LOCUS       NM_130786               3382 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens alpha-1-B glycoprotein (A1BG), mRNA.
ACCESSION   NM_130786
VERSION     NM_130786.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3382)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   2  (bases 1 to 3382)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   3  (bases 1 to 3382)
  AUTHORS   McDonough,C.W., Gong,Y., Padmanabhan,S., Burkley,B., Langaee,T.Y.,
            Melander,O., Pepine,C.J., Dominiczak,A.F., Cooper-Dehoff,R.M. and
            Johnson,J.A.
  TITLE     Pharmacogenomic association of nonsynonymous SNPs in SIGLEC12,
            A1BG, and the selectin region and cardiovascular outcomes
  JOURNAL   Hypertension 62 (1), 48-54 (2013)
   PUBMED   23690342
  REMARK    GeneRIF: cardiovascular outcomes may differ based on A1BG genotype,
            and antihypertensive treatment strategy.
REFERENCE   4  (bases 1 to 3382)
  AUTHORS   Biswas,S., Sharma,S., Saroha,A., Bhakuni,D.S., Malhotra,R.,
            Zahur,M., Oellerich,M., Das,H.R. and Asif,A.R.
  TITLE     Identification of novel autoantigen in the synovial fluid of
            rheumatoid arthritis patients using an immunoproteomics approach
  JOURNAL   PLoS One 8 (2), e56246 (2013)
   PUBMED   23418544
  REMARK    GeneRIF: Data indicate that five important proteins, vimentin,
            gelsolin, alpha 2 HS glycoprotein (AHSG), glial fibrillary acidic
            protein (GFAP), and alpha1B-glycoprotein (A1BG) were expressed
            higher in Rheumatoid arthritis (RA) synovial fluid than non-RA
            samples.
REFERENCE   5  (bases 1 to 3382)
  AUTHORS   Liu,Y., Luo,X., Hu,H., Wang,R., Sun,Y., Zeng,R. and Chen,H.
  TITLE     Integrative proteomics and tissue microarray profiling indicate the
            association between overexpressed serum proteins and non-small cell
            lung cancer
  JOURNAL   PLoS One 7 (12), e51748 (2012)
   PUBMED   23284758
  REMARK    GeneRIF: Overexpression of serum A1BG is associated with non-small
            cell lung cancer.
REFERENCE   6  (bases 1 to 3382)
  AUTHORS   Yamada,S., Ohira,M., Horie,H., Ando,K., Takayasu,H., Suzuki,Y.,
            Sugano,S., Hirata,T., Goto,T., Matsunaga,T., Hiyama,E., Hayashi,Y.,
            Ando,H., Suita,S., Kaneko,M., Sasaki,F., Hashizume,K., Ohnuma,N.
            and Nakagawara,A.
  TITLE     Expression profiling and differential screening between
            hepatoblastomas and the corresponding normal livers: identification
            of high expression of the PLK1 oncogene as a poor-prognostic
            indicator of hepatoblastomas
  JOURNAL   Oncogene 23 (35), 5901-5911 (2004)
   PUBMED   15221005
REFERENCE   7  (bases 1 to 3382)
  AUTHORS   Bunkenborg,J., Pilch,B.J., Podtelejnikov,A.V. and Wisniewski,J.R.
  TITLE     Screening for N-glycosylated proteins by liquid chromatography mass
            spectrometry
  JOURNAL   Proteomics 4 (2), 454-465 (2004)
   PUBMED   14760718
REFERENCE   8  (bases 1 to 3382)
  AUTHORS   Eiberg,H., Bisgaard,M.L. and Mohr,J.
  TITLE     Linkage between alpha 1B-glycoprotein (A1BG) and Lutheran (LU) red
            blood group system: assignment to chromosome 19: new genetic
            variants of A1BG
  JOURNAL   Clin Genet 36 (6), 415-418 (1989)
   PUBMED   2591067
REFERENCE   9  (bases 1 to 3382)
  AUTHORS   Gahne,B., Juneja,R.K. and Stratil,A.
