LOCUS       XM_011515725            5729 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens aminoadipate-semialdehyde synthase (AASS),
            transcript variant X1, mRNA.
ACCESSION   XM_011515725
VERSION     XM_011515725.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000007.14) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011515725.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5729
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
     gene            1..5729
                     /gene="AASS"
                     /gene_synonym="LKR/SDH; LKRSDH; LORSDH"
                     /note="aminoadipate-semialdehyde synthase; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 23 ESTs, 1062 long SRA reads, and 98% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     47 samples with support for all annotated introns"
                     /db_xref="GeneID:10157"
                     /db_xref="HGNC:HGNC:17366"
                     /db_xref="MIM:605113"
     CDS             105..2789
                     /gene="AASS"
                     /gene_synonym="LKR/SDH; LKRSDH; LORSDH"
                     /codon_start=1
                     /product="alpha-aminoadipic semialdehyde synthase,
                     mitochondrial isoform X1"
                     /protein_id="XP_011514027.1"
                     /db_xref="GeneID:10157"
                     /db_xref="HGNC:HGNC:17366"
                     /db_xref="MIM:605113"
                     /translation="MLQVHRTGLGRLGVSLSKGLHHKAVLAVRREDVNAWERRAPLAP
                     KHIKGITNLGYKVLIQPSNRRAIHDKDYVKAGGILQEDISEACLILGVKRPPEEKLMS
                     RKTYAFFSHTIKAQEANMGLLDEILKQEIRLIDYEKMVDHRGVRVVAFGQWAGVAGMI
                     NILHGMGLRLLALGHHTPFMHIGMAHNYRNSSQAVQAVRDAGYEISLGLMPKSIGPLT
                     FVFTGTGNVSKGAQAIFNELPCEYVEPHELKEVSQTGDLRKVYGTVLSRHHHLVRKTD
                     AVYDPAEYDKHPERYISRFNTDIAPYTTCLINGIYWEQNTPRLLTRQDAQSLLAPGKF
                     SPAGVEGCPALPHKLVAICDISADTGGSIEFMTECTTIEHPFCMYDADQHIIHDSVEG
                     SGILMCSIDNLPAQLPIEATECFGDMLYPYVEEMILSDATQPLESQNFSPVVRDAVIT
                     SNGTLPDKYKYIQTLRESRERAQSLSMGTRRKVLVLGSGYISEPVLEYLSRDGNIEIT
                     VGSDMKNQIEQLGKKYNINPVSMDICKQEEKLGFLVAKQDLVISLLPYVLHPLVAKAC
                     ITNKVNMVTASYITPALKELEKSVEDAGITIIGELGLDPGLDHMLAMETIDKAKEVGA
                     TIESYISYCGGLPAPEHSNNPLRYKFSWSPVGVLMNVMQSATYLLDGKVVNVAGGISF
                     LDAVTSMDFFPGLNLEGYPNRDSTKYAEIYGISSAHTLLRGTLRYKKQLLCDLVGISP
                     SSEHDVLKEAVLKKLGGDNTQLEAAEWLGLLGDEQVPQAESILDALSKHLVMKLSYGP
                     EEKDMIVMRDSFGIRHPSGHLEHKTIDLVAYGDINGFSAMAKTVGLPTAMAAKMLLDG
                     EIGAKGLMGPFSKEIYGPILERIKAEGIIYTTQSTIKP"
ORIGIN      
        1 agtttcttct aggaattcgg agcctcccct gcagcgactc ggaagattcg aggcggcggg
       61 ggacaagtcg gcgccccaga gcggacgagt caccaggtgt caagatgctg caagtacata
      121 ggactggact gggcaggctg ggggtcagcc tctccaaggg tcttcaccac aaagctgtgt
      181 tggccgtccg gagggaggat gtgaacgcct gggagagaag ggccccgcta gctcccaagc
      241 acatcaaagg catcaccaat ctgggataca aggtcttgat acagccttcg aatcggcggg
      301 ccattcatga taaggactat gtcaaagctg gtggcattct tcaggaggat atttctgaag
      361 cttgtctaat tttaggagtt aaaagacctc cagaggaaaa attaatgtcc aggaagactt
      421 atgcattttt ctcccacaca ataaaagctc aggaggccaa tatgggcttg ttggatgaga
