LOCUS       NM_005502              10408 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens ATP binding cassette subfamily A member 1 (ABCA1),
            mRNA.
ACCESSION   NM_005502
VERSION     NM_005502.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10408)
  AUTHORS   Boh,J., Suligoj,E., Mankoc Ramus,S. and Petrovic,D.
  TITLE     The ABCA1 gene polymorphisms rs1800977 and rs2230806 are
            differentially associated with the risk for myocardial infarction
            in Slovenian subjects with type 2 diabetes mellitus
  JOURNAL   Gene 927, 148705 (2024)
   PUBMED   38901534
  REMARK    GeneRIF: The ABCA1 gene polymorphisms rs1800977 and rs2230806 are
            differentially associated with the risk for myocardial infarction
            in Slovenian subjects with type 2 diabetes mellitus.
REFERENCE   2  (bases 1 to 10408)
  AUTHORS   Torres-Paz,Y.E., Gamboa,R., Fuentevilla-Alvarez,G.,
            Cardoso-Saldana,G., Martinez-Alvarado,R., Soto,M.E. and
            Huesca-Gomez,C.
  TITLE     Involvement of Expression of miR33-5p and ABCA1 in Human Peripheral
            Blood Mononuclear Cells in Coronary Artery Disease
  JOURNAL   Int J Mol Sci 25 (16), 8605 (2024)
   PUBMED   39201292
  REMARK    GeneRIF: Involvement of Expression of miR33-5p and ABCA1 in Human
            Peripheral Blood Mononuclear Cells in Coronary Artery Disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10408)
  AUTHORS   Majeed,A., Baig,Z.A. and Rashid,A.
  TITLE     Identification and Molecular Simulation of Genetic Variants in
            ABCA1 Gene Associated with Susceptibility to Dyslipidemia in Type 2
            Diabetes
  JOURNAL   Int J Mol Sci 25 (12), 6796 (2024)
   PUBMED   38928502
  REMARK    GeneRIF: Identification and Molecular Simulation of Genetic
            Variants in ABCA1 Gene Associated with Susceptibility to
            Dyslipidemia in Type 2 Diabetes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10408)
  AUTHORS   Kumari,A., Saini,V. and Kumar,V.
  TITLE     Decreased mRNA expression of NR1H3 and ABCA1 in pulmonary
            tuberculosis patients from population of Punjab, India
  JOURNAL   Mol Biol Rep 51 (1), 657 (2024)
   PUBMED   38740636
  REMARK    GeneRIF: Decreased mRNA expression of NR1H3 and ABCA1 in pulmonary
            tuberculosis patients from population of Punjab, India.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10408)
  AUTHORS   Zhuo,S., Song,S., Wang,C., Wang,Z., Zhang,M., Lin,D. and Chen,K.
  TITLE     Inflammatory corpuscle AIM2 facilitates macrophage foam cell
            formation by inhibiting cholesterol efflux protein ABCA1
  JOURNAL   Sci Rep 14 (1), 10782 (2024)
   PUBMED   38734775
  REMARK    GeneRIF: Inflammatory corpuscle AIM2 facilitates macrophage foam
            cell formation by inhibiting cholesterol efflux protein ABCA1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10408)
  AUTHORS   Rust,S., Walter,M., Funke,H., von Eckardstein,A., Cullen,P.,
            Kroes,H.Y., Hordijk,R., Geisel,J., Kastelein,J., Molhuizen,H.O.,
            Schreiner,M., Mischke,A., Hahmann,H.W. and Assmann,G.
  TITLE     Assignment of Tangier disease to chromosome 9q31 by a graphical
            linkage exclusion strategy
  JOURNAL   Nat Genet 20 (1), 96-98 (1998)
   PUBMED   9731541
  REMARK    Erratum:[Nat Genet 1998 Nov;20(3):312]
REFERENCE   7  (bases 1 to 10408)
  AUTHORS   Becq,F., Hamon,Y., Bajetto,A., Gola,M., Verrier,B. and Chimini,G.
  TITLE     ABC1, an ATP binding cassette transporter required for phagocytosis
            of apoptotic cells, generates a regulated anion flux after
            expression in Xenopus laevis oocytes
  JOURNAL   J Biol Chem 272 (5), 2695-2699 (1997)
   PUBMED   9006906
REFERENCE   8  (bases 1 to 10408)
  AUTHORS   Allikmets,R., Gerrard,B., Glavac,D., Ravnik-Glavac,M.,
            Jenkins,N.A., Gilbert,D.J., Copeland,N.G., Modi,W. and Dean,M.
