LOCUS       NM_001087               1760 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens angio associated migratory cell protein (AAMP),
            transcript variant 2, mRNA.
ACCESSION   NM_001087
VERSION     NM_001087.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1760)
  AUTHORS   Ren,H., Li,Y., Liu,H., Fan,J., Li,J., Li,H., Wei,H., Meng,L. and
            Cao,S.
  TITLE     A crucial exosome-related gene pair (AAMP and ABAT) is associated
            with inflammatory cells in intervertebral disc degeneration
  JOURNAL   Front Immunol 14, 1160801 (2023)
   PUBMED   37122729
  REMARK    GeneRIF: A crucial exosome-related gene pair (AAMP and ABAT) is
            associated with inflammatory cells in intervertebral disc
            degeneration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1760)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1760)
  AUTHORS   Yao,S., Shi,F., Mu,N., Li,X., Ma,G., Wang,Y., Sun,X., Liu,X. and
            Su,L.
  TITLE     Angio-associated migratory cell protein (AAMP) interacts with cell
            division cycle 42 (CDC42) and enhances migration and invasion in
            human non-small cell lung cancer cells
  JOURNAL   Cancer Lett 502, 1-8 (2021)
   PUBMED   33279622
  REMARK    GeneRIF: Angio-associated migratory cell protein (AAMP) interacts
            with cell division cycle 42 (CDC42) and enhances migration and
            invasion in human non-small cell lung cancer cells.
REFERENCE   4  (bases 1 to 1760)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1760)
  AUTHORS   Yao,S., Shi,F., Wang,Y., Sun,X., Sun,W., Zhang,Y., Liu,X., Liu,X.
            and Su,L.
  TITLE     Angio-associated migratory cell protein interacts with epidermal
            growth factor receptor and enhances proliferation and drug
            resistance in human non-small cell lung cancer cells
  JOURNAL   Cell Signal 61, 10-19 (2019)
   PUBMED   31075398
  REMARK    GeneRIF: Angio-associated migratory cell protein interacts with
            epidermal growth factor receptor and enhances proliferation and
            drug resistance in human non-small cell lung cancer cells.
REFERENCE   6  (bases 1 to 1760)
  AUTHORS   Vogt,F., Zernecke,A., Beckner,M., Krott,N., Bosserhoff,A.K.,
            Hoffmann,R., Zandvoort,M.A., Jahnke,T., Kelm,M., Weber,C. and
            Blindt,R.
  TITLE     Blockade of angio-associated migratory cell protein inhibits smooth
            muscle cell migration and neointima formation in accelerated
            atherosclerosis
  JOURNAL   J Am Coll Cardiol 52 (4), 302-311 (2008)
   PUBMED   18634987
  REMARK    GeneRIF: important functional role of AAMP in the migration of
            smooth muscle cells (SMCs), identifying AAMP as a potential target
            to limit lesion formation after injury.
REFERENCE   7  (bases 1 to 1760)
  AUTHORS   Beckner,M.E., Jagannathan,S. and Peterson,V.A.
  TITLE     Extracellular angio-associated migratory cell protein plays a
            positive role in angiogenesis and is regulated by astrocytes in
            coculture
  JOURNAL   Microvasc Res 63 (3), 259-269 (2002)
   PUBMED   11969303
REFERENCE   8  (bases 1 to 1760)
  AUTHORS   Beckner,M.E., Peterson,V.A. and Moul,D.E.
  TITLE     Angio-associated migratory cell protein is expressed as an
            extracellular protein by blood-vessel-associated mesenchymal cells
  JOURNAL   Microvasc Res 57 (3), 347-352 (1999)
   PUBMED   10329261
REFERENCE   9  (bases 1 to 1760)
  AUTHORS   Beckner,M.E., Krutzsch,H.C., Klipstein,S., Williams,S.T.,
            Maguire,J.E., Doval,M. and Liotta,L.A.
  TITLE     AAMP, a newly identified protein, shares a common epitope with
            alpha-actinin and a fast skeletal muscle fiber protein
  JOURNAL   Exp Cell Res 225 (2), 306-314 (1996)
   PUBMED   8660919
REFERENCE   10 (bases 1 to 1760)
  AUTHORS   Beckner,M.E., Krutzsch,H.C., Stracke,M.L., Williams,S.T.,
            Gallardo,J.A. and Liotta,L.A.
  TITLE     Identification of a new immunoglobulin superfamily protein
            expressed in blood vessels with a heparin-binding consensus
            sequence
  JOURNAL   Cancer Res 55 (10), 2140-2149 (1995)
   PUBMED   7743515
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA465288.1, BC008809.2,
            HY374777.1 and BC014122.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001087.4.
            
            Summary: The gene is a member of the immunoglobulin superfamily.
