg gccgcccgtg tggacccgcc
      661 cgaggtctac cacctgctct ttggtccctc atctgccctg gattcacagt ctggcctcca
      721 caagggtcag gagccctgga gccgcctagg gggcaatccc ctgttccgga tggaggagct
      781 gctgctggct cctgccctcc tggagcagct cacctgcacg ccgggctcgg gggagctggg
      841 ccggatcctc actgtgcctg agagtcagaa gggagccctg cagggctacc gggatgctgt
      901 ctgcagtggg caggctgctg cgcgtgccag gcgcttctct gggctgtctg ctgagctccg
      961 gaaccagctg gacgtggcca aggtctccca gcagctgggc ctggatgccc ccaacggctc
     1021 ggactcctcg ccacaggcgc cacccccacg gaggctgcag gcgcttctgg gggacctgct
     1081 ggatgcccag aaggttctgc aggatgtgga tgtcctgtcg gccctggccc tgctactgcc
     1141 ccagggtgcc tgcactggcc ggacccccgg acccccagcc agtggtgcgg gtggggcggc
     1201 caatggcact ggggcagggg cagtcatggg ccccaacgcc accgctgagg agggcgcacc
     1261 ctctgctgca gcactggcca ccccggacac gctgcagggc cagtgctcag ccttcgtaca
     1321 gctctgggcc ggcctgcagc ccatcttgtg tggcaacaac cgcaccattg aacccgaggc
     1381 gctgcggcgg ggcaacatga gctccctggg cttcacgagc aaggagcagc ggaacctggg
     1441 cctcctcgtg cacctcatga ccagcaaccc caaaatcctg tacgcgcctg cgggctctga
     1501 ggtcgaccgc gtcatcctca aggccaacga gacttttgct tttgtgggca acgtgactca
     1561 ctatgcccag gtctggctca acatctcggc ggagatccgc agcttcctgg agcagggcag
     1621 gctgcagcaa cacctgcgct ggctgcagca gtatgtagca gagctgcggc tgcaccccga
     1681 ggcactgaac ctgtcactgg atgagctgcc gccggccctg agacaggaca acttctcgct
     1741 gcccagtggc atggccctcc tgcagcagct ggataccatt gacaacgcgg cctgcggctg
     1801 gatccagttc atgtccaagg tgagcgtgga catcttcaag ggcttccccg acgaggagag
     1861 cattgtcaac tacaccctca accaggccta ccaggacaac gtcactgttt ttgccagtgt
     1921 gatcttccag acccggaagg acggctcgct cccgcctcac gtgcactaca agatccgcca
     1981 gaactccagc ttcaccgaga aaaccaacga gatccgccgc gcctactggc ggcctgggcc
     2041 caatactggc ggccgcttct acttcctcta cggcttcgtc tggatccagg acatgatgga
     2101 gcgcgccatc atcgacactt ttgtggggca cgatgtggtg gagccaggca gctacgtgca
     2161 gatgttcccc tacccctgct acacacgcga tgacttcctg tttgtcattg agcacatgat
     2221 gccgctgtgc atggtgatct cctgggtcta ctccgtggcc atgaccatcc agcacatcgt
     2281 ggcggagaag gagcaccggc tcaaggaggt gatgaagacc atgggcctga acaacgcggt
     2341 gcactgggtg gcctggttca tcaccggctt tgtgcagctg tccatctccg tgacagcact
     2401 caccgccatc ctgaagtacg gccaggtgct tatgcacagc cacgtggtca tcatctggct
     2461 cttcctggca gtctacgcgg tggccaccat catgttctgc ttcctggtgt ctgtgctgta
     2521 ctccaaggcc aagctggcct cggcctgcgg tggcatcatc tacttcctga gctacgtgcc
     2581 ctacatgtac gtggcgatcc gagaggaggt ggcgcatgat aagatcacgg ccttcgagaa
     2641 gtgcatcgcg tccctcatgt ccacgacggc ctttggtctg ggctctaagt acttcgcgct
     2701 gtatgaggtg gccggcgtgg gcatccagtg gcacaccttc agccagtccc cggtggaggg
     2761 ggacgacttc aacttgctcc tggctgtcac catgctgatg gtggacgccg tggtctatgg
     2821 catcctcacg tggtacattg aggctgtgca cccaggcatg tacgggctgc cccggccctg
     2881 gtacttccca ctgcagaagt cctactggct gggcagtggg cggacagaag cctgggagtg
     2941 gagctggccg tgggcacgca ccccccgcct cagtgtcatg gaggaggacc aggcctgtgc
     3001 catggagagc cggcgctttg aggagacccg tggcatggag gaggagccca cccacctgcc
     3061 tctggttgtc tgcgtggaca aactcaccaa ggtctacaag gacgacaaga agctggccct
