LOCUS       NM_001411042            8100 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens ATP binding cassette subfamily A member 2 (ABCA2),
            transcript variant 3, mRNA.
ACCESSION   NM_001411042 XM_006716996
VERSION     NM_001411042.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8100)
  AUTHORS   Inoue,Y., Tsuchida,N., Kim,C.A., de Oliveira Stephan,B.,
            Castro,M.A.A., Honjo,R.S., Bertola,D.R., Uchiyama,Y., Hamanaka,K.,
            Fujita,A., Koshimizu,E., Misawa,K., Miyatake,S., Mizuguchi,T. and
            Matsumoto,N.
  TITLE     Novel compound heterozygous ABCA2 variants cause IDPOGSA, a
            variable phenotypic syndrome with intellectual disability
  JOURNAL   J Hum Genet 69 (3-4), 163-167 (2024)
   PUBMED   38228874
  REMARK    GeneRIF: Novel compound heterozygous ABCA2 variants cause IDPOGSA,
            a variable phenotypic syndrome with intellectual disability.
REFERENCE   2  (bases 1 to 8100)
  AUTHORS   Shibata,Y., Matsumoto,N., Murase,R., Kubota,Y., Ishida,H.,
            Shimada,K. and Fujita,K.I.
  TITLE     A polymorphism in ABCA2 is associated with neutropenia induced by
            capecitabine in Japanese patients with colorectal cancer
  JOURNAL   Cancer Chemother Pharmacol 92 (6), 465-474 (2023)
   PUBMED   37653272
  REMARK    GeneRIF: A polymorphism in ABCA2 is associated with neutropenia
            induced by capecitabine in Japanese patients with colorectal
            cancer.
REFERENCE   3  (bases 1 to 8100)
  AUTHORS   Kim,M.S., Yang,S.H. and Kim,M.S.
  TITLE     Role of ABCA2 and its single nucleotide polymorphisms (4873T>A and
            4879G>C) in the regulation of multi-drug resistance in oral
            squamous carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 666, 1-9 (2023)
   PUBMED   37167718
  REMARK    GeneRIF: Role of ABCA2 and its single nucleotide polymorphisms
            (4873T>A and 4879G>C) in the regulation of multi-drug resistance in
            oral squamous carcinoma cells.
REFERENCE   4  (bases 1 to 8100)
  AUTHORS   Nedoszytko,B., Sobalska-Kwapis,M., Strapagiel,D., Lange,M.,
            Gorska,A., Elberink,J.N.G.O., van Doormaal,J., Slomka,M.,
            Kalinowski,L., Gruchala-Niedoszytko,M., Nowicki,R.J., Valent,P. and
            Niedoszytko,M.
  TITLE     Results from a Genome-Wide Association Study (GWAS) in Mastocytosis
            Reveal New Gene Polymorphisms Associated with WHO Subgroups
  JOURNAL   Int J Mol Sci 21 (15), 5506 (2020)
   PUBMED   32752121
  REMARK    GeneRIF: Results from a Genome-Wide Association Study (GWAS) in
            Mastocytosis Reveal New Gene Polymorphisms Associated with WHO
            Subgroups.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8100)
  AUTHORS   Sweeney,M.D., Zhao,Z., Montagne,A., Nelson,A.R. and Zlokovic,B.V.
  TITLE     Blood-Brain Barrier: From Physiology to Disease and Back
  JOURNAL   Physiol Rev 99 (1), 21-78 (2019)
   PUBMED   30280653
  REMARK    Review article
REFERENCE   6  (bases 1 to 8100)
  AUTHORS   Kaminski,W.E., Piehler,A., Pullmann,K., Porsch-Ozcurumez,M.,
            Duong,C., Bared,G.M., Buchler,C. and Schmitz,G.
  TITLE     Complete coding sequence, promoter region, and genomic structure of
            the human ABCA2 gene and evidence for sterol-dependent regulation
            in macrophages
  JOURNAL   Biochem Biophys Res Commun 281 (1), 249-258 (2001)
   PUBMED   11178988
REFERENCE   7  (bases 1 to 8100)
  AUTHORS   Zhao,L.X., Zhou,C.J., Tanaka,A., Nakata,M., Hirabayashi,T.,
            Amachi,T., Shioda,S., Ueda,K. and Inagaki,N.
