LOCUS       NM_001025357            2291 bp    mRNA    linear   PRI 17-DEC-2024
DEFINITION  Homo sapiens alanine and arginine rich domain containing protein
            (AARD), mRNA.
ACCESSION   NM_001025357 XM_496990
VERSION     NM_001025357.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2291)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2291)
  AUTHORS   Geng,Q., Ni,L.W., Ouyang,B., Hu,Y.H., Zhao,Y. and Guo,J.
  TITLE     Alanine and arginine rich domain containing protein, Aard, is
            directly regulated by androgen receptor in mouse Sertoli cells
  JOURNAL   Mol Med Rep 15 (1), 352-358 (2017)
   PUBMED   27959439
REFERENCE   3  (bases 1 to 2291)
  AUTHORS   Feng,T. and Zhu,X.
  TITLE     Genome-wide searching of rare genetic variants in WTCCC data
  JOURNAL   Hum Genet 128 (3), 269-280 (2010)
   PUBMED   20549515
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087350.3, BC140924.1, AB181519.1 and BC142621.1.
            
            On May 17, 2019 this sequence version replaced NM_001025357.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC142621.1, SRR7346977.252154.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378279.4/ ENSP00000367528.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC087350.3         27362-27379         c
            19-37               BC140924.1         27-45
            38-777              AB181519.1         1-740
            778-825             BC142621.1         760-807
            826-1804            BC142621.1         809-1787
            1805-2291           AC087350.3         21099-21585         c
FEATURES             Location/Qualifiers
     source          1..2291
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.11"
     gene            1..2291
                     /gene="AARD"
                     /gene_synonym="C8orf85"
                     /note="alanine and arginine rich domain containing
                     protein"
                     /db_xref="GeneID:441376"
                     /db_xref="HGNC:HGNC:33842"
                     /db_xref="MIM:621042"
     exon            1..361
                     /gene="AARD"
                     /gene_synonym="C8orf85"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..505
                     /gene="AARD"
                     /gene_synonym="C8orf85"
                     /codon_start=1
                     /product="alanine and arginine-rich domain-containing
                     protein"
                     /protein_id="NP_001020528.1"
                     /db_xref="CCDS:CCDS34935.1"
                     /db_xref="GeneID:441376"
                     /db_xref="HGNC:HGNC:33842"
                     /db_xref="MIM:621042"
                     /translation="MGPGDFRRCRERISQGLQGLPGRAELWFPPRPACDFFGDGRSTD
                     IQEEALAASPLLEDLRRRLTRAFQWAVQRAISRRVQEAAAAAAAREEQSWTGVEATLA
                     RLRAELVEMHFQNHQLARTLLDLNMKVQQLKKEYELEITSDSQSPKDDAANPE"
     exon            362..2291
                     /gene="AARD"
                     /gene_synonym="C8orf85"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1781..1786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AARD"
                     /gene_synonym="C8orf85"
                     /note="hexamer: AATAAA"
     polyA_site      1804
                     /gene="AARD"
                     /gene_synonym="C8orf85"
                     /note="major polyA site"
     regulatory      1876..1881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AARD"
                     /gene_synonym="C8orf85"
                     /note="hexamer: AATAAA"
