LOCUS       NM_138932               9245 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens APOBEC1 complementation factor (A1CF), transcript
            variant 2, mRNA.
ACCESSION   NM_138932
VERSION     NM_138932.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9245)
  AUTHORS   Liu,Y., Yang,J., Weng,D. and Xie,Y.
  TITLE     A1CF Binding to the p65 Interaction Site on NKRF Decreased IFN-beta
            Expression and p65 Phosphorylation (Ser536) in Renal Carcinoma
            Cells
  JOURNAL   Int J Mol Sci 25 (7), 3576 (2024)
   PUBMED   38612387
  REMARK    GeneRIF: A1CF Binding to the p65 Interaction Site on NKRF Decreased
            IFN-beta Expression and p65 Phosphorylation (Ser536) in Renal
            Carcinoma Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9245)
  AUTHORS   Liu,Q., Chen,C.Y. and Chen,G.L.
  TITLE     High APOBEC1 Complementation Factor Expression Positively Modulates
            the Proliferation, Invasion, and Migration of Endometrial Cancer
            Cells Through Regulating P53/P21 Signaling Pathway
  JOURNAL   Cancer Biother Radiopharm 37 (9), 750-758 (2022)
   PUBMED   32818382
  REMARK    GeneRIF: High APOBEC1 Complementation Factor Expression Positively
            Modulates the Proliferation, Invasion, and Migration of Endometrial
            Cancer Cells Through Regulating P53/P21 Signaling Pathway.
REFERENCE   3  (bases 1 to 9245)
  AUTHORS   Kawaguchi,M., Nakayama,A., Aoyagi,Y., Nakamura,T., Shimizu,S.,
            Kawamura,Y., Takao,M., Tamura,T., Hishida,A., Nagayoshi,M.,
            Nagase,M., Ooyama,K., Ooyama,H., Shinomiya,N. and Matsuo,H.
  TITLE     Both variants of A1CF and BAZ1B genes are associated with gout
            susceptibility: a replication study and meta-analysis in a Japanese
            population
  JOURNAL   Hum Cell 34 (2), 293-299 (2021)
   PUBMED   33517564
  REMARK    GeneRIF: Both variants of A1CF and BAZ1B genes are associated with
            gout susceptibility: a replication study and meta-analysis in a
            Japanese population.
REFERENCE   4  (bases 1 to 9245)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 9245)
  AUTHORS   Song,Y., Shao,L., Xue,Y., Ruan,X., Liu,X., Yang,C., Zheng,J.,
            Shen,S., Chen,J., Li,Z. and Liu,Y.
  TITLE     Inhibition of the aberrant A1CF-FAM224A-miR-590-3p-ZNF143 positive
            feedback loop attenuated malignant biological behaviors of glioma
            cells
  JOURNAL   J Exp Clin Cancer Res 38 (1), 248 (2019)
   PUBMED   31186064
  REMARK    GeneRIF: this study revealed that A1CF can upregulate the
            expression of FAM224A via strengthening its stability, which in
            turn, influenced the negative modulation of miR-590-3p on
            transcription factor ZNF143.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9245)
  AUTHORS   Blanc,V., Navaratnam,N., Henderson,J.O., Anant,S., Kennedy,S.,
            Jarmuz,A., Scott,J. and Davidson,N.O.
  TITLE     Identification of GRY-RBP as an apolipoprotein B RNA-binding
            protein that interacts with both apobec-1 and apobec-1
            complementation factor to modulate C to U editing
  JOURNAL   J Biol Chem 276 (13), 10272-10283 (2001)
   PUBMED   11134005
REFERENCE   7  (bases 1 to 9245)
  AUTHORS   Chester,A., Scott,J., Anant,S. and Navaratnam,N.
  TITLE     RNA editing: cytidine to uridine conversion in apolipoprotein B
            mRNA
  JOURNAL   Biochim Biophys Acta 1494 (1-2), 1-13 (2000)
   PUBMED   11072063
  REMARK    Review article
REFERENCE   8  (bases 1 to 9245)
  AUTHORS   Yang,Y., Sowden,M.P. and Smith,H.C.
