LOCUS       NM_001080395            5461 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens apoptosis associated tyrosine kinase (AATK),
            transcript variant 1, mRNA.
ACCESSION   NM_001080395 XM_001128317
VERSION     NM_001080395.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5461)
  AUTHORS   Woods,M.L., Weiss,A., Sokol,A.M., Graumann,J., Boettger,T.,
            Richter,A.M., Schermuly,R.T. and Dammann,R.H.
  TITLE     Epigenetically silenced apoptosis-associated tyrosine kinase (AATK)
            facilitates a decreased expression of Cyclin D1 and WEE1,
            phosphorylates TP53 and reduces cell proliferation in a
            kinase-dependent manner
  JOURNAL   Cancer Gene Ther 29 (12), 1975-1987 (2022)
   PUBMED   35902728
  REMARK    GeneRIF: Epigenetically silenced apoptosis-associated tyrosine
            kinase (AATK) facilitates a decreased expression of Cyclin D1 and
            WEE1, phosphorylates TP53 and reduces cell proliferation in a
            kinase-dependent manner.
REFERENCE   2  (bases 1 to 5461)
  AUTHORS   Salokas,K., Liu,X., Ohman,T., Chowdhury,I., Gawriyski,L.,
            Keskitalo,S. and Varjosalo,M.
  TITLE     Physical and functional interactome atlas of human receptor
            tyrosine kinases
  JOURNAL   EMBO Rep 23 (6), e54041 (2022)
   PUBMED   35384245
REFERENCE   3  (bases 1 to 5461)
  AUTHORS   Komaki,K., Takano,T., Sato,Y., Asada,A., Ikeda,S., Yamada,K.,
            Wei,R., Huo,A., Fukuchi,A., Saito,T., Ando,K., Murayama,S.,
            Araki,W., Kametani,F., Hasegawa,M., Iwatsubo,T., Tomomura,M.,
            Fukuda,M. and Hisanaga,S.I.
  TITLE     Lemur tail kinase 1 (LMTK1) regulates the endosomal localization of
            beta-secretase BACE1
  JOURNAL   J Biochem 170 (6), 729-738 (2022)
   PUBMED   34523681
  REMARK    GeneRIF: Lemur tail kinase 1 (LMTK1) regulates the endosomal
            localization of beta-secretase BACE1.
            Erratum:[J Biochem. 2022 Mar 31;171(4):467. doi:
            10.1093/jb/mvab152.. PMID: 35137094]
REFERENCE   4  (bases 1 to 5461)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   5  (bases 1 to 5461)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 5461)
  AUTHORS   Tomomura,M., Hasegawa,Y., Hashikawa,T., Tomomura,A., Yuzaki,M.,
            Furuichi,T. and Yano,R.
  TITLE     Differential expression and function of apoptosis-associated
            tyrosine kinase (AATYK) in the developing mouse brain
  JOURNAL   Brain Res Mol Brain Res 112 (1-2), 103-112 (2003)
   PUBMED   12670708
REFERENCE   7  (bases 1 to 5461)
  AUTHORS   Tomomura,M., Fernandez-Gonzales,A., Yano,R. and Yuzaki,M.
  TITLE     Characterization of the apoptosis-associated tyrosine kinase
            (AATYK) expressed in the CNS
  JOURNAL   Oncogene 20 (9), 1022-1032 (2001)
   PUBMED   11314040
REFERENCE   8  (bases 1 to 5461)
  AUTHORS   Baker,S.J., Sumerson,R., Reddy,C.D., Berrebi,A.S., Flynn,D.C. and
            Reddy,E.P.
  TITLE     Characterization of an alternatively spliced AATYK mRNA: expression
            pattern of AATYK in the brain and neuronal cells
  JOURNAL   Oncogene 20 (9), 1015-1021 (2001)
   PUBMED   11314039
REFERENCE   9  (bases 1 to 5461)
  AUTHORS   Raghunath,M., Patti,R., Bannerman,P., Lee,C.M., Baker,S.,
            Sutton,L.N., Phillips,P.C. and Damodar Reddy,C.
