LOCUS       NP_055391                586 aa            linear   PRI 27-APR-2025
DEFINITION  APOBEC1 complementation factor isoform 1 [Homo sapiens].
ACCESSION   NP_055391
VERSION     NP_055391.2
DBSOURCE    REFSEQ: accession NM_014576.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 586)
  AUTHORS   Liu,Y., Yang,J., Weng,D. and Xie,Y.
  TITLE     A1CF Binding to the p65 Interaction Site on NKRF Decreased IFN-beta
            Expression and p65 Phosphorylation (Ser536) in Renal Carcinoma
            Cells
  JOURNAL   Int J Mol Sci 25 (7), 3576 (2024)
   PUBMED   38612387
  REMARK    GeneRIF: A1CF Binding to the p65 Interaction Site on NKRF Decreased
            IFN-beta Expression and p65 Phosphorylation (Ser536) in Renal
            Carcinoma Cells.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 586)
  AUTHORS   Liu,Q., Chen,C.Y. and Chen,G.L.
  TITLE     High APOBEC1 Complementation Factor Expression Positively Modulates
            the Proliferation, Invasion, and Migration of Endometrial Cancer
            Cells Through Regulating P53/P21 Signaling Pathway
  JOURNAL   Cancer Biother Radiopharm 37 (9), 750-758 (2022)
   PUBMED   32818382
  REMARK    GeneRIF: High APOBEC1 Complementation Factor Expression Positively
            Modulates the Proliferation, Invasion, and Migration of Endometrial
            Cancer Cells Through Regulating P53/P21 Signaling Pathway.
REFERENCE   3  (residues 1 to 586)
  AUTHORS   Kawaguchi,M., Nakayama,A., Aoyagi,Y., Nakamura,T., Shimizu,S.,
            Kawamura,Y., Takao,M., Tamura,T., Hishida,A., Nagayoshi,M.,
            Nagase,M., Ooyama,K., Ooyama,H., Shinomiya,N. and Matsuo,H.
  TITLE     Both variants of A1CF and BAZ1B genes are associated with gout
            susceptibility: a replication study and meta-analysis in a Japanese
            population
  JOURNAL   Hum Cell 34 (2), 293-299 (2021)
   PUBMED   33517564
  REMARK    GeneRIF: Both variants of A1CF and BAZ1B genes are associated with
            gout susceptibility: a replication study and meta-analysis in a
            Japanese population.
REFERENCE   4  (residues 1 to 586)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (residues 1 to 586)
  AUTHORS   Song,Y., Shao,L., Xue,Y., Ruan,X., Liu,X., Yang,C., Zheng,J.,
            Shen,S., Chen,J., Li,Z. and Liu,Y.
  TITLE     Inhibition of the aberrant A1CF-FAM224A-miR-590-3p-ZNF143 positive
            feedback loop attenuated malignant biological behaviors of glioma
            cells
  JOURNAL   J Exp Clin Cancer Res 38 (1), 248 (2019)
   PUBMED   31186064
  REMARK    GeneRIF: this study revealed that A1CF can upregulate the
            expression of FAM224A via strengthening its stability, which in
            turn, influenced the negative modulation of miR-590-3p on
            transcription factor ZNF143.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 586)
  AUTHORS   Blanc,V., Navaratnam,N., Henderson,J.O., Anant,S., Kennedy,S.,
            Jarmuz,A., Scott,J. and Davidson,N.O.
  TITLE     Identification of GRY-RBP as an apolipoprotein B RNA-binding
            protein that interacts with both apobec-1 and apobec-1
            complementation factor to modulate C to U editing
  JOURNAL   J Biol Chem 276 (13), 10272-10283 (2001)
   PUBMED   11134005
REFERENCE   7  (residues 1 to 586)
  AUTHORS   Chester,A., Scott,J., Anant,S. and Navaratnam,N.
  TITLE     RNA editing: cytidine to uridine conversion in apolipoprotein B
            mRNA
  JOURNAL   Biochim Biophys Acta 1494 (1-2), 1-13 (2000)
   PUBMED   11072063
  REMARK    Review article
REFERENCE   8  (residues 1 to 586)
  AUTHORS   Yang,Y., Sowden,M.P. and Smith,H.C.
