LOCUS       NM_207365               5060 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens arylacetamide deacetylase like 2 (AADACL2), mRNA.
ACCESSION   NM_207365
VERSION     NM_207365.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5060)
  AUTHORS   Uno,Y., Hosokawa,M. and Imai,T.
  TITLE     Isolation and characterization of arylacetamide deacetylase in
            cynomolgus macaques
  JOURNAL   J Vet Med Sci 77 (6), 721-724 (2015)
   PUBMED   25715734
REFERENCE   2  (bases 1 to 5060)
  AUTHORS   Toulza,E., Mattiuzzo,N.R., Galliano,M.F., Jonca,N., Dossat,C.,
            Jacob,D., de Daruvar,A., Wincker,P., Serre,G. and Guerrin,M.
  TITLE     Large-scale identification of human genes implicated in epidermal
            barrier function
  JOURNAL   Genome Biol 8 (6), R107 (2007)
   PUBMED   17562024
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC065724.1, CU449274.1, BX118873.1, AC069067.17 and AC068647.10.
            
            On May 17, 2019 this sequence version replaced NM_207365.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065724.1, EL736598.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356517.4/ ENSP00000348911.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-664               BC065724.1         5-668
            665-777             CU449274.1         498-610
            778-1485            BC065724.1         782-1489
            1486-1489           BX118873.1         705-708
            1490-3219           AC069067.17        170484-172213
            3220-5060           AC068647.10        2006-3846
FEATURES             Location/Qualifiers
     source          1..5060
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.1"
     gene            1..5060
                     /gene="AADACL2"
                     /note="arylacetamide deacetylase like 2"
                     /db_xref="GeneID:344752"
                     /db_xref="HGNC:HGNC:24427"
     exon            1..247
                     /gene="AADACL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1315
                     /gene="AADACL2"
                     /codon_start=1
                     /product="arylacetamide deacetylase-like 2 precursor"
                     /protein_id="NP_997248.2"
                     /db_xref="CCDS:CCDS3161.2"
                     /db_xref="GeneID:344752"
                     /db_xref="HGNC:HGNC:24427"
                     /translation="MGLKALCLGLLCVLFVSHFYTPMPDNIEESWKIMALDAIAKTCT
                     FTAMCFENMRIMRYEEFISMIFRLDYTQPLSDEYITVTDTTFVDIPVRLYLPKRKSET
                     RRRAVIYFHGGGFCFGSSKQRAFDFLNRWTANTLDAVVVGVDYRLAPQHHFPAQFEDG
                     LAAVKFFLLEKILTKYGVDPTRICIAGDSSGGNLATAVTQQVQNDAEIKHKIKMQVLL
                     YPGLQITDSYLPSHRENEHGIVLTRDVAIKLVSLYFTKDEALPWAMRRNQHMPLESRH
                     LFKFVNWSILLPEKYRKDYVYTEPILGGLSYSLPGLTDSRALPLLANDSQLQNLPLTY
                     ILTCQHDLLRDDGLMYVTRLRNVGVQVVHEHIEDGIHGALSFMTSPFYLRLGLRIRDM
                     YVSWLDKNL"
     exon            248..470
                     /gene="AADACL2"
                     /inference="alignment:Splign:2.1.0"
     exon            471..540
                     /gene="AADACL2"
                     /inference="alignment:Splign:2.1.0"
     exon            541..712
                     /gene="AADACL2"
                     /inference="alignment:Splign:2.1.0"
     exon            713..5060
