LOCUS       NM_001080438            1023 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens alpha 1,3-galactosyltransferase 2 (A3GALT2), mRNA.
ACCESSION   NM_001080438 XM_060537
VERSION     NM_001080438.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1023)
  AUTHORS   Tahiri,F., Li,Y., Hawke,D., Ganiko,L., Almeida,I., Levery,S. and
            Zhou,D.
  TITLE     Lack of iGb3 and Isoglobo-Series Glycosphingolipids in Pig Organs
            Used for Xenotransplantation: Implications for Natural Killer
            T-Cell Biology
  JOURNAL   J Carbohydr Chem 32 (1), 44-67 (2013)
   PUBMED   23378701
REFERENCE   2  (bases 1 to 1023)
  AUTHORS   Christiansen,D., Milland,J., Mouhtouris,E., Vaughan,H.,
            Pellicci,D.G., McConville,M.J., Godfrey,D.I. and Sandrin,M.S.
  TITLE     Humans lack iGb3 due to the absence of functional iGb3-synthase:
            implications for NKT cell development and transplantation
  JOURNAL   PLoS Biol 6 (7), e172 (2008)
   PUBMED   18630988
  REMARK    GeneRIF: iGb3 is unlikely to represent natural ligand for NKT cells
            in humans. Furthermore, the absence of iGb3 in humans implies that
            it is another source of foreign Galalpha(1,3)Gal xenoantigen, with
            obvious significance in the field of xenotransplantation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL513327.34.
            
            On Jan 18, 2007 this sequence version replaced XM_060537.10.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on orthologous alignments.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: PMID: 23378701
            MANE Ensembl match        :: ENST00000442999.3/ ENSP00000475261.1
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AL513327.34        118906-118928       c
            24-107              AL513327.34        110637-110720       c
            108-197             AL513327.34        110331-110420       c
            198-335             AL513327.34        109882-110019       c
            336-1023            AL513327.34        104596-105283       c
FEATURES             Location/Qualifiers
     source          1..1023
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.1"
     gene            1..1023
                     /gene="A3GALT2"
                     /gene_synonym="A3GALT2P; IGB3S; IGBS3S"
                     /note="alpha 1,3-galactosyltransferase 2"
                     /db_xref="GeneID:127550"
                     /db_xref="HGNC:HGNC:30005"
                     /db_xref="MIM:619850"
     CDS             1..1023
                     /gene="A3GALT2"
                     /gene_synonym="A3GALT2P; IGB3S; IGBS3S"
                     /note="isoglobotriaosylceramide synthase; iGb3 synthase;
                     alpha 1,3-galactosyltransferase 2, pseudogene"
                     /codon_start=1
                     /product="alpha-1,3-galactosyltransferase 2"
                     /protein_id="NP_001073907.1"
                     /db_xref="CCDS:CCDS60080.1"
                     /db_xref="GeneID:127550"
                     /db_xref="HGNC:HGNC:30005"
                     /db_xref="MIM:619850"
                     /translation="MALKEGLRAWKRIFWRQILLTLGLLGLFLYGLPKFRHLEALIPM
                     GVCPSATMSQLRDNFTGALRPWARPEVLTCTPWGAPIIWDGSFDPDVAKQEARQQNLT
                     IGLTIFAVGRYLEKYLERFLETAEQHFMAGQSVMYYVFTELPGAVPRVALGPGRRLPV
                     ERVARERRWQDVSMARMRTLHAALGGLPGREAHFMFCMDVDQHFSGTFGPEALAESVA
                     QLHSWHYHWPSWLLPFERDAHSAAAMAWGQGDFYNHAAVFGGSVAALRGLTAHCAGGL
                     DWDRARGLEARWHDESHLNKFFWLHKPAKVLSPEFCWSPDIGPRAEIRRPRLLWAPKG
                     YRLLRN"
     exon            1..23
                     /gene="A3GALT2"
                     /gene_synonym="A3GALT2P; IGB3S; IGBS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            24..107
                     /gene="A3GALT2"
                     /gene_synonym="A3GALT2P; IGB3S; IGBS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            108..197
                     /gene="A3GALT2"
                     /gene_synonym="A3GALT2P; IGB3S; IGBS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            198..335
                     /gene="A3GALT2"
                     /gene_synonym="A3GALT2P; IGB3S; IGBS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            336..1023
                     /gene="A3GALT2"
                     /gene_synonym="A3GALT2P; IGB3S; IGBS3S"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggctctca aggagggact cagggcctgg aagagaatct tctggcggca gatcctactt
       61 acacttggcc tcttaggcct gtttctgtat ggcctcccta aattcaggca tctggaagcc
      121 ctcatcccca tgggcgtctg cccttcggcc acaatgtccc agctgagaga caacttcaca
      181 ggtgccctgc gtccctgggc ccggcctgaa gttctgacct gtaccccctg gggggctccc
      241 attatttggg atggctcttt cgacccagat gtggccaagc aagaggctag acagcagaac
      301 ctcaccattg ggctgactat ctttgctgta ggcagatacc tggagaagta cctggagcgc
      361 ttcctggaga cggcggagca gcacttcatg gcgggccaga gcgtgatgta ctacgtgttc
      421 accgagcttc cgggagcggt gccccgcgtg gcgctgggcc cgggacgccg gctgcccgtg
      481 gagcgcgtgg cgcgcgagcg gcgctggcaa gacgtgtcga tggcgcgcat gcgcacgttg
      541 cacgcggcgc tgggcgggct gccgggccgc gaggcgcact tcatgttctg catggacgtg
      601 gaccagcact tcagcggcac ttttgggccc gaggcgctgg ccgagtcggt ggcgcagctg
      661 cactcctggc actaccactg gccgtcgtgg ctgctgccct tcgaacgcga cgcgcattcg
      721 gccgccgcga tggcgtgggg ccagggcgac ttctataacc acgcggcggt gttcgggggc
      781 agcgtggcgg cgctgcgcgg gctgacggcg cactgtgcgg ggggcctgga ctgggaccgc
      841 gcgcgcggcc tggaggcgcg ctggcacgac gagagccacc tcaacaagtt cttctggctg
      901 cacaagcccg ccaaggtgct gtcgcccgag ttctgctgga gcccggacat cggcccgcgg
      961 gccgagatcc gccgcccgcg actgctgtgg gcgcccaagg ggtaccggct gctgcggaac
     1021 tag
//