  TITLE     Cloning, characterization and tissue distribution of the rat
            ATP-binding cassette (ABC) transporter ABC2/ABCA2
  JOURNAL   Biochem J 350 Pt 3 (Pt 3), 865-872 (2000)
   PUBMED   10970803
REFERENCE   8  (bases 1 to 8100)
  AUTHORS   Klucken,J., Buchler,C., Orso,E., Kaminski,W.E.,
            Porsch-Ozcurumez,M., Liebisch,G., Kapinsky,M., Diederich,W.,
            Drobnik,W., Dean,M., Allikmets,R. and Schmitz,G.
  TITLE     ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a
            regulator of macrophage cholesterol and phospholipid transport
  JOURNAL   Proc Natl Acad Sci U S A 97 (2), 817-822 (2000)
   PUBMED   10639163
REFERENCE   9  (bases 1 to 8100)
  AUTHORS   Allikmets,R., Gerrard,B., Glavac,D., Ravnik-Glavac,M.,
            Jenkins,N.A., Gilbert,D.J., Copeland,N.G., Modi,W. and Dean,M.
  TITLE     Characterization and mapping of three new mammalian ATP-binding
            transporter genes from an EST database
  JOURNAL   Mamm Genome 6 (2), 114-117 (1995)
   PUBMED   7766993
REFERENCE   10 (bases 1 to 8100)
  AUTHORS   Luciani,M.F., Denizot,F., Savary,S., Mattei,M.G. and Chimini,G.
  TITLE     Cloning of two novel ABC transporters mapping on human chromosome 9
  JOURNAL   Genomics 21 (1), 150-159 (1994)
   PUBMED   8088782
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL807752.10 and KF458947.1.
            
            On Aug 20, 2022 this sequence version replaced XM_006716996.5.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intracellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the ABC1 subfamily. Members of
            the ABC1 subfamily comprise the only major ABC subfamily found
            exclusively in multicellular eukaryotes. This protein is highly
            expressed in brain tissue and may play a role in macrophage lipid
            metabolism and neural development. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF327657.1, AF178941.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               AL807752.10        98037-98199         c
            164-257             AL807752.10        94105-94198         c
            258-369             AL807752.10        92903-93014         c
            370-533             AL807752.10        92664-92827         c
            534-661             AL807752.10        92313-92440         c
            662-772             AL807752.10        91853-91963         c
            773-991             AL807752.10        91354-91572         c
            992-1359            AL807752.10        90656-91023         c
            1360-1519           AL807752.10        90298-90457         c
            1520-1648           AL807752.10        89140-89268         c
            1649-1796           AL807752.10        88885-89032         c
            1797-1816           KF458947.1         1-20
            1817-1913           KF458947.1         108-204
            1914-2087           AL807752.10        88140-88313         c
            2088-2190           AL807752.10        87935-88037         c
            2191-2305           AL807752.10        87749-87863         c
            2306-2496           AL807752.10        87464-87654         c
            2497-2647           AL807752.10        87158-87308         c
            2648-2852           AL807752.10        86882-87086         c
            2853-3017           AL807752.10        86536-86700         c
            3018-3198           AL807752.10        86253-86433         c
            3199-3411           AL807752.10        85924-86136         c
            3412-3608           AL807752.10        85637-85833         c
            3609-3791           AL807752.10        85376-85558         c
            3792-3976           AL807752.10        84875-85059         c
            3977-4097           AL807752.10        84652-84772         c
            4098-4334           AL807752.10        84130-84366         c
            4335-4541           AL807752.10        83794-84000         c