  TITLE     Induction of cytidine to uridine editing on cytoplasmic
            apolipoprotein B mRNA by overexpressing APOBEC-1
  JOURNAL   J Biol Chem 275 (30), 22663-22669 (2000)
   PUBMED   10833526
REFERENCE   9  (bases 1 to 9245)
  AUTHORS   Lellek,H., Kirsten,R., Diehl,I., Apostel,F., Buck,F. and Greeve,J.
  TITLE     Purification and molecular cloning of a novel essential component
            of the apolipoprotein B mRNA editing enzyme-complex
  JOURNAL   J Biol Chem 275 (26), 19848-19856 (2000)
   PUBMED   10781591
REFERENCE   10 (bases 1 to 9245)
  AUTHORS   Mehta,A., Kinter,M.T., Sherman,N.E. and Driscoll,D.M.
  TITLE     Molecular cloning of apobec-1 complementation factor, a novel
            RNA-binding protein involved in the editing of apolipoprotein B
            mRNA
  JOURNAL   Mol Cell Biol 20 (5), 1846-1854 (2000)
   PUBMED   10669759
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK291982.1, BC130519.1 and
            AL589794.7.
            
            On Aug 13, 2020 this sequence version replaced NM_138932.2.
            
            Summary: Mammalian apolipoprotein B mRNA undergoes site-specific C
            to U deamination, which is mediated by a multi-component enzyme
            complex containing a minimal core composed of APOBEC-1 and a
            complementation factor encoded by this gene. The gene product has
            three non-identical RNA recognition motifs and belongs to the hnRNP
            R family of RNA-binding proteins. It has been proposed that this
            complementation factor functions as an RNA-binding subunit and
            docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest
            that the protein may also be involved in other RNA editing or RNA
            processing events. Several transcript variants encoding a few
            different isoforms have been found for this gene. [provided by
            RefSeq, Nov 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 5. The resulting isoform (2)
            has a shorter and distinct N-terminus compared to isoform 4.
            Variants 2 and 8 encode the same isoform (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.774297.1,
                                           SRR14038196.1163450.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AK291982.1         1-55
            56-2013             BC130519.1         1-1958
            2014-9245           AL589794.7         159409-166640       c
FEATURES             Location/Qualifiers
     source          1..9245
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.23"
     gene            1..9245
                     /gene="A1CF"
                     /gene_synonym="ACF; ACF64; ACF65; APOBEC1CF; ASP"
                     /note="APOBEC1 complementation factor"
                     /db_xref="GeneID:29974"
                     /db_xref="HGNC:HGNC:24086"
                     /db_xref="MIM:618199"
     exon            1..47
                     /gene="A1CF"
                     /gene_synonym="ACF; ACF64; ACF65; APOBEC1CF; ASP"
                     /inference="alignment:Splign:2.1.0"
     exon            48..95
                     /gene="A1CF"
