LOCUS       NM_012138               2062 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens apoptosis antagonizing transcription factor (AATF),
            transcript variant 1, mRNA.
ACCESSION   NM_012138
VERSION     NM_012138.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2062)
  AUTHORS   Thuy,P.X., Jang,T.K. and Moon,E.Y.
  TITLE     Vinblastine Resistance Is Associated with Nephronophthisis
            3-Mediated Primary Cilia via Intraflagellar Transport Protein 88
            and Apoptosis-Antagonizing Transcription Factor
  JOURNAL   Int J Mol Sci 25 (19), 10369 (2024)
   PUBMED   39408701
  REMARK    GeneRIF: Vinblastine Resistance Is Associated with Nephronophthisis
            3-Mediated Primary Cilia via Intraflagellar Transport Protein 88
            and Apoptosis-Antagonizing Transcription Factor.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2062)
  AUTHORS   Pisani,C., Onori,A., Gabanella,F., Iezzi,S., De Angelis,R.,
            Fanciulli,M., Colizza,A., de Vincentiis,M., Di Certo,M.G.,
            Passananti,C. and Corbi,N.
  TITLE     HAX1 is a novel binding partner of Che-1/AATF. Implications in
            oxidative stress cell response
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (1), 119587 (2024)
   PUBMED   37742722
  REMARK    GeneRIF: HAX1 is a novel binding partner of Che-1/AATF.
            Implications in oxidative stress cell response.
REFERENCE   3  (bases 1 to 2062)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2062)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   5  (bases 1 to 2062)
  AUTHORS   Catena,V., Bruno,T., Iezzi,S., Matteoni,S., Salis,A., Sorino,C.,
            Damonte,G. and Fanciulli,M.
  TITLE     CK2-mediated phosphorylation of Che-1/AATF is required for its
            pro-proliferative activity
  JOURNAL   J Exp Clin Cancer Res 40 (1), 232 (2021)
   PUBMED   34266450
  REMARK    GeneRIF: CK2-mediated phosphorylation of Che-1/AATF is required for
            its pro-proliferative activity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2062)
  AUTHORS   Salehi,A.H., Xanthoudakis,S. and Barker,P.A.
  TITLE     NRAGE, a p75 neurotrophin receptor-interacting protein, induces
            caspase activation and cell death through a JNK-dependent
            mitochondrial pathway
  JOURNAL   J Biol Chem 277 (50), 48043-48050 (2002)
   PUBMED   12376548
REFERENCE   7  (bases 1 to 2062)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   8  (bases 1 to 2062)
  AUTHORS   Lindfors,K., Halttunen,T., Huotari,P., Nupponen,N., Vihinen,M.,
            Visakorpi,T., Maki,M. and Kainulainen,H.
  TITLE     Identification of novel transcription factor-like gene from human
            intestinal cells
  JOURNAL   Biochem Biophys Res Commun 276 (2), 660-666 (2000)
   PUBMED   11027528
REFERENCE   9  (bases 1 to 2062)
  AUTHORS   Fanciulli,M., Bruno,T., Di Padova,M., De Angelis,R., Iezzi,S.,
            Iacobini,C., Floridi,A. and Passananti,C.
  TITLE     Identification of a novel partner of RNA polymerase II subunit 11,
            Che-1, which interacts with and affects the growth suppression
            function of Rb
  JOURNAL   FASEB J 14 (7), 904-912 (2000)
   PUBMED   10783144
REFERENCE   10 (bases 1 to 2062)
  AUTHORS   Page,G., Lodige,I., Kogel,D. and Scheidtmann,K.H.
  TITLE     AATF, a novel transcription factor that interacts with Dlk/ZIP
            kinase and interferes with apoptosis
  JOURNAL   FEBS Lett 462 (1-2), 187-191 (1999)
   PUBMED   10580117
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK057229.1, AF083208.1 and
            BC000591.2.
            
            On Nov 22, 2018 this sequence version replaced NM_012138.3.
            
            Summary: The protein encoded by this gene was identified on the
            basis of its interaction with MAP3K12/DLK, a protein kinase known
            to be involved in the induction of cell apoptosis. This gene
            product contains a leucine zipper, which is a characteristic motif
            of transcription factors, and was shown to exhibit strong
            transactivation activity when fused to Gal4 DNA binding domain.
