LOCUS       NM_001261434            1320 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens alanyl-tRNA synthetase domain containing 1 (AARSD1),
            mRNA.
ACCESSION   NM_001261434
VERSION     NM_001261434.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1320)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1320)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 1320)
  AUTHORS   Echeverria,P.C., Briand,P.A. and Picard,D.
  TITLE     A Remodeled Hsp90 Molecular Chaperone Ensemble with the Novel
            Cochaperone Aarsd1 Is Required for Muscle Differentiation
  JOURNAL   Mol Cell Biol 36 (8), 1310-1321 (2016)
   PUBMED   26884463
  REMARK    GeneRIF: Aarsd1 inhibits the activity of a paradigmatic Hsp90
            client protein.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1320)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   5  (bases 1 to 1320)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   6  (bases 1 to 1320)
  AUTHORS   Miki,Y., Swensen,J., Shattuck-Eidens,D., Futreal,P.A., Harshman,K.,
            Tavtigian,S., Liu,Q., Cochran,C., Bennett,L.M., Ding,W. et al.
  TITLE     A strong candidate for the breast and ovarian cancer susceptibility
            gene BRCA1
  JOURNAL   Science 266 (5182), 66-71 (1994)
   PUBMED   7545954
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP368900.1, AC055866.19, AL515977.3 and AW296090.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001261434.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1177615.1,
                                           SRR5189652.51095.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093, SAMEA2159080
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000427569.7/ ENSP00000400870.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                BP368900.1         23-95
            74-74               AC055866.19        148508-148508       c
            75-229              AL515977.3         64-218
            230-230             AC055866.19        145598-145598       c
            231-433             AL515977.3         220-422
            434-551             AC055866.19        140704-140821       c
            552-946             AL515977.3         541-935
            947-1320            AW296090.1         14-387              c
FEATURES             Location/Qualifiers
     source          1..1320
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..1320
                     /gene="AARSD1"
                     /gene_synonym="AlaXp"
                     /note="alanyl-tRNA synthetase domain containing 1"
                     /db_xref="GeneID:80755"
                     /db_xref="HGNC:HGNC:28417"
                     /db_xref="MIM:613212"
     exon            1..53
                     /gene="AARSD1"
                     /gene_synonym="AlaXp"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1253
                     /gene="AARSD1"
                     /gene_synonym="AlaXp"
                     /note="alanyl-tRNA synthetase domain-containing protein 1"
                     /codon_start=1
                     /product="alanyl-tRNA editing protein Aarsd1"
                     /protein_id="NP_001248363.1"
                     /db_xref="CCDS:CCDS58552.1"
                     /db_xref="GeneID:80755"
                     /db_xref="HGNC:HGNC:28417"
                     /db_xref="MIM:613212"
                     /translation="MAFWCQRDSYAREFTTTVVSCCPAELQTEGSNGKKEVLSGFQVV
                     LEDTVLFPEGGGQPDDRGTINDISVLRVTRRGEQADHFTQTPLDPGSQVLVRVDWERR
                     FDHMQQHSGQHLITAVADHLFKLKTTSWELGRFRSAIELDTPSMTAEQVAAIEQSVNE
                     KIRDRLPVNVRELSLDDPEVEQVSGRGLPDDHAGPIRVVNIEGVDSNMCCGTHVSNLS
                     DLQVIKILGTEKGKKNRTNLIFLSGNRVLKWMERSHGTEKALTALLKCGAEDHVEAVK
                     KLQNSTKILQKNNLNLLRDLAVHIAHSLRNSPDWGGVVILHRKEGDSEFMNIIANEIG