                     /gene_synonym="ACF; ACF64; ACF65; APOBEC1CF; ASP"
                     /inference="alignment:Splign:2.1.0"
     exon            96..239
                     /gene="A1CF"
                     /gene_synonym="ACF; ACF64; ACF65; APOBEC1CF; ASP"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1925
                     /gene="A1CF"
                     /gene_synonym="ACF; ACF64; ACF65; APOBEC1CF; ASP"
                     /note="isoform 2 is encoded by transcript variant 2;
                     APOBEC-1 stimulating protein; apo-B RNA editing protein;
                     apobec-1 complementation factor (ACF) (ASP)"
                     /codon_start=1
                     /product="APOBEC1 complementation factor isoform 2"
                     /protein_id="NP_620310.1"
                     /db_xref="CCDS:CCDS7242.1"
                     /db_xref="GeneID:29974"
                     /db_xref="HGNC:HGNC:24086"
                     /db_xref="MIM:618199"
                     /translation="MESNHKSGDGLSGTQKEAALRALVQRTGYSLVQENGQRKYGGPP
                     PGWDAAPPERGCEIFIGKLPRDLFEDELIPLCEKIGKIYEMRMMMDFNGNNRGYAFVT
                     FSNKVEAKNAIKQLNNYEIRNGRLLGVCASVDNCRLFVGGIPKTKKREEILSEMKKVT
                     EGVVDVIVYPSAADKTKNRGFAFVEYESHRAAAMARRKLLPGRIQLWGHGIAVDWAEP
                     EVEVDEDTMSSVKILYVRNLMLSTSEEMIEKEFNNIKPGAVERVKKIRDYAFVHFSNR
                     EDAVEAMKALNGKVLDGSPIEVTLAKPVDKDSYVRYTRGTGGRGTMLQGEYTYSLGQV
                     YDPTTTYLGAPVFYAPQTYAAIPSLHFPATKGHLSNRAIIRAPSVREIYMNVPVGAAG
                     VRGLGGRGYLAYTGLGRGYQVKGDKREDKLYDILPGMELTPMNPVTLKPQGIKLAPQI
                     LEEICQKNNWGQPVYQLHSAIGQDQRQLFLYKITIPALASQNPAIHPFTPPKLSAFVD
                     EAKTYAAEYTLQTLGIPTDGGDGTMATAAAAATAFPGYAVPNATAPVSAAQLKQAVTL
                     GQDLAAYTTYEVYPTFAVTARGDGYGTF"
     exon            240..374
                     /gene="A1CF"
                     /gene_synonym="ACF; ACF64; ACF65; APOBEC1CF; ASP"
                     /inference="alignment:Splign:2.1.0"
     exon            375..505
                     /gene="A1CF"
                     /gene_synonym="ACF; ACF64; ACF65; APOBEC1CF; ASP"
                     /inference="alignment:Splign:2.1.0"
     exon            506..744
                     /gene="A1CF"
                     /gene_synonym="ACF; ACF64; ACF65; APOBEC1CF; ASP"
                     /inference="alignment:Splign:2.1.0"
     exon            745..909
                     /gene="A1CF"
                     /gene_synonym="ACF; ACF64; ACF65; APOBEC1CF; ASP"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1007
                     /gene="A1CF"
                     /gene_synonym="ACF; ACF64; ACF65; APOBEC1CF; ASP"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1281
                     /gene="A1CF"
                     /gene_synonym="ACF; ACF64; ACF65; APOBEC1CF; ASP"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1487
                     /gene="A1CF"
                     /gene_synonym="ACF; ACF64; ACF65; APOBEC1CF; ASP"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1624
                     /gene="A1CF"