                     /gene="AADACL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1461..1466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AADACL2"
                     /note="hexamer: ATTAAA"
     polyA_site      1498
                     /gene="AADACL2"
                     /note="major polyA site"
ORIGIN      
        1 atatcacctg agagagttcc caagtctaca attgctctac tagttactat tcagtgtttg
       61 tgaaaaattt taatctcagt actgtgaaga agctggaaaa agggatatta tggggctaaa
      121 agctctctgt ttggggctgc tttgtgttct ttttgtctct catttttaca cacccatgcc
      181 agacaacatt gaagaaagct ggaaaataat ggccttggat gccatcgcta aaacttgtac
      241 atttacggct atgtgttttg aaaatatgcg tattatgaga tatgaagagt ttatatccat
      301 gatattcagg ctggattata cccaaccact ttcagatgaa tacatcacag tgactgatac
      361 aacatttgtt gacattccag tacgattgta cttgccaaaa agaaagtcag aaacccgaag
      421 gcgagctgtg atatattttc atggtggtgg tttttgtttt ggaagttcca aacagagggc
      481 ttttgacttc ctgaatagat ggacggcaaa cacgcttgat gctgttgttg taggcgtgga
      541 ctataggctg gctcctcaac accactttcc tgctcagttt gaagatggcc ttgctgcagt
      601 caaatttttt cttttggaaa aaattcttac aaaatatgga gtggatccca cccgaatctg
      661 cattgcggga gacagttctg ggggcaattt agcaacagcg gtcactcaac aggtgcagaa
      721 tgatgctgaa ataaaacata aaatcaagat gcaagtctta ctttaccctg gcttacagat
      781 aacagattct tatttgccat ctcaccgaga aaatgagcat ggtatagttt tgaccaggga
      841 tgtagccata aaactcgtga gcttatattt caccaaggat gaagcacttc cctgggcaat
      901 gagaagaaac caacacatgc ctctggagtc aagacatctg tttaagtttg ttaactggag
      961 tattcttctt cctgagaagt atagaaaaga ctatgtatat actgaaccaa ttcttggagg
     1021 acttagttat tcattgccag gacttacaga cagcagagca ttacccttgt tggccaatga
     1081 ttctcagtta cagaatttgc cactaaccta tattcttact tgtcaacatg atctcttaag
     1141 agatgatgga cttatgtatg ttacaagact tcgaaatgtt ggagtccaag ttgttcatga
     1201 acatattgag gatggaattc atggagcttt atcattcatg acttcaccat tttatttacg
     1261 tctaggtctt aggataagag atatgtatgt aagttggctg gataagaatt tataaatatg
     1321 tgatgtgtat gtatagccct tacatagtgg attgtaattt gtgatatttt gtggttttgg
     1381 agcaaagaac aatgtcattt gagttatcta aatctacatt tgcaacattt gtagcagtta
     1441 atgtgtgtcc ttgaagagtt attaaatttt ctgacttgca gaccctgaat atgtaaaatg
     1501 tatgtaatcc tgcctatttt ctccttactt ataatttatt ataattatgt tggttctaat
     1561 aagaaccaat gcttattaaa gttgagaaat aagagtggtt attggcaaat taagcaagat
     1621 actttccaga taggcacaga aattgttgta gtgagtggga agaggaaaaa acatggaaca
     1681 aacttgctgc taaaaatata tggaaaccac tggactaaat aaaccctaag gaccctatat
     1741 tagtttcctg tgactattgt agcaaattac tacaaattca gtcgctttaa acaacagata
     1801 tttattcttt tacagttctg gggtcctaaa gcatgaaatt agtattaact aggcccaaac
     1861 caagtcacag gcaagagaca tgactccctt ggagactctc tagaaggtgc tctttgcctc
     1921 ttttaacctc tggtggctgc cagtattctt tgactattct tagatcagtt taatcttgaa
     1981 ggccagcatc ttccaatctc tttctgcttc atcttcacat tgccttcttc tctgcctgtg
     2041 tctaatctcc ctatgggctt ctcttagaaa aacacatgtg tttacattta ggagggtcca
     2101 cctgaatagt ctaggataat ctctgcatct cacgatcctc aatttaattg tatttgcaga
     2161 tttccccacc cttttctata taaagtaacc ttcagagatt aggatgtagt tatcttttgg
     2221 gaggccattt ttaaaaatat tttttaaagg aggcagcaga tcaatattat aattcaagaa
     2281 tctgatctaa atatgcattc aataatgaag aacatttgag tatggactag aaaagcttct
     2341 ccaaaaaact ttcaaatata tcatctcaaa ttacctaaag aataaatcac ttctgtagcc