  TITLE     Characterization and mapping of three new mammalian ATP-binding
            transporter genes from an EST database
  JOURNAL   Mamm Genome 6 (2), 114-117 (1995)
   PUBMED   7766993
REFERENCE   9  (bases 1 to 10408)
  AUTHORS   Luciani,M.F., Denizot,F., Savary,S., Mattei,M.G. and Chimini,G.
  TITLE     Cloning of two novel ABC transporters mapping on human chromosome 9
  JOURNAL   Genomics 21 (1), 150-159 (1994)
   PUBMED   8088782
REFERENCE   10 (bases 1 to 10408)
  AUTHORS   Burnett,J.R., Hooper,A.J., McCormick,S.P.A. and Hegele,R.A.
  TITLE     Tangier Disease
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   31751110
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX955241.1, AB445477.1,
            BC146856.1, AL359846.11 and BU753834.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005502.3.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intracellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the ABC1 subfamily. Members of
            the ABC1 subfamily comprise the only major ABC subfamily found
            exclusively in multicellular eukaryotes. With cholesterol as its
            substrate, this protein functions as a cholesteral efflux pump in
            the cellular lipid removal pathway. Mutations in both alleles of
            this gene cause Tangier disease and familial high-density
            lipoprotein (HDL) deficiency. [provided by RefSeq, Sep 2019].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF285167.1, BC146856.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374736.8/ ENSP00000363868.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-572               BX955241.1         92-663
            573-5290            AB445477.1         260-4977
            5291-7419           BC146856.1         5192-7320
            7420-9935           AL359846.11        178201-180716       c
            9936-10408          BU753834.1         17-489              c
FEATURES             Location/Qualifiers
     source          1..10408
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.1"
     gene            1..10408
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /note="ATP binding cassette subfamily A member 1"
                     /db_xref="GeneID:19"
                     /db_xref="HGNC:HGNC:29"
                     /db_xref="MIM:600046"
     exon            1..221
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            222..379
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..7099
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /EC_number="7.6.2.1"
                     /note="cholesterol efflux regulatory protein; ATP-binding
                     cassette sub-family A member 1; ATP-binding cassette
                     transporter A1; membrane-bound; ATP-binding cassette,
                     sub-family A (ABC1), member 1"
                     /codon_start=1
                     /product="phospholipid-transporting ATPase ABCA1"
                     /protein_id="NP_005493.2"
                     /db_xref="CCDS:CCDS6762.1"
                     /db_xref="GeneID:19"
                     /db_xref="HGNC:HGNC:29"
                     /db_xref="MIM:600046"
                     /translation="MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRL
                     SYPPYEQHECHFPNKAMPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIV
                     ARLFSDARRLLLYSQKDTSMKDMRKVLRTLQQIKKSSSNLKLQDFLVDNETFSGFLYH
                     NLSLPKSTVDKMLRADVILHKVFLQGYQLHLTSLCNGSKSEEMIQLGDQEVSELCGLP
                     REKLAAAERVLRSNMDILKPILRTLNSTSPFPSKELAEATKTLLHSLGTLAQELFSMR
                     SWSDMRQEVMFLTNVNSSSSSTQIYQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALF
                     GGNGTEEDAETFYDNSTTPYCNDLMKNLESSPLSRIIWKALKPLLVGKILYTPDTPAT
                     RQVMAEVNKTFQELAVFHDLEGMWEELSPKIWTFMENSQEMDLVRMLLDSRDNDHFWE
                     QQLDGLDWTAQDIVAFLAKHPEDVQSSNGSVYTWREAFNETNQAIRTISRFMECVNLN
