LOCUS       NM_014911              21157 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens AP2 associated kinase 1 (AAK1), transcript variant 1,
            mRNA.
ACCESSION   NM_014911 XM_930257 XM_941900
VERSION     NM_014911.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 21157)
  AUTHORS   Lian,J., Zhu,X., Du,J., Huang,B., Zhao,F., Ma,C., Guo,R., Zhang,Y.,
            Ji,L., Yahaya,B.H. and Lin,J.
  TITLE     Extracellular vesicle-transmitted miR-671-5p alleviates lung
            inflammation and injury by regulating the AAK1/NF-kappaB axis
  JOURNAL   Mol Ther 31 (5), 1365-1382 (2023)
   PUBMED   36733250
  REMARK    GeneRIF: Extracellular vesicle-transmitted miR-671-5p alleviates
            lung inflammation and injury by regulating the AAK1/NF-kappaB axis.
REFERENCE   2  (bases 1 to 21157)
  AUTHORS   Cantini,F., Niccoli,L., Nannini,C., Matarrese,D., Natale,M.E.D.,
            Lotti,P., Aquilini,D., Landini,G., Cimolato,B., Pietro,M.A.D.,
            Trezzi,M., Stobbione,P., Frausini,G., Navarra,A., Nicastri,E.,
            Sotgiu,G. and Goletti,D.
  TITLE     Beneficial impact of Baricitinib in COVID-19 moderate pneumonia;
            multicentre study
  JOURNAL   J Infect 81 (4), 647-679 (2020)
   PUBMED   32592703
REFERENCE   3  (bases 1 to 21157)
  AUTHORS   Cantini,F., Niccoli,L., Matarrese,D., Nicastri,E., Stobbione,P. and
            Goletti,D.
  TITLE     Baricitinib therapy in COVID-19: A pilot study on safety and
            clinical impact
  JOURNAL   J Infect 81 (2), 318-356 (2020)
   PUBMED   32333918
REFERENCE   4  (bases 1 to 21157)
  AUTHORS   Misra,D.P., Agarwal,V., Gasparyan,A.Y. and Zimba,O.
  TITLE     Rheumatologists' perspective on coronavirus disease 19 (COVID-19)
            and potential therapeutic targets
  JOURNAL   Clin Rheumatol 39 (7), 2055-2062 (2020)
   PUBMED   32277367
  REMARK    Review article
REFERENCE   5  (bases 1 to 21157)
  AUTHORS   Rismanbaf,A.
  TITLE     Potential Treatments for COVID-19; a Narrative Literature Review
  JOURNAL   Arch Acad Emerg Med 8 (1), e29 (2020)
   PUBMED   32232214
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 21157)
  AUTHORS   Wang,C., Wang,J., Shuai,L., Ma,X., Zhang,H., Liu,R., Chen,W.,
            Wang,X., Ge,J., Wen,Z. and Bu,Z.
  TITLE     The Serine/Threonine Kinase AP2-Associated Kinase 1 Plays an
            Important Role in Rabies Virus Entry
  JOURNAL   Viruses 12 (1), 45 (2019)
   PUBMED   31905947
  REMARK    GeneRIF: The Serine/Threonine Kinase AP2-Associated Kinase 1 Plays
            an Important Role in Rabies Virus Entry.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 21157)
  AUTHORS   Conner,S.D. and Schmid,S.L.
  TITLE     Differential requirements for AP-2 in clathrin-mediated endocytosis
  JOURNAL   J Cell Biol 162 (5), 773-779 (2003)
   PUBMED   12952931
REFERENCE   8  (bases 1 to 21157)
  AUTHORS   Manning,G., Whyte,D.B., Martinez,R., Hunter,T. and Sudarsanam,S.
  TITLE     The protein kinase complement of the human genome
  JOURNAL   Science 298 (5600), 1912-1934 (2002)
   PUBMED   12471243
  REMARK    Review article
REFERENCE   9  (bases 1 to 21157)
  AUTHORS   Conner,S.D. and Schmid,S.L.
  TITLE     Identification of an adaptor-associated kinase, AAK1, as a
            regulator of clathrin-mediated endocytosis
  JOURNAL   J Cell Biol 156 (5), 921-929 (2002)
   PUBMED   11877461
REFERENCE   10 (bases 1 to 21157)
  AUTHORS   Ricotta,D., Conner,S.D., Schmid,S.L., von Figura,K. and Honing,S.
  TITLE     Phosphorylation of the AP2 mu subunit by AAK1 mediates high
            affinity binding to membrane protein sorting signals
  JOURNAL   J Cell Biol 156 (5), 791-795 (2002)
   PUBMED   11877457
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AW451954.1, DB285703.1,
            BC111965.1, AC079121.5, DA121999.1, AW969393.1, AC136007.3,
            AC114772.5 and CA436375.1.
            
            On May 21, 2020 this sequence version replaced NM_014911.4.