            Overexpression of this gene interfered with MAP3K12 induced
            apoptosis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.705445.1, AK057229.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000619387.5/ ENSP00000477848.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AK057229.1         80-137
            59-61               AF083208.1         67-69
            62-1416             AK057229.1         141-1495
            1417-1630           AF083208.1         1410-1623
            1631-1896           AK057229.1         1710-1975
            1897-2027           AF083208.1         1893-2023
            2028-2062           BC000591.2         1987-2021
FEATURES             Location/Qualifiers
     source          1..2062
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..2062
                     /gene="AATF"
                     /gene_synonym="BFR2; CHE-1; CHE1; DED"
                     /note="apoptosis antagonizing transcription factor"
                     /db_xref="GeneID:26574"
                     /db_xref="HGNC:HGNC:19235"
                     /db_xref="MIM:608463"
     exon            1..263
                     /gene="AATF"
                     /gene_synonym="BFR2; CHE-1; CHE1; DED"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1855
                     /gene="AATF"
                     /gene_synonym="BFR2; CHE-1; CHE1; DED"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein AATF; rb-binding protein Che-1"
                     /codon_start=1
                     /product="protein AATF isoform 1"
                     /protein_id="NP_036270.1"
                     /db_xref="CCDS:CCDS32632.1"
                     /db_xref="GeneID:26574"
                     /db_xref="HGNC:HGNC:19235"
                     /db_xref="MIM:608463"
                     /translation="MAGPQPLALQLEQLLNPRPSEADPEADPEEATAARVIDRFDEGE
                     DGEGDFLVVGSIRKLASASLLDTDKRYCGKTTSRKAWNEDHWEQTLPGSSDEEISDEE
                     GSGDEDSEGLGLEEYDEDDLGAAEEQECGDHRESKKSRSHSAKTPGFSVQSISDFEKF
                     TKGMDDLGSSEEEEDEESGMEEGDDAEDSQGESEEDRAGDRNSEDDGVVMTFSSVKVS
                     EEVEKGRAVKNQIALWDQLLEGRIKLQKALLTTNQLPQPDVFPLFKDKGGPEFSSALK
                     NSHKALKALLRSLVGLQEELLFQYPDTRYLVDGTKPNAGSEEISSEDDELVEEKKQQR
                     RRVPAKRKLEMEDYPSFMAKRFADFTVYRNRTLQKWHDKTKLASGKLGKGFGAFERSI
                     LTQIDHILMDKERLLRRTQTKRSVYRVLGKPEPAAQPVPESLPGEPEILPQAPANAHL
                     KDLDEEIFDDDDFYHQLLRELIERKTSSLDPNDQVAMGRQWLAIQKLRSKIHKKVDRK
                     ASKGRKLRFHVLSKLLSFMAPIDHTTMNDDARTELYRSLFGQLHPPDEGHGD"
     exon            264..455
                     /gene="AATF"
                     /gene_synonym="BFR2; CHE-1; CHE1; DED"
                     /inference="alignment:Splign:2.1.0"
     exon            456..866
                     /gene="AATF"
                     /gene_synonym="BFR2; CHE-1; CHE1; DED"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1004
                     /gene="AATF"
                     /gene_synonym="BFR2; CHE-1; CHE1; DED"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1119
                     /gene="AATF"
                     /gene_synonym="BFR2; CHE-1; CHE1; DED"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1321
                     /gene="AATF"
                     /gene_synonym="BFR2; CHE-1; CHE1; DED"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1486
                     /gene="AATF"
                     /gene_synonym="BFR2; CHE-1; CHE1; DED"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1570
                     /gene="AATF"