                     /gene_synonym="ACF; ACF64; ACF65; APOBEC1CF; ASP"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1773
                     /gene="A1CF"
                     /gene_synonym="ACF; ACF64; ACF65; APOBEC1CF; ASP"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..9245
                     /gene="A1CF"
                     /gene_synonym="ACF; ACF64; ACF65; APOBEC1CF; ASP"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      8964
                     /gene="A1CF"
                     /gene_synonym="ACF; ACF64; ACF65; APOBEC1CF; ASP"
                     /note="major polyA site"
     regulatory      9223..9228
                     /regulatory_class="polyA_signal_sequence"
                     /gene="A1CF"
                     /gene_synonym="ACF; ACF64; ACF65; APOBEC1CF; ASP"
                     /note="hexamer: TATAAA"
     polyA_site      9245
                     /gene="A1CF"
                     /gene_synonym="ACF; ACF64; ACF65; APOBEC1CF; ASP"
ORIGIN      
        1 ataatcaagg aaaccttttc cgggtgggga tctctgaaat tactcagata acagtgctgt
       61 gccaaaaacc tgtggatttt ctctacaaaa attattgagc aaccctaatt aacctgattt
      121 tttgctgata atcactctca atggaatcaa atcacaaatc cggggatgga ttgagcggca
      181 ctcagaagga agcagccctc cgcgcactgg tccagcgcac aggatatagc ttggtccagg
      241 aaaatggaca aagaaaatat ggtggccctc cacctggttg ggatgctgca ccccctgaaa
      301 ggggctgtga aatttttatt ggaaaacttc cccgagacct ttttgaggat gagcttatac
      361 cattatgtga aaaaatcggt aaaatttatg aaatgagaat gatgatggat tttaatggca
      421 acaatagagg atatgcattt gtaacatttt caaataaagt ggaagccaag aatgcaatca
      481 agcaacttaa taattatgaa attagaaatg ggcgcctctt aggggtttgt gccagtgtgg
      541 acaactgccg attatttgtt gggggcatcc caaaaaccaa aaagagagaa gaaatcttat
      601 cggagatgaa aaaggttact gaaggtgttg tcgatgtcat cgtctaccca agcgctgcag
      661 ataaaaccaa aaaccgaggc tttgccttcg tggagtatga gagtcatcga gcagctgcca
      721 tggcgaggag gaaactgcta ccaggaagaa ttcagttatg gggacatggt attgcagtag
      781 actgggcaga gccagaagta gaagttgatg aagatacaat gtcttcagtg aaaatcctat
      841 atgtaagaaa tcttatgctg tctacctctg aagagatgat tgaaaaggaa ttcaacaata
      901 tcaaaccagg tgctgtggag agggtgaaga aaattcgaga ctatgctttt gtgcacttca
      961 gtaaccgaga agatgcagtt gaggctatga aagctttaaa tggcaaggtg ctggatggtt
     1021 cccccattga agtcacccta gcaaaaccag tggacaagga cagttatgtt aggtataccc
     1081 gaggcacagg tggaaggggc accatgctgc aaggagagta tacctactct ttgggccaag
     1141 tttatgatcc caccacaacc taccttggag ctcctgtctt ctatgccccc cagacctatg
     1201 cagcaattcc cagtcttcat ttcccagcca ccaaaggaca tctcagcaac agagccatta
     1261 tccgagcccc ttctgttaga gaaatttaca tgaatgtacc tgtaggggct gcgggagtga
     1321 gaggactggg cggccgtggc tatttggcat acacaggcct gggtcgagga taccaggtca
     1381 aaggagacaa aagagaagac aaactctatg acattttacc tgggatggag ctcaccccaa
     1441 tgaatcctgt cacattaaaa ccccaaggaa ttaaactcgc tccccagata ttagaagaga
     1501 tttgtcagaa aaataactgg ggacagccag tgtaccagct gcactctgct attggacaag
     1561 accaaagaca gctattcttg tacaaaataa ctattcctgc tctagccagc cagaatcctg
     1621 caatccaccc tttcacacct ccaaagctga gtgcctttgt ggatgaagca aagacgtatg
     1681 cagccgaata caccctgcag accctgggca tccccactga tggaggcgat ggcaccatgg