                     KLEPIATEVWLINKSMELLDERKFWAGIVFTGITPGSIELPHHVKYKIRMDIDNVERT
                     NKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAIIRVLTGTEKKTGVYMQQMPY
                     PCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILW
                     FSWFISSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLF
                     SRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFTLKIFASLLSPVAFGFGCEYFALFE
                     EQGIGVQWDNLFESPVEEDGFNLTTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPW
                     YFPCTKSYWFGEESDEKSHPGSNQKRISEICMEEEPTHLKLGVSIQNLVKVYRDGMKV
                     AVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIR
                     QNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKT
                     SQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILST
                     HHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSS
                     STVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHEL
                     TYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETS
                     DGTLPARRNRRAFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVK
                     GWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLE
                     LQPWMYNEQYTFVSNDAPEDTGTLELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEW
                     TTAPVPQTIMDLFQNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTA
                     DILQDLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVN
                     DAIKQMKKHLKLAKDSSADRFLNSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVIN
                     NAILRANLQKGENPSHYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFV
                     PASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQ
                     KSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVA
                     TFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVS
                     PLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVNAKLSPLNDEDEDVRRERQ
                     RILDGGGQNDILEIKELTKIYRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKM
                     LTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGV
                     PEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTG
                     MDPKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLK
                     NRFGDGYTIVVRIAGSNPDLKPVQDFFGLAFPGSVLKEKHRNMLQYQLPSSLSSLARI
                     FSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKDLSLHKNQTVVDVAVLT
                     SFLQDEKVKESYV"
     exon            380..473
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            474..615
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            616..734
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            735..856
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1033
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1126
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1367
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1507
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1624
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1822
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..2028
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2205
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2428
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2650
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2855
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            2856..2969
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3141
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            3142..3273
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            3274..3416
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            3417..3554