            
            Summary: This gene encodes a member of the SNF1 subfamily of
            serine/threonine protein kinases. Adaptor-related protein complex 2
            (AP-2 complexes) functions during receptor-mediated endocytosis to
            trigger clathrin assembly, interact with membrane-bound receptors,
            and recruit encodytic accessory factors. The encoded protein
            interacts with and phosphorylates a subunit of the AP-2 complex,
            which promotes binding of AP-2 to sorting signals found in
            membrane-bound receptors and subsequent receptor endocytosis. Its
            kinase activity is stimulated by clathrin. This kinase has been
            shown to play an important role in regulating the clathrin-mediated
            endocytosis of the rabies virus, facilitating infection. Inhibitors
            of this kinase are being studied as candidate therapeutics to
            disrupt the entry of viruses, including SARS-CoV-2, into target
            cells. It is also involved in positive regulation of Notch pathway
            signaling in mammals. Alternatively spliced transcript variants
            have been described, but their biological validity has not been
            determined. [provided by RefSeq, Aug 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in SARS-CoV-2 infection
            MANE Ensembl match     :: ENST00000409085.9/ ENSP00000386456.3
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-347               AW451954.1         1-347               c
            348-375             DB285703.1         262-289
            376-1923            BC111965.1         1-1548
            1924-1924           AC079121.5         37491-37491         c
            1925-2805           BC111965.1         1550-2430
            2806-3151           DA121999.1         190-535
            3152-3434           AW969393.1         1-283               c
            3435-11863          AC136007.3         1-8429              c
            11864-20595         AC114772.5         152587-161318       c
            20596-21157         CA436375.1         21-582              c
FEATURES             Location/Qualifiers
     source          1..21157
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.3"
     gene            1..21157
                     /gene="AAK1"
                     /note="AP2 associated kinase 1"
                     /db_xref="GeneID:22848"
                     /db_xref="HGNC:HGNC:19679"
                     /db_xref="MIM:616405"
     exon            1..165
                     /gene="AAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            166..562
                     /gene="AAK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             400..3285
                     /gene="AAK1"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     adaptor-associated kinase 1; AP2-associated protein kinase
                     1; alternative protein AAK1"
                     /codon_start=1
                     /product="AP2-associated protein kinase 1 isoform 1"
                     /protein_id="NP_055726.4"
                     /db_xref="CCDS:CCDS1893.2"
                     /db_xref="GeneID:22848"
                     /db_xref="HGNC:HGNC:19679"
                     /db_xref="MIM:616405"
                     /translation="MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQ
                     QVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKN
                     IVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCE
                     AVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIK
                     KYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTI
                     PDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLP
                     EPVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRK
                     RATVQPPPQAAGSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQA
                     QGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQ
                     KPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQK
                     PTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQPKVQTTPPPAVQGQKVGSLTPPSS
                     PKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTS
                     QQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLGEGKHPEKLGGSAESLIPGFQ
                     STQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFIPLQVPDAPEKLIEGLKSP
                     DTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPVPQRLPSQTESVTSNRT
                     DSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVA
                     EDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL"
     exon            563..681
