LOCUS       NM_001086               1563 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens arylacetamide deacetylase (AADAC), mRNA.
ACCESSION   NM_001086
VERSION     NM_001086.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1563)
  AUTHORS   Huang,Z., Li,Y., Konishi,K., Sakai,Y., Tashiro,K., Fukami,T. and
            Borjigin,J.
  TITLE     In vitro deacetylation of N-acetylserotonin by arylacetamide
            deacetylase
  JOURNAL   J Pineal Res 75 (1), e12870 (2023)
   PUBMED   37002641
  REMARK    GeneRIF: In vitro deacetylation of N-acetylserotonin by
            arylacetamide deacetylase.
REFERENCE   2  (bases 1 to 1563)
  AUTHORS   Wang,H., Wang,D., Gu,T., Zhu,M., Cheng,L. and Dai,W.
  TITLE     AADAC promotes therapeutic activity of cisplatin and imatinib
            against ovarian cancer cells
  JOURNAL   Histol Histopathol 37 (9), 899-907 (2022)
   PUBMED   35451495
  REMARK    GeneRIF: AADAC promotes therapeutic activity of cisplatin and
            imatinib against ovarian cancer cells.
REFERENCE   3  (bases 1 to 1563)
  AUTHORS   Wang,Y., Fang,T., Wang,Y., Yin,X., Zhang,L., Zhang,X., Zhang,D.,
            Zhang,Y., Wang,X., Wang,H. and Xue,Y.
  TITLE     Impact of AADAC gene expression on prognosis in patients with
            Borrmann type III advanced gastric cancer
  JOURNAL   BMC Cancer 22 (1), 635 (2022)
   PUBMED   35681154
  REMARK    GeneRIF: Impact of AADAC gene expression on prognosis in patients
            with Borrmann type III advanced gastric cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1563)
  AUTHORS   Sakai,Y., Fukami,T., Nagaoka,M., Hirosawa,K., Ichida,H., Sato,R.,
            Suzuki,K., Nakano,M. and Nakajima,M.
  TITLE     Arylacetamide deacetylase as a determinant of the hydrolysis and
            activation of abiraterone acetate in mice and humans
  JOURNAL   Life Sci 284, 119896 (2021)
   PUBMED   34450168
  REMARK    GeneRIF: Arylacetamide deacetylase as a determinant of the
            hydrolysis and activation of abiraterone acetate in mice and
            humans.
REFERENCE   5  (bases 1 to 1563)
  AUTHORS   Levano,K.S., Jaramillo-Valverde,L., Tarazona,D.D., Sanchez,C.,
            Capristano,S., Vasquez-Loarte,T., Solari,L., Mendoza-Ticona,A.,
            Soto,A., Rojas,C., Zegarra-Chaponan,R. and Guio,H.
  TITLE     Allelic and genotypic frequencies of NAT2, CYP2E1, and AADAC genes
            in a cohort of Peruvian tuberculosis patients
  JOURNAL   Mol Genet Genomic Med 9 (10), e1764 (2021)
   PUBMED   34510815
  REMARK    GeneRIF: Allelic and genotypic frequencies of NAT2, CYP2E1, and
            AADAC genes in a cohort of Peruvian tuberculosis patients.
REFERENCE   6  (bases 1 to 1563)
  AUTHORS   Mziaut,H., Korza,G., Hand,A.R., Gerard,C. and Ozols,J.
  TITLE     Targeting proteins to the lumen of endoplasmic reticulum using
            N-terminal domains of 11beta-hydroxysteroid dehydrogenase and the
            50-kDa esterase
  JOURNAL   J Biol Chem 274 (20), 14122-14129 (1999)
   PUBMED   10318829
  REMARK    GeneRIF: two intrinsic endoplasmic reticulum (ER) proteins,
            11beta-hydroxysteroid dehydrogenase, isozyme 1 (11beta-HSD) and the
            50-kDa esterase (E3), sharing some amino acid sequence motifs in
            their N-terminal transmembrane (TM) domains.