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            3555..3775
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            3776..3848
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            3849..4051
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            4052..4100
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            4101..4214
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            4215..4363
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            4364..4488
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            4489..4587
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            4588..4777
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            4778..4872
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            4873..4905
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            4906..5011
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            5012..5086
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            5087..5256
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            5257..5434
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            5435..5550
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            5551..5695
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            5696..5819
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            5820..5949
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            5950..6070
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            6071..6133
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            6134..6240
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            6241..6382
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            6383..6517
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            6518..6621
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            6622..6714
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            6715..6958
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     exon            6959..10408
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9830..9835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
                     /note="hexamer: ATTAAA"
     polyA_site      9851
                     /gene="ABCA1"
                     /gene_synonym="ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1;
                     HPALP1; TGD"
ORIGIN      
        1 gtaattgcga gcgagagtga gtggggccgg gacccgcaga gccgagccga cccttctctc
       61 ccgggctgcg gcagggcagg gcggggagct ccgcgcacca acagagccgg ttctcagggc
      121 gctttgctcc ttgttttttc cccggttctg ttttctcccc ttctccggaa ggcttgtcaa
      181 ggggtaggag aaagagacgc aaacacaaaa gtggaaaaca gttaatgacc agccacggcg
      241 tccctgctgt gagctctggc cgctgccttc cagggctccc gagccacacg ctgggggtgc
      301 tggctgaggg aacatggctt gttggcctca gctgaggttg ctgctgtgga agaacctcac
      361 tttcagaaga agacaaacat gtcagctgct gctggaagtg gcctggcctc tatttatctt
      421 cctgatcctg atctctgttc ggctgagcta cccaccctat gaacaacatg aatgccattt
      481 tccaaataaa gccatgccct ctgcaggaac acttccttgg gttcagggga ttatctgtaa
      541 tgccaacaac ccctgtttcc gttacccgac tcctggggag gctcccggag ttgttggaaa
      601 ctttaacaaa tccattgtgg ctcgcctgtt ctcagatgct cggaggcttc ttttatacag
      661 ccagaaagac accagcatga aggacatgcg caaagttctg agaacattac agcagatcaa
      721 gaaatccagc tcaaacttga agcttcaaga tttcctggtg gacaatgaaa ccttctctgg
      781 gttcctgtat cacaacctct ctctcccaaa gtctactgtg gacaagatgc tgagggctga
      841 tgtcattctc cacaaggtat ttttgcaagg ctaccagtta catttgacaa gtctgtgcaa
      901 tggatcaaaa tcagaagaga tgattcaact tggtgaccaa gaagtttctg agctttgtgg
      961 cctaccaagg gagaaactgg ctgcagcaga gcgagtactt cgttccaaca tggacatcct
     1021 gaagccaatc ctgagaacac taaactctac atctcccttc ccgagcaagg agctggctga
     1081 agccacaaaa acattgctgc atagtcttgg gactctggcc caggagctgt tcagcatgag