  TITLE     A novel kinase, AATYK induces and promotes neuronal differentiation
            in a human neuroblastoma (SH-SY5Y) cell line
  JOURNAL   Brain Res Mol Brain Res 77 (2), 151-162 (2000)
   PUBMED   10837911
REFERENCE   10 (bases 1 to 5461)
  AUTHORS   Seki,N., Hayashi,A., Hattori,A., Kozuma,S., Ohira,M., Hori,T. and
            Saito,T.
  TITLE     Chromosomal assignment of a human apoptosis-associated tyrosine
            kinase gene on chromosome 17q25.3 by somatic hybrid analysis and
            fluorescence in situ hybridization
  JOURNAL   J Hum Genet 44 (2), 141-142 (1999)
   PUBMED   10083745
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC115099.6, AK131529.1,
            AB014541.2 and BI256809.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001080395.2.
            
            Summary: The protein encoded by this gene contains a tyrosine
            kinase domain at the N-terminus and a proline-rich domain at the
            C-terminus. This gene is induced during apoptosis, and expression
            of this gene may be a necessary pre-requisite for the induction of
            growth arrest and/or apoptosis of myeloid precursor cells. This
            gene has been shown to produce neuronal differentiation in a
            neuroblastoma cell line. Two transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jun
            2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326724.9/ ENSP00000324196.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AC115099.6         153447-153595       c
            150-582             AK131529.1         1-433
            583-2335            AB014541.2         212-1964
            2336-2336           AC115099.6         109203-109203       c
            2337-2820           AB014541.2         1966-2449
            2821-2821           AC115099.6         108718-108718       c
            2822-5202           AB014541.2         2451-4831
            5203-5203           AC115099.6         104927-104927       c
            5204-5452           AB014541.2         4833-5081
            5453-5461           BI256809.1         286-294
FEATURES             Location/Qualifiers
     source          1..5461
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..5461
                     /gene="AATK"
                     /gene_synonym="AATYK; AATYK1; LMR1; LMTK1; p35BP; PPP1R77"
                     /note="apoptosis associated tyrosine kinase"
                     /db_xref="GeneID:9625"
                     /db_xref="HGNC:HGNC:21"
                     /db_xref="MIM:605276"
     exon            1..284
                     /gene="AATK"
                     /gene_synonym="AATYK; AATYK1; LMR1; LMTK1; p35BP; PPP1R77"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..4354
                     /gene="AATK"
                     /gene_synonym="AATYK; AATYK1; LMR1; LMTK1; p35BP; PPP1R77"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1; lemur
                     tyrosine kinase 1; serine/threonine-protein kinase LMTK1;
                     CDK5-binding protein; p35-binding protein; brain