                     /gene="AAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            682..790
                     /gene="AAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..933
                     /gene="AAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1055
                     /gene="AAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1137
                     /gene="AAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1270
                     /gene="AAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1374
                     /gene="AAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1454
                     /gene="AAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1609
                     /gene="AAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1896
                     /gene="AAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2175
                     /gene="AAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2405
                     /gene="AAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2563
                     /gene="AAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2564..2668
                     /gene="AAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..2764
                     /gene="AAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2866
                     /gene="AAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..2968
                     /gene="AAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2969..3079
                     /gene="AAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3080..3190
                     /gene="AAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3191..21157
                     /gene="AAK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      21134..21139
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AAK1"
                     /note="hexamer: ATTAAA"
     polyA_site      21157
                     /gene="AAK1"
                     /note="major polyA site"
ORIGIN      
        1 agtctccgcc cggcgctccc gggatcagct ggcgggcggg cgggagccga gcgcggcccc
       61 ggctctcgct gcagcgccgc ctcttctctg cgtcgcaggc cggcccggcg gccgtgacaa
      121 tgtcgcgggg ctggtagcag ggcgccggcc gccgagccgt ctcaagttta aacttacacg
      181 aatcgctttc tggaggagga ggggacccgc tgcgcgattg acacgcatat tcctataggc
      241 atcctccctc agcccccacc cccacggccg gattcgggtg gctcctctcc gaggtgaaat
      301 ctgagaagaa atccttggat ctcttttctt aaaaaaaaaa aaaaaaaaaa aaaatctaga
      361 aaccatcggt attttgcttt gctgctccct attcgcaaga tgaagaagtt tttcgactcc
      421 cggcgagagc agggcggctc tggcctgggc tccggctcca gcggaggagg gggcagcacc
      481 tcgggcctgg gcagtggcta catcggaaga gtcttcggca tcgggcgaca gcaggtcaca
      541 gtggacgagg tgttggcgga aggtggattt gctattgtat ttctggtgag gacaagcaat
      601 gggatgaaat gtgccttgaa acgcatgttt gtcaacaatg agcatgatct ccaggtgtgc
      661 aagagagaaa tccagataat gagggatctt tcagggcaca agaatattgt gggttacatt
      721 gattctagta tcaacaacgt gagtagcggt gatgtatggg aagtgctcat tctgatggac
      781 ttttgtagag gtggccaggt ggtaaacctg atgaaccagc gcctgcaaac aggctttaca
      841 gagaatgaag tgctccagat attttgtgat acctgtgaag ctgttgcccg cctgcatcag
      901 tgcaaaactc ctattatcca ccgggacctg aaggttgaaa acatcctctt gcatgaccga
      961 ggccactatg tcctgtgtga ctttggaagc gccaccaaca aattccagaa tccacaaact
     1021 gagggagtca atgcagtaga agatgagatt aagaaataca caacgctgtc ctatcgagca
     1081 ccagaaatgg tcaacctgta cagtggcaaa atcatcacta cgaaggcaga catttgggct
     1141 cttggatgtt tgttgtataa attatgctac ttcactttgc catttgggga aagtcaggtg
     1201 gcaatttgtg atggaaactt cacaattcct gataattctc gatattctca agacatgcac
     1261 tgcctaatta ggtatatgtt ggaaccagac cctgacaaaa ggccggatat ttaccaggtg
     1321 tcctacttct catttaagct actcaagaaa gagtgcccaa ttccaaatgt acagaactct
     1381 cccattcctg caaagcttcc tgaaccagtg aaagccagtg aggcagctgc aaaaaagacc
     1441 cagccaaagg ccagactgac agatcccatt cccaccacag agacttcaat tgcaccccgc
     1501 cagaggccta aagctgggca gactcagccg aacccaggaa tccttcccat ccagccagcg
     1561 ctgacacccc ggaagagggc cactgttcag cccccacctc aggctgcagg atccagcaat
     1621 cagcctggcc ttttagccag tgttccccaa ccaaaacccc aagccccacc cagccagcct
     1681 ctgccgcaaa ctcaggccaa gcagccacag gctcctccca ctccacagca gacgccttct
     1741 actcaggccc agggtctgcc cgctcaggcc caggccacac cccagcacca gcagcaactc
     1801 ttcctcaagc agcaacagca gcagcaacag ccaccgccag cacagcagca gccggcaggc
     1861 acgttttacc agcagcagca ggcccagact cagcagtttc aggcagtaca tccagcaacc
     1921 cagaaaccag caattgctca gttccctgtg gtgtcccaag gaggctctca acagcagcta
     1981 atgcagaatt tctaccagca gcagcagcag cagcaacaac aacagcaaca gcaacagctg
     2041 gccacagccc tgcatcaaca acagctgatg actcagcagg ctgccttgca gcaaaagccc
     2101 actatggcag caggacagca gccccagcca cagccagctg cagccccaca gccagcccct
     2161 gcccaggagc cagcgattca agccccagta agacaacagc caaaggttca gacaacccca