     1141 aagctggagt gacatgcgac aggaggtgat gtttctgacc aatgtgaaca gctccagctc
     1201 ctccacccaa atctaccagg ctgtgtctcg tattgtctgc gggcatcccg agggaggggg
     1261 gctgaagatc aagtctctca actggtatga ggacaacaac tacaaagccc tctttggagg
     1321 caatggcact gaggaagatg ctgaaacctt ctatgacaac tctacaactc cttactgcaa
     1381 tgatttgatg aagaatttgg agtctagtcc tctttcccgc attatctgga aagctctgaa
     1441 gccgctgctc gttgggaaga tcctgtatac acctgacact ccagccacaa ggcaggtcat
     1501 ggctgaggtg aacaagacct tccaggaact ggctgtgttc catgatctgg aaggcatgtg
     1561 ggaggaactc agccccaaga tctggacctt catggagaac agccaagaaa tggaccttgt
     1621 ccggatgctg ttggacagca gggacaatga ccacttttgg gaacagcagt tggatggctt
     1681 agattggaca gcccaagaca tcgtggcgtt tttggccaag cacccagagg atgtccagtc
     1741 cagtaatggt tctgtgtaca cctggagaga agctttcaac gagactaacc aggcaatccg
     1801 gaccatatct cgcttcatgg agtgtgtcaa cctgaacaag ctagaaccca tagcaacaga
     1861 agtctggctc atcaacaagt ccatggagct gctggatgag aggaagttct gggctggtat
     1921 tgtgttcact ggaattactc caggcagcat tgagctgccc catcatgtca agtacaagat
     1981 ccgaatggac attgacaatg tggagaggac aaataaaatc aaggatgggt actgggaccc
     2041 tggtcctcga gctgacccct ttgaggacat gcggtacgtc tgggggggct tcgcctactt
     2101 gcaggatgtg gtggagcagg caatcatcag ggtgctgacg ggcaccgaga agaaaactgg
     2161 tgtctatatg caacagatgc cctatccctg ttacgttgat gacatctttc tgcgggtgat
     2221 gagccggtca atgcccctct tcatgacgct ggcctggatt tactcagtgg ctgtgatcat
     2281 caagggcatc gtgtatgaga aggaggcacg gctgaaagag accatgcgga tcatgggcct
     2341 ggacaacagc atcctctggt ttagctggtt cattagtagc ctcattcctc ttcttgtgag
     2401 cgctggcctg ctagtggtca tcctgaagtt aggaaacctg ctgccctaca gtgatcccag
     2461 cgtggtgttt gtcttcctgt ccgtgtttgc tgtggtgaca atcctgcagt gcttcctgat
     2521 tagcacactc ttctccagag ccaacctggc agcagcctgt gggggcatca tctacttcac
     2581 gctgtacctg ccctacgtcc tgtgtgtggc atggcaggac tacgtgggct tcacactcaa
     2641 gatcttcgct agcctgctgt ctcctgtggc ttttgggttt ggctgtgagt actttgccct
     2701 ttttgaggag cagggcattg gagtgcagtg ggacaacctg tttgagagtc ctgtggagga
     2761 agatggcttc aatctcacca cttcggtctc catgatgctg tttgacacct tcctctatgg
     2821 ggtgatgacc tggtacattg aggctgtctt tccaggccag tacggaattc ccaggccctg
     2881 gtattttcct tgcaccaagt cctactggtt tggcgaggaa agtgatgaga agagccaccc
     2941 tggttccaac cagaagagaa tatcagaaat ctgcatggag gaggaaccca cccacttgaa
     3001 gctgggcgtg tccattcaga acctggtaaa agtctaccga gatgggatga aggtggctgt
     3061 cgatggcctg gcactgaatt tttatgaggg ccagatcacc tccttcctgg gccacaatgg
     3121 agcggggaag acgaccacca tgtcaatcct gaccgggttg ttccccccga cctcgggcac
     3181 cgcctacatc ctgggaaaag acattcgctc tgagatgagc accatccggc agaacctggg
     3241 ggtctgtccc cagcataacg tgctgtttga catgctgact gtcgaagaac acatctggtt
     3301 ctatgcccgc ttgaaagggc tctctgagaa gcacgtgaag gcggagatgg agcagatggc
     3361 cctggatgtt ggtttgccat caagcaagct gaaaagcaaa acaagccagc tgtcaggtgg
     3421 aatgcagaga aagctatctg tggccttggc ctttgtcggg ggatctaagg ttgtcattct
     3481 ggatgaaccc acagctggtg tggaccctta ctcccgcagg ggaatatggg agctgctgct
     3541 gaaataccga caaggccgca ccattattct ctctacacac cacatggatg aagcggacgt
     3601 cctgggggac aggattgcca tcatctccca tgggaagctg tgctgtgtgg gctcctccct
     3661 gtttctgaag aaccagctgg gaacaggcta ctacctgacc ttggtcaaga aagatgtgga
     3721 atcctccctc agttcctgca gaaacagtag tagcactgtg tcatacctga aaaaggagga
     3781 cagtgtttct cagagcagtt ctgatgctgg cctgggcagc gaccatgaga gtgacacgct
     3841 gaccatcgat gtctctgcta tctccaacct catcaggaag catgtgtctg aagcccggct
     3901 ggtggaagac atagggcatg agctgaccta tgtgctgcca tatgaagctg ctaaggaggg
     3961 agcctttgtg gaactctttc atgagattga tgaccggctc tcagacctgg gcatttctag
     4021 ttatggcatc tcagagacga ccctggaaga aatattcctc aaggtggccg aagagagtgg
     4081 ggtggatgct gagacctcag atggtacctt gccagcaaga cgaaacaggc gggccttcgg
     4141 ggacaagcag agctgtcttc gcccgttcac tgaagatgat gctgctgatc caaatgattc