                     apoptosis-associated tyrosine kinase; protein phosphatase
                     1, regulatory subunit 77"
                     /codon_start=1
                     /product="serine/threonine-protein kinase LMTK1 isoform 1"
                     /protein_id="NP_001073864.2"
                     /db_xref="CCDS:CCDS45807.1"
                     /db_xref="GeneID:9625"
                     /db_xref="HGNC:HGNC:21"
                     /db_xref="MIM:605276"
                     /translation="MSSSFFNPSFAFSSHFDPDGAPLSELSWPSSLAVVAVSFSGLFA
                     VIVLMLACLCCKKGGIGFKEFENAEGDEYAADLAQGSPATAAQNGPDVYVLPLTEVSL
                     PMAKQPGRSVQLLKSTDVGRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQVVVKELQA
                     SASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCR
                     VAESMAPDPRTLQRMACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAH
                     CKYREDYFVTADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELG
                     TQPYPQHSDQQVLAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCWLQPEQRPTAEEVH
                     LLLSYLCAKGATEAEEEFERRWRSLRPGGGGVGPGPGAAGPMLGGVVELAAASSFPLL
                     EQFAGDGFHADGDDVLTVTETSRGLNFEYKWEAGRGAEAFPATLSPGRTARLQELCAP
                     DGAPPGVVPVLSAHSPSLGSEYFIRLEEAAPAAGHDPDCAGCAPSPPATADQDDDSDG
                     STAASLAMEPLLGHGPPVDVPWGRGDHYPRRSLARDPLCPSRSPSPSAGPLSLAEGGA
                     EDADWGVAAFCPAFFEDPLGTSPLGSSGAPPLPLTGEDELEEVGARRAAQRGHWRSNV
                     SANNNSGSRCPESWDPVSAGGHAEGCPSPKQTPRASPEPGYPGEPLLGLQAASAQEPG
                     CCPGLPHLCSAQGLAPAPCLVTPSWTETASSGGDHPQAEPKLATEAEGTTGPRLPLPS
                     VPSPSQEGAPLPSEEASAPDAPDALPDSPTPATGGEVSAIKLASALNGSSSSPEVEAP
                     SSEDEDTAEATSGIFTDTSSDGLQARRPDVVPAFRSLQKQVGTPDSLDSLDIPSSASD
                     GGYEVFSPSATGPSGGQPRALDSGYDTENYESPEFVLKEAQEGCEPQAFAELASEGEG
                     PGPETRLSTSLSGLNEKNPYRDSAYFSDLEAEAEATSGPEKKCGGDRAPGPELGLPST
                     GQPSEQVCLRPGVSGEAQGSGPGEVLPPLLQLEGSSPEPSTCPSGLVPEPPEPQGPAK
                     VRPGPSPSCSQFFLLTPVPLRSEGNSSEFQGPPGLLSGPAPQKRMGGPGTPRAPLRLA
                     LPGLPAALEGRPEEEEEDSEDSDESDEELRCYSVQEPSEDSEEEAPAVPVVVAESQSA
                     RNLRSLLKMPSLLSETFCEDLERKKKAVSFFDDVTVYLFDQESPTRELGEPFPGAKES
                     PPTFLRGSPGSPSAPNRPQQADGSPNGSTAEEGGGFAWDDDFPLMTAKAAFAMALDPA
                     APAPAAPTPTPAPFSRFTVSPAPTSRFSITHVSDSDAESKRGPEAGAGGESKEA"
     exon            285..418
                     /gene="AATK"
                     /gene_synonym="AATYK; AATYK1; LMR1; LMTK1; p35BP; PPP1R77"
                     /inference="alignment:Splign:2.1.0"
     exon            419..563
                     /gene="AATK"
                     /gene_synonym="AATYK; AATYK1; LMR1; LMTK1; p35BP; PPP1R77"
                     /inference="alignment:Splign:2.1.0"
     exon            564..643
                     /gene="AATK"
                     /gene_synonym="AATYK; AATYK1; LMR1; LMTK1; p35BP; PPP1R77"
                     /inference="alignment:Splign:2.1.0"