     2221 cctcctgccg tccaggggca gaaagttgga tctctcactc caccctcatc ccccaaaacc
     2281 caacgtgctg ggcacaggcg tattctcagt gacgtaaccc acagtgcagt ctttggggtc
     2341 cctgccagca aatcaaccca gctgctccag gcagctgcag ctgaggccag tctcaataag
     2401 tccaagtctg caaccaccac tccatcaggc tctcctcgga cctctcaaca aaacgtttat
     2461 aatccttcag aagggtctac gtggaatccc tttgatgacg ataatttctc caaactcaca
     2521 gctgaagaac tgctaaacaa ggactttgcc aagcttgggg aaggcaaaca tcccgagaag
     2581 cttggaggct cagctgagag tttgatccca ggctttcaat caacccaagg tgatgctttt
     2641 gctacgacct cattttctgc tggaactgct gaaaaaagga agggtgggca gactgtggac
     2701 tctggcctcc cgcttctaag cgtgtctgat cctttcattc ctcttcaagt acctgatgca
     2761 ccagaaaaac taattgaggg actcaaatct cctgacactt ctcttctgct ccctgacctc
     2821 ttgcctatga cagatccttt tggtagcact tctgatgctg taattgaaaa agctgatgtt
     2881 gctgttgaga gtctcatacc aggactggag cccccagttc cccagcgcct cccatctcag
     2941 acggaatctg tgacctcgaa tcgcacagat tctctcaccg gggaagattc cctgcttgat
     3001 tgctctctgc tctctaaccc tactactgac cttctggaag agtttgcccc cacagcaatc
     3061 tctgctccag tccataaagc tgcagaagat agtaatctca tctcaggttt tgatgtccct
     3121 gagggctcgg acaaggtggc tgaagatgag tttgacccta ttcctgtatt gataaccaaa
     3181 aacccacaag gtgggcactc tagaaacagc agtgggagct ctgagtccag tcttcccaac
     3241 ctagccaggt ctttactgct ggtggatcag ctcatagacc tgtagccgtg acccagtagc
     3301 agatgcagtt ctgtaacctt cataccgtaa aatacatttt cattacggag ttatgaaaaa
     3361 aatgattttt ttaaaaaaat ctgcaaataa ggggccctcc agcccttttc tcctacccct
     3421 tgccttctcc tgtagaaatg ataaggaaag aaaatcactt tggccctcca gatattcctt
     3481 ggccagttcc tccttgttag tttgctgtgt tttctcatta cccttcttca atagcattat
     3541 cttaaatcaa gcactagatg ccatgagctt cacctctgct ggaatcaact ccaccaaaag
     3601 cttaactgta actgaaacta gtgaattgac acttttgtct cgttcttgct aggaatggcc
     3661 tcccagatca attctcccaa cccccgtctc ctttggccag atgctgatga atgtatttcc
     3721 ctgtttttgc tttttatcct gatgcattat catgaggaca tggctacttc agttggtctt
     3781 aactctaggc agtagcctgg agatgggtgt gtggtttaag aaagggtaaa acttactgac
     3841 tggtagtata tatttgagaa gagaaattga gcccagctct agccaaccaa ctttgacctt
     3901 gtttgatcat agacttagcc aagggatttt acaccccatg caacctgccc agcattcgtc
     3961 cagctttctg gcttccattg aaccgtgatt tctcagatct ggagacgtga ctgcaagtat
     4021 ttgagatcct tggatacaat gtgtacgtta tataaatccc aagtattgcc attccttttc
     4081 atgttaactg ttccaagtgg gatctcagaa ttagaccaaa acaagacggt ggtaatatga
     4141 taccttttat tagaagactt ttcactgggg cgggggtggg gggaggatgg ggaggggaag
     4201 gaattgtagc agaaacagat gtatttttct tgtgattttt attttgaatc aaatattgta
     4261 aattgtgtat aaatgaagat gctgaatagt tctgtttcca cttggcattt caagtctgat
     4321 atcaggtgtc tgtacagggt tttgatttct ttcccttgta taactacaca acaatcctac
     4381 agtgtaacat atggaatcat tttgaataga cttgtgtgct ataagctttc agcaggtcct
     4441 ctgtctctag aataagcatg ttgtttattt tcagataatc agaaataagt gtgctgacaa
     4501 gctggacaca atctgggtgt gcccagctta cctttctttc tgatgtttaa attgaaggct
     4561 gcagccaatg gaatatgttc agctggtttt ccttggcttc ctagattaaa aaaaaataat
     4621 aaagcatagt tctttattaa ctttaggata ttgttcataa aataaataaa ggcccctgca
     4681 ctaacatgac aacatgcctc atggtcaccc tctctatatg tacttactca ttaaagtgta
     4741 ttttatttcc ttatgtggaa agcactttta taaaatcacc cttttgaaaa gaagtgggca
     4801 cagagaaccc cactcctgtt cttttcctct agtgccattg tccatcatca aaagggaaac
     4861 tcttagttaa tcagatctgt acaaataaaa ttccaagtcc atttgcttgt tttgctatct
     4921 agtacttttg tttcttcttc ctcacatttg cactttatgg gggaaaaaag tttaacagca
     4981 acaacagcct ataaaacact gcattctgga gggcaaggtt tgaccctagg aatgtgcgag
     5041 tagcctttga aaggcattgg aggaaaagtc tgaatcttcc agccttcctt ctgtctttaa
     5101 atacttcccg tgctggctga aacaagatga gctaggtaaa ggcctctagt tgaataacag
     5161 accatttcca aaactgagag aggcacaagc ttcctgccga ggattaaaaa gcaaaagata
     5221 tccacgaagg gctctctgtg gttggatagc agtgaaaata ggacttggtt taccccttta
     5281 tggacaggaa aattgctgca ggtcagaatt gtattctctt tcctggacat agaaagaatg
     5341 tataaattaa tgaaggaaat gtttattttt aaataagaat aatgtttgag ttctatgttt
     5401 tcatatttga tttttttcgt atatacatgt tagaaatata atgaaatatc tagtttctca
     5461 atttaattga aactatgaag agtacagttt agaaattagg tatctctaaa ttgttctttt
     5521 catatattac ccataattac attgaaatat attatctagt catttggctc agtaaagctt
     5581 aatggaggca gttaatgaaa atgagcagac tagaagccag agacggcagt agaagcctaa
     5641 gggagataat gacaagaaat tgtcttgggc ttatttagag taaggcctcc tcaaagggga
     5701 gaactatttt tctgttaagg aacacatatg agtgctttgg taaacggagc cttccttggt
     5761 ttagagcatc atccctgagc tgaaagagtt tatttgagtt gagcatagtg tcctggtacc
     5821 tgtggaatca tagcctgagc tacaaaggga cctttgagac catcctctag tccaccatcc
     5881 tcttcatttt acaggtgtgg gacctgagct ggattgaaca gggtcggggg agaagaggcc
     5941 tgggcaggac aggccacctg ggatctcatc ctggcccttg ccagccactg gctgagtgac