     4201 tgacatagac ccagaatcca gagagacaga cttgctcagt gggatggatg gcaaagggtc
     4261 ctaccaggtg aaaggctgga aacttacaca gcaacagttt gtggcccttt tgtggaagag
     4321 actgctaatt gccagacgga gtcggaaagg attttttgct cagattgtct tgccagctgt
     4381 gtttgtctgc attgcccttg tgttcagcct gatcgtgcca ccctttggca agtaccccag
     4441 cctggaactt cagccctgga tgtacaacga acagtacaca tttgtcagca atgatgctcc
     4501 tgaggacacg ggaaccctgg aactcttaaa cgccctcacc aaagaccctg gcttcgggac
     4561 ccgctgtatg gaaggaaacc caatcccaga cacgccctgc caggcagggg aggaagagtg
     4621 gaccactgcc ccagttcccc agaccatcat ggacctcttc cagaatggga actggacaat
     4681 gcagaaccct tcacctgcat gccagtgtag cagcgacaaa atcaagaaga tgctgcctgt
     4741 gtgtccccca ggggcagggg ggctgcctcc tccacaaaga aaacaaaaca ctgcagatat
     4801 ccttcaggac ctgacaggaa gaaacatttc ggattatctg gtgaagacgt atgtgcagat
     4861 catagccaaa agcttaaaga acaagatctg ggtgaatgag tttaggtatg gcggcttttc
     4921 cctgggtgtc agtaatactc aagcacttcc tccgagtcaa gaagttaatg atgccatcaa
     4981 acaaatgaag aaacacctaa agctggccaa ggacagttct gcagatcgat ttctcaacag
     5041 cttgggaaga tttatgacag gactggacac caaaaataat gtcaaggtgt ggttcaataa
     5101 caagggctgg catgcaatca gctctttcct gaatgtcatc aacaatgcca ttctccgggc
     5161 caacctgcaa aagggagaga accctagcca ttatggaatt actgctttca atcatcccct
     5221 gaatctcacc aagcagcagc tctcagaggt ggctctgatg accacatcag tggatgtcct
     5281 tgtgtccatc tgtgtcatct ttgcaatgtc cttcgtccca gccagctttg tcgtattcct
     5341 gatccaggag cgggtcagca aagcaaaaca cctgcagttc atcagtggag tgaagcctgt
     5401 catctactgg ctctctaatt ttgtctggga tatgtgcaat tacgttgtcc ctgccacact
     5461 ggtcattatc atcttcatct gcttccagca gaagtcctat gtgtcctcca ccaatctgcc
     5521 tgtgctagcc cttctacttt tgctgtatgg gtggtcaatc acacctctca tgtacccagc
     5581 ctcctttgtg ttcaagatcc ccagcacagc ctatgtggtg ctcaccagcg tgaacctctt
     5641 cattggcatt aatggcagcg tggccacctt tgtgctggag ctgttcaccg acaataagct
     5701 gaataatatc aatgatatcc tgaagtccgt gttcttgatc ttcccacatt tttgcctggg
     5761 acgagggctc atcgacatgg tgaaaaacca ggcaatggct gatgccctgg aaaggtttgg
     5821 ggagaatcgc tttgtgtcac cattatcttg ggacttggtg ggacgaaacc tcttcgccat
     5881 ggccgtggaa ggggtggtgt tcttcctcat tactgttctg atccagtaca gattcttcat
     5941 caggcccaga cctgtaaatg caaagctatc tcctctgaat gatgaagatg aagatgtgag
     6001 gcgggaaaga cagagaattc ttgatggtgg aggccagaat gacatcttag aaatcaagga
     6061 gttgacgaag atatatagaa ggaagcggaa gcctgctgtt gacaggattt gcgtgggcat
     6121 tcctcctggt gagtgctttg ggctcctggg agttaatggg gctggaaaat catcaacttt
     6181 caagatgtta acaggagata ccactgttac cagaggagat gctttcctta acaaaaatag
     6241 tatcttatca aacatccatg aagtacatca gaacatgggc tactgccctc agtttgatgc
     6301 catcacagag ctgttgactg ggagagaaca cgtggagttc tttgcccttt tgagaggagt
     6361 cccagagaaa gaagttggca aggttggtga gtgggcgatt cggaaactgg gcctcgtgaa
     6421 gtatggagaa aaatatgctg gtaactatag tggaggcaac aaacgcaagc tctctacagc
     6481 catggctttg atcggcgggc ctcctgtggt gtttctggat gaacccacca caggcatgga
     6541 tcccaaagcc cggcggttct tgtggaattg tgccctaagt gttgtcaagg aggggagatc
     6601 agtagtgctt acatctcata gtatggaaga atgtgaagct ctttgcacta ggatggcaat
     6661 catggtcaat ggaaggttca ggtgccttgg cagtgtccag catctaaaaa ataggtttgg
     6721 agatggttat acaatagttg tacgaatagc agggtccaac ccggacctga agcctgtcca
     6781 ggatttcttt ggacttgcat ttcctggaag tgttctaaaa gagaaacacc ggaacatgct
     6841 acaataccag cttccatctt cattatcttc tctggccagg atattcagca tcctctccca
     6901 gagcaaaaag cgactccaca tagaagacta ctctgtttct cagacaacac ttgaccaagt
     6961 atttgtgaac tttgccaagg accaaagtga tgatgaccac ttaaaagacc tctcattaca
     7021 caaaaaccag acagtagtgg acgttgcagt tctcacatct tttctacagg atgagaaagt
     7081 gaaagaaagc tatgtatgaa gaatcctgtt catacggggt ggctgaaagt aaagaggaac
     7141 tagactttcc tttgcaccat gtgaagtgtt gtggagaaaa gagccagaag ttgatgtggg
     7201 aagaagtaaa ctggatactg tactgatact attcaatgca atgcaattca atgcaatgaa
     7261 aacaaaattc cattacaggg gcagtgcctt tgtagcctat gtcttgtatg gctctcaagt