  TITLE     Genetic polymorphism of human plasma alpha 1B-glycoprotein:
            phenotyping by immunoblotting or by a simple method of 2-D
            electrophoresis
  JOURNAL   Hum Genet 76 (2), 111-115 (1987)
   PUBMED   3610142
REFERENCE   10 (bases 1 to 3382)
  AUTHORS   Ishioka,N., Takahashi,N. and Putnam,F.W.
  TITLE     Amino acid sequence of human plasma alpha 1B-glycoprotein: homology
            to the immunoglobulin supergene family
  JOURNAL   Proc Natl Acad Sci U S A 83 (8), 2363-2367 (1986)
   PUBMED   3458201
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB073611.1, AK056201.1 and
            AC012313.7.
            
            On May 17, 2019 this sequence version replaced NM_130786.3.
            
            Summary: The protein encoded by this gene is a plasma glycoprotein
            of unknown function. The protein shows sequence similarity to the
            variable regions of some immunoglobulin supergene family member
            proteins. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB073611.1, EU794585.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162895, SAMN04284274
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263100.8/ ENSP00000263100.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1715              AB073611.1         1-1715
            1716-1759           AK056201.1         462-505
            1760-3382           AC012313.7         3389-5011           c
FEATURES             Location/Qualifiers
     source          1..3382
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..3382
                     /gene="A1BG"
                     /gene_synonym="A1B; ABG; GAB; HYST2477"
                     /note="alpha-1-B glycoprotein"
                     /db_xref="GeneID:1"
                     /db_xref="HGNC:HGNC:5"
                     /db_xref="MIM:138670"
     exon            1..89
                     /gene="A1BG"
                     /gene_synonym="A1B; ABG; GAB; HYST2477"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1543
                     /gene="A1BG"
                     /gene_synonym="A1B; ABG; GAB; HYST2477"
                     /note="HEL-S-163pA; epididymis secretory sperm binding
                     protein Li 163pA"
                     /codon_start=1
                     /product="alpha-1B-glycoprotein precursor"
                     /protein_id="NP_570602.2"
                     /db_xref="CCDS:CCDS12976.1"
                     /db_xref="GeneID:1"
                     /db_xref="HGNC:HGNC:5"
                     /db_xref="MIM:138670"
                     /translation="MSMLVVFLLLWGVTWGPVTEAAIFYETQPSLWAESESLLKPLAN
                     VTLTCQAHLETPDFQLFKNGVAQEPVHLDSPAIKHQFLLTGDTQGRYRCRSGLSTGWT
                     QLSKLLELTGPKSLPAPWLSMAPVSWITPGLKTTAVCRGVLRGVTFLLRREGDHEFLE
                     VPEAQEDVEATFPVHQPGNYSCSYRTDGEGALSEPSATVTIEELAAPPPPVLMHHGES
                     SQVLHPGNKVTLTCVAPLSGVDFQLRRGEKELLVPRSSTSPDRIFFHLNAVALGDGGH
                     YTCRYRLHDNQNGWSGDSAPVELILSDETLPAPEFSPEPESGRALRLRCLAPLEGARF
                     ALVREDRGGRRVHRFQSPAGTEALFELHNISVADSANYSCVYVDLKPPFGGSAPSERL