     6001 cttcagcagg cacttcacct ctcagagttg ctgttcctta gagttatacg atgggtttgg
     6061 actagatggt ctttaagatt atagaagtat agggtcctaa gtatatatta ttatattgag
     6121 aagggctatg aaggatttat ataatcctga tgttcttcag ttatcttctg tagttcctgc
     6181 tattacggta gcagtgttta cattttaaag aattataatg ggcttttact aacttgctct
     6241 ttcttgatta tctgaataga agcctaaatc ataatcttag agattttcct ttttaagtat
     6301 tacagaaaca catgcgtgga cacacaccta cctattctaa taaaatggta tcagaagatt
     6361 tctttttaaa tgtataatca ggcatctacc agtttaaaac gggcaaatac tataagcata
     6421 tgtttctgat ttgcttttat tccagctatg taagaggagt aactatagca gaaaacatga
     6481 caaattgatt tttcccttta caacattcaa atgagtccca atgttttcaa aaatacatac
     6541 ctcagaggag ataaggctta agtggacact tctaagtatg attataatta ttataattaa
     6601 tgatttcttt agcagacata tcagaatttt gacatctaat taagtgttgt tcccctcaat
     6661 gtcatctagt tttacttaag aagttaatac ttattctaat gatgctgcca tccttaaagt
     6721 tatttttgaa actcctctcc ttagaaataa tatcaaggaa ggtaataagg tataagaaaa
     6781 tcagctatat tatttaatta gtatcacttt gagaaagcac ctggaagtat attctttctt
     6841 tgtctacttt ttctactact cttggttctg agtaacattt agccatttcc agaaagcaaa
     6901 ttcaaccctg taagatgaag agtggttact gttgaagaca gtaaaaagga taatccacaa
     6961 aaaattctca gagaggacct tataatagaa agtgaacatg attaagactt aatttctgta
     7021 attttctgaa taaggaaact tctgtgattc cttagtcttt agaatggttt aaaacattga
     7081 aagatatggg tattaaaaca cctctgaaag aagttgtcac tttgttcagt gttatttgat
     7141 attggacttc gctcttcctg aattagaatt acacaacttg gattgctaat acttgtggaa
     7201 aaacaaaccc aagaaacgaa ctactttctc aagatgtaat atttgtttta ttattaatac
     7261 ttttggttgt tttgattact tatttcctac tctcctgaca gataattgat caaccaatat
     7321 aaccttcccc aggttaggaa cagttctgcc ttcagcagtg ctgtgggaat gaagggatct
     7381 ttggggctga cagcctatga tgtggaggga tctgcactca gctaaataaa tacatgctat
     7441 agataccttg ggccaaaata aagtctctct tgataaggtt tttctgtgat ttcccagagt
     7501 ccttaacctt ctctgtctgc aagattatca ggctcccata gccactaact ttgagctttg
     7561 ggatgaaaat gacaggattg cccagtgtgc cgggttaagc aaattagagg ctgcctggca
     7621 gaacagaaaa actatcacat gaatatttag aatggaagct ttcctgaaac actccagata
     7681 ctgcaaagct atctttattc ctctctaaag gctataattt tatcaacaca aagtcagcct
     7741 tttctttttc cacattagta atgtttctga agttggatgt gcttagattt cttaaatcag
     7801 aatgagtgct aggaaatcta taacaagaaa cctcttttgc ttctcccaga tttcctttca
     7861 ctaatacggg atagggaggc tccttgggta atgctaacct atgcaaagaa gttaccaaat
     7921 ggtggtagtt gctagaatta aagacacgtt cttggttcac actttgatgt agtgacctga
     7981 atttactctt ttcctgtgag tattctactc tgccctattg cactctcctt tgtcatgtgg
     8041 atgtgtgttt atcataggtc tttaacgcgt ccttcccaag aagacaaagc atacagttgt
     8101 acatgaagat atcttatgca gtaaaaacgt gaaatttgaa cattgctgca caagtattgt
     8161 ataaaaaaaa gtctgtaaag aactttctta tgtaaacata caggggaata aagactttta
     8221 tctgttcaaa tgggagcatg atgtttagag atgtaaataa cttaaaataa gttgctcttt
     8281 tcctgagctg aaaacccact tttttgcaga aaggatttaa tcacagtatt gagtgacaat
     8341 aagtacctgg gcacaagaaa agtatagcta cacactgagg acatattaat gaatcatggc
     8401 tacctgagag agtaaaaccc ctgttttagt ctcaaggaga ataagacgcc tgccagccta
     8461 cactggatat gaccagactc agggttgtaa aatggagcgc aggtttgcag cttccctcct
     8521 ctaacttaat ccctaatata cccaggccaa cttaattaaa cattttgtgt tggcaagaat
     8581 aattttatcc ccagtgagaa aactcactca tttaattgcc tcattggcct gagaggcaca
     8641 gctggccatt tttggcttcc atgaggtccc tcatttccca gtcgtgggtt ttaatgcagc
     8701 tacctaatat atggtggaac caaatgctta attttgttat gtgagctaga aggtcatggt
     8761 aattattagt ttgatgtacg tctcttgatt tccccagttt ggttctaaaa ttttacgttt
     8821 caattgctgc tgcatttcca agttcttgtg aagggatatt ttgctttctg tttactaact
     8881 atatgtgaga aggcttcttc tcaatgctcc aagtcttcgt tttctgtttt tggcaagaat
     8941 catatctttg atactccctg taaccgttct ttcagttttt ggtatgagga aaagtaaact
     9001 tctggtgttg tgtgatgtat ttcattaagg aatatccagc ctgacattta agtcttcaga
     9061 ttttaattct gtagggagca ttctgatggc cctcactatg tcaatcagat ggagtttcca
     9121 ggggaaaccc atcctaaatg attcagcact ttgggttgct ttggaagtga atagggagct
     9181 ggtgaggata gttgccaagt tgtcaggtat tttaggaact ccttctcttc cctgaagcat
     9241 gtgagttctt gctgaaatct acataatttg gagcctcaaa atagactaat atggagttac
     9301 ccatattgaa agtgtcaacg tgcctaacct ggcacacagt cctacatcag agcaagaaaa
     9361 agaagtatgt tttgacttct tgcttaattt tatgtgtgaa accaaaataa aaagaggcat
     9421 gatccagttt gagggaatta taacaaaacc ctacgttagg ctctatgata agtaagaccc
     9481 tgtgcagact atgaagccag gccctgggct ttagcccctg aggtacaaca ggcagtgttt
     9541 actgagctct atggccacag ggtatctgct atgacgtgcc attggttacc aaaggaactg
     9601 ggtcaaggca tgtggttagg ttagtataaa tccttcaatg ctagtaaaga gactgcttca
     9661 aacacgtttt cttgttgaca caatgctacc ttcatataaa ggaactgttc accctgaaaa
     9721 cacattttcc ctgtaagaac acattcacat actcaaaaaa agacttttat ctgccaacaa