      481 ttctaaaaca ggaaattcgc cttattgatt atgagaaaat ggtggatcat agaggagtac
      541 gggtagtggc atttggacag tgggctggtg tggcaggaat gatcaacatt ttacatggaa
      601 tgggtttaag gctccttgct ttgggacatc acacaccttt tatgcacatt ggcatggctc
      661 ataactacag gaatagcagt caggctgtgc aagctgtccg tgatgctggc tatgaaatat
      721 ctttgggttt gatgcctaag tcaataggac ccttaacatt tgtgttcaca ggaactggta
      781 atgtttctaa gggagcccaa gcaatcttta atgagctacc ttgtgaatat gtggagcccc
      841 atgaattaaa agaagtttcc caaactggag acctcagaaa agtgtatggg acggtgttaa
      901 gtcgtcatca tcatcttgtc aggaaaacag atgctgtgta tgatcctgca gagtatgaca
      961 aacatccgga gcgctacata agtcgtttta atactgatat tgcaccctat acaacttgct
     1021 taattaatgg aatctactgg gaacaaaaca ctcctcgcct cctaacccgc caagatgctc
     1081 agagtctcct ggctccgggc aagttctcac ctgctggtgt ggaaggctgc cctgcattac
     1141 cacacaaact cgtggcaata tgtgacattt cagctgacac aggagggtct atagagttta
     1201 tgactgagtg tacaacaata gagcatccct tttgcatgta tgatgcagac cagcatatta
     1261 ttcatgacag tgttgaaggc tcggggatcc tgatgtgttc cattgacaat ttgccggcac
     1321 agctcccaat tgaagctaca gaatgctttg gagacatgct ttacccttat gttgaagaaa
     1381 tgatattatc agacgcgaca cagcctcttg aaagtcagaa tttttctcct gtggtgagag
     1441 atgcagtgat tacatccaac ggtacattac ctgataaata taaatatatc cagacactcc
     1501 gggagagcag ggaacgtgct cagtcacttt caatgggcac caggagaaag gttttggttc
     1561 ttggatctgg ctacatatct gagcctgtat tagaatattt atcaagagat ggcaatatag
     1621 aaataacagt aggatctgac atgaagaatc aaattgaaca gttaggcaag aaatataata
     1681 ttaatcctgt tagcatggac atttgtaaac aagaagagaa gctgggcttc ttggtggcaa
     1741 aacaggatct tgtcatcagc ttgttgcctt atgtattgca ccctcttgtg gccaaggcct
     1801 gcatcacaaa caaagttaac atggtcactg caagctacat cacaccagca ctaaaagaat
     1861 tggaaaagag tgtggaagat gctggcatca caatcattgg tgaattggga ttggaccctg
     1921 gtctggatca catgttagca atggaaacaa tagataaagc caaggaagtg ggagccacga
     1981 ttgaatcata tatttcctac tgtggtgggc ttccagcccc tgaacattca aacaatccat
     2041 tgagatataa atttagctgg agtccagtgg gagttttgat gaatgtaatg cagtctgcca
     2101 cctatctgct cgatggaaag gttgtgaatg ttgcaggagg catctccttt cttgatgccg
     2161 ttacgtccat ggattttttt ccaggattaa atttggaagg ctatcctaac agagacagta
     2221 cgaaatatgc tgagatttat ggcatttctt ctgctcacac tttgttgcgg gggacactga
     2281 gatataagaa acaactcctc tgtgacctag ttgggatttc accctcctct gagcatgatg
     2341 tgttgaagga agctgttctt aagaaactag gaggagacaa tacccagttg gaggctgctg
     2401 aatggttggg cttacttggg gatgaacaag ttcctcaggc agagtccatt ctggatgccc
     2461 tctccaagca tttggtcatg aagctttcct atggtcctga agaaaaagat atgattgtga
     2521 tgagagacag ctttggaatc agacatcctt ctggacattt agaacataaa acgattgatc
     2581 ttgtggctta tggggacatc aatggctttt cagccatggc taaaaccgtg gggttaccca
     2641 ccgccatggc agccaaaatg ttgcttgatg gtgaaattgg agccaaaggc ctaatggggc
     2701 ccttttcaaa ggagatctat ggaccaatat tggagcgaat taaagcagaa ggcattatat
     2761 atactacaca gagtacaatt aaaccataat tgggaattat attttgtttt tttcttccca
     2821 ggcaatacac ctctgaacat gtgtgtgata aatgggtttg ctaatgtgct gttttaaagt
     2881 ataaagcata atatgttttg gttaacacaa tgtacttttt gaactataaa tctttatttt
     2941 aatatggaaa tgtttggaac aggagatgca agccactaac agagaacttt aataattcta
     3001 ccctgtattt tataaatacg tatgtgaaag tgatgatcat gctatttgtt aatttattgt
     3061 gccacttttt ttcttttgtt ttttttttgt tgttgttgtt ttttgagatg gagtctcgct