REFERENCE   7  (bases 1 to 1563)
  AUTHORS   Ozols,J.
  TITLE     Determination of lumenal orientation of microsomal 50-kDa
            esterase/N-deacetylase
  JOURNAL   Biochemistry 37 (28), 10336-10344 (1998)
   PUBMED   9665742
REFERENCE   8  (bases 1 to 1563)
  AUTHORS   Yamazaki,K., Kusano,K., Tadano,K. and Tanaka,I.
  TITLE     Radiation hybrid mapping of human arylacetamide deacetylase (AADAC)
            locus to chromosome 3
  JOURNAL   Genomics 44 (2), 248-250 (1997)
   PUBMED   9299245
REFERENCE   9  (bases 1 to 1563)
  AUTHORS   Probst,M.R., Beer,M., Beer,D., Jeno,P., Meyer,U.A. and Gasser,R.
  TITLE     Human liver arylacetamide deacetylase. Molecular cloning of a novel
            esterase involved in the metabolic activation of arylamine
            carcinogens with high sequence similarity to hormone-sensitive
            lipase
  JOURNAL   J Biol Chem 269 (34), 21650-21656 (1994)
   PUBMED   8063807
REFERENCE   10 (bases 1 to 1563)
  AUTHORS   Probst,M.R., Jeno,P. and Meyer,U.A.
  TITLE     Purification and characterization of a human liver arylacetamide
            deacetylase
  JOURNAL   Biochem Biophys Res Commun 177 (1), 453-459 (1991)
   PUBMED   2043131
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from L32179.1 and BC032309.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001086.2.
            
            Summary: Microsomal arylacetamide deacetylase competes against the
            activity of cytosolic arylamine N-acetyltransferase, which
            catalyzes one of the initial biotransformation pathways for
            arylamine and heterocyclic amine carcinogens [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.80955.1,
                                           SRR5189664.54243.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142363, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000232892.12/ ENSP00000232892.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               L32179.1           39-242
            205-1563            BC032309.1         183-1541
FEATURES             Location/Qualifiers
     source          1..1563
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.1"
     gene            1..1563
                     /gene="AADAC"
                     /gene_synonym="CES5A1; DAC"
                     /note="arylacetamide deacetylase"
                     /db_xref="GeneID:13"
                     /db_xref="HGNC:HGNC:17"
                     /db_xref="MIM:600338"
     exon            1..185
                     /gene="AADAC"
                     /gene_synonym="CES5A1; DAC"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1247
                     /gene="AADAC"
                     /gene_synonym="CES5A1; DAC"
                     /EC_number="3.1.1.3"
                     /note="arylacetamide deacetylase (esterase)"
                     /codon_start=1
                     /product="arylacetamide deacetylase"
                     /protein_id="NP_001077.2"
                     /db_xref="CCDS:CCDS33877.1"
                     /db_xref="GeneID:13"
                     /db_xref="HGNC:HGNC:17"
                     /db_xref="MIM:600338"
                     /translation="MGRKSLYLLIVGILIAYYIYTPLPDNVEEPWRMMWINAHLKTIQ
                     NLATFVELLGLHHFMDSFKVVGSFDEVPPTSDENVTVTETKFNNILVRVYVPKRKSEA
                     LRRGLFYIHGGGWCVGSAALSGYDLLSRWTADRLDAVVVSTNYRLAPKYHFPIQFEDV