     7321 gaaagacttg aatttagttt tttacctata cctatgtgaa actctattat ggaacccaat
     7381 ggacatatgg gtttgaactc acactttttt tttttttttt gttcctgtgt attctcattg
     7441 gggttgcaac aataattcat caagtaatca tggccagcga ttattgatca aaatcaaaag
     7501 gtaatgcaca tcctcattca ctaagccatg ccatgcccag gagactggtt tcccggtgac
     7561 acatccattg ctggcaatga gtgtgccaga gttattagtg ccaagttttt cagaaagttt
     7621 gaagcaccat ggtgtgtcat gctcactttt gtgaaagctg ctctgctcag agtctatcaa
     7681 cattgaatat cagttgacag aatggtgcca tgcgtggcta acatcctgct ttgattccct
     7741 ctgataagct gttctggtgg cagtaacatg caacaaaaat gtgggtgtct ccaggcacgg
     7801 gaaacttggt tccattgtta tattgtccta tgcttcgagc catgggtcta cagggtcatc
     7861 cttatgagac tcttaaatat acttagatcc tggtaagagg caaagaatca acagccaaac
     7921 tgctggggct gcaagctgct gaagccaggg catgggatta aagagattgt gcgttcaaac
     7981 ctagggaagc ctgtgcccat ttgtcctgac tgtctgctaa catggtacac tgcatctcaa
     8041 gatgtttatc tgacacaagt gtattatttc tggctttttg aattaatcta gaaaatgaaa
     8101 agatggagtt gtattttgac aaaaatgttt gtacttttta atgttatttg gaattttaag
     8161 ttctatcagt gacttctgaa tccttagaat ggcctctttg tagaaccctg tggtatagag
     8221 gagtatggcc actgccccac tatttttatt ttcttatgta agtttgcata tcagtcatga
     8281 ctagtgccta gaaagcaatg tgatggtcag gatctcatga cattatattt gagtttcttt
     8341 cagatcattt aggatactct taatctcact tcatcaatca aatatttttt gagtgtatgc
     8401 tgtagctgaa agagtatgta cgtacgtata agactagaga gatattaagt ctcagtacac
     8461 ttcctgtgcc atgttattca gctcactggt ttacaaatat aggttgtctt gtggttgtag
     8521 gagcccactg taacaatact gggcagcctt tttttttttt tttttaattg caacaatgca
     8581 aaagccaaga aagtataagg gtcacaagtc taaacaatga attcttcaac agggaaaaca
     8641 gctagcttga aaacttgctg aaaaacacaa cttgtgttta tggcatttag taccttcaaa
     8701 taattggctt tgcagatatt ggatacccca ttaaatctga cagtctcaaa tttttcatct
     8761 cttcaatcac tagtcaagaa aaatataaaa acaacaaata cttccatatg gagcattttt
     8821 cagagttttc taacccagtc ttatttttct agtcagtaaa catttgtaaa aatactgttt
     8881 cactaatact tactgttaac tgtcttgaga gaaaagaaaa atatgagaga actattgttt
     8941 ggggaagttc aagtgatctt tcaatatcat tactaacttc ttccactttt tccagaattt
     9001 gaatattaac gctaaaggtg taagacttca gatttcaaat taatctttct atatttttta
     9061 aatttacaga atattatata acccactgct gaaaaagaaa aaaatgattg ttttagaagt
     9121 taaagtcaat attgatttta aatataagta atgaaggcat atttccaata actagtgata
     9181 tggcatcgtt gcattttaca gtatcttcaa aaatacagaa tttatagaat aatttctcct
     9241 catttaatat ttttcaaaat caaagttatg gtttcctcat tttactaaaa tcgtattcta
     9301 attcttcatt atagtaaatc tatgagcaac tccttacttc ggttcctctg atttcaaggc
     9361 catattttaa aaaatcaaaa ggcactgtga actattttga agaaaacaca acattttaat
     9421 acagattgaa aggacctctt ctgaagctag aaacaatcta tagttataca tcttcattaa
     9481 tactgtgtta ccttttaaaa tagtaatttt ttacattttc ctgtgtaaac ctaattgtgg
     9541 tagaaatttt taccaactct atactcaatc aagcaaaatt tctgtatatt ccctgtggaa
     9601 tgtacctatg tgagtttcag aaattctcaa aatacgtgtt caaaaatttc tgcttttgca
     9661 tctttgggac acctcagaaa acttattaac aactgtgaat atgagaaata cagaagaaaa
     9721 taataagccc tctatacata aatgcccagc acaattcatt gttaaaaaac aaccaaacct
     9781 cacactactg tatttcatta tctgtactga aagcaaatgc tttgtgacta ttaaatgttg
     9841 cacatcattc attcactgta tagtaatcat tgactaaagc catttgtctg tgttttcttc
     9901 ttgtggttgt atatatcagg taaaatattt tccaaagagc catgtgtcat gtaatactga
     9961 accactttga tattgagaca ttaatttgta cccttgttat tatctactag taataatgta
    10021 atactgtaga aatattgctc taattctttt caaaattgtt gcatccccct tagaatgttt
    10081 ctatttccat aaggatttag gtatgctatt atcccttctt ataccctaag atgaagctgt
    10141 ttttgtgctc tttgttcatc attggccctc attccaagca ctttacgctg tctgtaatgg
    10201 gatctatttt tgcactggaa tatctgagaa ttgcaaaact agacaaaagt ttcacaacag
    10261 atttctaagt taaatcattt tcattaaaag gaaaaaagaa aaaaaatttt gtatgtcaat
    10321 aactttatat gaagtattaa aatgcatatt tctatgttgt aatataatga gtcacaaaat
    10381 aaagctgtga cagttctgtt ggtctaca
//