            4542-4644           AL807752.10        83423-83525         c
            4645-4961           AL807752.10        82964-83280         c
            4962-5175           AL807752.10        82674-82887         c
            5176-5281           AL807752.10        82447-82552         c
            5282-5393           AL807752.10        82227-82338         c
            5394-5454           AL807752.10        82064-82124         c
            5455-5629           AL807752.10        81806-81980         c
            5630-5745           AL807752.10        81596-81711         c
            5746-5893           AL807752.10        81369-81516         c
            5894-6017           AL807752.10        81148-81271         c
            6018-6150           AL807752.10        80935-81067         c
            6151-6268           AL807752.10        80582-80699         c
            6269-6447           AL807752.10        80155-80333         c
            6448-6589           AL807752.10        79945-80086         c
            6590-6724           AL807752.10        79731-79865         c
            6725-6828           AL807752.10        79503-79606         c
            6829-6921           AL807752.10        79332-79424         c
            6922-7024           AL807752.10        78913-79015         c
            7025-7162           AL807752.10        78693-78830         c
            7163-7369           AL807752.10        78378-78584         c
            7370-8100           AL807752.10        77196-77926         c
FEATURES             Location/Qualifiers
     source          1..8100
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..8100
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /note="ATP binding cassette subfamily A member 2"
                     /db_xref="GeneID:20"
                     /db_xref="HGNC:HGNC:32"
                     /db_xref="MIM:600047"
     exon            1..163
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..7405
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /note="isoform c is encoded by transcript variant 3;
                     ATP-binding cassette, sub-family A, member 2; ATP-binding
                     cassette 2; ATP-binding cassette transporter 2;
                     ATP-binding cassette, sub-family A (ABC1), member 2"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family A member 2
                     isoform c"
                     /protein_id="NP_001397971.1"
                     /db_xref="CCDS:CCDS94538.1"
                     /db_xref="GeneID:20"
                     /db_xref="HGNC:HGNC:32"
                     /db_xref="MIM:600047"
                     /translation="MGFLHQLQLLLWKNVTLKRRSPWVLAFEIFIPLVLFFILLGLRQ
                     KKPTISVKEAFYTAAPLTSAGILPVMQSLCPDGQRDEFGFLQYANSTVTQLLERLDRV
                     VEEGNLFDPARPSLGSELEALRQHLEALSAGPGTSGSHLDRSTVSSFSLDSVARNPQE
                     LWRFLTQNLSLPNSTAQALLAARVDPPEVYHLLFGPSSALDSQSGLHKGQEPWSRLGG
                     NPLFRMEELLLAPALLEQLTCTPGSGELGRILTVPESQKGALQGYRDAVCSGQAAARA
                     RRFSGLSAELRNQLDVAKVSQQLGLDAPNGSDSSPQAPPPRRLQALLGDLLDAQKVLQ
                     DVDVLSALALLLPQGACTGRTPGPPASGAGGAANGTGAGAVMGPNATAEEGAPSAAAL
                     ATPDTLQGQCSAFVQLWAGLQPILCGNNRTIEPEALRRGNMSSLGFTSKEQRNLGLLV
                     HLMTSNPKILYAPAGSEVDRVILKANETFAFVGNVTHYAQVWLNISAEIRSFLEQGRL
                     QQHLRWLQQYVAELRLHPEALNLSLDELPPALRQDNFSLPSGMALLQQLDTIDNAACG
                     WIQFMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGSLPPHVHYK
                     IRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLYGFVWIQDMMERAIIDTFVGHDVVEP
                     GSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKT
                     MGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAVATIM
                     FCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTT
                     AFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDAVVYGILTWYIE
                     AVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRR
                     FEETRGMEEEPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGK
                     TTTMSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFY
                     SRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIIL
                     DEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGS
                     PLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQFIRKHVA
                     SCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEEVFLK
                     VSEEDQSLENSEADVKESRKDVLPGAEGPASGEGHAGNLARCSELTQSQASLQSASSV
                     GSARGDEGAGYTDVYGDYRPLFDNPQDPDNVSLQEVEAEALSRVGQGSRKLDGGWLKV
                     RQFHGLLVKRFHCARRNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQY
                     HNYTQPRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSL
                     GPTLNLSSGESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQA
                     WNVSLPPTAGPEMWTSAPSLPRLVREPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTGD
                     ILTDITGHNVSEYLLFTSDRFRLHRYGAITFGNVLKSIPASFGTRAPPMVRKIAVRRA
                     AQVFYNNKGYHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLD
                     YLLQGTDVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVW
                     DMLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEVP
                     SSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLM
                     EMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMAVEGVVGFLLTIMCQYNFLRR
                     PQRMPVSTKPVEDDVDVASERQRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDRLC
                     LGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKELLQVQQSLGYC
                     PQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYADKPAGTYSGGN
                     KRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEEC
                     EALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVRFFNRNFPEA
                     MLKERHHTKVQYQLKSEHISLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFAKKQ
                     SDNLEQQETEPPSALQSPLGCLLSLLRPRSAPTELRALVADEPEDLDTEDEGLISFEE
                     ERAQLSFNTDTLC"
     exon            164..257
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            258..369
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            370..533
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            534..661
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            662..772
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            773..991
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1359
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1519
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1648
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1816
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1913
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2087
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2190
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2305
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2496
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2647
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2852
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..3017
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3198
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            3199..3411
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            3412..3608
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            3609..3791
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            3792..3976
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            3977..4097
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            4098..4334
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            4335..4541
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            4542..4644