     3121 gaacaagctg agcctgaacc tctacgagaa ccaggtggtc tccttcttgg gccacaacgg
     3181 ggcgggcaag accaccacca tgtccatcct gaccggcctg ttccctccaa cgtcgggttc
     3241 cgccaccatc tacgggcacg acatccgcac ggagatggat gagatccgca agaacctggg
     3301 catgtgcccg cagcacaatg tgctctttga ccggctcacg gtggaggaac acctctggtt
     3361 ctactcacgg ctcaagagca tggctcagga ggagatccgc agagagatgg acaagatgat
     3421 cgaggacctg gagctctcca acaaacggca ctcactggtg cagacattgt cgggtggcat
     3481 gaagcgcaag ctgtccgtgg ccatcgcctt cgtgggcggc tctcgcgcca tcatcctgga
     3541 cgagcccacg gcgggcgtgg acccctacgc gcgccgcgcc atctgggacc tcatcctgaa
     3601 gtacaagcca ggccgcacca tccttctgtc cacccaccac atggatgagg ctgacctgct
     3661 tggggaccgc attgccatca tctcccatgg gaagctcaag tgctgcggct ccccgctctt
     3721 cctcaagggc acctatggcg acgggtaccg cctcacgctg gtcaagcggc ccgccgagcc
     3781 ggggggcccc caagagccag ggctggcatc cagcccccca ggtcgggccc cgctgagcag
     3841 ctgctccgag ctccaggtgt cccagttcat ccgcaagcat gtggcctcct gcctgctggt
     3901 ctcagacaca agcacggagc tctcctacat cctgcccagc gaggccgcca agaagggggc
     3961 tttcgagcgc ctcttccagc acctggagcg cagcctggat gcactgcacc tcagcagctt
     4021 cgggctgatg gacacgaccc tggaggaagt gttcctcaag gtgtcggagg aggatcagtc
     4081 gctggagaac agtgaggccg atgtgaagga gtccaggaag gatgtgctcc ctggggcgga
     4141 gggcccggcg tctggggagg gtcacgctgg caatctggcc cggtgctcgg agctgaccca
     4201 gtcgcaggca tcgctgcagt cggcgtcatc tgtgggctct gcccgtggcg acgagggagc
     4261 tggctacacc gacgtctatg gcgactaccg ccccctcttt gataacccac aggacccaga
     4321 caatgtcagc ctgcaagagg tggaggcaga ggccctgtcg agggtcggcc agggcagccg
     4381 caagctggac ggcgggtggc tgaaggtgcg ccagttccac gggctgctgg tcaaacgctt
     4441 ccactgcgcc cgccgcaact ccaaggcact cttctcccag atcttgctgc cagccttctt
     4501 cgtctgcgtg gccatgaccg tggccctgtc cgtcccggag attggtgatc tgcccccgct
     4561 ggtcctgtca ccttcccagt accacaacta cacccagccc cgtggcaatt tcatccccta
     4621 cgccaacgag gagcgccgcg agtaccggct gcggctatcg cccgacgcca gcccccagca
     4681 gctcgtgagc acgttccggc tgccgtcggg ggtgggtgcc acctgcgtgc tcaagtctcc
     4741 cgccaacggc tcgctggggc ccacgttgaa cctgagcagc ggggagtcgc gcctgctggc
     4801 ggctcggttc ttcgacagca tgtgtctgga gtccttcaca caggggctgc cactgtccaa
     4861 tttcgtgcca cccccaccct cgcccgcccc atctgactcg ccagcgtccc cggatgagga
     4921 cctgcaggcc tggaacgtct ccctgccgcc caccgctggg ccagaaatgt ggacgtcggc
     4981 accctccctg ccgcgcctgg tacgggagcc cgtccgctgc acctgctctg cgcagggcac
     5041 cggcttctcc tgccccagca gtgtgggcgg gcacccgccc cagatgcggg tggtcacagg
     5101 cgacatcctg accgacatca ccggccacaa tgtctctgag tacctgctct tcacctccga
     5161 ccgcttccga ctgcaccggt atggggccat cacctttgga aacgtcctga agtccatccc
     5221 agcctcattt ggcaccaggg ccccacccat ggtgcggaag atcgcggtgc gcagggctgc
     5281 ccaggttttc tacaacaaca agggctatca cagcatgccc acctacctca acagcctcaa
     5341 caacgccatc ctgcgtgcca acctgcccaa gagcaagggc aacccggcgg cttacggcat
     5401 caccgtcacc aaccacccca tgaataagac cagcgccagc ctctccctgg attacctgct
     5461 gcagggcacg gatgtcgtca tcgccatctt catcatcgtg gccatgtcct tcgtgccggc
     5521 cagcttcgtt gtcttcctcg tggccgagaa gtccaccaag gccaagcacc tgcagtttgt
     5581 cagcggctgc aaccccatca tctactggct ggcgaactac gtgtgggaca tgctcaacta