     exon            644..762
                     /gene="AATK"
                     /gene_synonym="AATYK; AATYK1; LMR1; LMTK1; p35BP; PPP1R77"
                     /inference="alignment:Splign:2.1.0"
     exon            763..850
                     /gene="AATK"
                     /gene_synonym="AATYK; AATYK1; LMR1; LMTK1; p35BP; PPP1R77"
                     /inference="alignment:Splign:2.1.0"
     exon            851..984
                     /gene="AATK"
                     /gene_synonym="AATYK; AATYK1; LMR1; LMTK1; p35BP; PPP1R77"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1069
                     /gene="AATK"
                     /gene_synonym="AATYK; AATYK1; LMR1; LMTK1; p35BP; PPP1R77"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1191
                     /gene="AATK"
                     /gene_synonym="AATYK; AATYK1; LMR1; LMTK1; p35BP; PPP1R77"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1341
                     /gene="AATK"
                     /gene_synonym="AATYK; AATYK1; LMR1; LMTK1; p35BP; PPP1R77"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..3964
                     /gene="AATK"
                     /gene_synonym="AATYK; AATYK1; LMR1; LMTK1; p35BP; PPP1R77"
                     /inference="alignment:Splign:2.1.0"
     exon            3965..4112
                     /gene="AATK"
                     /gene_synonym="AATYK; AATYK1; LMR1; LMTK1; p35BP; PPP1R77"
                     /inference="alignment:Splign:2.1.0"
     exon            4113..4313
                     /gene="AATK"
                     /gene_synonym="AATYK; AATYK1; LMR1; LMTK1; p35BP; PPP1R77"
                     /inference="alignment:Splign:2.1.0"
     exon            4314..5461
                     /gene="AATK"
                     /gene_synonym="AATYK; AATYK1; LMR1; LMTK1; p35BP; PPP1R77"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5440..5445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AATK"
                     /gene_synonym="AATYK; AATYK1; LMR1; LMTK1; p35BP; PPP1R77"
                     /note="hexamer: AATGAA"
     polyA_site      5461
                     /gene="AATK"
                     /gene_synonym="AATYK; AATYK1; LMR1; LMTK1; p35BP; PPP1R77"
                     /note="major polyA site"
ORIGIN      
        1 ggactgcacc agcggagccc cgcggcgcca gggccgggcg gagcgcctcg tctgtcgccg
       61 ccgcccccac cggtgcgggc tctgcggctg cggcgggggg cgcggggcgc gggggccggc
      121 gcgctccgca cctgcggcgg ccgctgggtg atgcggcggc tcgggccggg gccgcgggcg
      181 tcctgagcgc agcgccctcc cgggatgccc gccggccgct ggcccggcca tgtcgtcgtc
      241 cttcttcaac cccagcttcg ccttcagctc gcacttcgac cccgacggcg ccccgctcag
      301 cgagctgtcc tggccatcct ccctcgccgt ggtggctgtg tctttctccg ggctcttcgc
      361 cgtcatcgtc ctcatgctgg cctgcctgtg ctgtaagaag ggcggtatcg ggttcaagga
      421 gtttgagaat gcggaggggg acgagtacgc agccgacctg gcgcagggct ccccggccac
      481 ggcagcacag aacgggcccg acgtgtacgt cctgccactc acggaggtct ccttgcccat
      541 ggccaagcag cctgggcgct cagtgcagct cctcaagtcc acagacgtgg gccggcacag