     9781 gatttaatgg ttaccttctg tttctagtat atttggaatt tatccttctc tcgactacct
     9841 tgtttctggt gctgccacca ccagaattcc ttaagggaat gtggaggtct gggcttcccc
     9901 catattctct ggcatttctt tgcccttcag agtgccaggc ctggagagtt gcaaagtgtg
     9961 gttgctctcc gcctcagcca cactgtacct cctctaacaa gaatagaaag gttaagggac
    10021 ttggccttct caggacaacc ctttaaatgt acttttccat tcctacaaag cctgttgatg
    10081 ctgaaagaaa gataggaaat agctcttgtc cttgttttga aggacaggag actaattttc
    10141 ccttcaaact tgatattctg gtgtttttgt gactgttttt gtaaattatt caaagttgtt
    10201 ggaattttaa gtctgatttt cccagtactc atcatgaagg tcatagaata tgctctgagt
    10261 tggaaggttt tccaaatggg ttctcgacca aaaacccact ttttaacaaa taattttgat
    10321 gggttagaca tgttcttcca tcctctccaa ccctgaatat gggcacatac acacacccct
    10381 tggtacttcc tagttctcaa aatgtaatct agcacttcag gcatccaaag tgcccctggt
    10441 tcaatagata gctgcttttt tgccagtctc tgtgcacaaa ttgttttaac tgaattcagt
    10501 ttaaatttcc aaaaaacact gactctgttc aaactagtgt tcattggatt attgacctgt
    10561 atgatgccag agttggtcac tggcttgact aagttttcca ttttttttcc ctaagagata
    10621 ttttgctctc ctgcagaaca agcttaataa catcaacttt caaggtagtt ttggaagatg
    10681 agaaattgtg cttttgtttt ggcaactgaa aactttgtcc aactgatact atgtgaggaa
    10741 ggtggttcaa ggagttttag ggccctcttg tccttcttta aggctctgca aaccttattt
    10801 tggaaaactt atttttctcc cttttatttg aatttcctcc cagaaattat catcttggta
    10861 tcactgagac aaatctaata tcaatttact tgcctgagaa attaggatta tgtctgtcca
    10921 cataaatcgc aaggaagaag gtattctgtt tatttcctgt ccactgactg atgctttcgt
    10981 atcaccatgt agctgcacat actaaaatta taatacaagg aaaaatttat tcttttcaaa
    11041 atcttattct tcaaatacta ttctgaaagc catttggcac cagtacagaa tttaacttaa
    11101 cgccccaatc tggaattcac tgaacgcatt caaactgtta gaaaggaaaa taaaaatgga
    11161 ggacaaacac atttttgttc tgtttctgaa aacaatattt aaggtcagaa ctgtttaaaa
    11221 agaagcactg ctaaaaagtt ataggattca gagaaacata gtatttttgt acagtatctt
    11281 ataaaatgtt cagacctctc tctacattct ctttacaatg taatgtctct aagtgactgg
    11341 tttcccaata aactgatttt aatgcctctt ctgctgtggt ctgtgtgctt aattcatgca
    11401 gaaactttag caggggataa tttttggcag aaatttctgc tagctaatgg tttgcatagg
    11461 aggggagagg gtcagtatgg gaaggggatc attgagttcc atctctacag aggttctggg
    11521 tcatctatgg ctccaaatca ttgtatctaa tattcttatc ctggtgggtt gggaaactcc
    11581 agtagtatct ctttactgag cccatgatga aatgatacct ttacccccaa ccaccctttc
    11641 tctggattct tcttgcttag ttacatatgc ctttttcctg ccctcttgct aacatgtgcc
    11701 caatgacata cttctaacct gctaatattt cttggaaggt aagctctctt gcattctgat
    11761 aattgtctat ttgattttaa aagccagagc accctgaggc acctctacct agatagaaat
    11821 agactagtat attggagttt gctaatgctt ctgtaatggc ccatgcattt tactccttct
    11881 gcttaaagaa ctttatggca gattcattta agcagaggag atctttatga acttagaaga
    11941 ctgaaaacaa aattctgggg caactccagc tgaaggtgat ttatttggtc tgattttgat
    12001 gctgtatgct cccctcagaa ggtaccttca gtatttatat tttgggcact cgtatgctct
    12061 ttgagtagtg cttgtgatgt aagtcatcaa gtaaacttgc atttatcaag cagccacatt
    12121 ctgcttcttt tcagagagtt tgtccctctg catgtggcgc ggatgaccac atgccagatt
    12181 ctgaattgag tcatccccag acagtgtttc tacataatcc aaaactgtca tggtatatgt
    12241 ggagatgaat gactgggttt gttttcattc cataatgagc cagtgccagg tagagcaggt
    12301 gtccgtgcct ggccctgtgt gtaggagcat tgcatagtta cgctgaatgt ctgtgtgcct
    12361 aacatcttca tctcctttcc tgtacgtcgt gcctatcatg ttccaaaacg tgagacagtg
    12421 gttgattgtg ttccagtttg tgtgcagttt ccttgcctga cttttatttt tatgtttttc
    12481 ctgttgcatt ttcaacatct attatttggt cccacaatgt ttttgccgcg ggttgaccat
    12541 taaatgttcc aaatagagtt gaattgacct acacattaat tctgcatttt atgcttttct
    12601 agatctccag agggagtcca atccctgtcc tgtaataact gtagagcact ttaaagaatc
    12661 actgggtgtt aaaggccttc cgctgtatcc agacccctcc agagtacctg gcacaaagac
    12721 tcagaacaac ttagaatctg actacttggc cagagatggc ccttcaagca acagctcatt
    12781 ccacagcagc gaagaggaag ggactgacct tgaaggagac atgctggact gcagtgggtc
    12841 tcggcctctc cttatggagt ctgaagaaga agatgagagc tgcagacccc ccccggggaa
    12901 gctgggagga gccgttccat tcgctccacc agaagtctct cctgagcaag caaagacagt
    12961 gcaaggtgga agaaagaacc agtttcaagc cttcacacag ccagccactg atgggctcag
    13021 tgagccagat gtttttgcca tagctccctt caggagctca agggttccaa atgatgacat
    13081 ggacattttc tccaaagccc catttgtctc caagagcagt atggctcctt cccagccaga
    13141 ggagtcagac gtgtttttga gagctccttt cactaagaag aaaagcatgg aggagttaac
    13201 agttatccaa tgcacctccc aggagctgcc tgcacagacc ggtctcctca gtcagacagg
    13261 tgatgtcccc ctgcccgcgg gccgtgagag agctgtgtac acctctgtcc aagctcagta
    13321 ttccacagct ggttttgtgc aacagtctaa cctcctgtcc cattctgtac aagcagcaga
    13381 ccatctggac agcatctctc ccaggggatc ctgcctggaa tctgggggtc attctaatga
    13441 cagaaacaaa ggacctcagc tccagaaaga agctgtctca ggccccatgg ctggcaaacc
    13501 attccgcccc cagtccttat ccaagtattc ccgtcactat agcccagaag acgagccaag