                     ELHVDGPPPRPQLRATWSGAVLAGRDAVLRCEGPIPDVTFELLREGETKAVKTVRTPG
                     AAANLELIFVGPQHAGNYRCRYRSWVPHTFESELSDPVELLVAES"
     exon            90..125
                     /gene="A1BG"
                     /gene_synonym="A1B; ABG; GAB; HYST2477"
                     /inference="alignment:Splign:2.1.0"
     exon            126..395
                     /gene="A1BG"
                     /gene_synonym="A1B; ABG; GAB; HYST2477"
                     /inference="alignment:Splign:2.1.0"
     exon            396..668
                     /gene="A1BG"
                     /gene_synonym="A1B; ABG; GAB; HYST2477"
                     /inference="alignment:Splign:2.1.0"
     exon            669..965
                     /gene="A1BG"
                     /gene_synonym="A1B; ABG; GAB; HYST2477"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1247
                     /gene="A1BG"
                     /gene_synonym="A1B; ABG; GAB; HYST2477"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1535
                     /gene="A1BG"
                     /gene_synonym="A1B; ABG; GAB; HYST2477"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..3382
                     /gene="A1BG"
                     /gene_synonym="A1B; ABG; GAB; HYST2477"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1682..1687
                     /regulatory_class="polyA_signal_sequence"
                     /gene="A1BG"
                     /gene_synonym="A1B; ABG; GAB; HYST2477"
                     /note="hexamer: AATAAA"
     polyA_site      1715
                     /gene="A1BG"
                     /gene_synonym="A1B; ABG; GAB; HYST2477"
                     /note="major polyA site"
     polyA_site      2721
                     /gene="A1BG"
                     /gene_synonym="A1B; ABG; GAB; HYST2477"
     polyA_site      2821
                     /gene="A1BG"
                     /gene_synonym="A1B; ABG; GAB; HYST2477"
ORIGIN      
        1 attgctgcag acgctcaccc cagacactca ctgcaccgga gtgagcgcga ccatcatgtc
       61 catgctcgtg gtctttctct tgctgtgggg tgtcacctgg ggcccagtga cagaagcagc
      121 catattttat gagacgcagc ccagcctgtg ggcagagtcc gaatcactgc tgaaaccctt
      181 ggccaatgtg acgctgacgt gccaggccca cctggagact ccagacttcc agctgttcaa
      241 gaatggggtg gcccaggagc ctgtgcacct tgactcacct gccatcaagc accagttcct
      301 gctgacgggt gacacccagg gccgctaccg ctgccgctcg ggcttgtcca caggatggac
      361 ccagctgagc aagctcctgg agctgacagg gccaaagtcc ttgcctgctc cctggctctc
      421 gatggcgcca gtgtcctgga tcacccccgg cctgaaaaca acagcagtgt gccgaggtgt
      481 gctgcggggt gtgacttttc tgctgaggcg ggagggcgac catgagtttc tggaggtgcc
      541 tgaggcccag gaggatgtgg aggccacctt tccagtccat cagcctggca actacagctg
      601 cagctaccgg accgatgggg aaggcgccct ctctgagccc agcgctactg tgaccattga
      661 ggagctcgct gcaccaccac cgcctgtgct gatgcaccat ggagagtcct cccaggtcct
      721 gcaccctggc aacaaggtga ccctcacctg cgtggctccc ctgagtggag tggacttcca
      781 gctacggcgc ggggagaaag agctgctggt acccaggagc agcaccagcc cagatcgcat
      841 cttctttcac ctgaacgcgg tggccctggg ggatggaggt cactacacct gccgctaccg