                     SEETLLFLTVGDEKGGGLFLLAGPPASVETLGPRVAEVLEGKGAGKKGRFQGKATKMS
                     RRMEAQALLQDYISTQSAKE"
     exon            54..185
                     /gene="AARSD1"
                     /gene_synonym="AlaXp"
                     /inference="alignment:Splign:2.1.0"
     exon            186..345
                     /gene="AARSD1"
                     /gene_synonym="AlaXp"
                     /inference="alignment:Splign:2.1.0"
     exon            346..403
                     /gene="AARSD1"
                     /gene_synonym="AlaXp"
                     /inference="alignment:Splign:2.1.0"
     exon            404..560
                     /gene="AARSD1"
                     /gene_synonym="AlaXp"
                     /inference="alignment:Splign:2.1.0"
     exon            561..677
                     /gene="AARSD1"
                     /gene_synonym="AlaXp"
                     /inference="alignment:Splign:2.1.0"
     exon            678..808
                     /gene="AARSD1"
                     /gene_synonym="AlaXp"
                     /inference="alignment:Splign:2.1.0"
     exon            809..875
                     /gene="AARSD1"
                     /gene_synonym="AlaXp"
                     /inference="alignment:Splign:2.1.0"
     exon            876..967
                     /gene="AARSD1"
                     /gene_synonym="AlaXp"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1022
                     /gene="AARSD1"
                     /gene_synonym="AlaXp"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1117
                     /gene="AARSD1"
                     /gene_synonym="AlaXp"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1320
                     /gene="AARSD1"
                     /gene_synonym="AlaXp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1304..1309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AARSD1"
                     /gene_synonym="AlaXp"
                     /note="hexamer: AATAGA"
     polyA_site      1320
                     /gene="AARSD1"
                     /gene_synonym="AlaXp"
                     /note="major polyA site"
ORIGIN      
        1 acacgcctgc aggtatggcg ttctggtgtc agcgtgacag ttatgcccga gagttcacca
       61 ccaccgtggt ctcctgctgt cccgcggagc tgcagactga agggagcaac ggcaagaaag
      121 aagtgctgag cggtttccaa gtggtgctgg aagacacagt gcttttccct gagggcgggg
      181 gacagcctga tgaccgtggt acaatcaatg acatctctgt gctgagagtg actcgccgtg
      241 gggaacaggc tgatcatttc acccagacac ccctggatcc aggaagccag gttctggtcc
      301 gggtagattg ggagcggagg tttgaccaca tgcagcagca ttcagggcag catctcatca
      361 cggcagttgc tgaccatcta tttaagctga agacaacatc atgggagtta gggagatttc
      421 ggagtgcgat tgagctggac accccctcta tgactgcaga gcaagtagct gccattgagc
      481 agagcgtcaa tgaaaaaatc agagatcggc tgcctgtgaa tgtccgagaa ctgagcctgg
      541 atgatcctga ggtggagcag gtgagtggcc ggggtttgcc tgatgatcat gctgggccca
      601 ttcgggttgt taacatcgag ggcgttgatt ccaacatgtg ctgtgggacc catgtgagca
      661 atctcagtga ccttcaggtc attaagattc tgggcactga gaaggggaaa aagaacagaa
      721 ccaacctgat atttctgtct gggaaccggg tgctgaagtg gatggagaga agtcatggaa
      781 ctgaaaaagc actgactgct ctgcttaagt gtggagcaga ggatcatgtg gaagcagtga
      841 aaaagctcca gaactccacc aagatcctgc agaagaataa cctgaatctg ctcagagacc
      901 tggctgtgca cattgcccat agcctcagga acagtccaga ctggggaggt gtggtcatat
      961 tacacaggaa ggagggtgat tcagagttca tgaatatcat tgccaatgag attgggtcag
     1021 aggagaccct cctgttctta actgtgggcg atgagaaagg tggtggactc ttcttactgg
     1081 cagggccacc tgcgtctgtg gagaccctgg ggcccagggt ggctgaggtc ctggaaggca
     1141 aaggagcagg gaagaaaggc cgttttcagg gcaaggccac caagatgagc cggcggatgg
     1201 aggcgcaggc gcttctccag gactacatca gcacgcagag tgctaaggag tgagggctta
     1261 gggcactcac ctcctgtttc cacaggaatc ttttggtcaa taaaatagat tgactcagaa
//