      601 cctcctgtac ctgaaggaaa tcggccgtgg ctggttcggg aaggtgttcc tgggggaggt
      661 gaactctggc atcagcagtg cccaggtggt ggtgaaggag ctgcaggcta gtgccagcgt
      721 gcaggagcag atgcagttcc tggaggaggt gcagccctac agggccctga agcacagcaa
      781 cctgctccag tgcctggccc agtgcgccga ggtgacgccc tacctgctgg tgatggagtt
      841 ctgcccactg ggggacctca agggctacct gcggagctgc cgggtggcgg agtccatggc
      901 tcccgacccc cggaccctgc agcgcatggc ctgtgaggtg gcctgtggcg tcctgcacct
      961 tcatcgcaac aatttcgtgc acagcgacct ggccctgcgg aactgcctgc tcacggctga
     1021 cctgacggtg aagattggtg actatggcct ggctcactgc aagtacagag aggactactt
     1081 cgtgactgcc gaccagctgt gggtgcctct gcgctggatc gcgccagagc tggtggacga
     1141 ggtgcatagc aacctgctcg tcgtggacca gaccaagagc gggaatgtgt ggtccctggg
     1201 cgtgaccatc tgggagctct ttgagctggg cacgcagccc tatccccagc actcggacca
     1261 gcaggtgctg gcgtacacgg tccgggagca gcagctcaag ctgcccaagc cccagctgca
     1321 gctgaccctg tcggaccgct ggtacgaggt gatgcagttc tgctggctgc agcccgagca
     1381 gcggcccaca gccgaggagg tgcacctgct gctgtcctac ctgtgtgcca agggcgccac
     1441 cgaagcagag gaggagtttg aacggcgctg gcgctctctg cggcccggcg ggggcggcgt
     1501 ggggcccggg cccggtgcgg cggggcccat gctgggcggc gtggtggagc tcgccgctgc
     1561 ctcgtccttc ccgctgctgg agcagttcgc gggcgacggc ttccacgcgg acggcgacga
     1621 cgtgctgacg gtgaccgaga ccagccgagg cctcaatttt gagtacaagt gggaggcggg
     1681 ccgcggcgcg gaggccttcc cggccacgct gagccctggc cgcaccgcac gcctgcagga
     1741 gctgtgcgcc cccgacggcg cgcccccggg cgtggttccg gtgctcagcg cgcacagccc
     1801 gtcgctgggc agcgagtact tcatccgcct agaggaggcc gcacccgccg ccggccacga
     1861 ccctgactgc gccggctgcg cccccagtcc acctgccacc gcggaccagg acgacgactc
     1921 tgacggcagc accgccgcct cgctggccat ggagccgctg ctgggccacg ggccacccgt
     1981 cgacgtcccc tggggccgcg gcgaccacta ccctcgcaga agcttggcgc gggacccgct
     2041 ctgcccctca cgctctccct cgccctcggc ggggcccctg agtctggcgg agggaggagc
     2101 ggaggatgca gactggggcg tggccgcctt ctgtcctgcc ttcttcgagg acccactggg
     2161 cacgtcccct ttggggagct caggggcgcc cccgctgccg ctgactggcg aggatgagct
     2221 agaggaggtg ggagcgcgga gggccgccca gcgcgggcac tggcgctcca acgtgtcagc
     2281 caacaacaac agcggcagcc gctgtccaga gtcctgggac cccgtctctg cgggcggcca
     2341 cgctgagggc tgccccagtc caaagcagac cccacgggcc tcccccgagc cggggtaccc
     2401 tggagagcct ctgcttgggc tccaggcagc ctctgcccag gagccaggct gctgccccgg
     2461 cctccctcat ctatgctctg cccagggcct ggcacctgct ccctgcctgg ttacaccctc
     2521 ctggacagag acagccagta gtgggggtga ccacccgcag gcagagccca agcttgccac
     2581 ggaggctgag ggcactaccg gaccccgcct gccccttcct tccgtcccct ccccatccca
     2641 ggagggagcc ccacttccct cggaggaggc cagtgccccc gacgcccctg atgccctgcc
     2701 tgactctccc acgcctgcta ctggtggcga ggtgtctgcc atcaagctgg cttctgccct
     2761 gaatggcagc agcagctctc ccgaggtgga ggcacccagc agtgaggatg aggacacggc
     2821 cgaggccacc tcaggcatct tcaccgacac gtccagcgac ggcctgcagg ccaggaggcc
     2881 ggatgtggtg ccagccttcc gctctctgca gaagcaggtg gggacccccg actccctgga
     2941 ctccctggac atcccgtcct cagccagtga tggtggctat gaggtcttca gcccgtcggc
     3001 cactggcccc tctggagggc agccgcgagc gctggacagt ggctatgaca ccgagaacta