      901 gctgcatgac aaccaaaacg gctggtccgg ggacagcgcg ccggtcgagc tgattctgag
      961 cgatgagacg ctgcccgcgc cggagttctc cccggagccg gagtccggca gggccttgcg
     1021 gctgcggtgc ctggcgcccc tggagggcgc gcgcttcgcc ctggtgcgcg aggacagggg
     1081 cgggcgccgc gtgcaccgtt tccagagccc cgctgggacc gaggcgctct tcgagctgca
     1141 caacatttcc gtggctgact ccgccaacta cagctgcgtc tacgtggacc tgaagccgcc
     1201 tttcgggggc tccgcgccca gcgagcgctt ggagctgcac gtggacggac cccctcccag
     1261 gcctcagctc cgggcgacgt ggagtggggc ggtcctggcg ggccgagatg ccgtcctgcg
     1321 ctgcgaggga cccatccccg acgtcacctt cgagctgctg cgcgagggcg agacgaaggc
     1381 cgtgaagacg gtccgcaccc ccggggccgc ggcgaacctc gagctgatct tcgtggggcc
     1441 ccagcacgcc ggcaactaca ggtgccgcta ccgctcctgg gtgccccaca ccttcgaatc
     1501 ggagctcagc gaccctgtgg agctcctggt ggcagaaagc tgatgcagcc gcgggcccag
     1561 ggtgctgttg gtgtcctcag aagtgccggg gattctggac tggctccctc ccctcctgtt
     1621 gcagcacaag gccggggtct ctggggggct ggagaagcct ccctcattcc tcccaggaat
     1681 taataaatgt gaagagaggc tctgtttaaa atgtctttgg actcccaggg ctgagtgggc
     1741 tgggatctcg tgtcctcaaa gtggatgggt tctggggtgg ctcctgaggt agaggagtgg
     1801 agaactggct cttaagagca cagttttctt ttcttttttc ttttttgaga cagggtctca
     1861 cactgtcacc caggctggag tgcagtgttg cagtccggct cactgcagtt ttgacctccc
     1921 aggctcaagc gatcctcctg cctcagcctc ccaagtagct gggagcctgg gcatgcatcg
     1981 ccacgtctgg ctaattatta ttttttgtag acagggtctc actgtgttgc ccaagcttgt
     2041 cttgaactcc tggccttaag tgatcctccc acctcagcct cctgagtagc tgggactaca
     2101 ggcatgagcc accatgcctg gccaactcac atttttcttt ctattattta ttttttgtag
     2161 agatgagtct cactatgttg cccaggctgg tcttgaactc ttgggctcaa gtgatcctcc
     2221 cgcctcagcc tcccaaagtg ttgggattac aggtgtgagc cacagcacct ggccaaccaa
     2281 cacttctcag ggcctctttc atctgtgctc ttccaggatg ctgcctctta ctccctgggc
     2341 acctcggcct ggtcccagca ggtatgggca gttgcttgag gctccagaca tactcacctc
     2401 tacctcgacc acatcaaccc catcaccaag aggaggttca gggaagctgc attttgtggt
     2461 cttgtcctcc cagtccaggg tggtagtgct gggctgttcc cagcctccca cagcagagct
     2521 ggacgctgtg gaaatggctg gattcctctg tgttctttcc cattatccct cagctctgag
     2581 tcctcttgtg ccatctgaca tctgatgcct tcccaaccac tgccgagttt ctgcctggag
     2641 cagggcctca aggccctggc acacagaaga tgcgtatcag tattatcaac caatagttga
     2701 tgaattgtgt ttttcaacga atttgctagt gatctggttt actgccttag taatatctag
     2761 ttcctaatat gcctatgcct tttaatgtct gcacagtcta tgatgatgtc acttctctca
     2821 agcctgatgt gtcctctctc tctttcttgc tagtggttta tcaattttta aaaccttttc
     2881 ttgtttattt gtttttgaga cagaattttg ctcttgttgc ccaggctgga gtgcaatggc
     2941 gtgatcttgg ctcacagcaa cctctacctc ctgggttcaa gtgattctcg tgcctcagcc
     3001 tcctgagtag ctgggctgac aggcacccac caccacaccc agctaatttt tatgttttta
     3061 gtagagatgg ggtttcacct tgttgggtgg ccaggctggt ctccaactcc tgagctcaag
     3121 tgatccaccc gcctcagcct cccaaagtgc tgggattaca ggggtgagcc accacgccca
     3181 gccccagctt agttttttaa aaagtttatt ttagccattc taataggtat gtagacatat
     3241 ctaatagtgg ttttccttgc gtttccttaa tgtctgatga tgttaagcat tttttcccca
     3301 agtgcttagt tgccatctat atagcatctt tgatgaaatg tctgtttata tattttgcac
     3361 actttaaaat attgggttgt tt
//