            The encoded protein is associated with angiogenesis, with potential
            roles in endothelial tube formation and the migration of
            endothelial cells. It may also regulate smooth muscle cell
            migration via the RhoA pathway. The encoded protein can bind to
            heparin and may mediate heparin-sensitive cell adhesion. [provided
            by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. It
            encodes isoform 2 which is shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039866.1, M95627.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248450.9/ ENSP00000248450.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-522               DA465288.1         50-571
            523-1551            BC008809.2         78-1106
            1552-1757           HY374777.1         1-206               c
            1758-1760           BC014122.2         1728-1730
FEATURES             Location/Qualifiers
     source          1..1760
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..1760
                     /gene="AAMP"
                     /note="angio associated migratory cell protein"
                     /db_xref="GeneID:14"
                     /db_xref="HGNC:HGNC:18"
                     /db_xref="MIM:603488"
     exon            1..172
                     /gene="AAMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1356
                     /gene="AAMP"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="angio-associated migratory cell protein isoform
                     2"
                     /protein_id="NP_001078.2"
                     /db_xref="CCDS:CCDS33378.1"
                     /db_xref="GeneID:14"
                     /db_xref="HGNC:HGNC:18"
                     /db_xref="MIM:603488"
                     /translation="MESESESGAAADTPPLETLSFHGDEEIIEVVELDPGPPDPDDLA
                     QEMEDVDFEEEEEEEGNEEGWVLEPQEGVVGSMEGPDDSEVTFALHSASVFCVSLDPK
                     TNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKV
                     WQVDTKEEVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCKTFQGPNCPA
                     TCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLIL
                     TGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAV
                     GYLDGTLAIYDLATQTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRL
                     LTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQRPDR"
     exon            173..325
                     /gene="AAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            326..445
                     /gene="AAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            446..585
                     /gene="AAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            586..730
                     /gene="AAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            731..814
                     /gene="AAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            815..930
                     /gene="AAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1034
                     /gene="AAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1125
                     /gene="AAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1280
                     /gene="AAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1760
                     /gene="AAMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1741..1746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AAMP"
                     /note="hexamer: AATAAA"
     polyA_site      1760
                     /gene="AAMP"
                     /note="major polyA site"
ORIGIN      
        1 gactctggga ggcgtttggg cccagagaag tggatccgcc gcttgcgccg catggagtcc
       61 gaatcggaaa gcggggctgc tgctgacacc cccccactgg agaccctaag cttccatggt
      121 gatgaagaga ttatcgaggt ggtagaactt gatcccggtc cgccggaccc agatgacctg
      181 gcccaggaga tggaagatgt ggactttgag gaagaagagg aggaagaggg caacgaagag
      241 ggctgggttc tagaacccca ggaaggggtg gtcggcagca tggagggccc cgacgatagc
      301 gaggtcacct ttgcattgca ctcagcatct gtgttttgtg tgagcctgga ccccaagacc
      361 aataccttgg cagtgaccgg gggtgaagat gacaaagcct tcgtatggcg gctcagcgat
      421 ggggagctgc tctttgagtg tgcaggccat aaagactctg tgacttgtgc tggtttcagc
      481 catgactcca ctctagtggc cacaggggac atgagtggcc tcttgaaagt gtggcaggtg
      541 gacactaagg aggaggtctg gtcctttgaa gcgggagacc tggagtggat ggagtggcat
      601 cctcgggcac ctgtcctgtt ggcgggcaca gctgacggca acacctggat gtggaaagtc
      661 ccgaatggtg actgcaagac cttccagggt cccaactgcc cagccacctg tggccgagtc
      721 ctccctgatg ggaagagagc tgtggtaggc tatgaagatg ggaccatcag gatttgggac
      781 ctgaagcagg gaagccctat ccatgtactg aaagggactg agggtcacca gggcccactc
      841 acctgtgttg ctgccaacca ggatggcagc ttgatcctaa ctggctctgt ggactgccag
      901 gccaagctgg tcagtgccac caccggcaag gtggtgggtg tttttagacc tgagactgtg
      961 gcctcccagc ccagcctggg agaaggggag gagagtgagt ccaactcggt ggagtccttg
     1021 ggcttctgca gtgtgatgcc cctggcagct gttggctacc tggatgggac cttggccatc
     1081 tatgacctgg ctacgcagac tcttaggcat cagtgtcagc accagtcggg catcgtgcag
     1141 ctgctgtggg aggcaggcac tgccgtggta tatacctgca gcctggatgg catcgtgcgc
     1201 ctctgggacg cccggaccgg ccgcctgctt actgactacc ggggccacac ggctgagatc
     1261 ctggactttg ccctcagcaa agatgcctcc ctggtggtga ccacgtcagg agaccacaaa
     1321 gcgaaagtat tttgtgtcca aaggcctgac cgttaatggc tgcagcccct gcctgtgtgt
     1381 ctggtgttga ggggacgaag ggacccctgc ccctgtctgc cagcagaggc agtagggcac
     1441 agagggaaga ggagggtggg gccctggatg actttccagc ctcttcaact gacttgctcc
     1501 cctctccttt tcttctcttt agagacccag cccagggccc tcccaccctt gtccagacct
     1561 ggtgggccct tcagagggag gggtggacct gtttctcttt cactttcatt tgctggtgtg
     1621 agccatgggg tgtgtatttg tatgtgggga gtaggtgttt gaggttcccg ttctttccct
     1681 tcccaagtct ctgggggtgg aaaggaggaa gagatactag ttaaagattt taaaaatgta
     1741 aataaaatat acttcccaga
//