  TITLE     Induction of cytidine to uridine editing on cytoplasmic
            apolipoprotein B mRNA by overexpressing APOBEC-1
  JOURNAL   J Biol Chem 275 (30), 22663-22669 (2000)
   PUBMED   10833526
REFERENCE   9  (residues 1 to 586)
  AUTHORS   Lellek,H., Kirsten,R., Diehl,I., Apostel,F., Buck,F. and Greeve,J.
  TITLE     Purification and molecular cloning of a novel essential component
            of the apolipoprotein B mRNA editing enzyme-complex
  JOURNAL   J Biol Chem 275 (26), 19848-19856 (2000)
   PUBMED   10781591
REFERENCE   10 (residues 1 to 586)
  AUTHORS   Mehta,A., Kinter,M.T., Sherman,N.E. and Driscoll,D.M.
  TITLE     Molecular cloning of apobec-1 complementation factor, a novel
            RNA-binding protein involved in the editing of apolipoprotein B
            mRNA
  JOURNAL   Mol Cell Biol 20 (5), 1846-1854 (2000)
   PUBMED   10669759
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF209192.1, AL512366.12,
            AK000324.1 and AL589794.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 30, 2002 this sequence version replaced NP_055391.1.
            
            Summary: Mammalian apolipoprotein B mRNA undergoes site-specific C
            to U deamination, which is mediated by a multi-component enzyme
            complex containing a minimal core composed of APOBEC-1 and a
            complementation factor encoded by this gene. The gene product has
            three non-identical RNA recognition motifs and belongs to the hnRNP
            R family of RNA-binding proteins. It has been proposed that this
            complementation factor functions as an RNA-binding subunit and
            docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest
            that the protein may also be involved in other RNA editing or RNA
            processing events. Several transcript variants encoding a few
            different isoforms have been found for this gene. [provided by
            RefSeq, Nov 2010].
            
            Transcript Variant: This dominant variant (1), also referred to as
            the wild type, differs in the 5' UTR and coding sequence and lacks
            an alternate in-frame segment compared to variant 5. The resulting
            isoform (1) has a shorter and distinct N-terminus and lacks a short
            internal segment compared to isoform 4. Variants 1, 4, and 7 encode
            the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF209192.1, SRR14038196.3338988.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373997.8/ ENSP00000363109.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..586
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.23"
     Protein         1..586
                     /product="APOBEC1 complementation factor isoform 1"
                     /note="APOBEC-1 stimulating protein; apo-B RNA editing
                     protein; apobec-1 complementation factor (ACF) (ASP)"
                     /calculated_mol_wt=64125
     Region          2..586
                     /region_name="hnRNP-R-Q"
                     /note="heterogeneous nuclear ribonucleoprotein R, Q
                     family; TIGR01648"
                     /db_xref="CDD:273732"
     Site            491
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (Q9NQ94.1)"
     CDS             1..586
                     /gene="A1CF"
                     /gene_synonym="ACF; ACF64; ACF65; APOBEC1CF; ASP"
                     /coded_by="NM_014576.4:141..1901"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS7241.1"
                     /db_xref="GeneID:29974"
                     /db_xref="HGNC:HGNC:24086"
                     /db_xref="MIM:618199"
ORIGIN      
        1 mesnhksgdg lsgtqkeaal ralvqrtgys lvqengqrky ggpppgwdaa ppergceifi
       61 gklprdlfed eliplcekig kiyemrmmmd fngnnrgyaf vtfsnkveak naikqlnnye
      121 irngrllgvc asvdncrlfv ggipktkkre eilsemkkvt egvvdvivyp saadktknrg
      181 fafveyeshr aaamarrkll pgriqlwghg iavdwaepev evdedtmssv kilyvrnlml
      241 stseemieke fnnikpgave rvkkirdyaf vhfsnredav eamkalngkv ldgspievtl
      301 akpvdkdsyv rytrgtggrg tmlqgeytys lgqvydpttt ylgapvfyap qtyaaipslh
      361 fpatkghlsn raiirapsvr gaagvrglgg rgylaytglg rgyqvkgdkr edklydilpg
      421 meltpmnpvt lkpqgiklap qileeicqkn nwgqpvyqlh saigqdqrql flykitipal
      481 asqnpaihpf tppklsafvd eaktyaaeyt lqtlgiptdg gdgtmataaa aatafpgyav
      541 pnatapvsaa qlkqavtlgq dlaayttyev yptfavtarg dgygtf
//