    13561 tccagaagcc cagcccattg ctgcctacaa aattgtttca caaaccaaca agcagtcgat
    13621 agctgggtct gtttctatca catccctttc ctccaggact acggagctgc cagctgctga
    13681 tccatttgct ctagcaccct tcccttcaaa atcaggcaag aaaccctagg agcaaaacct
    13741 gagcctcaag cctcttgtct ctatcccacc ctcaataccc gccatggcac tcccagctta
    13801 gccttctgaa gaagaaatat tatcagttct tatatttcaa ttccctgcgt cagagcagaa
    13861 tttcttgagt caacaaactc agttgcagtg atatttagtt gaagcccctt taagttatgt
    13921 tcatttttgt ttgtttgttt gtttgtttat attgatttct ggacttggag gcattttcat
    13981 ctccttcaca gaggtcatcc acttccacca agaactctgc tttccccccg ccccacccac
    14041 agaaactgtt taaatcctga aatacttctt caccccaatc ccaaaggggc cctattgttg
    14101 ctagttttaa ttcctgtagc tcctgttcta agtcatgccc atcgaagaat caagattagt
    14161 ccctccacta aatcaagatt tagtactctt gaaaagggga gatgtctgga aagaagagca
    14221 agataaaaac cctgcacatc aacaggaagt ataatcctgc agttactaat aattcctgta
    14281 gaagcagcag ctctaggagt ctccagatct gattctcagt ctgtgtgcaa gccaggctgg
    14341 ctctcgtgca tgactgtcta tgggtgtgga atgtacgtca gagcctgtgt agagatacag
    14401 gcagatgggc taactcctca tgtctagtca tgctggcagg gctttcccca catccatgct
    14461 tttgaaatta gtgtgagtgt acaggtttgt gtgtgcatgt atacgtgtgt gtgcacagga
    14521 agcatttcca cttgagggaa atcctgcccc atcatgccta cctccacaat gaaatcactc
    14581 gttttttggt gtttgctcgc ctaactgact tgaaccccat tttatttatt tagttttttt
    14641 ctcatggcaa agtagaatac gttggaaggt gtagggaaat cctgctggaa ctggtgtttc
    14701 agagtaaatc ttttttctct ccggaatttc ttgttttgct attaacaaat tatatttacc
    14761 tgattatgaa aaattaattt tccttataca ttttcccctt acaacactag aaaagagcac
    14821 cttgttacag ttccggcctc tcagtatgtg ggctaaatgc cagcattagg gaattcatta
    14881 atcatgagac taggctacaa actaggcttg cttgttttgg ggtggttttg ttgttgttgt
    14941 tgttgttgtt gttgttgttt ccaaatctct actgcctttt gaggaaatgt aaatctgaga
    15001 catggaaata agtgtttggg agaatggaaa agagctgaat caggtaggca tgaaaacttt
    15061 tacattctct atcctcttta gatgttgaaa taggccagac aggttaactg atgtttttta
    15121 aaattgtctt ttatttctgg aaagatctga cttattccta gcttttttca taccctttat
    15181 tattagtgcc ttaaaataaa gctggccagg tgcagtgcca cacacctgta ataccagcat
    15241 tttggaaggc tgaggcagga ggatcagttg agcccaggaa gttcaagacc aactctggca
    15301 acacagcgag accctgtccc ttcaaaaaat aaataaaaaa ataggctggg catggtggct
    15361 cacacctgta atcccagcac tttgggaggc caaggtgggc agatcacaag gtcaggagtt
    15421 tgagaccagc ctggccaaca tggtgaaacc ccatctctac taaaaataca aaaaattagc
    15481 tggacgtggt ggtgcacacc tgtagtccca gctactcagg aggctgaggc aggagaatcg
    15541 cttgaacccg ggaggcagag gttgcagtga gcagagattg cgccactgca ctctggcctg
    15601 ggcgacagag cgagtctaaa aaataaaatt aaataaaata atgaaaaaaa ttagctgggt
    15661 atggtgacat atgcctgtag ctactcagga ggctgagctg gaaggatcac ttgagcccag
    15721 gagtttgagg ctgcagtgag ttgtgagtcc agcctgggtg acagagtgag acactgtctc
    15781 caaaaatata ataataaaaa taaagcctgt atctcaatgg gaagatttct gctaaggcag
    15841 ttcaactcac tggaaagaac tgctgcatta ggtttcaact ttaatgcttt ctgttacttc
    15901 tagtaaaggt taagtgattt ttccattagc tgtagaagtt tggagagcta tttaccaagc
    15961 cagatcaatg atttaaaaat tattggaaat tcatctaaga atcaagtctg aatgcccaat
    16021 tctattgcgg ttgattaggt gtgatattct ttaaagttca ggaatattgg cagtaaaaaa
    16081 tgagcagcta cttttcaata ctttgtcctt ttttggtggt ctctgcctat ttcaaatgtc
    16141 ctgatcaaaa gataaataat tggcactgtg ccaaggtttg gttttccaac taaggtttca
    16201 actgtgccag aaacctatgt ccttcacttt ggtggatgct aaatgttatt ctaagaatat
    16261 gctttttccc aattctcctt tctgattttt atgtattagt ggatgcaaaa ttgtctttct
    16321 agttgaatga ataatttcgg ctaatgcacg tggaactttg caccccagat tcttcccatg
    16381 gtcattatca agtgaagccc tcaaaaacat gagcgaagag cctagaaata ctcagggaga
    16441 tttctcaccc caactcagaa attttttttt tttttttcaa gacggcgtct tgctctgtcg
    16501 ctcaggcggg agtgcagtgg tgtgatctcg gctcactgca acctccattt tccgagttca
    16561 agcgattctg cctcagcctc ccgagtagct gggattatag gcacacacca ccgcgcctgg
    16621 ctaatttttg tattcttagt agagatgggg tttcaccatg ttggccaggt tggtcttgaa
    16681 ctcttgacct tgtgatccac ccaccttggc ttcccaaagt gctaggatta caggcgtgag
    16741 ccaccgcacc tggcccagaa attctttttt tttttttaaa ttattattat actttaagtt
    16801 ttagggtaca tgtgcacaat gtgcaggtta gttacatatg tatacatgtg ccatgctcgt
    16861 gtgctgcacc cactaactcg tcatttagca ttaggtatat ctcctaatgc tatcccgccc
    16921 ccctcccccc accccacaac agtccccaga gtgtgatgtt ccccttactg tgtccatgtg
    16981 ttctctttgt tcaattccca cctatgagtg agaacatgcg gtgtttggtt cagaaattct
    17041 taaagtaaga gatcattcta attccccttt ccaaatattc aggattatct ctgtaacagc
    17101 ccagcaaaat gtttttcctt tggttatttg ataattccct tctaatcaag tgactatttt
    17161 aattctcaag gtgcaaatca ggataaaatc atggtgattt tactacatag ttgaatactt
    17221 cgtcaagtat gagcttgtat cctttttaaa tttttcactg gaggccaggc gcggtggctc
    17281 acgcttgtaa tcccagcact ttgggaggcc gaggtgggtg gatcacttga gggtaggagt