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            4645..4961
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            4962..5175
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            5176..5281
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            5282..5393
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            5394..5454
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            5455..5629
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            5630..5745
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            5746..5893
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            5894..6017
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            6018..6150
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            6151..6268
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            6269..6447
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            6448..6589
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            6590..6724
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            6725..6828
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            6829..6921
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            6922..7024
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            7025..7162
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            7163..7369
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     exon            7370..8100
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8082..8087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /note="hexamer: AATAAA"
     polyA_site      8100
                     /gene="ABCA2"
                     /gene_synonym="ABC2; IDPOGSA"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgggcga tgcccagcgg cgcggcgggc tgcggggccc ggcggggcgc gcagaggagc
       61 gggccgcggc gctgaggcgg cggagcgtgg ccccgccatg ggcttcctgc accagctgca
      121 gctgctgctc tggaagaacg tgacgctcaa acgccggagc ccgtgggtcc tggccttcga
      181 gatcttcatc cccctggtgc tgttctttat cctgctgggg ctgcgacaga agaagcccac
      241 catctccgtg aaggaagcct tctacacagc ggcgcccctg acgtctgccg gcatcctgcc
      301 tgtcatgcaa tcgctgtgcc cggacggcca gcgagacgag ttcggcttcc tgcagtacgc
      361 caactccacg gtcacgcagc tgcttgagcg cctggaccgc gtggtggagg aaggcaacct
      421 gtttgaccca gcgcggccca gcctgggctc agagctcgag gccctacgcc agcatctgga
      481 ggccctcagt gcgggcccgg gcacctcggg gagccacctg gacagatcca cagtgtcttc
      541 cttctctctg gactcggtgg ccagaaaccc gcaggagctc tggcgtttcc tgacgcaaaa
      601 cttgtcgctg cccaatagca cggcccaagc actcttggcc gcccgtgtgg acccgcccga
      661 ggtctaccac ctgctctttg gtccctcatc tgccctggat tcacagtctg gcctccacaa
      721 gggtcaggag ccctggagcc gcctaggggg caatcccctg ttccggatgg aggagctgct
      781 gctggctcct gccctcctgg agcagctcac ctgcacgccg ggctcggggg agctgggccg
      841 gatcctcact gtgcctgaga gtcagaaggg agccctgcag ggctaccggg atgctgtctg
      901 cagtgggcag gctgctgcgc gtgccaggcg cttctctggg ctgtctgctg agctccggaa
      961 ccagctggac gtggccaagg tctcccagca gctgggcctg gatgccccca acggctcgga
     1021 ctcctcgcca caggcgccac ccccacggag gctgcaggcg cttctggggg acctgctgga
     1081 tgcccagaag gttctgcagg atgtggatgt cctgtcggcc ctggccctgc tactgcccca
     1141 gggtgcctgc actggccgga cccccggacc cccagccagt ggtgcgggtg gggcggccaa
     1201 tggcactggg gcaggggcag tcatgggccc caacgccacc gctgaggagg gcgcaccctc
     1261 tgctgcagca ctggccaccc cggacacgct gcagggccag tgctcagcct tcgtacagct
     1321 ctgggccggc ctgcagccca tcttgtgtgg caacaaccgc accattgaac ccgaggcgct
     1381 gcggcggggc aacatgagct ccctgggctt cacgagcaag gagcagcgga acctgggcct
     1441 cctcgtgcac ctcatgacca gcaaccccaa aatcctgtac gcgcctgcgg gctctgaggt
     1501 cgaccgcgtc atcctcaagg ccaacgagac ttttgctttt gtgggcaacg tgactcacta
     1561 tgcccaggtc tggctcaaca tctcggcgga gatccgcagc ttcctggagc agggcaggct
     1621 gcagcaacac ctgcgctggc tgcagcagta tgtagcagag ctgcggctgc accccgaggc
     1681 actgaacctg tcactggatg agctgccgcc ggccctgaga caggacaact tctcgctgcc