                     YNALRWFLRKKVLAKYGVNPERIGISGDSAGGNLAAAVTQQLLDDPDVKIKLKIQSLI
                     YPALQPLDVDLPSYQENSNFLFLSKSLMVRFWSEYFTTDRSLEKAMLSRQHVPVESSH
                     LFKFVNWSSLLPERFIKGHVYNNPNYGSSELAKKYPGFLDVRAAPLLADDNKLRGLPL
                     TYVITCQYDLLRDDGLMYVTRLRNTGVQVTHNHVEDGFHGAFSFLGLKISHRLINQYI
                     EWLKENL"
     exon            186..408
                     /gene="AADAC"
                     /gene_synonym="CES5A1; DAC"
                     /inference="alignment:Splign:2.1.0"
     exon            409..478
                     /gene="AADAC"
                     /gene_synonym="CES5A1; DAC"
                     /inference="alignment:Splign:2.1.0"
     exon            479..650
                     /gene="AADAC"
                     /gene_synonym="CES5A1; DAC"
                     /inference="alignment:Splign:2.1.0"
     exon            651..1563
                     /gene="AADAC"
                     /gene_synonym="CES5A1; DAC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1541..1546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AADAC"
                     /gene_synonym="CES5A1; DAC"
                     /note="hexamer: AATAAA"
     polyA_site      1563
                     /gene="AADAC"
                     /gene_synonym="CES5A1; DAC"
                     /note="major polyA site"
ORIGIN      
        1 aggtttactt tctgtgtttc tagagaccaa gaagcgggac gttcaccatg ggaagaaaat
       61 cgctgtacct tctgattgtg gggatcctca tagcatatta tatttatacg cctctcccag
      121 ataacgttga ggagccatgg agaatgatgt ggataaacgc acatctgaaa actatacaaa
      181 atttggctac atttgtggag ctcctgggac ttcaccattt tatggattcc tttaaggttg
      241 tcgggagctt tgatgaagtc ccaccaacct cagatgaaaa tgtcactgtg actgagacaa
      301 aattcaacaa cattcttgtt cgggtatatg tgccaaagag aaagtctgaa gcactaagaa
      361 gggggttgtt ttacatccat ggtggaggct ggtgcgtggg aagtgctgct ctaagtggtt
      421 atgacttgct gtcaagatgg acagcagaca gacttgatgc tgtcgtcgta tcaaccaact
      481 acagattagc acctaagtat catttcccaa ttcaatttga agatgtatat aatgccttaa
      541 ggtggttctt acgtaaaaaa gttcttgcaa aatatggtgt gaaccctgag agaatcggta
      601 tttctggaga tagtgcagga gggaatttag ctgcagcagt gactcaacag ctccttgatg
      661 acccagatgt caagatcaaa ctcaagatcc agtctttaat ttatcctgcc cttcagcctc
      721 ttgatgtaga tttaccgtca tatcaagaaa attcaaattt tctatttcta tccaaatcac
      781 tcatggtcag attctggagt gaatatttta ccactgatag atcacttgaa aaagccatgc
      841 tttccagaca acatgtacct gtggaatcaa gtcatctctt caaatttgtt aattggagtt
      901 ccctgctccc tgagaggttt ataaaaggac atgtttataa caatccaaat tatggcagtt
      961 ctgagctggc taaaaaatat ccagggttcc tagatgtgag ggcagcccct ttgttggctg
     1021 atgacaacaa attacgtggc ttacccctga cctatgtcat cacctgtcaa tatgatctct
     1081 taagagatga tggactcatg tatgtcaccc gacttcgcaa cactggggtt caggtgactc
     1141 ataaccatgt tgaggatgga ttccatggag cattttcatt tctgggactt aaaattagtc
     1201 acagacttat aaatcagtat attgagtggc taaaggaaaa tctatagtaa aacatgtagc
     1261 tataacatat tttaaaaata aaatctgaaa acctcagaaa atttgcatta gaaattggtc
     1321 tttcttagaa tggtctagtt aagttccaca tgtagcataa ttcttaaata ggcacttttc
     1381 tgtttttttt ttcttactgt gggatttcat ttcaattttc tacattgtct atctgctttt
     1441 tctgagattt tccttcttac actgttaatc ttattttaaa aaatattaca ttcttgtata
     1501 ctttattttt gtgagttggc tactatttac gatgcaagag aataaatgtg agcaaatatt
     1561 gcc
//