     2401 cttttgttga gtggaatcat aaacaaaaaa ctgaaaattt attgctatga aaacagatcc
     2461 atggtacaat gttataaatt ttgagtatta agcatagtca gttgaatcca actaagaagt
     2521 taaaaatgta gtaagaaatg tgtatatgta tgagtatgtg catgtgtgtg ggaaaaatct
     2581 accatccaat tgacccaaaa acaacttact cagttgggac cagacatttt tctcaattct
     2641 ccatgattca gaaggcaatt aagaattaca atttcaacag tccacaaaca aaataagatt
     2701 tttttaatgt agagagaaat taattatgtt caaagagccc tttttctttc actcaatttc
     2761 agtaccccaa agctaaaaac gcaaacatga ctatgacaaa tgaaaataag tatcatggga
     2821 atctgttttt ttcctctgag aaataaaatc taaatggaga tttgatacta tatgctatac
     2881 tacatacact aagaatattg tatttttcat aattctgatt taatctcctg taaacttgat
     2941 atattttaaa atttgtaatt tgtttttcat gatactgaat ctggttccag ttctttttca
     3001 tcatttaata tactggctac ccgttctaat taggaaaaca agtcctagaa atctcttcat
     3061 tttgacagca agtgctgatt tgtaagaaaa tcattaaaaa tgcagctctc taggaagcac
     3121 attttgttga ttgtcctatt gtctgaacat tttcacagtg attcctgact aaaaatcctt
     3181 ttaattttgt aagcactaca ctagtgtgtc atgtcactag tatgtacttt caagccttta
     3241 aacagaaagg atggctcaca gctagataat aactaagttt gttttcgttt tgaaaaagtt
     3301 tgtatcttgc agagcagaaa agcacttctt tttttgctac ataagtatgt ggtagaaatg
     3361 tatgctaagg taggccagtc aatccttttt tatttatttt gtaaatttgg tcccagaata
     3421 tttctggaag gaaccacagg tagactagct tccattgcag tcccttacct cactaacttc
     3481 ttttgtggct ttatccaggc actgttactg tttgtatgct aaagggttca tttcactggg
     3541 tcttactttc aaagtttgtt ccattttgtg tggtggcatg agcattgtga tcaagccatt
     3601 aagtttggaa acaactgaat gaaagtcgtc tgttataatg tattttactt tatttttaaa
     3661 tttcatttta aattgacaat aattgtacat attcatggga tacatagtga cgtttcaata
     3721 catatcatgt atagtgatta tatcagggta atcggcacat catctcaaac atttatcatt
     3781 tctttgtgtt gggaatttca atatcttttt tttagctgtt tgagattatg taatatatta
     3841 ttgttaacta tagtcatcct acagtggtat agaaactacc tagctgtaat gatgtatctt
     3901 ttaacaaatc taatttattt cttgacagta taggggaaga cttgattaca ccccatggca
     3961 ttacagctaa aaattccaac gttttcagtc tctttgtagc tatgttatcc agacattgat
     4021 ttgtatttac atctcatctt cctttctaag agaaacagtg atgcagaacc tgagagtcaa
     4081 atttaatatt ctctaggtac caaggcaagg gtttatgtta cagtttgtgt actagtccaa
     4141 gtcccaagtt gtgacgatac agctccataa cctaccttta taccacccag ggaaagtata
     4201 cagaagaaat tcttgacttc atctatccga atttctacaa gtcatctgtt atttttctga
     4261 taatctgcct gtgtctcctg gaaacataag gtgtaggttt ctgacacata tatctaacat
     4321 gtaaagaagt aacaatttcc aaaatacctc caaacagcgc cacatcctaa aggaaatttc
     4381 taggtttttc tgctgaaata tccattccag cattgtgttt gtttgctaga gctgctataa
     4441 caaagtatca caaactgagt gccttaaata aacaaaagga atttattact ttgtggttca
     4501 gaaggctaga agttggagat caaggtgtca tcacaccatg gtccctctga aggcaccaag
     4561 gatggatctg tttcaggact cctggcctgt agcagcataa ctccaatctt cacatgatat
     4621 tctcccgttg tatgtgttct tccccaattt tcccttttta taaagatagc agtcagatta
     4681 gattagggcc tatcctaata atttcatttt aacctgactg tctttgtaaa gaccctatct
     4741 gcaaataaaa tcacatgtaa agtattgggg cttaggactc caacatatag atatgtttta
     4801 tatatatggt gagatatata tatatttttt tatatatggt gagatatata tttatatatg
     4861 gtgagatata tatatatatg gtgagatata tatttatata tatggtgaga tatatacata
     4921 ttgtgatata tatatatata tatatatata tatatatata tatgaatttg gtggaacaca
     4981 aaagaacacc tagcaagtat catatgttcc aatttcttaa aagtaaataa aggccttgtg
     5041 ccattggtgg tgttctgaaa
//