     1741 ctactgctgc tgctgctgct actgctttcc caggatatgc tgtccctaat gcaactgcac
     1801 ccgtgtctgc agcccagctc aagcaagcgg taacccttgg acaagactta gcagcatata
     1861 caacctatga ggtctaccca acttttgcag tgactgcccg aggggatgga tatggcacct
     1921 tctgaagatg cttttttaaa tttaagaata agacacacaa aactctatta aaaaaaaaaa
     1981 agaaataaac ctctaactcg gtccccaatg atcataaata atatgtttcc taaagaaatg
     2041 cctttccaga gactgtatag cttataccaa ttatagaatc atgaagtaag aacgttattc
     2101 tgaaatgaaa tcaaatgtta aagagccttt tgtttaacag aaagctggag agccactgcc
     2161 ccaaaagttg ttcttccagt cttcctgagt gtttggggag tatgtttaca aatcctgcca
     2221 gggtgaagag agatcttgta gctggcaaga tttgggaggg atggagcaga cctgggcagt
     2281 cagtaataat caagggaagc caagtaaact ccagagtctt acctctggct cacagctgct
     2341 tttgtgatac acaaagtcac aaagaggaaa agggaaggga ggaggttgct tttcaaaatg
     2401 cattcaccat ggctcactgt gtggggcatg attgcaggcc tgagctcatg aaagactgtc
     2461 caagattttg tggtttcaac ctctcttcag cctgaaaatt ccatccagtc gatttgtcac
     2521 agatcaggat cttcctgtcc cctgcagccc atggggactt cctagaaata gatatgatat
     2581 gttgtagatg tggttaaaac aaatccaggc cccattgttt attcagctca ttagtccaca
     2641 cctatttttc cctagaactc ctaccttttc caataatcat gccagcatga aatgaccttt
     2701 tctactttaa aattttttga cttgttcata ttgcttgatt ttcatcatct cagactcatt
     2761 tttctcctac ctaatatcat aaaaaagtaa atcagatata cagaatatca tttatgatac
     2821 ttcttccttt cagcaaattg actgaaaagt cattttaaag agagaagtgc agatttgctc
     2881 tcatttcttt gatattgttg cagtatccac cccaccatct agcaatcaga gatgcttata
     2941 ttaacttggg attagctttg cattatctaa cccatttatt ttaaatctgc caggaaatcc
     3001 tctaactttc cttccttttt gtttcagtaa gtatcaggca gcttcaccat acctgagtcc
     3061 ttttgtcttg aagctgccac agaaaaatct tacagcaatc attgctgatt agaaactgtt
     3121 tcagacaatc agcatgggtg ttatttacca aattcccccc agagtcctag gcctcttctc
     3181 cagaaatatc tgatgatgaa gtgaggggag ggcaacggtg ctacaaaaca cggaacagag
     3241 gtaaagagaa ggcactactt tcttgccata cttgtaaatg attgctttgt tcaaacataa
     3301 ataatcttaa gtccaacacc aaatacctgt tactcctaca tcaatctcat tagtggttta
     3361 agacacagta ctagaatttt cattttttaa aatcccttgg cccttaaaaa aatttacaga
     3421 acacaaagga aaacataaac acaaagacat ggaaaatttt gtcaactcct taatggaatt
     3481 ctgtgatcaa aaagcaggcc agattctaat caaaatcagg taaattttaa tcacaatcag
     3541 aagtacttgt aacatttcag ttgtcctaac tccaatgaga taacaaagcc tccaaggcta
     3601 cagctgaaac tctgaaaggc cctgtgcttt ctactttaca tttagcgtct aatatttcct
     3661 aggacagtag ttcccaaagt aggctgtaca ttagaatctc ctggagagct ttttaaatgc
     3721 taatgccaat aacatatctc ataaaattta cactagaatt tccttggatg ggtgcctggc
     3781 atcagtattt tttaatgatc cctaggtgat ttcaatgtgc acctaggttt gggaattgct
     3841 atattcttgt atttatactc tatctcttta tttcttttcc tttttatttc acttttagta
     3901 aatagaaaaa tgcaattaaa aaatcatcta agttaagaca aatagccaaa tcatatttat
     3961 cccataaata gtatgaattt aaatgtaact tacgtaggct tcaaactaac tctaaaaatg
     4021 agaaagtaaa acaatcttgt cctaaaacaa ttcttagatc caaatttaca ctcccctaca
     4081 gatctgcttt tattctcaaa gacagtgatt acattgacat aacaaatgtc cattggggca
     4141 ggcaaatttc tactgagtct aaaaagcatt ccaaattcta ggagcaaaag ttctgatttt
     4201 ccttaaaatc tttgcaaata aacagcaaag ggtattctgg atgtcttgtc aatgcaaatt