     3121 ctgtcaccca ggctggagtg cagtggcgcg atctcggctc actgcaagct ccgcctcctg
     3181 ggttcacgcc attctcctgc ctcagcctcc caagtagctg ggactacagg cacccgccac
     3241 cacgcccggc taaatttttt gtatttttca gtagagacgg ggtttcacca tgttagccag
     3301 gatgtccact tttttcttaa atgaacatat tgtcttataa ccagcaaatg aagttttact
     3361 tttttagtca gaaaaaattt cgtcataaag ctatattttt atatttttaa aattgataca
     3421 gttagatacc ttcagattac ctaagttaag tttttgccaa aatgctattt tatgcccttt
     3481 ttgtaaagtt atgatttatt ttgtaaatat agttccttat agttttctct tgagtgtttg
     3541 gacatgagaa tagataagat taaattacaa tttacaagat cacttcatta ggcacaggaa
     3601 aagtatttaa caaaattcaa caccctttca caataaaaaa taaaaaataa aaaaccctca
     3661 acaaactagg aatagaagga aacttcctca acctgataaa gggcatctat gaagaaccca
     3721 tggttagcat catacttaat ggtgaaggac tggattattt ccccctgaga tcagaaacaa
     3781 gacaaggatg tctgctttgg ccatttctat tcaacttgta ctggacagtc aagaaagggc
     3841 aattaggcaa gaaaataaaa taaaagtcat ctaggttgga aaggaagaag tataactaaa
     3901 tagagatggg agacgatatg gtggttttgt gcatagtaat ccaagggaaa actatagaaa
     3961 atccaaaggc atgatttatt aataaataaa ttcagcaaag ttacaggata caggattaaa
     4021 tatgcagaaa ttggttatct ttcaatatag tatcaatgaa taaatcaaaa atgatgttaa
     4081 gaaaacaatt taattttcaa caatggtcaa gcttggtggc ttgtgcctgt aatcccaaca
     4141 ctttgggagt ctgaggcaga aagactgcta gaggccagga gaccagcctg ggaaacagtg
     4201 agatcccatc tctacaaaaa caaacaaaca aaaaacaaca agcaaacaaa aaacagctgg
     4261 atgtgatgac actcatctgt cgtctcagct actcagaggc tgaggtgtaa ggatggcttg
     4321 agccccaaag ttcgaagctg caatgagcta taactgggtc actgcaatcc agcctggatg
     4381 acagagttag accttgactc aaaaaaaaca aaaaagaaaa gaaaaaaatt gacagcatca
     4441 gaaagagtaa aataccaata taattgaggg tccagaaata ttgatcacat ttatcatcaa
     4501 ctgacttttg aaaatagtgc taagacaatt caatgggggc aaaatagtct ttttcattaa
     4561 atgatgcttg gaaacatgga tatccacatg caaaataatg aaattggact cctacctcat
     4621 attgcatata aaaattaact caaagttgac ctaagatcta aatgtaagag ctaatattgt
     4681 aagtatcttc aaagaaaaca tggcgtaaat ctttctgact ttgaattagg caatgatttc
     4741 ttaaataaat gacactaaaa acacaagcaa caaaagaaga aaataggtaa attaaaatta
     4801 aaaccatttg tgtttccaag gacaatatca agaaagcaaa aatacaaccc acagaatgag
     4861 ataatttttt ttaaaatcat gtattagtta agggaggaat ttgtatttag aatatgtaaa
     4921 gaactgttac aataataatt aaaaggcata taattcaatt tttaaaaatc aacaagagat
     4981 ctgaattaac agttctccaa agaagataca caaaaggcca ataagcacat gaaaaggttc
     5041 tcaacatcac tagccatcag ggaaatgcaa atgagatcta caatgagata tcacttaaca
     5101 ctcactggaa tagatatata atcaaagtga taatatcaag tgttggtgag gatgcagaga
     5161 aattggaacc ctcatgcact gttggtggat acccacgtga tataaaaaca aatgtctaca
     5221 caaaaacttg tgcacagatg ttctttgcag cattatttat aatagcccaa aattgaaaca
     5281 gccctaattt ctatcaacta acaagtgaat aaacaaaacg tggcatatcc atacaaggaa
     5341 tattattcag caataaaaaa agagatgaag tactgatatg caccacaaca tggaaaaacc
     5401 ttgaaaacat atcaagtgaa gaatgccaga catgaaaggc cacatattat atgatttcat
     5461 ttatatgaaa tgtccagaac aggcgaatat atatagagag aaggcagatt agtggttgct
     5521 taggctgaag ggttggggag gacaaagggg tgactgctaa ttagtatggg gtttcttttt
     5581 tggggtgatg taaacgttgt aaagttgatt gtggtaatgg tggcacaact ctgaatatac
     5641 taaaaaccac tgaattgtat actttgaatg tttgaactgt gtggtatgta gattttatct
     5701 caagttgtta taaaaaatta aattacaaa
//