     3061 tgagtcccct gagtttgtgc tcaaggaggc gcaggaaggg tgtgagcccc aggcctttgc
     3121 ggagctggcc tcagagggtg agggccccgg gcccgagaca cggctctcca cctccctcag
     3181 tggcctcaac gagaagaatc cctaccgaga ctctgcctac ttctcagacc tcgaggctga
     3241 ggccgaggcc acctcaggcc cagagaagaa gtgcggcggg gaccgagccc ccgggccaga
     3301 gctgggcctg ccgagcactg ggcagccgtc tgagcaggtc tgtctcaggc ctggggtttc
     3361 cggggaggca caaggctctg gccccgggga ggtgctgccc ccactgctgc agcttgaagg
     3421 gtcctcccca gagcccagca cctgcccctc gggcctggtc ccagagcctc cggagcccca
     3481 aggcccagcc aaggtgcggc ctgggcccag ccccagctgc tcccagtttt tcctgctgac
     3541 cccggttccg ctgagatcag aaggcaacag ctctgagttc caggggcccc caggactgtt
     3601 gtcagggccg gccccacaaa agcggatggg gggcccaggc acccccagag ccccactccg
     3661 cctggctctg cccggcctcc ctgcggcctt ggagggccgg ccggaggagg aggaggagga
     3721 cagtgaggac agcgacgagt ctgacgagga gctccgctgc tacagcgtcc aggagcctag
     3781 cgaggacagc gaagaggagg cgccggcggt gcccgtggtg gtggctgaga gccagagcgc
     3841 gcgcaacctg cgcagcctgc tcaagatgcc cagcctgctg tccgagacct tctgcgagga
     3901 cctggaacgc aagaagaagg ccgtgtcctt cttcgacgac gtcaccgtct acctctttga
     3961 ccaggaaagc cccacccggg agctcgggga gcccttcccg ggcgccaagg aatcgccccc
     4021 tacgttcctt agggggagcc ccggctctcc cagcgccccc aaccggccgc agcaggctga
     4081 tggctcccca aatggctcca cagcggaaga gggtggtggg ttcgcgtggg acgacgactt
     4141 cccgctgatg acggccaagg cagccttcgc catggcccta gacccggccg cacccgcccc
     4201 ggctgcgccc acgcccacgc ccgctccctt ctcgcgcttc acggtgtcgc ccgcgcccac
     4261 gtcccgcttc tccatcacgc acgtgtctga ctcggacgcc gagtccaaga gaggacctga
     4321 agctggtgcc gggggtgaga gtaaagaggc ttgagacctg ggcagctcct gcccctcaag
     4381 gctggcgtca ccggagcccc tgccaggcag cagcgaggat ggtgaccgag aaggtgggga
     4441 ccacgtcctg gtggctgttg gcagcagatt caggtgcctc tgccccacgc ggtgtcctgg
     4501 agaagcccgt gggatgagag gccctggatg gtagatcggc catgctccgc cccagaggca
     4561 gaattcgtct gggcttttag gcttgctgct agcccctggg ggcgcctgga gccacagtgg
     4621 gtgtctgtac acacatacac actcaaaagg ggccagtgcc cctgggcacg gcggccccca
     4681 ccctctgccc tgcctgcctg gcctcggagg acccgcatgc cccatccggc agctcctccg
     4741 gtgtgctcac aggacactta aaccaggacg aggcatggcc ccgagacact ggcaggtttg
     4801 tgagcctctt cccaccccct gtgcccccac ccttgcctgg ttcctggtgg ctcagggcaa
     4861 ggagtggccc tgggcgcccg tgtcggtcct gtttccgctg cccttatctc aaagtccgtg
     4921 gctgtttccc cttcactgac tcagctagac ccgtaagccc acccttccca cagggaacag
     4981 gctgctccca cctgggtccc gctgtggcca cggtgggcag cccaaaagat caggggtgga
     5041 ggggcttcca ggctgtactc ctgccccgtg ggccccgttc tagaggtgcc cttggcagga
     5101 ccgtgcaggc agctcccctc tgtggggcag tatctggtcc tgtgccccag ctgccaaagg
     5161 agagtggggg ccatgccccg cagtcagtgt tggggggctc ctacctacag ggagagggat
     5221 ggtggggaag gggtggagct gggggcaggg cagcacaggg aatatttttg taactaacta
     5281 actgctgtgg ttggagcgaa tggaagttgg gtgattttaa gttattgttg ccaaagagat
     5341 gtaaagttta ttgttgcttc gcagggggat ttgttttgtg ttttgtttga ggcttagaac
     5401 gctggtgcaa tgttttcttg ttccttgttt tttaagagaa atgaagctaa gacaaaagaa
     5461 a
//