     4261 aggtttgatt tagagaagtt ttaaatttaa tcgcaatgaa aagattagtt aatacatgaa
     4321 tctttttatg agaaaaaatc attattctgg ataaagtcat aattgtttgt ttacaatatt
     4381 aagagcagac acctaaacat acaataatac caaagtattg agaaaattac cactggaaca
     4441 ccatctcaag ttatcacacc atttacctct ttagagccag ttttgtataa gtaggtagaa
     4501 gtggttttgg tttttttgct aaaattttac tttgttttag taatatctag ggaatacttt
     4561 gaattccatt aaaatacctt catagaaagt gttaatgtgt ctaccatgcc atatgtttat
     4621 ttttactttc cccaagttag gtagatagag caagtcctgc taccataagt ttaaaattat
     4681 taagacaacg ggctttttta aattgctggt agaaccaaag gctaattttg cataggttta
     4741 tatttttaga cttaagaaat tagcacctat ataatacctt cataccttct gcatcactat
     4801 caatttttct gtaatttctt atttgaatgc ttcctaattc tttacagaaa aaattaaaat
     4861 ttgtcaccca accaggtgat aataacaaaa caataattta ggaacatcca gtaaatttga
     4921 attagttctc taaattttgg taattaatag cttattgata attaaaatca gcctaatgtt
     4981 gcttaagtag gaggaaattg atcagcaatg ggattgggta tctattttct ttcctataaa
     5041 agtgctgcct cttctcaaat tgctttattt ctctcccact gcattagtat atctagaaca
     5101 gcaccttcaa ctgcaacaaa atataattct cctagatgac taggatatcc tccaatctgg
     5161 tatcatgcca aacaacacta tgtttgggga acagcacccg aaatgctgct aaaaagctac
     5221 ctcatgtcaa gaaaatatgg atttcaaaaa atatctggca cagtggccca tgcctataac
     5281 cccagtactt tgggaggcca aggcaggagg attgctggag gccaggagtt caagaccagc
     5341 ctgggcaaca tggagagact ccgcctctac aaaaaaaaaa aaaacaaatt taatttaatt
     5401 ggccagttgt ggtggcgtgg gcctgtggtc ccagctactt gggaagctaa ggcaggagga
     5461 ttgctggagg cctggagggc aaggctgcag tgagccatgt tcacatcgct gcactccagc
     5521 ctgggtgaca gagcaagacc ctgtctccaa aaaagcaaaa ataaatatct aacaaaaagg
     5581 aacctgtttc caaaccacag tttcttaact ttttcatgat ggaatagaaa ttaaactata
     5641 agtatatact gataatagct gtgcaggaaa ttggttttta ttttacttaa aagtattttt
     5701 tagaaaaaat gttattctga ttgcatagat tagcaaaata ttgcatcaat ataatgttcc
     5761 atttttatta atttttgtta tattctaaat gaccgtttta taattctgtc ttggacaact
     5821 gggccacagt tagaatccac atagacaggg aggttcttag gtgtgccatt tgtagaataa
     5881 agggcaatca agttaatatt cggggtaaat tttcattgca ttctaaccta tgaagtttga
     5941 taaagtatat tattattgaa caactctaac actaagattt cctaaaagta acttacaaca
     6001 aaaaatgaac tatgtgctca atattcacat aaagtcatga ttattctctt cttgcattca
     6061 tataaaagtt cccaggggga agaaaatata tctaaaaatt agactagaaa cttggcactt
     6121 tttatgtatt gtagatacac tttcatatat tgtaaataca tctgttaaag ataaaactaa
     6181 gtttctaaca tagcactaca aggaaacttt ggataaatat ttttaaaaag aaaatgttaa
     6241 taggataact taagattttg tatatactta ttggaagaca ggaagaaact aggcagtaaa
     6301 tattcctacc tgacgtgcaa ccattgtcaa tcaggttttg ttaaactgtc aaatttgatt
     6361 ttgaaatttt agtttgccca aataatatct tgaaaatgct ctgaatttta ctagaacata
     6421 ttcatagaaa gtgtaatgta tctaccaggc tctatgtttg tgtttgccaa cattagaaaa
     6481 acaaagtaag ttgcgctata atgagtgaaa ctaaggaaaa tgagattttt ctgactccca
     6541 ttccctctct taaaaagtaa aatatttaag ctttttttat taaaggaaaa atgggtacag
     6601 aatactctat tgccctccaa atgtccaaca tttttaaagc catgttgtcc aacaatgttt
     6661 atacagaaaa tagaatgcat aggtttaata tagatagcaa tgtatatgta ggctcatttg
     6721 tgggagattg caaactttat gtgcccccag ttctccttgg ttttgtagga aagctaaaag