     1741 cagtggcatg gccctcctgc agcagctgga taccattgac aacgcggcct gcggctggat
     1801 ccagttcatg tccaaggtga gcgtggacat cttcaagggc ttccccgacg aggagagcat
     1861 tgtcaactac accctcaacc aggcctacca ggacaacgtc actgtttttg ccagtgtgat
     1921 cttccagacc cggaaggacg gctcgctccc gcctcacgtg cactacaaga tccgccagaa
     1981 ctccagcttc accgagaaaa ccaacgagat ccgccgcgcc tactggcggc ctgggcccaa
     2041 tactggcggc cgcttctact tcctctacgg cttcgtctgg atccaggaca tgatggagcg
     2101 cgccatcatc gacacttttg tggggcacga tgtggtggag ccaggcagct acgtgcagat
     2161 gttcccctac ccctgctaca cacgcgatga cttcctgttt gtcattgagc acatgatgcc
     2221 gctgtgcatg gtgatctcct gggtctactc cgtggccatg accatccagc acatcgtggc
     2281 ggagaaggag caccggctca aggaggtgat gaagaccatg ggcctgaaca acgcggtgca
     2341 ctgggtggcc tggttcatca ccggctttgt gcagctgtcc atctccgtga cagcactcac
     2401 cgccatcctg aagtacggcc aggtgcttat gcacagccac gtggtcatca tctggctctt
     2461 cctggcagtc tacgcggtgg ccaccatcat gttctgcttc ctggtgtctg tgctgtactc
     2521 caaggccaag ctggcctcgg cctgcggtgg catcatctac ttcctgagct acgtgcccta
     2581 catgtacgtg gcgatccgag aggaggtggc gcatgataag atcacggcct tcgagaagtg
     2641 catcgcgtcc ctcatgtcca cgacggcctt tggtctgggc tctaagtact tcgcgctgta
     2701 tgaggtggcc ggcgtgggca tccagtggca caccttcagc cagtccccgg tggaggggga
     2761 cgacttcaac ttgctcctgg ctgtcaccat gctgatggtg gacgccgtgg tctatggcat
     2821 cctcacgtgg tacattgagg ctgtgcaccc aggcatgtac gggctgcccc ggccctggta
     2881 cttcccactg cagaagtcct actggctggg cagtgggcgg acagaagcct gggagtggag
     2941 ctggccgtgg gcacgcaccc cccgcctcag tgtcatggag gaggaccagg cctgtgccat
     3001 ggagagccgg cgctttgagg agacccgtgg catggaggag gagcccaccc acctgcctct
     3061 ggttgtctgc gtggacaaac tcaccaaggt ctacaaggac gacaagaagc tggccctgaa
     3121 caagctgagc ctgaacctct acgagaacca ggtggtctcc ttcttgggcc acaacggggc
     3181 gggcaagacc accaccatgt ccatcctgac cggcctgttc cctccaacgt cgggttccgc
     3241 caccatctac gggcacgaca tccgcacgga gatggatgag atccgcaaga acctgggcat
     3301 gtgcccgcag cacaatgtgc tctttgaccg gctcacggtg gaggaacacc tctggttcta
     3361 ctcacggctc aagagcatgg ctcaggagga gatccgcaga gagatggaca agatgatcga
     3421 ggacctggag ctctccaaca aacggcactc actggtgcag acattgtcgg gtggcatgaa
     3481 gcgcaagctg tccgtggcca tcgccttcgt gggcggctct cgcgccatca tcctggacga
     3541 gcccacggcg ggcgtggacc cctacgcgcg ccgcgccatc tgggacctca tcctgaagta
     3601 caagccaggc cgcaccatcc ttctgtccac ccaccacatg gatgaggctg acctgcttgg
     3661 ggaccgcatt gccatcatct cccatgggaa gctcaagtgc tgcggctccc cgctcttcct
     3721 caagggcacc tatggcgacg ggtaccgcct cacgctggtc aagcggcccg ccgagccggg
     3781 gggcccccaa gagccagggc tggcatccag ccccccaggt cgggccccgc tgagcagctg
     3841 ctccgagctc caggtgtccc agttcatccg caagcatgtg gcctcctgcc tgctggtctc
     3901 agacacaagc acggagctct cctacatcct gcccagcgag gccgccaaga agggggcttt
     3961 cgagcgcctc ttccagcacc tggagcgcag cctggatgca ctgcacctca gcagcttcgg
     4021 gctgatggac acgaccctgg aggaagtgtt cctcaaggtg tcggaggagg atcagtcgct
     4081 ggagaacagt gaggccgatg tgaaggagtc caggaaggat gtgctccctg gggcggaggg
     4141 cccggcgtct ggggagggtc acgctggcaa tctggcccgg tgctcggagc tgacccagtc
     4201 gcaggcatcg ctgcagtcgg cgtcatctgt gggctctgcc cgtggcgacg agggagctgg
     4261 ctacaccgac gtctatggcg actaccgccc cctctttgat aacccacagg acccagacaa
     4321 tgtcagcctg caagaggtgg aggcagaggc cctgtcgagg gtcggccagg gcagccgcaa
     4381 gctggacggc gggtggctga aggtgcgcca gttccacggg ctgctggtca aacgcttcca
     4441 ctgcgcccgc cgcaactcca aggcactctt ctcccagatc ttgctgccag ccttcttcgt
     4501 ctgcgtggcc atgaccgtgg ccctgtccgt cccggagatt ggtgatctgc ccccgctggt
     4561 cctgtcacct tcccagtacc acaactacac ccagccccgt ggcaatttca tcccctacgc
     4621 caacgaggag cgccgcgagt accggctgcg gctatcgccc gacgccagcc cccagcagct
     4681 cgtgagcacg ttccggctgc cgtcgggggt gggtgccacc tgcgtgctca agtctcccgc
     4741 caacggctcg ctggggccca cgttgaacct gagcagcggg gagtcgcgcc tgctggcggc
     4801 tcggttcttc gacagcatgt gtctggagtc cttcacacag gggctgccac tgtccaattt
     4861 cgtgccaccc ccaccctcgc ccgccccatc tgactcgcca gcgtccccgg atgaggacct