                     /gene_synonym="BFR2; CHE-1; CHE1; DED"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1638
                     /gene="AATF"
                     /gene_synonym="BFR2; CHE-1; CHE1; DED"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1719
                     /gene="AATF"
                     /gene_synonym="BFR2; CHE-1; CHE1; DED"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1791
                     /gene="AATF"
                     /gene_synonym="BFR2; CHE-1; CHE1; DED"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..2062
                     /gene="AATF"
                     /gene_synonym="BFR2; CHE-1; CHE1; DED"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2040..2045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AATF"
                     /gene_synonym="BFR2; CHE-1; CHE1; DED"
                     /note="hexamer: AATAAA"
     polyA_site      2062
                     /gene="AATF"
                     /gene_synonym="BFR2; CHE-1; CHE1; DED"
                     /note="major polyA site"
ORIGIN      
        1 gcgcctcccg gaagtggccg gtccagagct gtggggtggc ctccgcgcgg tctctggcgg
       61 agtcggggaa tcggatcaag gcgagaggat ccggcaggga aggagcttcg gggccggggg
      121 ttgggccgca catttacgtg cgcgaagcgg agtggaccgg gagctggtga cgatggcggg
      181 gccgcagccc ctggcgctgc aactggaaca gttgttgaac ccgcgaccaa gcgaggcgga
      241 ccctgaagcg gaccccgagg aagccactgc tgccagggtg attgacaggt ttgatgaagg
      301 ggaagatggg gaaggtgatt tcctagtagt gggtagcatt agaaaactgg catcagcctc
      361 cctcttggac acggacaaaa ggtattgcgg caaaaccacc tctagaaaag catggaatga
      421 agaccattgg gagcagactc tgccaggatc gtctgatgag gaaatatctg atgaggaagg
      481 gtctggagat gaagattcag agggactggg tctggaggaa tatgatgagg acgacctggg
      541 tgctgctgag gaacaggagt gtggtgatca cagggagagc aagaagagca gaagccactc
      601 tgcaaaaaca ccgggcttca gtgtccagag tatcagtgac tttgagaaat ttaccaaggg
      661 aatggatgac cttgggagca gtgaggagga ggaagacgaa gagagtggca tggaagaagg
      721 ggatgacgcg gaagactccc aaggcgagag tgaggaagac agggctggag atagaaacag
      781 tgaggatgat ggtgtggtga tgaccttctc tagtgtcaaa gtttctgagg aagtggagaa
      841 aggaagagcc gtgaagaacc agatagcact gtgggaccag ctcttggaag gaaggatcaa
      901 actacaaaaa gctctgttga ccaccaacca gcttcctcaa ccagatgttt tcccattgtt
      961 caaggacaaa ggtggcccag aattttccag tgccctgaaa aatagtcaca aggcacttaa
     1021 agcattgttg aggtcattgg taggtcttca ggaagagttg cttttccagt acccagacac
     1081 tagatatcta gtagatggga caaagcccaa tgcgggaagt gaggagattt ctagtgaaga
     1141 tgatgagctg gtagaagaga agaagcagca acgaagaagg gtccctgcaa agaggaagct
     1201 ggagatggag gactatccca gcttcatggc aaagcgcttt gccgacttta cagtctacag
     1261 gaaccgcaca cttcagaaat ggcacgataa gaccaaactg gcttctggaa aactggggaa
     1321 gggttttggt gcctttgaac gctcaatctt gactcagatc gaccatattc tgatggacaa
     1381 agagagatta cttcgaagga cacagaccaa gcgctctgtc tatcgagttc ttggcaaacc
     1441 tgagccagca gctcagcctg tcccagagag tttgccaggg gaaccggaga tccttcctca
     1501 agcccctgct aatgctcatc tgaaggactt ggatgaagaa atctttgatg atgatgactt
     1561 ttaccaccag ctccttcgag aactcataga acggaagacc agctccttgg atcccaacga
     1621 tcaggtggcc atgggaaggc agtggcttgc aatccagaag ttacgaagca aaatccacaa
     1681 aaaagtagat aggaaagcca gcaaaggcag gaaacttcgg tttcatgtcc ttagcaagct
     1741 actgagtttc atggcaccta ttgaccatac tacaatgaat gatgatgcca ggacagaact
     1801 gtaccgctct ctttttggcc agctccaccc tcccgacgaa ggccacgggg attgacatcg
     1861 cccacctccg acacccagtg ggcgccttgg ctggtgcggc tgctggtcca gatggaggaa
     1921 accagtgact ttatggggct gagctagtag ggaagcccct ggaaagatgc tgcgttccga
     1981 acctgtgcct aatacacgca agggcgctgt cccgcccaac cccgccttta aacgccacaa
     2041 ataaagagca ttgttaccgc ca
//