     5641 cctggtcccc gctacctgct gtgtcatcat cctgtttgtg ttcgacctgc cggcctacac
     5701 gtcgcccacc aacttccctg ccgtcctctc cctcttcctg ctctatgggt ggtccatcac
     5761 gcccatcatg tacccggcct ccttctggtt cgaggtcccc agctccgcct acgtgttcct
     5821 cattgtcatc aatctcttca tcggcatcac cgccaccgtg gccaccttcc tgctacagct
     5881 cttcgagcac gacaaggacc tgaaggttgt caacagttac ctgaaaagct gcttcctcat
     5941 tttccccaac tacaacctgg gccacgggct catggagatg gcctacaacg agtacatcaa
     6001 cgagtactac gccaagattg gccagtttga caagatgaag tccccgttcg agtgggacat
     6061 tgtcacccgc ggactggtgg ccatggcggt tgagggcgtc gtgggcttcc tcctgaccat
     6121 catgtgccag tacaacttcc tgcggcggcc acagcgcatg cctgtgtcta ccaagcctgt
     6181 ggaggatgat gtggacgtgg ccagtgagcg gcagcgagtg ctccggggag acgccgacaa
     6241 tgacatggtc aagattgaga acctgaccaa ggtctacaag tcccggaaga ttggccgtat
     6301 cctggccgtt gaccgcctgt gcctgggtgt gcgtcctggc gagtgcttcg ggctcctggg
     6361 cgtcaacggt gcgggcaaga ccagcacctt caagatgctg accggcgacg agagcacgac
     6421 ggggggcgag gccttcgtca atggacacag cgtgctgaag gagctgctcc aggtgcagca
     6481 gagcctcggc tactgcccgc agtgtgacgc gctgttcgac gagctcacgg cccgggagca
     6541 cctgcagctg tacacgcggc tgcgtgggat ctcctggaag gacgaggccc gggtggtgaa
     6601 gtgggctctg gagaagctgg agctgaccaa gtacgcagac aagccggctg gcacctacag
     6661 cggcggcaac aagcggaagc tctccacggc catcgccctc attgggtacc cagccttcat
     6721 cttcctggac gagcccacca caggcatgga ccccaaggcc cggcgcttcc tctggaacct
     6781 catccttgac ctcatcaaga cagggcgttc agtggtgctg acatcacaca gcatggagga
     6841 gtgcgaggcg ctgtgcacgc ggctggccat catggtgaac ggtcgcctgc ggtgcctggg
     6901 cagcatccag cacctgaaga accggtttgg agatggctac atgatcacgg tgcggaccaa
     6961 gagcagccag agtgtgaagg acgtggtgcg gttcttcaac cgcaacttcc cggaagccat
     7021 gctcaaggag cggcaccaca caaaggtgca gtaccagctc aagtcggagc acatctcgct
     7081 ggcccaggtg ttcagcaaga tggagcaggt gtctggcgtg ctgggcatcg aggactactc
     7141 ggtcagccag accacactgg acaatgtgtt cgtgaacttt gccaagaagc agagtgacaa
     7201 cctggagcag caggagacgg agccgccatc cgcactgcag tcccctctcg gctgcttgct
     7261 cagcctgctc cggccccggt ctgcccccac ggagctccgg gcacttgtgg cagacgagcc
     7321 cgaggacctg gacacggagg acgagggcct catcagcttc gaggaggagc gggcccagct
     7381 gtccttcaac acggacacgc tctgctgacc acccagagct gggccaggga ggacacgctc
     7441 cactgaccac ccagagctgg gccagggact caacaatggg gacagaagtc ccccagtgcc
     7501 tgccagggcc tggagtggag gttcaggacc aaggggcttc tggtcctcca gcccctgtac
     7561 tcggccatgc cctgtggtca ctgcggttgc cgcccctaat tgtgccaaag gctgacccgg
     7621 cccgggctgc gtacaccctt gccctgcttt gccttaaagc ctcggggtct gcccggcccc
     7681 tcgcccctgc ctggcactgc tcaccgccca aggcgacgcc ggctggacca ggcactgctg
     7741 gcctttctcc tgcccggcct cggaaccagc ttttctctct tacgatgaag gctgatgccg
     7801 agagcgggct gtgggcggag ctgggtcagt cccgtattta ttttgctttg agaagaggct
     7861 cctctggccc tgctctcctg cagggaggtg gctgtcctgc gggaagccat cagcttgggc
     7921 cagctggcag gtggcaggaa tggagaagct gaccctgctg gccaggcaag gggccagacc
     7981 ccccccaacc cccagctgcc atcgctctcc cacccagctt ggccccctgc ccgcccacct
     8041 ccctgggagc cgggcctgta catagcgcac agatgtttgt tttaaataaa taaacaaaat
     8101 gtc
//