     4921 gcaggcctgg aacgtctccc tgccgcccac cgctgggcca gaaatgtgga cgtcggcacc
     4981 ctccctgccg cgcctggtac gggagcccgt ccgctgcacc tgctctgcgc agggcaccgg
     5041 cttctcctgc cccagcagtg tgggcgggca cccgccccag atgcgggtgg tcacaggcga
     5101 catcctgacc gacatcaccg gccacaatgt ctctgagtac ctgctcttca cctccgaccg
     5161 cttccgactg caccggtatg gggccatcac ctttggaaac gtcctgaagt ccatcccagc
     5221 ctcatttggc accagggccc cacccatggt gcggaagatc gcggtgcgca gggctgccca
     5281 ggttttctac aacaacaagg gctatcacag catgcccacc tacctcaaca gcctcaacaa
     5341 cgccatcctg cgtgccaacc tgcccaagag caagggcaac ccggcggctt acggcatcac
     5401 cgtcaccaac caccccatga ataagaccag cgccagcctc tccctggatt acctgctgca
     5461 gggcacggat gtcgtcatcg ccatcttcat catcgtggcc atgtccttcg tgccggccag
     5521 cttcgttgtc ttcctcgtgg ccgagaagtc caccaaggcc aagcacctgc agtttgtcag
     5581 cggctgcaac cccatcatct actggctggc gaactacgtg tgggacatgc tcaactacct
     5641 ggtccccgct acctgctgtg tcatcatcct gtttgtgttc gacctgccgg cctacacgtc
     5701 gcccaccaac ttccctgccg tcctctccct cttcctgctc tatgggtggt ccatcacgcc
     5761 catcatgtac ccggcctcct tctggttcga ggtccccagc tccgcctacg tgttcctcat
     5821 tgtcatcaat ctcttcatcg gcatcaccgc caccgtggcc accttcctgc tacagctctt
     5881 cgagcacgac aaggacctga aggttgtcaa cagttacctg aaaagctgct tcctcatttt
     5941 ccccaactac aacctgggcc acgggctcat ggagatggcc tacaacgagt acatcaacga
     6001 gtactacgcc aagattggcc agtttgacaa gatgaagtcc ccgttcgagt gggacattgt
     6061 cacccgcgga ctggtggcca tggcggttga gggcgtcgtg ggcttcctcc tgaccatcat
     6121 gtgccagtac aacttcctgc ggcggccaca gcgcatgcct gtgtctacca agcctgtgga
     6181 ggatgatgtg gacgtggcca gtgagcggca gcgagtgctc cggggagacg ccgacaatga
     6241 catggtcaag attgagaacc tgaccaaggt ctacaagtcc cggaagattg gccgtatcct
     6301 ggccgttgac cgcctgtgcc tgggtgtgcg tcctggcgag tgcttcgggc tcctgggcgt
     6361 caacggtgcg ggcaagacca gcaccttcaa gatgctgacc ggcgacgaga gcacgacggg
     6421 gggcgaggcc ttcgtcaatg gacacagcgt gctgaaggag ctgctccagg tgcagcagag
     6481 cctcggctac tgcccgcagt gtgacgcgct gttcgacgag ctcacggccc gggagcacct
     6541 gcagctgtac acgcggctgc gtgggatctc ctggaaggac gaggcccggg tggtgaagtg
     6601 ggctctggag aagctggagc tgaccaagta cgcagacaag ccggctggca cctacagcgg
     6661 cggcaacaag cggaagctct ccacggccat cgccctcatt gggtacccag ccttcatctt
     6721 cctggacgag cccaccacag gcatggaccc caaggcccgg cgcttcctct ggaacctcat
     6781 ccttgacctc atcaagacag ggcgttcagt ggtgctgaca tcacacagca tggaggagtg
     6841 cgaggcgctg tgcacgcggc tggccatcat ggtgaacggt cgcctgcggt gcctgggcag
     6901 catccagcac ctgaagaacc ggtttggaga tggctacatg atcacggtgc ggaccaagag
     6961 cagccagagt gtgaaggacg tggtgcggtt cttcaaccgc aacttcccgg aagccatgct
     7021 caaggagcgg caccacacaa aggtgcagta ccagctcaag tcggagcaca tctcgctggc
     7081 ccaggtgttc agcaagatgg agcaggtgtc tggcgtgctg ggcatcgagg actactcggt
     7141 cagccagacc acactggaca atgtgttcgt gaactttgcc aagaagcaga gtgacaacct
     7201 ggagcagcag gagacggagc cgccatccgc actgcagtcc cctctcggct gcttgctcag
     7261 cctgctccgg ccccggtctg cccccacgga gctccgggca cttgtggcag acgagcccga
     7321 ggacctggac acggaggacg agggcctcat cagcttcgag gaggagcggg cccagctgtc
     7381 cttcaacacg gacacgctct gctgaccacc cagagctggg ccagggagga cacgctccac
     7441 tgaccaccca gagctgggcc agggactcaa caatggggac agaagtcccc cagtgcctgc
     7501 cagggcctgg agtggaggtt caggaccaag gggcttctgg tcctccagcc cctgtactcg
     7561 gccatgccct gtggtcactg cggttgccgc ccctaattgt gccaaaggct gacccggccc
     7621 gggctgcgta cacccttgcc ctgctttgcc ttaaagcctc ggggtctgcc cggcccctcg
     7681 cccctgcctg gcactgctca ccgcccaagg cgacgccggc tggaccaggc actgctggcc
     7741 tttctcctgc ccggcctcgg aaccagcttt tctctcttac gatgaaggct gatgccgaga
     7801 gcgggctgtg ggcggagctg ggtcagtccc gtatttattt tgctttgaga agaggctcct
     7861 ctggccctgc tctcctgcag ggaggtggct gtcctgcggg aagccatcag cttgggccag
     7921 ctggcaggtg gcaggaatgg agaagctgac cctgctggcc aggcaagggg ccagaccccc
     7981 cccaaccccc agctgccatc gctctcccac ccagcttggc cccctgcccg cccacctccc
     8041 tgggagccgg gcctgtacat agcgcacaga tgtttgtttt aaataaataa acaaaatgtc
//