     regulatory      1883..1888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AARD"
                     /gene_synonym="C8orf85"
                     /note="hexamer: TATAAA"
     polyA_site      1893
                     /gene="AARD"
                     /gene_synonym="C8orf85"
     polyA_site      1914
                     /gene="AARD"
                     /gene_synonym="C8orf85"
     regulatory      2253..2258
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AARD"
                     /gene_synonym="C8orf85"
                     /note="hexamer: AATAAA"
     polyA_site      2274
                     /gene="AARD"
                     /gene_synonym="C8orf85"
ORIGIN      
        1 agcagcagcg gtagagcagt gaccaggcgt ctccgcgatg ggccccgggg acttccgccg
       61 ctgcagagag agaatttccc aggggctcca gggactccca ggtagagcgg agctttggtt
      121 cccacctcgt cccgcgtgcg acttcttcgg ggacggcagg agcacggaca tccaggagga
      181 ggccctcgcc gccagcccgc tgctggagga cctcagacga cggctgacgc gcgccttcca
      241 gtgggcggtg cagcgcgcga tctcgaggcg cgtgcaggag gcggcggcgg cggcggcggc
      301 gcgggaggag cagagctgga cgggcgttga ggccaccctg gccaggctgc gggcggagct
      361 ggtggaaatg catttccaaa accaccagct ggctagaact ttactggacc taaacatgaa
      421 agtgcagcaa ttgaaaaagg agtatgaact ggaaattaca tcagactccc aaagcccaaa
      481 agatgatgct gcgaatccgg aataaagaaa tgcacacgca agggctgggc gcggtggctc
      541 acgcctgtaa tcccagcact ttgggaggcc gaggcgggcg gatcaagacg tcaggagatt
      601 gagaccatcc tggctaacac tgtgaaaccc tgcctctact aaaaatacaa aaaattagcc
      661 agacgtggtg gcaggcacct gtagtccctg ctactcagga gtctgaggca ggagaatggc
      721 gtgaacccag gagacagagc ttgcagtgag ccgaaatcct gccactgcac tccagcctgg
      781 gtgacagagc aagactccat ctcaaaaaaa aaaaaaaaaa aaaaagcaca cgcgaagctc
      841 tggatcctaa aactaacgca tacaaccctg aaacaattct gatgaacaca ttatgctttg
      901 cataagtttt gaggggcaat ttatagaccc aaaacaaatg acaggggaag gtgacagaaa
      961 aacatctaag agaggggaga gaaaaatgat gtattaccaa gttttaaagt tatttatttg
     1021 ttatttttac tgggacatag aagtaaaata taactataga taaatctctc tctgtctctc
     1081 tcactcaaag aatgctttaa tgccaacttt cggtattcaa ccttgtgtca cctgaccttt
     1141 ctggcattgc ctgagctttc agagtttgtg cttgttttgt tttacttgat tattctcagt
     1201 ttgtctgtcc agcagcctgc cctgcttctt gtggagaatt gtttctactt ggattctaac
     1261 catgcccttt aggtggtctg tgactaaggg tattccatct tcctggatat agtcatgcag
     1321 ctcaaggcag gcagatgggt ttgtccttag gatttttgaa tgggcactaa aagagtagat
     1381 gactatttct gccagtagaa gctgtggatc aggggcttgg aagctgctgg tggtcaccat
     1441 gtgagaaagc ccacacccta atggaggtga ctgaaacgga accactaaaa gcacaaaagg
     1501 ggagggaggg agggagggtg cttcgcttcc ttgttcctgg ggtcaagctg tataagactc
     1561 caggccttgc tcttgtttat gtacatgaaa tattctgata tccttctcat aaaatctctt
     1621 tttgcctaag taaattcaag ctggagtttc atgacttgta tctagtgttc ataactaata
     1681 cagttgttca gttttaggag ttaaaatggt tcttactgtt gaattggact atctaactgt
     1741 acccgaaaag tgctgtcttt ttaatgcaaa cagtaaagtt aataaaaaat agttgcagat
     1801 ctaagtgata tttataatgg ttattgtctg caaaatacaa attaatttat aacaagctat
     1861 gtaattttaa tatttaataa actataaaaa tcagttcttg aagacaaagg agaacagaag
     1921 agacacagtc tttctcttgt taaaagaaat acaaggacaa gcatggtgga tcacgcttgt
     1981 aattccagca ctttgggagg ctgaggtggg cagattgttt gagctcagga gtttgagacc
     2041 agcctggtca acatggcaaa accccatctc tactaaaaat acaaaaatta gccaggcgtg
     2101 gtggtgctcg cctatagtac cagctactca ggaggctgag gcataagaat cacttgaacc
     2161 tgggagatgg aggttgcagt gagccgagat catgcccctg cactccagcc tgggtgacag
     2221 agggggactt ggcctcgaaa aaataaataa ataataaaaa taaaataaat gcaagttgtt
     2281 ttatgtgtgt g
//
