LOCUS       NM_024684                522 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens adipogenesis associated Mth938 domain containing
            (AAMDC), transcript variant 3, mRNA.
ACCESSION   NM_024684 NM_014040
VERSION     NM_024684.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 522)
  AUTHORS   Golden,E., Rashwan,R., Woodward,E.A., Sgro,A., Wang,E., Sorolla,A.,
            Waryah,C., Tie,W.J., Cuyas,E., Ratajska,M., Kardas,I.,
            Kozlowski,P., Johnstone,E.K.M., See,H.B., Duffy,C., Parry,J.,
            Lagerborg,K.A., Czapiewski,P., Menendez,J.A., Gorczynski,A.,
            Wasag,B., Pfleger,K.D.G., Curtis,C., Lee,B.K., Kim,J., Cursons,J.,
            Pavlos,N.J., Biernat,W., Jain,M., Woo,A.J., Redfern,A. and
            Blancafort,P.
  TITLE     The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic
            reprograming in estrogen receptor-positive breast cancer
  JOURNAL   Nat Commun 12 (1), 1920 (2021)
   PUBMED   33772001
  REMARK    GeneRIF: The oncogene AAMDC links PI3K-AKT-mTOR signaling with
            metabolic reprograming in estrogen receptor-positive breast cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 522)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 522)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 522)
  AUTHORS   Xiao,R., Li,C., Wang,C., Cao,Y., Zhang,L., Guo,Y., Xin,Y., Zhang,H.
            and Zhou,G.
  TITLE     Adipogenesis associated Mth938 domain containing (AAMDC) protein
            expression is regulated by alternative polyadenylation and
            microRNAs
  JOURNAL   FEBS Lett 593 (14), 1724-1734 (2019)
   PUBMED   31116411
  REMARK    GeneRIF: AAMDC is post-transcriptionally regulated through APA and
            microRNAs
REFERENCE   5  (bases 1 to 522)
  AUTHORS   Ma,X., Ding,W., Wang,J., Wu,G., Zhang,H., Yin,J., Zhou,L. and Li,D.
  TITLE     LOC66273 isoform 2, a novel protein highly expressed in white
            adipose tissue, induces adipogenesis in 3T3-L1 cells
  JOURNAL   J Nutr 142 (3), 448-455 (2012)
   PUBMED   22279136
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP270361.1 and BC002752.2.
            
            On Aug 14, 2020 this sequence version replaced NM_024684.3.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and has
            an alternate exon in place of the last two exons compared to
            variant 1. The resulting isoform (c) has a shorter and distinct
            C-terminus compared to isoform a. Variants 3-6 and 13-16 all encode
            the same isoform (c).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ217769.1, AK024688.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393427.7/ ENSP00000377078.2
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BP270361.1         31-48
            19-522              BC002752.2         1-504
FEATURES             Location/Qualifiers
     source          1..522
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.1"
     gene            1..522
                     /gene="AAMDC"
                     /gene_synonym="C11orf67; CK067; PTD015"
                     /note="adipogenesis associated Mth938 domain containing"
                     /db_xref="GeneID:28971"
                     /db_xref="HGNC:HGNC:30205"
                     /db_xref="MIM:620474"
     exon            1..98
                     /gene="AAMDC"
                     /gene_synonym="C11orf67; CK067; PTD015"
                     /inference="alignment:Splign:2.1.0"
     exon            99..248
                     /gene="AAMDC"
                     /gene_synonym="C11orf67; CK067; PTD015"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..485
                     /gene="AAMDC"
                     /gene_synonym="C11orf67; CK067; PTD015"
                     /note="isoform c is encoded by transcript variant 3;
                     UPF0366 protein C11orf67; adipogenesis associated Mth938
                     domain-containing protein; mth938 domain-containing
                     protein"
                     /codon_start=1
                     /product="mth938 domain-containing protein isoform c"
                     /protein_id="NP_078960.1"
                     /db_xref="CCDS:CCDS8254.1"
                     /db_xref="GeneID:28971"
                     /db_xref="HGNC:HGNC:30205"
                     /db_xref="MIM:620474"
                     /translation="MTSPEIASLSWGQMKVKGSNTTYKDCKVWPGGSRTWDWRETGTE
                     HSPGVQPADVKEVVEKGVQTLVIGRGMSEALKVPSSTVEYLKKHGIDVRVLQTEQAVK
                     EYNALVAQGVRVGGVFHSTC"
     exon            249..344
                     /gene="AAMDC"
                     /gene_synonym="C11orf67; CK067; PTD015"
                     /inference="alignment:Splign:2.1.0"
     exon            345..522
                     /gene="AAMDC"
                     /gene_synonym="C11orf67; CK067; PTD015"
                     /inference="alignment:Splign:2.1.0"
     regulatory      503..508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AAMDC"
                     /gene_synonym="C11orf67; CK067; PTD015"
                     /note="hexamer: AATAAA"
     polyA_site      522
                     /gene="AAMDC"
                     /gene_synonym="C11orf67; CK067; PTD015"
                     /note="major polyA site"
ORIGIN      
        1 agttggggag cgcagatccc gaagcagcgc tgggagcgta agtgcgggca gagcactgcg
       61 ccgtttggga acgcaacttt gaggagacag tgcggtggac ttcagtgaag ttccttatga
      121 cttcccctga aattgcttcc ttatcatggg ggcaaatgaa agtaaaaggc tctaatacaa
      181 cctataagga ctgcaaagta tggccagggg gtagtcggac ttgggattgg agagaaacag
      241 gaactgagca ttctcctggt gtgcagcctg cagatgtgaa ggaagttgtt gagaagggtg
      301 tacagactct tgtgattggc cgagggatga gtgaggcctt gaaggtgcct tcatcaactg
      361 tggagtacct caagaaacat ggcattgatg tgcgggtcct ccagacagag caggcagtga
      421 aggagtataa tgccttggtt gcccaagggg tcagggtggg aggtgtcttc cattccacct
      481 gctgatggag ccttaagagg agaataaatc actaagtgcc ta
//