     6781 aaaaccttgt actctcacta ataatgaaat tcatagccaa tttagaaagg gaaaataacc
     6841 tgaaaaccaa aatacctcat tcatctgaag atgcctggaa taaaatatgg aattcttctg
     6901 tacctacctc ccccttacag acttttctcc tattttgaga gagaaattca agaagaagaa
     6961 tacagcttgt tctctttcca caaatgatac tttgtctaag ggaataggag ataccaagaa
     7021 acagtatctt taaaaaagta agctgcccac aggccttctt ggagaatgaa gaatatcagc
     7081 cccattcagg gtttaccaat gtctctctga ggtgacaata cattctggtt ttccaggaca
     7141 gtcctggctt aggtctgctg tccttctata aatattaaca atgatccctc ttatttccaa
     7201 acgtgtccca gtttagacaa caaattatac agtgtctgcc cccaacacac acacacacac
     7261 cccaccatct ttatgggttg ttgttgtttt cttgttgttt ttaattttgt agaattggct
     7321 ttgtcttctc caaagcagat aacagcttaa actaaagagc ctagctactt ctttctgact
     7381 gagcagggtc atagtaaaca gagaagaatg gatcacttcc tcctctgaaa tctccatcaa
     7441 tccactttct gtccaactat ctctctaccc agcctatttt tggtcctagt tttcctctca
     7501 taacccctgg gctgtgagtc ctgagttctg ccttcatatg gcagagcaag ctagtcatta
     7561 ttatgccagg ttaggtggtg gggcaagaca aaagatagct cttggggaca cttgcttggt
     7621 ctgtagagat ccacagggca ctagtagggt attagagcat ttattggttt ctttcttcct
     7681 tgagttgagt tacttctatc ccaaaacaga caggtcttac gttaaccttc accttaaaaa
     7741 ggatattgcc ttttttcctt ctgcttcaca aatttgctcc aacactaatt cccttgcatt
     7801 tgatttcatc attatgattg ttcatcaacc attcttcacg aaaaatcctc acatcacgtc
     7861 atataaaggt tttattattt ttaatggaaa ataacattga gagattattt tcctttttca
     7921 taaaatttcc ctttttccct ccctctattc tcttcactaa cattggaaat taaacaagtt
     7981 ttacaggctc tattgttatt aaccctcaaa tctattcttc agagaatata tgatcagcct
     8041 gtgtttacta tgcacctact cttataccag aaactgtgaa tacaaataca tatatttcct
     8101 acttctctct ttaattgggg cacacagtcc catggtccat tctgcatttt tcaaaattga
     8161 atataattgc aacacctgat aggttttgcc acttagaatt ctgaaaataa atcaactctg
     8221 ttctaaacct taagtttcca ctattattgc caaactctgg actgatacaa taagcctttt
     8281 aaaaggtgaa tttaacactt cacctattat ggttatttaa gtaaaatgag ttttcaaata
     8341 tttcccccag gagaaatata aaggactatg caaaaataga aggagaaaaa ggttagttag
     8401 aggtccagaa ggagaattaa aacatggaat tgataaattc acctactgat ttatgatgtt
     8461 aatgagcagg tacctataca ttttatttac ttgaaaacat tttggccatt aactatttct
     8521 gttttctaaa tacatttgtg tttataaaat tttaaaatct atatcacaag acttagacat
     8581 gcctttcttt gcaataaagt atatatacct ttttacaaat gtaaatttta ttttgaaact
     8641 tggcattttc tttataattc ctaagatatc tttgggcaca cagactacag ataaatctat
     8701 ttaaatcaat tcatcattat cactggttta aatatttaat gtaaccattg gaatttttat
     8761 tcttattcct tcagagaatt ctccttttct tctatgtttc tgactgcaat acagcccgat
     8821 attgttattc cctatatctt aatgaaaagc aagctgtcag caaaatgcat ttatagtttc
     8881 cagatgttta acaatctctt tcttcttttc ttttttgtta ttatttttat ttatgtgaag
     8941 ttagttagct gaggtaccaa aaaagagaca aagacagtat taaaaagtgt gcataaagca
     9001 cttatttttg tactttagta caatgtttta tagaactttg tgatctatct aaatatatta
     9061 agtaaaatta caccattcac ttgttgggaa aataatcttt ggtttggaag atattaacat
     9121 aatgggcatc ttagaatcat aaatcacatg aaatgagaga caatgcaata ttgtataatt
     9181 cctggatgat gcaattgttt taattgaatt ttcaagtgcc attataaagt tttaaaaatt
     9241 atcaa
//