    17341 ttgagaccag cctggccaac atggtgaaac cctgtctcta ccaaaaatac aaaaagtagc
    17401 tgggcgtgat ggcacgcacc tgtagtccca gttactaggg aggctgaggc agaattgctt
    17461 gacccaggga ggcagacttt gcagtgagcc aagattgtgt cattgcactc cagcctgggc
    17521 gagaagagca aaactccgcc tcaaaaaaaa aaaaaaaatt gtcactggag acatgatggg
    17581 tggagactct acataccttc tttgaataca gaaacggatg caaacacatg caaattactt
    17641 tttttttttt ttttggtgat gcatgaaaaa actttgactt gtggattaca ttaattatta
    17701 gtaacagtta gattctgccg acttgtatta cagtagggtc ttatttcctt aaagagaaaa
    17761 aaaaatacag tcatgcccca cttaatgatg agggagacat tcagagaaat gcatccttag
    17821 gtgattttgt cattgtgtga acatcacaga gtgtacttaa cacaaaccta gatggcacgg
    17881 cctactacct acctaggcta tatggtccag cctgttgctc ctgggctaca aacctgtaca
    17941 gcatgttact gtactgaata ctgtaggcag ttgtaacaca atggtaagta tttctgtatc
    18001 caaacatttt agacatagaa aaggtacagt aaaaatatgg tataatctta tgggaccatc
    18061 atggtatatg tggtccatca ttgatggaat cgtttttatg cagcacatga ctgtatataa
    18121 tcaacaaaca actctacttt cttgttttcg tttgttgtgt ttttgcttta cacatttgat
    18181 agggaacata gaagttgtga cctttcattt cagtggaaag cattgagcca gaatatattt
    18241 attcctaaac catcgagcca cacatgcatt gatgaaccct gaaagaatcc acagtaattg
    18301 actaacaggc agtactgaat gaaagatgtc atatgtggtg aaaaatattt aatatatcag
    18361 tttcttgggc tcacatacag ccctttagtt ccaagtgctt ggttagatta gaaaatggga
    18421 tgaacacaat ttgatgctga agcagctgct gagcagcacc cagggagtct aggtcatacg
    18481 ccctatattg ttttcggccc acttattgtt gagttgaaaa gtctcatatt tgtagactag
    18541 agtgtatgtg tttagaggct catgttgtat ctgagttttc tctggcaact aagatctctt
    18601 tctaaacgtt ctagaaagat actggtatct tactggccca ttatttagta agttttagaa
    18661 tacatgtaca tcagtgtttt caactgcttg gtggacattt cactgatgca taatcaaagt
    18721 agcagattat aatcatcaga gtgatctgac aaggaaattc tgtatttgct tccataaaga
    18781 aaaataatca aaacatatat cagatataat atatatgcag tatatcacat aggaaatttt
    18841 attgtaggaa attagagaag gatgctactc aattcattct ctagcaggaa gaatacagct
    18901 taaaaatcac ttgggtccct ttaataaaga aaagtgtgat tctgtgttgt gtgtttggaa
    18961 ctgaaattgg agaacacgtg ccagtcgact gtgaaatggt tgctggataa aaccacagat
    19021 gtggttttat ccgagaaatg tgggactgaa attattttga tgagaggtac ataagagagc
    19081 tgcagaaaag actgtagctt ctgaggaggc aggagtacct tgttaatatc caaaccaccc
    19141 ctgagttcta atgttccaac tccacctaaa cgaggaattg gaaactttaa atggaattat
    19201 ctaatttaaa ttcttagttt tttctttgtc tttctcagct gatacttgta gttttgtttt
    19261 gttttttaac caccaagaac acttgcaagt ttgttactga aaacatcact aaaggaaaag
    19321 aagagtttca aaatgcttga aaagtagtat gtggttggga attgtttttg ttcaagtccc
    19381 tggaagtcct cttggcttag ctcccttgtt cctgttccca cttcatttcc ttacttaaca
    19441 ttcccctatt ttgagcatgt caataagtgc atgatgaatg gcacagttga atgatcatgt
    19501 taactttaat tgcttccttt gttgctgtaa acagtttctt gttaagtttc agccaagtct
    19561 gtgacaatct caccaaataa gaatgaaatg ggcggggtgt ggtggctcac acttggaatc
    19621 ccagcactct gggaggctgt gttgggccga tcgcttgagc tcatgagttc aagaccaacc
    19681 tgggcaacat ggcaaaacct tgtctctaca aaaaatacaa aaattagcca ggcatggtgg
    19741 tgcacacctg tagtcccagc tacttgggag gcttaggtgg gaggatggct tgagcacggg
    19801 aggcagaggt tgcactaagc caagatcgtg tcactgcact ccagcccagg caatagagcc
    19861 agaccctgtc tcaaaaaaac aaaacaaaca aaacatgaat gaatgaaatg gctcaccttc
    19921 cctattatga actagaagaa aggatgaagg aaggttggca ggaccccagc cttactctgt
    19981 agtgacaacc cagaggtact tttcccggaa tgcagggtca agtttatgtg tgaagggact
    20041 ctagaatagc tggtaaaaat ggctacatgg taaccattct tgacttagtc cagtattccc
    20101 ataatttgta attccataaa tttattctca gctgtccccc agccatttct aatagaagga
    20161 tgtgtacccc agttttgaca atgttcttga aatcaagtta gtgttacctg cattgcatta
    20221 taatggaact atatgtacat gttaaaggga tccgtttgat tcctttcggc aaggaattgc
    20281 aaaaatagtt tttaccaata ccagttaaaa taggataggt tagactttgg gggcagggtg
    20341 agacagtgca gccttttcac tctgaaatgg caaatcagct gtactctttg agtctaccag
    20401 agattcctat ttgagtgtga atggggtgtg tgtgtgtgtg tgtgtgctca ttcatcttca
    20461 tgctttcttc catggtgtta attcaagctc tcctaataaa ggtatccaaa gagtactgag
    20521 aagtgaccat aggtatttgg catgagtaaa tgtagttcct tttgccaaaa aaactctcaa
    20581 aagttacaac tggagttctt cgcgataaaa ggttggggaa atcagccatg gctttagcct
    20641 tgttcccaag tacacatctt cttatccaca aggatgaaac tctgtagggc tcaccctgag
    20701 ggctcatgtg tggcattgag agggtagcag tgaccagaac accacaaggc ccacaagatg
    20761 ttttgaatga gggaacattt aatgtcattt gttaggagat agaaaccaaa taataaagga
    20821 caaggaccac gctcattccg tggagaagag gtgaactccc tctgctgact atttggaatg
    20881 gactgaatga ggaggtctct ccagccagaa ggagtattga ggtcatcagg cctcagaaaa
    20941 caatgtacac ataatctcgg gctgtgaaca agagaaagga gggggggaaa catgaaagtc
    21001 aatcttaaca atttttgcaa tacctcttat ttgcagacca ttggatttat gttattgcac
    21061 tctcggtgtg atttatcgta tgtatctgat aggttttatg aattgttttg agttgtaaac
    21121 tcctataccc tttattaaaa tggacctaat taagtga
//
